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Search Results for " d1-receptors "

Targets Recommended: Dopamine Receptor 5-HT Receptor Adrenergic Receptor

28

抑制剂 & 化合物

2

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T2226	Pergolide mesylate 甲磺酸培高利特,Pergolide mesylate salt,LY127809,Pergolide methanesulfonate	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Pergolide mesylate salt(LY127809) 是一种有效的，具有口服活性的多巴胺 D1和 D2受体激动剂，是一种 Ergoline 衍生物，可用于帕金森氏病和高泌乳素血症的研究。
T4117	Zuclopenthixol 珠氯噻醇,cis-Clopenthixol,Cisordinol,(Z)-Clopenthixol	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Zuclopenthixol (cis-Clopenthixol) 是一种多巴胺 D1/D2受体的拮抗剂，是一种噻吨衍生物。
T67729	UCM-1306	Dopamine Receptor	GPCR/G Protein; Neuroscience
	UCM-1306 是具有口服活性的人多巴胺 D1 受体变构调节剂 (PAM)。UCM-1306 增加结合在人和小鼠 D1 受体的内源性多巴胺 (DA) 效应。UCM-1306可以改善运动症状，解决与长期帕金森病(PD) 相关的关键共病认知障碍。
T22921	LE 300	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	LE 300 是选择性多巴胺 D1 样受体拮抗剂，作用于人多巴胺 D1 和 D5 受体的Kis 分别为 1.9 nM 和 7.5 nM。在大鼠尾动脉实验中，它作用于5-HT2A 受体的pA2 为 8.32。
T21446	Rotigotine Hydrochloride Rotigotine (Hydrochloride),N 0923,N-0924,Rotigotine HCl,盐酸罗替戈汀,N-0923,罗替戈汀盐酸盐	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Rotigotine Hydrochloride (N-0924) 是多巴胺受体激动剂，是5-HT1A 受体的部分激动剂，以及α2B-肾上腺素受体的拮抗剂，具有抗帕金森病活性。
T0074L	Chlorprothixene hydrochloride NSC 78193,Minithixen,泰尔登盐酸盐,Truxal hydrochloride,盐酸氯普噻吨,NSC 56379,NSC 169899,Minithixen hydrochloride	Dopamine Receptor; 5-HT Receptor; Antibacterial; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Chlorprothixene hydrochloride (Truxal hydrochloride) 是一种多巴胺和组胺受体拮抗剂，具有抗精神病作用，高亲和力地结合人 D1，D2，D3，D5，H1 受体，Ki 分别为 18 nM，2.96 nM，4.56 nM，9 nM 和 3.75 nM。
T23265	RS 67333 hydrochloride RS 67333 (hydrochloride),RS 67333 HCl,盐酸RS67333	5-HT Receptor	GPCR/G Protein; Neuroscience
	RS 67333 hydrochloride (RO5203648) 是一种有效的、选择性的5-HT4 受体 (5-HT4R) 部分激动剂，在豚鼠纹状体中的 pKi 为 8.7。RS 67333 hydrochloride 对其他几种受体的亲和力较低，包括 5-HT1A、5-HT1D、5-HT2A、5-HT2C、多巴胺 D1、D2 和毒蕈碱 M1-M3 受体。RS 67333 hydrochloride 具有神经保护作用，可用于阿尔茨海默病研究。
T60835	SKF83959	Dopamine Receptor	GPCR/G Protein; Neuroscience
	SKF83959 是苯并氮平类化合物，是一种具有选择性和有效性的多巴胺D1受体部分激动剂，对大鼠D1，D5，D2和D3受体的Ki 值分别为 1.18, 7.56, 920 和 399 nM。SKF83959 是 sigma (σ)-1受体的有效变构调节剂，可改善认知功能障碍，用于研究抑郁症和阿尔茨海默病。
T28167	NGB 2904 NGB2904 HCl,NGB-2904,NGB2904	Others; Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience; Others
	NGB 2904 是一种具有口服活性的、选择性的多巴胺(DA) D3受体拮抗剂，可用于具可卡因成瘾。
T14767	BP 897 hydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	BP 897 hydrochloride 是有效的部分多巴胺 D3受体激动剂和弱 D2受体拮抗剂，在多巴胺 D3 受体 (Ki=0.92 nM) 上显示出高亲和力，而在 D2 受体上显示出 70 倍的低亲和力 (Ki=61 nM)。它表现出对可卡因寻求行为的选择性抑制。
T9100	BP 897 2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-	Dopamine Receptor	GPCR/G Protein; Neuroscience
	BP 897 (2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-) 是一种有效的部分多巴胺D3受体激动剂和弱D2受体拮抗剂，在多巴胺 D3 受体(Ki=0.92 nM) 上显示出高亲和力，而在 D2 受体上显示出 70 倍的低亲和力 (Ki=61 nM)。它表现出对可卡因寻求行为的选择性抑制。
T2592	Ropinirole hydrochloride SKF 101468 hydrochloride,SKF-101468A,Ropinirole HCl,盐酸罗匹尼罗	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Ropinirole hydrochloride (SKF-101468A) 是D3/D2受体激动剂，对 D2受体的Ki=29 nM。它对 hD2，hD3和 hD4受体的pEC50分别为 7.4、8.4 和 6.8。它对 D1受体没有亲和力。它对帕金森氏病具有潜在的研究价值。
T0162	Quetiapine ICI204636,Quetiapin,喹硫平	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Quetiapine (ICI204636) 是5-HT 受体激动剂和多巴胺受体拮抗剂，对人5-HT1A 的 pEC50值为 4.77，对人 D2的 pIC50值为 6.33。它用于治疗精神分裂症，以及治疗与 I 型双相情感障碍相关的急性躁狂发作。它对人 D2、HT1、5-HT2A、5-HT2C 受体具有中高等亲和力，pKi 值为 7.25、5.74、7.54和5.55。
T2546	Pimozide R6238,匹莫奇特,匹莫齐特	Potassium Channel; Dopamine Receptor; Adrenergic Receptor; STAT	GPCR/G Protein; JAK/STAT signaling; Membrane transporter/Ion channel; Neuroscience; Stem Cells
	Pimozide (R6238) 是多巴胺受体拮抗剂，对多巴胺 D1、D2 和 D3 受体的 Ki 值分别为 588、1.4 和 2.5 nM。它也是STAT3和STAT5的抑制剂，对 α1 肾上腺素受体也有较高亲和性，Ki 值为 39 nM。
T30603	BT-Sch	Others	Others
	Bt-sch is an imaging agent based on D1 and D2 receptors of dopamine.
T29213	Zelandopam free base YM-435,YM435,MYD-37,MYD37,Zelandopam	Others	Others
	Zelandopam is a dopamine D1 agonist. Zelandopam is a potent stimulant of pancreatic exocrine secretion by acting on DA D1 receptors of the pancreas in dogs. Intravenous administration of Zelandopam produces renal vasodilating and diuretic/natriuretic effe
T4117L2	Zuclopenthixol dihydrochloride	Others	Others
	Zuclopenthixol dihydrochloride is an D1 and D2 dopamine receptors antagonist.
T68963	alpha-Clopenthixol dihydrochloride	Others	Others
	alpha-Clopenthixol dihydrochloride is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
TQ0315	Tandospirone 坦度螺酮,SM-3997	5-HT Receptor	GPCR/G Protein; Neuroscience
	Tandospirone (SM-3997) is a selective partial agonist of 5-HT1A receptor (Ki: 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Kis: 1300-41000 nM).
T68193	Clopenthixol	Others	Others
	Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
T35307	Zicronapine Lu-31130,Lu31-130,Lu 31130,Lu 31-130,Lu31130,Lu-31-130	Others	Others
	Zicronapine( LU 31-130) is an atypical antipsychotic. Zicronapine has monoaminergic activity and multi-receptor properties. It has shown effective antagonism against dopamine D1, D2, and serotonin 5HT2A receptors in vitro and in vivo.
T41014	MLS1082	Others	Others
	MLS1082 is a pyrimidone-derived compound that acts as a positive allosteric modulator of D1-like dopamine receptors. It exhibits an EC 50 value of 123 nM for stimulating G protein signaling in response to dopamine activation.
T69103	Clopenthixol decanoate	Others	Others
	Clopenthixol decanoate is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
T84445	(−)-Apomorphine (hydrochloride hydrate)	Others	Others
	(−)-Apomorphine, a non-selective dopamine receptor agonist, demonstrates pKi values of 6.43 (D1), 7.08 (D2L), 7.59 (D3), 8.36 (D4), and 7.83 (D5) for human recombinant receptors. It induces biphasic effects on locomotor activity and possesses anti-Parkinsonian and neuroprotective properties.[1,2,3,4]
T73823	DETQ	Others	Others
	DETQ是一种具有选择性、变构性和口服活性的多巴胺D1受体增强剂。在表达人类D1受体的HEK293细胞中，通过增加cAMP水平发挥作用，其EC50为5.8nM，Kb为26nM。DETQ对大鼠和小鼠的D1受体效力降低约30倍，对人类D5受体则无活性。
T60418	Ropinirole	Others	Others
	Ropinirole (SKF 101468) 是一种选择性 D2 样家族受体激动剂，但它对 D1 受体没有亲和力。它是一种具有口服活性的有效 D3/D2 受体激动剂，对 D2 受体的 Ki 为 29 nM，对 hD2、hD3 和 hD4 受体的 pEC50 分别为 7.4、8.4 和 6.8。Ropinirole 具有治疗帕金森氏病的研究潜力。
T74668	Zicronapine fumarate	Others	Others
	Zicronapine (Lu 31-130) fumarate 是抗精神病药，主要通过拮抗多巴胺D1/D2受体和5-HT2A受体发挥作用，在动物模型中显示出显著的前认知效果，展现出治疗多种神经和精神疾病的可能性。
T83776	Dopamine D3 Receptor Agonist 13a
	Dopamine D3 受体激动剂13a是一种Dopamine D3 受体激动剂。该化合物选择性地与Dopamine D3 受体结合，相较于Dopamine D1、D2和D4受体(Kis = 0.14、4,600、2.85和756 nM，分别)具有更高的亲和力，并且还能与血清素(5-HT)受体亚型5-HT1A、5-HT2A、5-HT2B和5-HT2C(Kis = 6、54、1.47和252 nM，分别)结合；然而，它是Dopamine D2受体的部分激动剂(EC50 = 2.26 nM，在G蛋白招募分析中)并且作为Dopamine D3受体的拮抗剂(IC50 = 4.62 nM)。在大鼠身上，当剂量为3 mg/kg时，Dopamine D3 受体激动剂13a能减少可卡因自我给药。

化合物

Pergolide mesylate

Cat.No: T2226

Synonym: 甲磺酸培高利特,Pergolide mesylate salt,LY127809,Pergolide methanesulfonate

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Cat.No: T4117

Synonym: 珠氯噻醇,cis-Clopenthixol,Cisordinol,(Z)-Clopenthixol

Target: Dopamine Receptor

Cat.No: T67729

Target: Dopamine Receptor

Cat.No: T22921

Target: Dopamine Receptor, 5-HT Receptor

Rotigotine Hydrochloride

Cat.No: T21446

Synonym: Rotigotine (Hydrochloride),N 0923,N-0924,Rotigotine HCl,盐酸罗替戈汀,N-0923,罗替戈汀盐酸盐

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Chlorprothixene hydrochloride

Cat.No: T0074L

Synonym: NSC 78193,Minithixen,泰尔登盐酸盐,Truxal hydrochloride,盐酸氯普噻吨,NSC 56379,NSC 169899,Minithixen hydrochloride

Target: Dopamine Receptor, 5-HT Receptor, Antibacterial, AChR, Histamine Receptor

RS 67333 hydrochloride

Cat.No: T23265

Synonym: RS 67333 (hydrochloride),RS 67333 HCl,盐酸RS67333

Target: 5-HT Receptor

Cat.No: T60835

Target: Dopamine Receptor

Cat.No: T28167

Synonym: NGB2904 HCl,NGB-2904,NGB2904

Target: Others, Dopamine Receptor, 5-HT Receptor

BP 897 hydrochloride

Cat.No: T14767

Target: Dopamine Receptor

Cat.No: T9100

Synonym: 2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-

Target: Dopamine Receptor

Ropinirole hydrochloride

Cat.No: T2592

Synonym: SKF 101468 hydrochloride,SKF-101468A,Ropinirole HCl,盐酸罗匹尼罗

Target: Dopamine Receptor

Cat.No: T0162

Synonym: ICI204636,Quetiapin,喹硫平

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR, Histamine Receptor

Cat.No: T2546

Synonym: R6238,匹莫奇特,匹莫齐特

Target: Potassium Channel, Dopamine Receptor, Adrenergic Receptor, STAT

Cat.No: T30603

Target: Others

Zelandopam free base

Cat.No: T29213

Synonym: YM-435,YM435,MYD-37,MYD37,Zelandopam

Target: Others

Zuclopenthixol dihydrochloride

Cat.No: T4117L2

Target: Others

alpha-Clopenthixol dihydrochloride

Cat.No: T68963

Target: Others

Cat.No: TQ0315

Synonym: 坦度螺酮,SM-3997

Target: 5-HT Receptor

Cat.No: T68193

Target: Others

Cat.No: T35307

Synonym: Lu-31130,Lu31-130,Lu 31130,Lu 31-130,Lu31130,Lu-31-130

Target: Others

Cat.No: T41014

Target: Others

Clopenthixol decanoate

Cat.No: T69103

Target: Others

(−)-Apomorphine (hydrochloride hydrate)

Cat.No: T84445

Target: Others

Cat.No: T73823

Target: Others

Cat.No: T60418

Target: Others

Zicronapine fumarate

Cat.No: T74668

Target: Others

Dopamine D3 Receptor Agonist 13a

Cat.No: T83776

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00150	IGF2/IGF-II Protein, Human, Recombinant PP9974,胰岛素样生长因子,C11orf43,IGF-II,insulin-like growth factor 2	Human	P. pastoris (Yeast)
	Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in br...
TMPY-04270	GPR133 Protein, Human, Recombinant (His) PGR25,GPR133	Human	HEK293 Cells
	ADGRD1 (Adhesion G Protein-Coupled Receptor D1, also known as GPR133) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. ADGRD1, an orphan member of the adhesion family of G-protein-coupled receptors, is a critical regulator of the response to hypoxia and tumor growth in Glioblastoma (GBM). ADGRD1 represents a novel molecular target in GBM and possibly other malignancies where hypoxia is fundamental to pathogenesis. Variations in the ADGRD1 locus are linked with...

重组蛋白

IGF2/IGF-II Protein, Human, Recombinant

Cat.No: TMPY-00150

Species: Human

Expression System: P. pastoris (Yeast)

GPR133 Protein, Human, Recombinant (His)

Cat.No: TMPY-04270

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0242	Tandospirone-d8
	Tandospirone-d8 是 Tandospirone 的氘代化合物。Tandospirone 的 CAS 号为 87760-53-0。

同位素标记化合物

Tandospirone-d8

Cat.No: TMIJ-0242

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