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Pipequaline (PK-8165) 是一种苯二氮卓受体部分激动剂,有抗焦虑作用。
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Pipequaline (PK-8165) 是一种苯二氮卓受体部分激动剂,有抗焦虑作用。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 627 | 5日内发货 | |
5 mg | ¥ 1,280 | 5日内发货 | |
25 mg | ¥ 4,840 | 6-8周 | |
50 mg | ¥ 6,290 | 6-8周 | |
100 mg | ¥ 9,850 | 6-8周 | |
1 mL x 10 mM (in DMSO) | ¥ 1,430 | 5日内发货 |
产品描述 | Pipequaline (PK-8165) is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely related to other drugs of this type. The drug has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and very little sedative, amnestic or anticonvulsant effects, and so is classified as a nonbenzodiazepine anxiolytic. |
体外活性 | Pipequaline is extensively bound to plasma proteins: i.e. human serum albumin (HSA), alpha-1-acid glycoprotein (AAG), lipoproteins and blood cells, mainly erythrocytes[1]. |
体内活性 | Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. In small intravenous doses, pipequaline potentiated the effect of microiontophoretically-applied flurazepam whereas, in larger doses, it suppressed the effects of microiontophoretically-applied flurazepam and of intravenously administered lorazepam on kainate-induced activation. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3]. |
动物实验 | Rats: Pipequaline is dissolved in water to give injection volumes of 2 mL/kg. Rats are injected with 5, 10, and 50 mg/kg pipequaline. Infrared cells in the walls of the box provided automated measures of locomotor activity and rearing, respectively[3]. |
别名 | PK-8165, 哌夸林 |
分子量 | 316.44 |
分子式 | C22H24N2 |
CAS No. | 77472-98-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | DMSO: 32 mg/mL |
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