GSK256066 Trifluoroacetate

Name: GSK256066 Trifluoroacetate
Brand: TargetMol
SKU: T11483
Price: 113 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T11483Cas号 1415560-64-3

别名 GSK 256066 Trifluoroacetate, GSK256066 (2,2,2-trifluoroacetic acid)

GSK 256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor (IC50: 3.2 pM for PDE4B). It can be used for the treatment of chronic obstructive pulmonary disease.

GSK256066 Trifluoroacetate

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产品编号 T11483 别名 GSK 256066 Trifluoroacetate, GSK256066 (2,2,2-trifluoroacetic acid)Cas号 1415560-64-3

GSK 256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor (IC50: 3.2 pM for PDE4B). It can be used for the treatment of chronic obstructive pulmonary disease.

规格	价格	库存
2 mg	¥ 692	5日内发货
5 mg	¥ 1,240	5日内发货
25 mg	¥ 4,280	1-2周
50 mg	¥ 5,570	1-2周
100 mg	¥ 8,580	1-2周

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产品介绍

生物活性

产品描述	GSK 256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor (IC50: 3.2 pM for PDE4B). It can be used for the treatment of chronic obstructive pulmonary disease.
靶点活性	PDE4B:3.2 pM
体外活性	GSK 256066 Trifluoroacetate is highly selective for PDE4, with >380,000-fold versus PDE1/2/3/5/6 and >2500-fold against PDE7, and inhibits PDE4 isoforms A-D with equal affinity.?GSK 256066 Trifluoroacetate inhibits tumor necrosis factor α production by lipopolysaccharide (LPS)-stimulated human peripheral blood monocytes with IC50 of 0.01 nM.GSK 256066 Trifluoroacetate ?is an exceptionally high-affinity inhibitor of PDE4 designed for inhaled administration.
体内活性	GSK 256066 Trifluoroacetate inhibits LPS-induced pulmonary neutrophilia, and no emetic episodes are observed in ferrets.GSK 256066 Trifluoroacetate (GSK256066 2,2,2-trifluoroacetic acid; 0.3-100 μg/kg; intratracheally) inhibits the eosinophil number increased in the bronchoalveolar lavage (BAL) in a dose-dependent fashion, in lipopolysaccharide (LPS)- and ovalbumin (OVA)-induced acute pulmonary inflammation rat models.
别名	GSK 256066 Trifluoroacetate, GSK256066 (2,2,2-trifluoroacetic acid)

化学信息

分子量	632.61
分子式	C₂₉H₂₇F₃N₄O₇S
CAS No.	1415560-64-3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 50 mg/mL (79.04 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5808 mL	7.9038 mL	15.8075 mL	79.0376 mL
5 mM	0.3162 mL	1.5808 mL	3.1615 mL	15.8075 mL
10 mM	0.1581 mL	0.7904 mL	1.5808 mL	7.9038 mL
20 mM	0.0790 mL	0.3952 mL	0.7904 mL	3.9519 mL
50 mM	0.0316 mL	0.1581 mL	0.3162 mL	1.5808 mL