TMC647055 Choline salt

Name: TMC647055 Choline salt
Brand: TargetMol
SKU: T13170
Rating: 4.5 (1 reviews)

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产品编号 T13170

TMC647055 choline salt is a selective and cell-permeating inhibitor of HCV NS5B (IC50: 34 nM).

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TMC647055 Choline salt

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产品编号 T13170

TMC647055 choline salt is a selective and cell-permeating inhibitor of HCV NS5B (IC50: 34 nM).

规格	价格	库存
2 mg	¥ 1,650	期货
5 mg	¥ 2,490	期货
10 mg	¥ 3,740	期货
50 mg	¥ 10,800	期货
100 mg	¥ 17,400	期货
200 mg	询价	期货
500 mg	询价	期货
1 mL x 10 mM (in DMSO)	¥ 3,990	期货

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TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述

TMC647055 choline salt is a selective and cell-permeating inhibitor of HCV NS5B (IC50: 34 nM).

体外活性

TMC647055 is a novel and potent nonnucleoside the HCV NS5B RNA-dependent RNA polymerase inhibitor. TMC647055 shows high selectivity for HCV when evaluated with a broad panel of human DNA and RNA viruses. TMC647055 shows median EC50 changes in the replicon assay of 9-, 3-, and 371-fold for L392I, V494A, and P495L, respectively, The median EC50 of TMC647055 on NS5B sequences derived from clinical isolates of genotypes 1a, 1b, 3a, 4a, and 6a ranged between 27 nM and 113 nM.

化学信息

分子量	727.91
分子式	C₃₇H₅₃N₅O₈S
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 43 mg/mL (59.07 mM)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3738 mL	6.8690 mL	13.7380 mL	68.6898 mL
5 mM	0.2748 mL	1.3738 mL	2.7476 mL	13.7380 mL
10 mM	0.1374 mL	0.6869 mL	1.3738 mL	6.8690 mL
20 mM	0.0687 mL	0.3434 mL	0.6869 mL	3.4345 mL
50 mM	0.0275 mL	0.1374 mL	0.2748 mL	1.3738 mL