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KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene) 是 IRF-3 依赖性信号传导的异黄酮激动剂,可诱导 IRF-3 核易位。 它对 RNA 病毒、HCV 和 RSV 具有抗病毒活性。
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KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene) 是 IRF-3 依赖性信号传导的异黄酮激动剂,可诱导 IRF-3 核易位。 它对 RNA 病毒、HCV 和 RSV 具有抗病毒活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 131 | 现货 | |
5 mg | ¥ 292 | 现货 | |
10 mg | ¥ 448 | 现货 | |
25 mg | ¥ 792 | 现货 | |
50 mg | ¥ 1,290 | 现货 | |
100 mg | ¥ 1,930 | 现货 | |
200 mg | ¥ 2,770 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 328 | 现货 |
产品描述 | KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV. |
靶点活性 | DNV:>5 μM , Influenza virus:2 μM |
体外活性 | KIN101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5[1].KIN101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance[1]. KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels. KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells[1]. KIN101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM[1]. |
别名 | 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene, 3-(4-溴苯基)-4-氧代-7-[(甲磺酰基)氧基]-4H-色烯 |
分子量 | 395.22 |
分子式 | C16H11BrO5S |
CAS No. | 610753-87-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 32 mg/mL (80.97 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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