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Targets Recommended: CDK

35

抑制剂 & 化合物

7

天然产物

22

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T8796 CAN508

CDK Cell Cycle/Checkpoint
CAN508 是一种有效的 ATP 竞争性 CDK9/cyclin T1 抑制剂,IC50 为 0.35 μM。它还是 Cdk2-cyclin E 对 ATP 的竞争性抑制剂,Ki 和 IC50 值分别为 13.3 和 20 µM。它对 CDK9/cyclin T 的选择性是其他 CDK/cyclin 复合物的 38 倍,有抗肿瘤活性。
T15771 Lobaplatin

D-19466,络铂

DNA Alkylation DNA Damage/DNA Repair
Lobaplatin (D-19466) 是一种铂 (II) 复合物的非对映混合物,是一种有前途的抗肿瘤化疗药物,在多种肿瘤类型的患者中具有活性。
T0992 Carbenoxolone disodium

Biogastrone,Duogastrone,甘珀酸钠,Bioral

Gap Junction Protein Cytoskeletal Signaling
Carbenoxolone disodium (Duogastrone) 是甘草酸的活性代谢物和人11β-HSD 和细菌3α, 20β-HSD 的抑制剂。它是一种缝隙连接的解耦剂,可抑制牛痘病毒生长,用于消化性、食道和口腔溃疡和炎症的相关研究。
T2455 PFK-015

PFK15,PFK 015

Glucokinase; Autophagy Autophagy; Metabolism
PFK-015 (PFK15) 是一种有效的 PFKFB3 抑制剂,对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性,IC50为20 nM。
T7322 Theliatinib

席栗替尼,西利替尼

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Theliatinib 是一种ATP 竞争性、口服活性和高度选择性的EGFR 抑制剂,Ki 为 0.05 nM,IC50为 3 nM。它具有抗肿瘤活性,对EGFR T790M/L858R 突变体的IC50值为 22 nM。它对EGFR 的选择性是其他激酶的 50 倍以上。
T0866 Propafenone

Rythmol,普罗帕酮,Propafenonum

Potassium Channel; MRP; Sodium Channel Immunology/Inflammation; Membrane transporter/Ion channel
Propafenone (Propafenonum) 是钠通道阻滞剂,它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ,具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡,从而抑制食管癌增殖。
T11918 Lysipressin

Lysine vasopressin,[Lys8]-Vasopressin,赖氨加压素

Others Others
Lysipressin ([Lys8]-Vasopressin) 是一种抗利尿激素,从猪身上发现,能够诱发兔膀胱平滑肌的收缩,激活腺苷酸环化酶。
T39640 JAB-3068

SHP2-IN-6

Phosphatase Metabolism
JAB-3068 (SHP2-IN-6) 是一种高效的 SHP2 抑制剂, 具有抗癌抗肿瘤活性,可用于研究乳腺癌肺癌和食道癌。
T8341 QX 314

QX-314

Others Others
QX 314 (Lidocaine N-ethyl bromide) 是一种非膜渗透性阻滞剂,可抑制酸诱导的食管伤害性 C 纤维神经元活化。
T21223 Isobutyl decanoate

Decanoic acid isobutyl ester

Others Others
Isobutyl decanoate (Decanoic acid isobutyl ester) 可作为食管鳞状细胞癌和肺癌的一种生物标记物,可从葡萄酒中分离得到。
T24610 Pegamotecan

Prothecan,PEG-camptothecin,PEG-beta-CPT

Topoisomerase DNA Damage/DNA Repair
Pegamotecan (PEG-camptothecin)是一种拓扑异构酶I(TOP1)抑制剂,具有抗癌活性,它可用于治疗食管癌、非小细胞肺癌和胰腺癌。
T38387 Compound C108

GTPase GPCR/G Protein
Compound C108 是 GTPase 激活蛋白 SH3 结构域结合蛋白 2 (G3BP2) 的抑制剂。 Compound C108可用于乳腺肿瘤和食管鳞状细胞癌的研究。
T0044 Oxethazaine

奥昔卡因,Oxetacaine

HBV; Sodium Channel Membrane transporter/Ion channel; Microbiology/Virology
Oxethazaine (Oxetacaine) 是一种具有耐酸性和口服活性试剂,是芬特明的酸性前体,有潜力缓解消化性溃疡疾病或食管炎引起的疼痛。
T76717 Serplulimab

HLX 10

COX Immunology/Inflammation; Neuroscience
Serplulimab (HLX 10) 是人源化 PD-1 单克隆抗抗体。Serplulimab 具有抗肿瘤活性,可用于小细胞肺癌和食管鳞状细胞癌。
T6136 Canertinib

PD-183805,CI-1033,卡纽替尼

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Canertinib (CI-1033) 是有效地,不可逆的EGFR 抑制剂;抑制细胞EGFR 和ErbB2自身磷酸化的IC50值分别为7.4和9 nM。
T35394 Sintilimab (anti-PD-1)

IBI308,Sintilimab (anti-PD-1)

PD-1/PD-L1 Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
Sintilimab (IBI308) 是一种人源化的 IgG4 单克隆抗体,具有显著的抗肿瘤活性,通过与 PD-1 结合从而阻断 PD-1 与其配体 (PD-L1 和 PL-L2) 的相互作用,进而恢复内源性抗肿瘤 T 细胞反应。Sintilimab 联合其他化合物来治疗经典霍奇金淋巴瘤、非小细胞肺癌和食管癌。
T1291 Cisapride

西沙必利,西沙比利,Prepulsid,R 51619,Pridesia,Kaudalit,(±)-Cisaprid,Kinestase

Potassium Channel; 5-HT Receptor; HER Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
Cisapride (R 51619) 是一种5-HT4受体激动剂,还是 hERG 抑制剂。它可作用于肠道中的血清素受体,促进肠道蠕动,增加胃排空并减少食管反流。
T61699 Osunprotafib

AC 484,Osunprotafib,AC484,ABBV-CLS-484

Phosphatase Metabolism
ABBV-CLS-484 (Osunprotafib) 是一种具有亚纳摩尔活性的有效的PTPN2抑制剂,具有抗肿瘤活性,可增强T细胞抗肿瘤免疫力。ABBV-CLS-484可用于治疗肿瘤、食管癌和消化系统疾病。
T9636 Dalpiciclib

SHR-6390

CDK Cell Cycle/Checkpoint
Dalpiciclib (SHR-6390) 是一种高选择性、口服生物利用度和相当效力的 CDK4 和 CKD6 抑制剂,IC50 分别为 12.4 nM 和 9.9 nM。它通过抑制磷酸化 Rb 蛋白和诱导 G1 细胞周期阻滞在食管鳞状细胞癌中发挥有效的抗肿瘤活性。
T7057 Methylstat

Histone Demethylase; Others Chromatin/Epigenetic; Others
Methylstat 是一种含有 Jumonji C 结构域的组蛋白去甲基化酶 (JMJD) 抑制剂的甲酯前药,具有良好的细胞渗透性。在体外试验中,methylstat 的游离酸可抑制 JMJD2A、JMJD2C、JMJD2E、PHF8 和 JMJD3,IC50 值分别约为 4.3、3.4、5.9、10 和 43 µM。 Methylstat 抑制 JMJD2C 敏感的食管癌细胞系 KYSE150 的生长,GI50 为 5.1 µM,而 methylstat 的游离酸在高达 100 µM 时不抑制细胞生长。 Methylstat 以浓度依赖性方式在多个位点诱导组蛋白高甲基化(KYSE150 细胞中 H3K4me3 和 H3K9me3 的 EC50 = 10.3 和 8.6 µM,MCF-7 细胞中的 EC50 分别为 6.7 和 6.3 µM)。
T33471 Monoethanolamine Oleate

FO-611,Ethamolin,brand name: Ethamolin,FO 611,FO611

Others Others
Monoethanolamine Oleate (Etamolin, FO-611) is a hardening agent used in the treatment of varicose and esophageal veins.
T1552L Itopride free base

HSR803,HSR-803,Itopride hydrochloride,HSR 803

Others Others
Itopride HCl is an AChE inhibitor and dopamine D2 receptor antagonist. It inhibits lower esophageal sphincter relaxation. It also used to treat functional dyspepsia and gastroesophageal reflux disease
T80599 Dectrekumab

QAX576

Dectrekumab (QAX576) 是针对IL-13的人源化单克隆抗体。它能显著降低嗜酸性粒细胞性食管炎 (EoE) 患者上皮内的嗜酸性粒细胞数量,并改善食管疾病相关的转录失调情况,适用于免疫炎症研究。
T11691 IV-23

Others Others
IV-23, a potent inhibitor of cell growth both in vitro and in vivo, effectively reduces colony formation, arrests the cell cycle at the M phase, and induces apoptosis in esophageal squamous cell carcinoma through Noxa-mediated pathways. This compound emerges as a promising anticancer agent with significant potential.
T74997 ERK-IN-6

Others Others
ERK-IN-6 (compound 6g) 是有效的食管鳞状细胞癌 (ESCC) 的抗增殖剂。ERK-IN-6 通过ERK 通路诱导细胞凋亡。ERK-IN-6 可用于食管鳞状细胞癌的研究。
T36709 N’-Nitrosonornicotine

Others Others
N’-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N’-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N’-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2 1.Hecht, S....
T35822 CAY10722

Others Others
CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patie...
T63199 Dalpiciclib hydrochloride

Others Others
Dalpiciclib (SHR-6390) hydrochloride 是高度选择性的、口服具有活力的CDK4/6抑制剂,他们的IC50值分别为 12.4 nM 和 9.9 nM,能够作用于乳腺癌和食道鳞状细胞癌,具有出抗肿瘤作用。
T40572 Lesogaberan napadisylate

AZD-3355 napadisylate

Others Others
Lesogaberan (AZD-3355) napadisylate is a potent and selective agonist of GABA B receptors, with an EC 50 of 8.6 nM for human recombinant GABA B receptors. It demonstrates an affinity (Ki) of 5.1 nM for rat GABA B receptors and 1.4 μM for GABA A receptors, as determined by its displacement of [3H]GABA binding in brain membranes. Notably, Lesogaberan napadisylate exerts a peripheral mode of action, inhibiting transient lower esophageal sphincter relaxation.
T76997 Socazolimab

Socazolimab (ZKAB001) 是一种针对PD-L1的单克隆抗体,在治疗复发或转移性宫颈癌方面展现了持久的安全性和有效性。此外,Socazolimab 也被认为在小细胞肺癌、食管鳞状细胞癌 (ESCC)、晚期尿路上皮癌及骨肉瘤治疗中具有潜在应用价值。
T72912 (R)-Afatinib

(R)-BIBW 2992

Others Others
(R)-Afatinib ((R)-BIBW 2992) 是 Afatinib 异构体。Afatinib 是一种口服有效且不可逆的 ErbB 家族 (EGFR 和HER2) 双特异性抑制剂,对 EGFRwt, EGFRL858R, EGFRL858R/T790M 和 HER2 的 IC50值分别为 0.5 nM、0.4 nM、10 nM 和 14 nM。Afatinib 可用于食管鳞状细胞癌 (ESCC)、非小细胞肺癌 (NSCLC) 和胃癌的研究。
T36714 Sucrose octasulfate (potassium salt)

Others Others
Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. It can bind to exosite II of thrombin (KD = ~1.4 μM) and inhibit its catalytic activity (IC50 = 4.5 μM) and, as such, has been used as a surrogate for heparin. Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by pr...
T35616 Migrastatin

Others Others
Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 μM, respectively) and inhibits calcium mobilization induced by carbamoylcholine in SK-N-SH cells (IC50= 28 μM), as well as in primary rat bladder smooth muscle cells.1Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay (IC50= 10 μg/ml) and 4T1 mouse mam...
T64075 Afatinib oxalate

Others Others
Afatinib (BIBW 2992) oxalate 是一种不可逆的、口服具有活力的 ErbB 家族 (EGFR 和 HER2) 双特异性抑制剂,能够作用于 EGFRwt (IC50: 0.5 nM)、EGFRL858R (IC50: 0.4 nM)、EGFRL858R/T790M (IC50: 10 nM) 和 HER2 (IC50: 14 nM)。Afatinib oxalate 能够用于研究食管鳞状细胞癌 (ESCC)、非小细胞肺癌 (NSCLC) 和胃癌。
T72215 Lesogaberan hydrochloride

AZD-3355 hydrochloride

Others Others
Lesogaberan (AZD-3355) hydrochloride 是一种有效的选择性 GABAB 受体激动剂,对人重组 GABAB 受体的 EC50为 8.6 nM。通过脑膜中 [3H]GABA 结合位移测量,Lesogaberan hydrochloride 对大鼠 GABAB 和 GABAA 受体的亲和力 (Kis):分别为 5.1 nM 和 1.4 μM。Lesogaberan hydrochloride 通过外周作用模式抑制短暂的食管下括约肌松弛。

化合物

CAN508
Cat.No: T8796
Synonym:
Target: CDK
Lobaplatin
Cat.No: T15771
Synonym: D-19466,络铂
Target: DNA Alkylation
Carbenoxolone disodium
Cat.No: T0992
Synonym: Biogastrone,Duogastrone,甘珀酸钠,Bioral
Target: Gap Junction Protein
PFK-015
Cat.No: T2455
Synonym: PFK15,PFK 015
Target: Glucokinase, Autophagy
Theliatinib
Cat.No: T7322
Synonym: 席栗替尼,西利替尼
Target: EGFR
Propafenone
Cat.No: T0866
Synonym: Rythmol,普罗帕酮,Propafenonum
Target: Potassium Channel, MRP, Sodium Channel
Lysipressin
Cat.No: T11918
Synonym: Lysine vasopressin,[Lys8]-Vasopressin,赖氨加压素
Target: Others
JAB-3068
Cat.No: T39640
Synonym: SHP2-IN-6
Target: Phosphatase
QX 314
Cat.No: T8341
Synonym: QX-314
Target: Others
Isobutyl decanoate
Cat.No: T21223
Synonym: Decanoic acid isobutyl ester
Target: Others
Pegamotecan
Cat.No: T24610
Synonym: Prothecan,PEG-camptothecin,PEG-beta-CPT
Target: Topoisomerase
Compound C108
Cat.No: T38387
Synonym:
Target: GTPase
Oxethazaine
Cat.No: T0044
Synonym: 奥昔卡因,Oxetacaine
Target: HBV, Sodium Channel
Serplulimab
Cat.No: T76717
Synonym: HLX 10
Target: COX
Canertinib
Cat.No: T6136
Synonym: PD-183805,CI-1033,卡纽替尼
Target: EGFR
Sintilimab (anti-PD-1)
Cat.No: T35394
Synonym: IBI308,Sintilimab (anti-PD-1)
Target: PD-1/PD-L1
Cisapride
Cat.No: T1291
Synonym: 西沙必利,西沙比利,Prepulsid,R 51619,Pridesia,Kaudalit,(±)-Cisaprid,Kinestase
Target: Potassium Channel, 5-HT Receptor, HER
Osunprotafib
Cat.No: T61699
Synonym: AC 484,Osunprotafib,AC484,ABBV-CLS-484
Target: Phosphatase
Dalpiciclib
Cat.No: T9636
Synonym: SHR-6390
Target: CDK
Methylstat
Cat.No: T7057
Synonym:
Target: Histone Demethylase, Others
Monoethanolamine Oleate
Cat.No: T33471
Synonym: FO-611,Ethamolin,brand name: Ethamolin,FO 611,FO611
Target: Others
Itopride free base
Cat.No: T1552L
Synonym: HSR803,HSR-803,Itopride hydrochloride,HSR 803
Target: Others
Dectrekumab
Cat.No: T80599
Synonym: QAX576
Target:
IV-23
Cat.No: T11691
Synonym:
Target: Others
ERK-IN-6
Cat.No: T74997
Synonym:
Target: Others
N’-Nitrosonornicotine
Cat.No: T36709
Synonym:
Target: Others
CAY10722
Cat.No: T35822
Synonym:
Target: Others
Dalpiciclib hydrochloride
Cat.No: T63199
Synonym:
Target: Others
Lesogaberan napadisylate
Cat.No: T40572
Synonym: AZD-3355 napadisylate
Target: Others
Socazolimab
Cat.No: T76997
Synonym:
Target:
(R)-Afatinib
Cat.No: T72912
Synonym: (R)-BIBW 2992
Target: Others
Sucrose octasulfate (potassium salt)
Cat.No: T36714
Synonym:
Target: Others
Migrastatin
Cat.No: T35616
Synonym:
Target: Others
Afatinib oxalate
Cat.No: T64075
Synonym:
Target: Others
Lesogaberan hydrochloride
Cat.No: T72215
Synonym: AZD-3355 hydrochloride
Target: Others
Cat. No. Product Name Target Signaling Pathways
T6S1844 Tenacissoside H

Tenacissimoside C,通关藤苷H

Others Others
Tenacissoside H (Tenacissimoside C) 是一种分离自通关藤中的天然产物,具有抗肿瘤作用。
T4S1796 Heterophyllin B

PI3K PI3K/Akt/mTOR signaling
Heterophyllin B 是一种活性环肽,从 Pseudostellaria heterophylla 中分离得到,可用于研究食管癌。
TN1721 Gypenoside L

ERK; p38 MAPK; Calcium Channel; NF-κB; ROS Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Metabolism; NF-κB
Gypenoside L 是存在于绞股蓝中的一种皂苷,可增加 SA-β-半乳糖苷酶活性,促进衰老相关分泌细胞因子的产生。它还可以激活p38和ERK MAPK 通路和NF-κB 通路以诱导衰老,具有抗肿瘤和抗炎活性。
T2836 Isorhamnetin

3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin

MEK; PI3K; Endogenous Metabolite MAPK; Metabolism; PI3K/Akt/mTOR signaling
Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮,可通过抑制MEK1和PI3K 来抑制皮肤癌。
T75569 Xerophilusin B

Others Others
Xerophilusin B 是一种从 Isodon xerophilus 中分离得到的抗癌剂,对食管鳞状细胞癌 (ESCC) 细胞系表现出抗增殖作用,可诱导 G2/M 细胞周期停滞,介导细胞凋亡 apoptosis。
TN4166 Griffipavixanthone

ERK; Raf; ROS; MEK; Caspase Apoptosis; Immunology/Inflammation; MAPK; Proteases/Proteasome
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. It can inhibit tumor metastasis
T36448 (E)-Ajoene

Others Others
(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth...

天然产物

Tenacissoside H
Cat.No: T6S1844
Synonym: Tenacissimoside C,通关藤苷H
Target: Others
Heterophyllin B
Cat.No: T4S1796
Synonym:
Target: PI3K
Gypenoside L
Cat.No: TN1721
Synonym:
Target: ERK, p38 MAPK, Calcium Channel, NF-κB, ROS
Isorhamnetin
Cat.No: T2836
Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin
Target: MEK, PI3K, Endogenous Metabolite
Xerophilusin B
Cat.No: T75569
Synonym:
Target: Others
Griffipavixanthone
Cat.No: TN4166
Synonym:
Target: ERK, Raf, ROS, MEK, Caspase
(E)-Ajoene
Cat.No: T36448
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPH-02234 TMPRSS11A Protein, Human, Recombinant (His)

Epidermal type-II transmembrane serine protease,Transmembran...

Human E. coli
Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
TMPY-01897 PRSS3 Protein, Human, Recombinant (His)

PRSS4,TRY4,TRY3,RP11-176F3.3,T9,MTG,protease, serine 3

Human HEK293 Cells
Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their ...
TMPY-02062 SULT1A1 Protein, Human, Recombinant (His)

HAST1/HAST2,PST,P-PST,ST1A1,STP,sulfotransferase family, cyt...

Human E. coli
Sulfate conjugation catalyzed by cytosolic sulfotransferase (SULT) enzymes. The SULTs are Phase II drug-metabolizing enzymes that catalyze the addition of a sulfuryl moiety to both endogenous compounds, including steroids and neurotransmitters, and certain xenobiotics, including N-hydroxy-2-acetylaminoflourine and phenolic compounds, like alpha-naphthol. SULTs may be involved in the individual genetic disposition, species differences, and organotropisms for toxicological effects of chemicals. Pa...
TMPY-01442 DMBT1 Protein, Human, Recombinant (His)

GP340,deleted in malignant brain tumors 1,muclin

Human HEK293 Cells
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo...
TMPK-01500 HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi)

CTAG1,CT6.1,CTAG1B,LAGE2A,MY-ESO-1,LAGE-2,MHC,NY-ESO-1,ESO1C...

Human HEK293 Cells
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01539 HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi), Biotinylated

CTAG1B,CT6.1,MY-ESO-1,LAGE2A,NY-ESO-1,MHC,LAGE-2,ESO1CTAG,CT...

Human HEK293 Cells
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01449 HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (E. coli, His & Avi)

MHC,CT6.1,CTAG1,LAGE-2,MY-ESO-1,NY-ESO-1,ESO1CTAG,LAGE2A,CTA...

Human E. coli
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01546 HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi)

MHC,CT6.1,CTAG1,MY-ESO-1,ESO1CTAG,CTAG1B,NY-ESO-1,LAGE-2,LAG...

Human HEK293 Cells
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01513 HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi), Biotinylated

CT6.1,LAGE2A,MHC,CTAG1B,CTAG1,ESO1CTAG,MY-ESO-1,LAGE-2,NY-ES...

Human HEK293 Cells
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01448 HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (E. coli, His & Avi)

MHC,LAGE-2,NY-ESO-1,ESO1CTAG,MY-ESO-1,CTAG1B,CTAG1,CT6.1,LAG...

Human E. coli
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01543 HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi)

LAGE2A,ESO1CTAG,LAGE-2,CTAG1,CT6.1,MHC,MY-ESO-1,NY-ESO-1,CTA...

Human HEK293 Cells
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01499 HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein, Human, MHC (His & Avi)

ESO1CTAG,LAGE-2,CTAG1B,LAGE2A,MY-ESO-1,CT6.1,NY-ESO-1,CTAG1,...

Human HEK293 Cells
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01497 HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

MY-ESO-1,MHC,ESO1CTAG,NY-ESO-1,CTAG1,LAGE2A,LAGE-2,CT6.1,CTA...

Human HEK293 Cells
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPH-02681 GPX7 Protein, Mouse, Recombinant (His & Myc)

Glutathione peroxidase 7,Gpx7

Mouse E. coli
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. GPX7 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 26.7 kDa and the accession number is Q99LJ6.
TMPJ-00703 Gankyrin Protein, Human, Recombinant

PSMD10,Gankyrin,26S Proteasome Non-ATPase Regulatory Subunit...

Human E. coli
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
TMPK-01160 GPA34/VSIG1 Protein, Mouse, Recombinant (His)

dJ889N15.1,Glycoprotein A34,VSIG1,MGC44287,1700062D20Rik,Gpa...

Mouse HEK293 Cells
VSIG1, a cell adhesion protein of the immunoglobulin superfamily, is preferentially expressed in stomach, testis, and certain gastric, esophageal and ovarian cancers. Here, we describe the expression patterns of three alternatively spliced isoforms of mouse Vsig1 during pre- and postnatal development of stomach and potential function of Vsig1 in differentiation of gastric epithelia. VSIG1 is required for the establishment of glandular versus squamous epithelia in the stomach. GPA34/VSIG1 Protein...
TMPK-01076 GPA34/VSIG1 Protein, Human, Recombinant (His)

MGC44287,1700062D20Rik,Glycoprotein A34,VSIG1,Gpa34,dJ889N15...

Human HEK293 Cells
VSIG1, a cell adhesion protein of the immunoglobulin superfamily, is preferentially expressed in stomach, testis, and certain gastric, esophageal and ovarian cancers. Here, we describe the expression patterns of three alternatively spliced isoforms of mouse Vsig1 during pre- and postnatal development of stomach and potential function of Vsig1 in differentiation of gastric epithelia. VSIG1 is required for the establishment of glandular versus squamous epithelia in the stomach. GPA34/VSIG1 Protein...
TMPJ-01372 Cornulin Protein, Human, Recombinant (His)

Tumor-Related Protein,58 kDa Heat Shock Protein,PDRC1,C1orf1...

Human E. coli
Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and ...
TMPY-02129 Transglutaminase 3/TGM3 Protein, Human, Recombinant (His)

transglutaminase 3,UHS2,TGE

Human Baculovirus Insect Cells
Transglutaminases (TGase) are a family of calcium-dependent acyl-transfer enzymes ubiquitously expressed in mammalian cells and responsible for catalyzing covalent cross-links between proteins or peptides. Transglutaminase 3 (TGM3) is a member of a family of Ca2+-dependent enzymes that catalyze covalent cross-linking reactions between proteins or peptides. TGM3 isoform is widely expressed and is important for epithelial barrier formation. It is a zymogen, requiring proteolysis for activity. Calc...
TMPY-02796 KIAA0101 Protein, Human, Recombinant (His)

L5,NS5ATP9,p15PAF,OEATC1,p15(PAF),OEATC,PAF,p15/PAF,OEATC-1,...

Human E. coli
KIAA11, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor that interacts with proliferating cell nuclear antigen(PCNA). It was initially isolated in a yeast two-hybrid screen for PCNA binding partners and was shown to bind PCNA competitively with the cell cycle regulator p21(WAF). KIAA11 is localized primarily in the nucleus. It shares the conserved PCNA binding motif with several other PCNA binding proteins including CDK inhibitor p21. KIAA11 is involved in cell ...
TMPY-01204 SMYD2 Protein, Human, Recombinant (His)

ZMYND14,SET and MYND domain containing 2,HSKM-B,KMT3C

Human Baculovirus Insect Cells
SET and MYND domain-containing protein 2, also known as HSKM-B, SMYD2, and KMT3C, is a member of the SMYD protein family. It contains one MYND-type zinc finger and one SET domain. Not much is known about SMYD2. However, the interest in better understanding the roles of SMYD2 has grown because of reports indicating that SMYD2 methylates p53 and histone H3. In Xenopus, SMYD1 and SMYD2 were expressed in various muscle tissues and related to muscle cell differentiation. SMYD2 mRNA is most highly exp...
TMPY-02228 p53 Protein, Cynomolgus, Recombinant

tumor protein p53,p53,TP53

Cynomolgus E. coli
p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damag...

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TMPRSS11A Protein, Human, Recombinant (His)
Cat.No: TMPH-02234
Species: Human
Expression System: E. coli
PRSS3 Protein, Human, Recombinant (His)
Cat.No: TMPY-01897
Species: Human
Expression System: HEK293 Cells
SULT1A1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02062
Species: Human
Expression System: E. coli
DMBT1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01442
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01500
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01539
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (E. coli, His & Avi)
Cat.No: TMPK-01449
Species: Human
Expression System: E. coli
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01546
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01513
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (E. coli, His & Avi)
Cat.No: TMPK-01448
Species: Human
Expression System: E. coli
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01543
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01499
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
Cat.No: TMPK-01497
Species: Human
Expression System: HEK293 Cells
GPX7 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02681
Species: Mouse
Expression System: E. coli
Gankyrin Protein, Human, Recombinant
Cat.No: TMPJ-00703
Species: Human
Expression System: E. coli
GPA34/VSIG1 Protein, Mouse, Recombinant (His)
Cat.No: TMPK-01160
Species: Mouse
Expression System: HEK293 Cells
GPA34/VSIG1 Protein, Human, Recombinant (His)
Cat.No: TMPK-01076
Species: Human
Expression System: HEK293 Cells
Cornulin Protein, Human, Recombinant (His)
Cat.No: TMPJ-01372
Species: Human
Expression System: E. coli
Transglutaminase 3/TGM3 Protein, Human, Recombinant (His)
Cat.No: TMPY-02129
Species: Human
Expression System: Baculovirus Insect Cells
KIAA0101 Protein, Human, Recombinant (His)
Cat.No: TMPY-02796
Species: Human
Expression System: E. coli
SMYD2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01204
Species: Human
Expression System: Baculovirus Insect Cells
p53 Protein, Cynomolgus, Recombinant
Cat.No: TMPY-02228
Species: Cynomolgus
Expression System: E. coli
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