128
23
4
13
9
Cat. No. | Product Name | ||
---|---|---|---|
L9830 | 抗帕金森病化合物库 | 857 compounds | |
857 种帕金森病相关的化合物集合,可用于高通量和高内涵筛选; | |||
L9840 | 抗阿尔茨海默症化合物库 | 986 compounds | |
986 种阿尔茨海默症相关的化合物集合,可用于高通量和高内涵筛选; | |||
L2196 | 抗卵巢癌化合物库 | 1867 compounds | |
1867 种与卵巢癌相关的化合物,可以用于抗卵巢癌药物研发和药理研究 | |||
L6720 | 抗COVID-19中药单体库 | 1147 compounds | |
根据抗新冠肺炎疫情过程中应用于临床治疗的中药方剂,收集了1147 种相关中药来源的单体化合物,可用于高通量和高内涵筛选,是抗新冠病毒药物研发的良好工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0082 |
Domperidone
R33812,多潘立酮 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Domperidone (R33812) 是多巴胺 2 受体拮抗剂,能够影响胃和小肠的化学感受器触发区和运动功能,具有止吐和促动力作用。 | |||
T1539 |
Iloperidone
伊潘立酮,HP 873 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Iloperidone (HP 873) 是一种D2/5-HT2受体拮抗剂,是非典型抗精神病药,可治疗精神分裂症。 | |||
T1536 |
Promestriene
3-propyl ethyl,舒经劳,17B-methyl estradiol,Promestriano |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Promestriene (3-propyl ethyl) 是局部有效的雌激素,是合成的雌二醇二乙醚。它对阴道萎缩有作用,但吸收量小。 | |||
T9317 |
TAK-041
NBI-1065846 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
TAK-041 (NBI-1065846) 是一种选择性 GPR139激动剂,EC50为 22 nM,有用于精神分裂症阴性症状的研究潜力。 | |||
T1504 |
Silodosin
西洛多辛,KAD 3213,KMD 3213 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Silodosin (KAD 3213) 是有选择性的、强效的、口服活性的 α1A-adrenergic receptor 阻滞剂,是一种有效且耐受性良好的试剂,可用于研究 LUTS/BPH。它对 α1A-AR 表现出高度的亲和力,是 α1B-AR 和 α1D-AR 亲和力的 162 和 50 倍。 | |||
T6653 |
Salmeterol Xinafoate
Salmetedur,昔美酸沙美特罗,沙美特罗昔萘酸酯,GR 33343X xinafoate,Arial |
HIV Protease; Adrenergic Receptor | GPCR/G Protein; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Salmeterol Xinafoate (GR 33343X xinafoate) 是选择性人β2肾上腺素受体激动剂。Salmeterol 有效刺激 cAMP 积累,能够作用于 CHO 细胞,对人β2,β1和β3肾上腺素受体的 pEC50分别为 9.6、6.1 和 5.9。 | |||
T21281 |
Zolamide
CL 5343,Tio-urasin,5-Amino-TDSNH2,乙酰唑胺杂质D |
Others | Others |
Zolamide (CL 5343) 可用于预防高原反应和减轻症状。 | |||
T16114 |
Pavinetant
MLE-4901,AZD4901,AZD2624 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Pavinetant (MLE-4901) 是一种可口服的神经激肽-3 受体 (NK3R) 拮抗剂,可用于改善更年期症状。 | |||
T0218 |
Biperiden
Bipariden,Akineton,KL 373,比哌立登,Biperidine |
AChR | Neuroscience |
Biperiden (Bipariden) 是中枢 M1胆碱受体阻断剂,有抗帕金森症活性。 | |||
T7160 |
Lofexidine
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Lofexidine 是一种选择性α2 受体激动剂,常用于缓解海洛因和其他阿片类戒断的躯体症状。 | |||
T0317 |
Buflomedil hydrochloride
Buflomedil HCl,Fonzylane,Loftyl,盐酸丁咯地尔,丁咯地尔盐酸盐 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Buflomedil hydrochloride (Fonzylane) 是一种血管扩张剂,可用于外周动脉疾病引发的一系列症状。 | |||
T22316 |
Doxazosin
UK 33274,多沙唑嗪 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Doxazosin (UK 33274) 是选择性的拮抗突触后的α1肾上腺素受体。 | |||
T21419 |
Diphenhydramine
苯海拉明,Debendrin,PM 255,PM255,Dabylen,Syntedril,PM-255 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Diphenhydramine (Syntedril) 是第一代具有抗胆碱能作用的H1 受体拮抗剂,它能透过血脑屏障。 | |||
T5023 |
Propiverine hydrochloride
|
Others; Calcium Channel; AChR | Membrane transporter/Ion channel; Metabolism; Neuroscience; Others |
Propiverine hydrochloride 是一种痉挛剂,具有钙拮抗和抗胆碱能特性,用于研究膀胱过度活动和尿失禁。 | |||
T0113 |
Mebhydrolin napadisylate
Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,美海屈林萘二磺酸盐,Omeril,Diazoline |
5-HT Receptor; AChR; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Mebhydrolin napadisylate (Incidal) 是一种抗组胺药,用于缓解组胺释放引起的过敏症状,如鼻过敏和过敏性皮肤病。 | |||
T0784 |
Tolfenamic Acid
托芬那酸,GEA 6414,托灭酸,Tolfedine |
COX | Immunology/Inflammation; Neuroscience |
Tolfenamic Acid (GEA 6414) 是一种非甾体抗炎剂和抗癌剂,可用于治疗偏头痛的症状。它能选择性地抑制COX-2的活性,在 LPS 诱导的犬 DH82 单核细胞/巨噬细胞中,对COX-2的IC50值为 13.49 μM(3.53 μg/mL)。 | |||
T39252 |
TAK-418
|
Histone Demethylase | Chromatin/Epigenetic |
TAK-418 是一种选择性、口服活性 LSD1/KDM1A 酶抑制剂,IC50 为 2.9 nM。TAK-418 能解锁异常表观遗传机制,改善神经发育障碍模型中的自闭症症状。 | |||
T6701 |
Terazosin hydrochloride dihydrate
Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate,盐酸特拉唑嗪(二水合物) |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Terazosin hydrochloride dihydrate (Heitrin dihydrate) 是一种竞争性和口服活性的 α1-肾上腺素受体(α1-adrenoceptor) 拮抗剂,是一种喹唑啉衍生物,通过舒张血管和打开膀胱的方式起作用。它可用于研究良性前列腺增生 (BPH) 和高血压。 | |||
T1180 |
Blonanserin
布南色林,AD-5423 |
Dopamine Receptor; Sigma receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Blonanserin (AD-5423) 是一种有效的5-HT2A 和多巴胺 D2 受体拮抗剂,Ki 为 0.812 和 0.142 nM,是一种非典型的抗精神病试剂。 | |||
T11986L |
Mebeverine acid hydrochloride
|
Others | Others |
Mebeverine acid hydrochloride 是一种有效的、可口服的、可直接作用于胃肠道平滑肌解除痉挛症状的化合物。 | |||
T4563 |
Thonzylamine
neohetramine,松齐拉敏 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Thonzylamine (neohetramine) 是可口服的H1组胺受体拮抗剂,具有抗组胺和抗过敏特性,可用于鼻充血、过敏性结膜炎和其他过敏性疾病的研究。 | |||
T19399 |
L-Ornithine L-aspartate
Ornithine Aspartate,L-鸟氨酸 L-天冬氨酸 |
Others | Others |
L-Ornithine L-aspartate (Ornithine Aspartate) 由鸟氨酸和天冬氨酸组成。它能够减少血氨浓度,并消除与肝硬化相关的肝性脑病的症状。 | |||
T50055 |
Milacemide
|
MAO | Metabolism; Neuroscience |
Milacemide 是一种甘氨酸前药和 MAO-B 抑制剂。已经研究了米拉塞米对人类记忆的影响以及作为阿尔茨海默病症状的潜在治疗方法。 | |||
T1458 |
Epalrestat
ONO2235,依帕斯他,依帕司他 |
Reductase | Endocrinology/Hormones; Metabolism |
Epalrestat (ONO2235) 是醛糖还原酶抑制剂,在长期治疗中具有良好的耐受性。 它可以有效改善糖尿病神经病变的相关症状并延缓疾病的进展,特别是在微血管病变有限且血糖控制良好的患者中。 | |||
T1292 |
Tiapride hydrochloride
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Tiapride 是一种大脑中 D2/3 多巴胺受体的选择性阻滞剂。 它用于治疗各种精神和神经系统疾病,包括运动障碍、酒精戒断综合征、精神病的阴性症状以及老年人的攻击和激动。 | |||
T1303 |
Auranofin
醋硫葡金,SKF-39162 |
Others; SARS-CoV; Antibacterial | Microbiology/Virology; Others |
Auranofin (SKF-39162) 是一种硫氧还蛋白还原酶 TrxR 抑制剂 (IC50=0.2 μM)。Auranofin 是一种抗风湿剂,用于治疗类风湿性关节炎,改善关节炎症状。Auranofin 也具有对 SARS-CoV21 的抗病毒活性。 | |||
T8634 |
8-Bromotheophylline
Bromotheophylline,8-溴茶碱 |
Others | Others |
8-Bromotheophylline (Bromotheophylline) 是 Pamabrom 的活性部分,用于 Oxazolo[2,3-f]purinediones 的合成。Oxazolo[2,3-f]purinediones 可用于腺苷 A1和 A2A 受体上的亲和力评估。 | |||
T21390 |
Fexofenadine
Carboxyterfenadine,Telfast,非索非那定,MDL 16.455,Allegra |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Fexofenadine (Carboxyterfenadine) 是一种抗组胺药物,用于治疗过敏症状,如鼻塞、花粉热和荨麻疹。与第一代抗组胺药相比,它通过血脑屏障并引起镇静的能力较差。 | |||
T79600 |
Zharp2-1
|
RIP kinase | Apoptosis; NF-κB |
Zharp2-1是一种 RIPK2 抑制剂,抑制了 MDP 诱导或单核细胞增生李斯特菌感染诱导的炎症细胞因子的转录,缓解MDP诱导的小鼠腹膜炎症状,可用于研究炎症性肠病 (IBD)。 | |||
T15239 |
Epristeride
SKF105657,ONO-9302 |
Apoptosis; Reductase | Apoptosis; Endocrinology/Hormones; Metabolism |
Epristeride (ONO-9302) 是具有口服活性、选择性和非竞争性类固醇 5-α-还原酶亚型2抑制剂,抑制SR 同工酶 2。Episteride 可减小前列腺大小并改善良性前列腺增生男性的症状。Episteride 诱导大鼠腹侧前列腺萎缩和凋亡。 | |||
T4195 |
Betahistine
PT 9 base,倍他司汀,Vasomotal,Serc base |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Betahistine (Vasomotal) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂,可用作血管扩张剂,用于类风湿性关节炎的研究。 | |||
T39229 |
YNT-185
|
OX Receptor | GPCR/G Protein; Neuroscience |
YNT-185 是一种非肽类、选择性的俄睾丸激素2型受体(OX2R)激动剂,对 OX2 R和 OX1R 的 EC50 值分别为 0.028 μM 和 2.75 μM。此外,YNT-185 在小鼠模型中有效缓解了嗜睡症-猝倒症的症状。 | |||
T0331 |
Moxifloxacin hydrochloride
盐酸莫西沙星,莫西沙星盐酸盐,BAY-128039,Moxifloxacin HCl,BAY12-8039 HCl |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Moxifloxacin hydrochloride (BAY12-8039 HCl) 是一种口服有效的 8-甲氧基喹诺酮类抗菌药物,可研究感染性肺炎,急性细菌性鼻窦炎和慢性支气管炎的急性细菌性加重。 | |||
T0477 |
Zileuton
Abbott 64077,齐留通,A 64077 |
Ferroptosis; Lipoxygenase; COX | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Zileuton (A 64077) 是羟基脲的合成衍生物,是一种选择性的5-脂氧合酶抑制剂,具有平喘特性。 | |||
T21385 |
Cinitapride
西尼必利,Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Cinitapride (Blaston) 是一种促胃药。它减缓肌肉的活动,以减轻诸如胃酸反流、胃排空延迟和溃疡性消化不良等病症的症状。 Cinitapride 作为 5-HT2 受体的拮抗剂和 5-HT1 和 5-HT4 受体的激动剂。 | |||
T28165 |
NF-1819
NF 1819,NF1819 |
Lipase | Metabolism |
NF-1819 是一种高效、选择性的不可逆 MGL (β-内酰胺基单酰甘油脂肪酶)抑制剂。NF-1819 在体内多发性硬化症模型中缓解疾病症状,在体内急性炎性疼痛模型中表现出镇痛作用。NF-1819 具有较高的膜通透性和血脑屏障通透性。 | |||
T0219 |
Valdecoxib
伐地考昔,代他考昔,SC 65872 |
COX | Immunology/Inflammation; Neuroscience |
Valdecoxib (SC 65872) 是可口服的高选择性 COX-2抑制剂,对 COX-2 和 COX-1 的 IC50值分别为 5 nM 和 140 μM,可用于治疗骨关节炎、类风湿性关节炎以及痛经和经期症状。 | |||
T22232 |
Alfuzosin
SL 77499 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Alfuzosin (SL 77499) 是一种可口服且具有竞争性的 α1-肾上腺素受体拮抗剂。Alfuzosin 诱导膀胱颈和前列腺的平滑肌松弛。Alfuzosin 可用于研究良性前列腺肥大、下尿路症状 (LUTS)和射精功能障碍 (EjD)。 | |||
T67729 |
UCM-1306
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
UCM-1306 是具有口服活性的人多巴胺 D1 受体变构调节剂 (PAM)。UCM-1306 增加结合在人和小鼠 D1 受体的内源性多巴胺 (DA) 效应。UCM-1306可以改善运动症状,解决与长期帕金森病(PD) 相关的关键共病认知障碍。 | |||
T60522 |
Letosteine
Viscotiol |
Others | Others |
Letosteine (Viscotiol) 是具有口服活性、有效且安全的祛痰剂, 可用于研究急性或慢性呼吸道疾病,如支气管肺炎。Letosteine 能够溶解支气管粘液并减轻呼吸道炎症症状,从而实现恢复肺部气体交换和自然防御机制。 | |||
TP1904L |
FSLLRY-NH2 TFA(245329-02-6 free base)
|
Protease-activated Receptor | GPCR/G Protein |
FSLLRY-NH2 TFA(245329-02-6 free base) 是一种蛋白酶激活受体 2 (PAR2) 抑制剂。在 ICR 小鼠中逆转紫杉醇诱导的机械异常性疼痛、热痛觉过敏和 PKC 激活。阻断分离的心脏成纤维细胞中的 ERK 活化和胶原蛋白生成。还可以减轻皮肤癣菌相关瘙痒小鼠模型的症状。 | |||
T22277L |
BMS-P5 free base
|
PAD | Chromatin/Epigenetic |
BMS-P5 free base 是一种特异性,可口服的肽精氨酸二亚胺酶抑制剂,可阻断多发性骨髓瘤诱导的 NET 形成,并延缓肿瘤进程。 | |||
T6426 |
Buclizine dihydrochloride
盐酸安其敏,Longifene,Buclina,Buclizine HCl,UCB-4445 |
5-HT Receptor; AChR; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Buclizine dihydrochloride (Buclina) 是可口服的一种哌嗪组胺 H1 受体拮抗剂,主要具有止吐和抗眩晕活性。 | |||
T1568 |
Amoxapine
阿莫沙平,CL-67772 |
GlyT | Neuroscience |
Amoxapine (CL-67772) 是一种dibenzoxazepine 家族的四环抗抑郁药,常被归类为仲胺三环类抗抑郁药。 | |||
T26684 |
Auten-99 HBr
Auten-99,Auten-99 hydrochloride. Auten-99 HBr,Auten99,Auten 99 |
Phosphatase | Metabolism |
Auten-99 HBr (Auten-99) 是新型肌管蛋白磷酸酶 Jumpy( MTMR14) 的抑制剂,可通过血脑屏障,具有强大的神经保护作用。 | |||
T2319 |
Acotiamide monohydrochloride trihydrate
Acotiamide hydrochloride,YM-443 HCl,盐酸阿考替胺,Z-338 HCl |
AChE | Neuroscience |
Acotiamide monohydrochloride trihydrate (Z-338 HCl) 是一种首创的、具有口服活性的胃肠动力药。它通过促毒蕈碱受体拮抗作用和乙酰胆碱酯酶(AChE)抑制作用增强肠神经元释放的乙酰胆碱,从而增强胃排空和胃部适应性,有潜力用于功能性消化不良的研究。 | |||
T11326 |
Frovatriptan succinate hydrate
Frovelan,夫罗曲坦琥珀酸盐水合物 ,Frova |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Frovatriptan succinate hydrate (Frova) 是一种有效、高亲和力、选择性和口服活性的 5-HT1B、HT1D 受体激动剂和中等有效的 5-HT7 受体激动剂,pKi 值分别为 8.6、8.4 和 6.7。它可有效治疗各种偏头痛,包括恶心、呕吐、畏光和畏声等相关症状。 | |||
T4616 |
Metoclopramide
甲氧氯普胺,胃复安,5-Chloro-2-methoxyprocainamide |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Metoclopramide (5-Chloro-2-methoxyprocainamide) 是5-HT3和多巴胺D2受体拮抗剂,IC50值分别为 308 和 483 nM,可用于恶心呕吐、胃食管反流和胃轻瘫的研究。 | |||
T0976 |
Propoxur
残杀威,Aprocarb,Propoxure,Baygon |
AChR; Antifungal | Microbiology/Virology; Neuroscience |
Propoxur (Propoxure) 是一种氨基甲酸酯类杀虫剂,用于控制蟑螂、苍蝇、蚊子以及草坪和草坪昆虫。 | |||
T28778 |
Silperisone HCl
RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336 |
Others | Others |
Silperisone HCl (RGH-5002) 阻断细胞中的钠和钙通道,使肌肉细胞的兴奋度和收缩度降低,降低外周张力,充当肌肉松弛剂和外周血管扩张剂。 Silperisone HCl 可用于治疗脊髓损伤引起的复发性疼痛性肌阵挛、脑血管病引起的异常高肌张力、肌张力症状、锥体紧张综合征、多发性硬化症肌痉挛和脊髓炎。Silperisone 是钠通道蛋白2型α通道阻滞剂。Silperisone 是一种类似于tolperisone 的有机硅化合物,具有中枢作用的肌肉松弛剂特性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMS0418 |
Dihydroergotoxine mesylate
甲磺酸二氢麦角碱,Ergoloid mesylates,甲磺酸双氢麦角毒碱 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Dihydroergotoxine mesylate (Ergoloid mesylates) 是系列生物碱盐混合物,对GABAA 受体高结合活性。它主要用于改善与衰老相关的精神退化的症状和身体症状。 | |||
T4S0290 |
Araloside A
Chikusetsusaponin IV,竹节参皂苷IV |
RAAS; Fas/FasL | Apoptosis; Endocrinology/Hormones |
Araloside A (Chikusetsusaponin IV) 是竹节参中的一种成分,对肾素renin 具有低抑制活性(IC50:77.4 μM)。 | |||
T73844 |
Nortriptyline
|
Others | Others |
Nortriptyline (Desmethylamitriptyline) 是三环类抗抑郁药,是 Amitriptyline 的主要活性代谢产物,用于缓解抑郁症症状。Nortriptyline 是有效自噬 (autophagy) 抑制剂。 | |||
T37177 |
Norcholic Acid
|
Others | Others |
Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,4 | |||
T0611 |
Vanillylmandelic acid
4-Hydroxy-3-methoxymandelic acid,3-甲氧基-4-羟基扁桃酸 |
Others; Antioxidant | Others; oxidation-reduction |
Vanillylmandelic acid 是儿茶酚胺、肾上腺素和去甲肾上腺素代谢的最终产物,具有抗氧化活性,常用于帮助诊断嗜铬细胞瘤,以及其升高与抑郁症状有关。 | |||
T4S1999 |
Valepotriate
戊曲酯/缬草素,Valtrate |
Apoptosis; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Valepotriate (Valtrate) 是从蜘蛛香分离而来的一种天然产物,是一类新的细胞毒剂和抗肿瘤剂,对 HTC 肝癌细胞是非常有效的细胞毒剂。 它可能对焦虑的精神症状具有潜在的抗焦虑作用。 | |||
T20754 |
Deltamethrin
Butoss,RU-22974,Esbecythrin,溴氰菊酯,K-Othrin,Decamethrin,RU 22974 |
Others | Others |
Deltamethrin (RU 22974) 是一种具有神经毒性的拟除虫菊酯杀虫剂,在大鼠中能够产生一系列可逆的运动症状(如包括后肢僵硬、舞蹈性关节炎)。 | |||
T3888 |
Scopolin
Murrayin,东莨菪甙,Scopoloside,东莨菪苷 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Scopolin (Scopoloside) 是从拟南芥根中分离出来的香豆素,可通过激活SIRT1介导的信号级联反应减轻了肝脂肪变性。 | |||
T8194L |
Soy Isoflavone
|
Others | Others |
Soy Isoflavone 是从豆科植物的种子中提取的。大豆中的异黄酮是天然植物雌激素,具有很好的药用价值,可以降低女性乳腺癌的发病率,缓解更年期症状,增加骨密度。 | |||
T4776 |
Glycerol
Glycerin,甘油 |
Endogenous Metabolite | Metabolism |
Glycerol 是甘油三酯(即脂肪和油)和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。 | |||
T2S2173 |
(E)-Naringenin chalcone
Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮 |
Others | Others |
Naringenin chalcone (Isosalipurpol) 是一种黄酮醇生物合成的中间体,在查耳酮异构酶的作用下,自发代谢成柚皮素。它具有抗炎和抗过敏活性。 | |||
T2520 |
Desloratadine
Sch34117,地氯雷他定,NSC 675447 |
Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Desloratadine (Sch34117) 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物,可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用,包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂,具有抗过敏和抗炎活性。 | |||
T15248 |
Estetrol
Donesta |
Estrogen Receptor/ERR; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Estetrol(Donesta) 是可口服且具有选择性核雌激素受体 (estrogen receptor) 调节剂,是一种在怀孕期间由人类胎儿肝脏合成的天然雌激素。Estetrol 对子宫内膜或中枢神经系统有作用,但对乳房有拮抗作用。Estetrol 在低浓度时可能有助于降低血栓形成。Estetrol 可用于缓解更年期症状。 | |||
T0729 |
Benzyl benzoate
Ascabiol,Novoscabin,Scabitox,苯甲酸苄酯,Benzoic acid benzyl ester |
Parasite | Microbiology/Virology |
Benzyl benzoate (Benzoic acid benzyl ester) 是化妆品中的香料成分,可研究疥疮和蠕形螨相关的炎症性皮肤病。 | |||
T6491 |
(-)-(S)-Equol
(−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) 是雌激素受体β的高亲和力配体。 | |||
T4723 |
D-Tagatose
塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos |
Others; Endogenous Metabolite | Metabolism; Others |
D-Tagatose (D-(-)-Tagatose) 是自然界中发现的一种罕见的单糖,具有益生元特性。它是研究II 型糖尿病的潜在抗糖尿病药物,也是帮助提升结肠有益细菌、预防结肠癌和抑制胆固醇的益生元。它是蔗糖的替代品,也是口香糖、果汁和饮料等食品中的低热量甜味剂。 | |||
T3011 |
2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine,犬尿氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是一种酮类和氨基酸衍生物,具有多种生物功能,包括血管舒张、免疫调节和神经调节活性。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是烟酸的前体。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 的异常产生与神经系统疾病相关的认知缺陷和抑郁症状有关。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 在某些类型的癌细胞中过度表达,可能被用作评估癌症风险的生物标志物。 | |||
TN1741 |
Homomangiferin
高芒果苷 |
Others | Others |
Homomangiferin has important medicinal properties and is widely used to relieve many symptoms, for example coughing and asthma.Homomangiferin shows antitumoural effects against MDA-MB-231 cells. | |||
TN2299 |
Vindesine
|
Others | Others |
Vindesine is a microtubule inhibitor and widely used to treat malignancies. Vindesine neuropathy seems to be the cause of the patient's neurological symptoms. | |||
TN4383 |
Kazinol U
|
IL Receptor; IκB/IKK; NOS; NF-κB | Immunology/Inflammation; NF-κB |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms. | |||
TN3351 |
Aflatrem
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamma-aminobutyric acid (GABA)-induced | |||
T36845 |
Isogarcinol
|
Others | Others |
Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental auto... | |||
T75600 |
Coronatine
|
Others | Others |
Coronatine 是丁香假单胞菌产生的一种植物生长调节剂。Coronatine 模拟生物活性茉莉酸 (jasmonic acid) 缀合物或高等植物的 octadecanoid 信号分子使植物出现致病症状。Coronatine 通过激活抑制水杨酸 (Salicylic acid) 积累的信号级联,促进植物中丁香假单胞菌的毒力。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04826 |
LILRB5/CD85c Protein, Human, Recombinant (His)
leukocyte immunoglobulin like receptor B5,LIR8,LIR-8,CD85C |
Human | HEK293 Cells |
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weig... | |||
TMPY-03855 |
DNase I Protein, Human, Recombinant (His)
DRNI,DNL1,deoxyribonuclease I |
Human | HEK293 Cells |
DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations i... | |||
TMPY-00117 |
FGF-16 Protein, Human, Cynomolgus, Recombinant
fibroblast growth factor 16 |
Human,Cynomolgus | Baculovirus Insect Cells |
Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of ... | |||
TMPH-03579 |
TSST-1 Protein, S. aureus, Recombinant (His & SUMO)
Toxic shock syndrome toxin-1,tst |
Staphylococcus aureus | E. coli |
Responsible for the symptoms of toxic shock syndrome. TSST-1 Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 37.9 kDa and the accession number is P06886. | |||
TMPH-03594 |
Exotoxin type A Protein, S. pyogenes, Recombinant (His & SUMO)
SPE A,Scarlet fever toxin,Exotoxin type A,speA,Erythrogenic ... |
Streptococcus pyogenes | E. coli |
Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever. Exotoxin type A Protein, S. pyogenes, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 38.6 kDa and the accession number is P0DJY7. | |||
TMPY-06273 |
LILRB5/CD85c Protein, Human, Recombinant (hFc)
LIR-8,LIR8,CD85C,leukocyte immunoglobulin like receptor B5 |
Human | HEK293 Cells |
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weig... | |||
TMPY-05186 |
LILRB5/CD85c Protein, Human, Recombinant (His), Biotinylated
LIR-8,LIR8,leukocyte immunoglobulin like receptor B5,CD85C |
Human | HEK293 Cells |
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted ... | |||
TMPJ-00869 |
GLB1 Protein, Human, Recombinant (His)
Lactase,Acid Beta-Galactosidase,Elastin Receptor 1,GLB1,Acid... |
Human | HEK293 Cells |
β Galactosidase is a lysosomal β Galactosidase that hydrolyzes the terminal β Galactose from Ganglioside and Keratan sulfate. In lysosome, the mature β Galactosidase protein associates with Cathepsin A and Neuraminidase 1 to form the lysosomal multienzyme complex . An alternative splicing at the RNA level of β Galactosidase results a catalytically inactive β Galactosidase that plays an important role in vascular development. Defects of β-galactosidase (GLB1) are the cause of diseases like GM1-ga... | |||
TMPJ-01277 |
CRT2 Protein, Human, Recombinant
CALR3,Calreticulin-3,calreticulin-2,calsperin,CRT2 |
Human | E. coli |
Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy t... | |||
TMPY-04476 |
MVK Protein, Human, Recombinant (His & GST)
POROK3,LRBP,MVLK,MK,mevalonate kinase |
Human | Baculovirus Insect Cells |
Mevalonate kinase belongs to the GHMP kinase family, Mevalonate kinase subfamily. It can be found in a wide variety of organisms from bacteria to mammals. Mevalonate kinase may be a regulatory site in the cholesterol biosynthetic pathway. Defects in mevalonate kinase can cause mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia,... | |||
TMPY-03452 |
PTS Protein, Human, Recombinant (His)
PTPS,PTS,6-pyruvoyltetrahydropterin synthase |
Human | E. coli |
PTS(6-pyruvoyltetrahydropterin synthase) belongs to the PTPS family. It catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia.... | |||
TMPY-02961 |
PANP/C12orf53 Protein, Human, Recombinant (hFc)
C12orf53,UNQ828/PRO1755,PILR α associated neural protein,PAN... |
Human | HEK293 Cells |
C12orf53 is mainly expressed in adult brain and cerebellum. It also can be detected in fetal brain and virtually no expression in spleen, heart, kidney, liver and dorsal ganglion relative to brain. C12orf53 acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation. Chromosome 12 encodes over 1,100 genes within 132 million bases. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan... | |||
TMPY-02516 |
Interferon alpha 10/IFNA10 Protein, Human, Recombinant (hFc)
interferon, α10,interferon, alpha 10,IFN-alphaC,MGC119879,干扰... |
Human | HEK293 Cells |
Interferon alpha-10 (IFNA10) is a member of the interferon family. Interferons belong to the group of the regulatory glycoproteins, of low molecular mass. They are the products of infected cell-genome, but not virus, as a consequence of the cause answer by different inductors. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogen... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMID-0210 |
Sildenafil-13C-d3
|
||
Sildenafil-13C-d3 是 Sildenafil 的 13C 和氘代化合物。Sildenafil 的 CAS 号为 139755-83-2。Sildenafil 是一种磷酸二酯酶 5 抑制剂,IC50为 5.22 nM。 | |||
TMID-0043 |
Sildenafil-d8
|
||
Sildenafil-d8 是 Sildenafil 的氘代化合物。Sildenafil 的 CAS 号为 139755-83-2。Sildenafil 是一种磷酸二酯酶 5 抑制剂,IC50为 5.22 nM。 | |||
TMIJ-0145 |
Blonanserin-d5
|
||
Blonanserin-d5 是 Blonanserin 的氘代化合物。Blonanserin 的 CAS 号为 132810-10-7。Blonanserin 是一种有效的5-HT2A和多巴胺 D2 受体拮抗剂,Ki为 0.812 和 0.142 nM,是一种非典型的抗精神病试剂。 | |||
TMIJ-0136 |
Moxifloxacin-d4 HCl
|
||
Moxifloxacin-d4 HCl 是 Moxifloxacin HCl 的氘代化合物。Moxifloxacin HCl 的 CAS 号为 186826-86-8。Moxifloxacin Hydrochloride是一种口服有效的 8-甲氧基喹诺酮类抗菌药物,可研究感染性肺炎,急性细菌性鼻窦炎和慢性支气管炎的急性细菌性加重。 | |||
TMID-0247 |
LacosaMide-d3
|
||
LacosaMide-d3 是 LacosaMide 的氘代化合物。LacosaMide 的 CAS 号为 175481-36-4。Lacosamide是一种功能化氨基酸。Lacosamide以一种新的方式调节钠通道:它选择性地增强钠通道缓慢失活,而对快速失活没有影响Lacosamine在不同的啮齿类动物癫痫发作模型中显示出抗癫痫作用,在反映神经性疼痛和慢性炎性疼痛的不同类型和症状的实验动物模型中显示了抗伤害潜力。 | |||
TMIJ-0202 |
Desloratadine-d5
|
||
Desloratadine-d5 是 Desloratadine 的氘代化合物。Desloratadine 的 CAS 号为 100643-71-8。Desloratadine 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物,可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用,包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂,具有抗过敏和抗炎活性。 | |||
TMIJ-0240 |
Lacosamide-d3 (Acetyl-d3)
|
||
Lacosamide-d3 (Acetyl-d3) 是 Lacosamide 的氘代化合物。Lacosamide 的 CAS 号为 175481-36-4。Lacosamide是一种功能化氨基酸。Lacosamide以一种新的方式调节钠通道:它选择性地增强钠通道缓慢失活,而对快速失活没有影响Lacosamine在不同的啮齿类动物癫痫发作模型中显示出抗癫痫作用,在反映神经性疼痛和慢性炎性疼痛的不同类型和症状的实验动物模型中显示了抗伤害潜力。 | |||
TMIJ-0052 |
Propionicacid-d5
|
||
Propionicacid-d5 是 Propionicacid 的氘代化合物。Propionicacid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中,并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中,作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。 | |||
TMIJ-0054 |
Propionic-2,2-d2 acid
|
||
Propionic-2,2-d2 acid 是 Propionic acid 的氘代化合物。Propionic acid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中,并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中,作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。 |