ELN318463

Name: ELN318463
Brand: TargetMol
SKU: T11178
Price: 1480 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T11178Cas号 851600-86-7

别名 ELN 318463

ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN 318463 is 51-fold more selective for PS1.ELN 318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor.

ELN318463

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产品编号 T11178 别名 ELN 318463Cas号 851600-86-7

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品介绍

生物活性

产品描述	ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN 318463 is 51-fold more selective for PS1.ELN 318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
靶点活性	PS1 γ-secretase:（EC50）12 nM , PS2 γ-secretase: 656 nM
体外活性	ELN 318463 is a typical wax-secreting enzyme inhibitor and can only replace the active site-directed inhibitor at high concentrations if the substrate is present.Compared with Notch signaling, ELN 318463 is 75-120 times more selective in inhibiting the production of trace iron in cells.
体内活性	ELN318463 ?leads acute reduction of brain Aβ in in the PDAPP transgene model of Alzheimer's disease (AD) as well as in wild-type FVB strain mice.
别名	ELN 318463