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TMPH-00634
|
Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant
Heat-stable enterotoxin ST-2
|
E. coli
|
E. coli
|
|
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 2.0 kDa and the accession number is P01560. |
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TMPH-00633
|
Heat-stable enterotoxin A2 Protein, E. coli, Recombinant (His & Myc & SUMO)
sta2,Heat-stable enterotoxin A2
|
E. coli
|
E. coli
|
|
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. |
|
TMPH-00635
|
Heat-stable enterotoxin ST-IA/ST-P Protein, E. coli, Recombinant (GST)
STh,sta1,Heat-stable enterotoxin ST-IA/ST-P,STp
|
E. coli
|
E. coli
|
|
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. |
|
TMPH-03715
|
Y-STB Protein, Yersinia enterocolitica, Recombinant (His & SUMO)
Y-STB,ystB,Heat-stable enterotoxin B
|
Yersinia enterocolitica
|
E. coli
|
|
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Could play an important role in pathogenesis. |
|
TMPY-03499
|
CARHSP1 Protein, Human, Recombinant (His)
CSDC1,calcium regulated heat stable protein 1, 24kD...
|
Human
|
E. coli
|
|
CARHSP1 is a biomarker for diabetic complications. Adenovirus-mediated CARHSP1 overexpression and siRNA-mediated knockdown experiments were performed to characterize the role of CARHSP1 in the regulation of gluconeogenic gene expression. CARHSP1 is regulated by nutrient status in the liver and functions at the transcriptional level to negatively regulate gluconeogenic genes, including the glucose-6-phosphatase catalytic subunit (G6Pc) and phosphoenolpyruvate carboxykinase 1 (PEPCK1). In add... |
|
TMPH-03310
|
GUCY2C Protein, Rat, Recombinant (His & Myc)
Guanylyl cyclase C,Gucy2c,Heat-stable enterotoxin r...
|
Rat
|
HEK293 Cells
|
|
Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin. GUCY2C Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 51.4 kDa and the accession number is P23897. |
|
TMPJ-00911
|
GUCY2C Protein, Human, Recombinant (hFc)
GUC2C,STAR,hSTAR,GC-C,STA receptor,GUCY2C,Guanylyl cyclase C...
|
Human
|
HEK293 Cells
|
|
GUCY2C Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is P25092. |
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TMPJ-00910
|
GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated
Intestinal guanylate cyclase,STAR,STA receptor,hSTAR,Heat-
|
Human
|
HEK293 Cells
|
|
GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 65-110 KDa and the accession number is P25092. |
|
TMPJ-01107
|
PAP Protein, Human, Recombinant (His)
PAP1,PAP,PDGFA-Associated Protein 1,HASPP28,28 kDa Heat- and...
|
Human
|
E. coli
|
|
Human PAP, also known as 28 kDa heat- and acid-stable phosphoprotein, PDGF-associated protein, PDGFA-associated protein 1, PDAP1, HASPP28, is a protein which belongs to the PDAP1 family. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. PDGF-Associated Protein (PAP) is a phosphoprotein that may enhance PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. PDAP1 expression is induced by TNF-alpha, and cells overexpressing PDAP1 sho... |
|
TMPH-00616
|
DNA-binding protein H-NS Protein, E. coli, Recombinant (His)
hns,DNA-binding protein H-NS,Protein B1,Protein H1,Heat-...
|
E. coli
|
E. coli
|
|
A DNA-binding protein implicated in transcriptional repression (silencing). Also involved in bacterial chromosome organization and compaction. H-NS binds tightly to AT-rich dsDNA and inhibits transcription. Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription. Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome. Many of these loci were horizontally transfe... |
|
TMPJ-01469
|
NGF Protein, Human, Recombinant (E. colli)
NGFB,神经生长因子,β-NGF,NGF,Beta-Nerve Growth Factor,β-Nerve Growt...
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Mouse
|
E. coli
|
|
NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an impo... |
|
TMPY-03962
|
AFM Protein, Human, Recombinant (His)
afamin,ALBA,ALB2,ALF
|
Human
|
HEK293 Cells
|
|
Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin's glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determination. Afamin, a human plasma glycoprotein and putative transporter of hydrophobic molecules, has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. The 2.1-Å crystal structure of... |
|
TMPH-00665
|
RecG Protein, E. coli O157:H7, Recombinant (His & SUMO)
ATP-dependent DNA helicase RecG,recG
|
E. coli
|
E. coli
|
|
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). Has a role in constitutive stable DNA replication (CsdR) and R-loop formation. |
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TMPH-01557
|
ILF2 Protein, Human, Recombinant (GST)
Interleukin enhancer-binding factor 2,ILF2,Nuclear factor of...
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Human
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E. coli
|
|
Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. ILF2 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 70.1 kDa and the acce... |
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TMPH-01424
|
GUCA2B Protein, Human, Recombinant (His)
Guanylate cyclase activator 2B,GUCA2B
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Human
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HEK293 Cells
|
|
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. GUCA2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 13.5 kDa and the accession number is Q16661. |
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TMPK-01241
|
CARHSP1 Protein, Human, Recombinant
CSDC1,CRHSP24,CRHSP-24
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Human
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E. coli
|
|
Ca2+-regulated heat-stable protein of 24 kDa (CRHSP-24) is a serine phosphoprotein originally identified as a physiological substrate for the Ca2+-calmodulin regulated protein phosphatase calcineurin (PP2B). CRHSP-24 is a paralog of the brain-specific mRNA-binding protein PIPPin and was recently shown to interact with the STYX/dead phosphatase protein in developing spermatids. |
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TMPY-03859
|
DHRS9 Protein, Human, Recombinant (His)
3α-HSD,RDHTBE,3ALPHA-HSD,RDH-E2,RETSDR8,dehydrogenase/reduct...
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Human
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E. coli
|
|
Dehydrogenase/reductase (SDR family) member 9 (DHRS9) is aberrantly expressed in colorectal cancer (CRC), the decreased expression of DHRS9 correlates with tumor progression and may serve as a potential prognostic biomarker in CRC. The human regulatory macrophage (Mreg) has emerged as a promising cell type for use as a cell-based adjunct immunosuppressive therapy in solid organ transplant recipients. DHRS9 is a specific and stable marker of human Mregs. |
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TMPK-00548
|
CLEC12A/MICL/CLL-1 Protein, Cynomolgus, Recombinant (His)
CD371,HECL,CLECSF11,CLEC12A,CD303,CLL-1,PRO34150,DLEC,DCAL2,...
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Cynomolgus
|
HEK293 Cells
|
|
CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Cynomolgus, Recombinant (His) is ... |
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TMPK-00995
|
CLEC12A/MICL/CLL-1 Protein, Mouse, Recombinant (aa 65-267, His)
HECL,CLL1,CD371,CLL-1,CLEC12A,MICL,DCAL-2,PRO34150,DLEC,CD30...
|
Mouse
|
HEK293 Cells
|
|
CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Mouse, Recombinant (aa 65-267, Hi... |
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TMPK-01005
|
CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His), FITC-Labeled
DCAL-2,HECL,CLL-1,CLECSF7,CD371,CLEC12A,PRO34150,MICL,CLECSF...
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Human
|
HEK293 Cells
|
|
CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His), FITC-La... |
|
TMPH-00175
|
YuaB Protein, Bacillus subtilis, Recombinant (His & SUMO)
Biofilm-surface layer protein A,bslA,ORF-1
|
Bacillus subtilis
|
E. coli
|
|
Involved in biofilm formation. Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm. The layer is stable and capable of resistance to high mechanical force compression. Required for complex colony architecture. May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix. YuaB Protein, Bacillus subtilis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xH... |
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TMPH-00612
|
MutL Protein, E. coli, Recombinant (His)
DNA mismatch repair protein MutL,mutL
|
E. coli
|
E. coli
|
|
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of MutL is stimulated by DNA. MutL Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag... |
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TMPK-01004
|
CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, hFc)
DCAL2,HECL,DCAL-2,DLEC,CLECSF11,CLEC12A,CD371,MICL,CLL-1,CLE...
|
Human
|
HEK293 Cells
|
|
CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, hF... |
|
TMPK-01006
|
CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, His)
CLECSF7,CLL-1,PRO34150,CLL1,DLEC,CLEC12A,DCAL2,CLECSF11,MICL...
|
Human
|
HEK293 Cells
|
|
CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, Hi... |
|
TMPK-01002
|
CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
HECL,DCAL-2,CD303,CLECSF7,DCAL2,CLECSF11,CLL1,CLL-1,CD371,MI...
|
Human
|
HEK293 Cells
|
|
CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (hFc & Avi), B... |
|
TMPY-03971
|
Statherin Protein, Human, Recombinant (mFc)
statherin,STATH,STR
|
Human
|
HEK293 Cells
|
|
Statherin, also known as STATH, belongs to the histatin/statherin family. Statherin may play an important role in the maintenance of oral health. It prevents calcium phospate precipitation in saliva, so maintaining a high calcium level in saliva and preventing teeth from dissolving. Statherin also inhibits spontaneous precipitation of calcium phosphate salts. Thus, statherin and PRPs may prevent build-up of harmful deposits in the salivary glands and on the tooth surfaces. Statherin is a highly ... |
|
TMPJ-00882
|
Desmin Protein, Human, Recombinant (His)
DES,Desmin
|
Human
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E. coli
|
|
Desmin is a cytoplasmic protein and belongs to the intermediate filament family. interacts with DST and MTM1. Desmin is only expressed in vertebrates, however homologous proteins are found in many organisms. Desmin is the main intermediate filament in mature skeletal, cardiac and smooth-muscle cells. DES founctions as homopolymers to form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. .Defects in DES are cause of the myopathy myofibr... |
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TMPH-03038
|
Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)
Cobra venom factor,Complement C3 homolog,CVFk,CVF
|
Naja kaouthia
|
E. coli
|
|
Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely re... |
|
TMPH-02395
|
Lassa virus (strain GA391) GPC Protein (His)
Pre-glycoprotein polyprotein GP complex,GPC
|
LASV
|
E. coli
|
|
class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversible conformational changes induced upon acidification in the endosome.; Stable signal peptide (SSP): cleaved and functions as a signal peptide. In addition, it is also retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation clea... |
|
TMPK-01003
|
CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His, Avi), Biotinylated
DCAL2,CD371,CLEC12A,CLL-1,MICL,CD303,HECL,PRO34150,CLL1,DLEC...
|
Human
|
HEK293 Cells
|
|
CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His, Avi), Bi... |
|
TMPJ-01410
|
LSM4 Protein, Human, Recombinant (His)
Glycine-Rich Protein,GRP,U6 snRNA-Associated Sm-Like Protein...
|
Human
|
E. coli
|
|
U6 snRNA-associated Sm-like protein LSm4 (LSM4) is a member of the snRNP Sm proteins family. Sm-like proteins contain the Sm sequence motif and are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. LSM4 forms a heteromer with a donut shape. The complexes are involved in various steps of RNA metabolism. LSM4 binds specifically to the 3-terminal U-tract of U6 snRNA. LSM4 contributes RNA protein interactions and structural changes which ar... |
|
TMPY-00323
|
Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)
NS3
|
HCV
|
E. coli
|
|
HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3/NS4A complex also prevents phosphorylation of human IRF3, t... |
|
TMPY-04930
|
Notch 2 Protein, Human, Recombinant (His)
AGS2,HJCYS,hN2,notch 2
|
Human
|
Baculovirus Insect Cells
|
|
NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of developmental processes by controlling cell fate decisions. Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced express... |
|
TMPY-03390
|
LSM1 Protein, Human, Recombinant (His)
LSM1 homolog, mRNA degradation associated,CASM,YJL124C,LSM1
|
Human
|
E. coli
|
|
LSM1 is an Sm-like protein. Sm-like proteins can be detected in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins include the Sm sequence motif, which consists of two regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. LSM1 has a role in replication-dependent histone mRNA degradation and binds specif... |
|
TMPY-03603
|
AHSP Protein, Human, Recombinant
ERAF,alpha hemoglobin stabilizing protein,α hemoglobin stabi...
|
Human
|
E. coli
|
|
AHSP, also known as ERAF, is a conserved mammalian erythroid protein which belongs to the AHSP family. It is expressed in blood and bone marrow. AHSP facilitates the production of Hemoglobin A by stabilizing free α-globin. It rapidly binds to ferrous α with association (k'(AHSP)) and dissociation (k(AHSP)) rate constants of ≈1 μm(-1) s(-1) and .2 s(-1), respectively, at pH 7.4 at 22 ℃. A small slow phase was observed when AHSP binds to excess ferrous αCO. This slow phase appears to be due to cis... |
|
TMPJ-00314
|
ACVR2B Protein, Human, Recombinant (hFc & His)
ACVR2B,Activin Receptor Type IIB,ACTR-IIB,Activin Receptor T...
|
Human
|
HEK293 Cells
|
|
Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, ... |
|
TMPJ-01173
|
TFF3 Protein, Mouse, Recombinant (His)
Itf,Trefoil factor 3,Intestinal trefoil factor,mITF,Tff3
|
Mouse
|
HEK293 Cells
|
|
Trefoil factors (TFF) are secretory products of mucin producing cells. They play a key role in the maintenance of the surface integrity of oral mucosa and enhance healing of the gastrointestinal mucosa by a process called restitution. TFF comprises the gastric peptides (TFF1), spasmolytic peptide (TFF2), and the intestinal trefoil factor (TFF3). They have an important and necessary role in epithelial restitution within the gastrointestinal tract. Members of the trefoil family are characterized b... |
|
TMPY-04373
|
CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST)
calcium/calmodulin-dependent protein kinase II alpha,calcium...
|
Human
|
Baculovirus Insect Cells
|
|
Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily. CaM kinase Ⅱ is thought to be an important mediator of learning and memory and is also necessary for Ca2+homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CAMKIIA is one of the major forms of CAMKII... |
|
TMPY-03344
|
LSM3 Protein, Human, Recombinant (His)
SMX4,YLR438C,USS2,LSM3 homolog, U6 small nuclear RNA associa...
|
Human
|
E. coli
|
|
LSM3 (LSM3 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated) is a Protein Coding gene. LSM3 is a member of the snRNP Sm proteins family. It plays role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as a component of the pre-catalytic spliceosome (spliceosome B complex). Sm-like proteins can be detected in a variety of organisms. They all have the Sm sequence motif, which consists of 2 regions separated by a linker ... |
|
TMPH-01269
|
SMURF2 Protein, Human, Recombinant (His)
SMAD ubiquitination regulatory factor 2,E3 ubiquitin-protein...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable com... |
|
TMPY-02763
|
DEP-1 Protein, Human, Recombinant (aa 997-1337, His)
HPTPeta,SCC1,protein tyrosine phosphatase, receptor type, J,...
|
Human
|
E. coli
|
|
DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 / PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-... |
|
TMPY-01657
|
SUV420H2 Protein, Human, Recombinant (His & GST)
suppressor of variegation 4-20 homolog 2 (Drosophila),KMT5C
|
Human
|
E. coli
|
|
Histone-lysine N-methyltransferase SUV42H2, also known as Suppressor of variegation 4-2 homolog 2, Su(var)4-2 homolog 2, Lysine N-methyltransferase 5C, SUV42H2 and KMT5C, is nucleus protein that belongs to the histone-lysine methyltransferase family and Suvar4-2 subfamily. SUV42H2 is a histone methyltransferase that specifically trimethylates 'Lys-2' of histone H4. H4 'Lys-2' trimethylation represents a specific tag for epigenetic transcriptional repression. SUV42H2 mainly functions in pericentr... |
|
TMPY-05250
|
CLEC3A Protein, Mouse, Recombinant (His)
C-type lectin domain family 3, member A,Gm796,1110019O10Rik,...
|
Mouse
|
Baculovirus Insect Cells
|
|
C-type lectin domain family 3 member A (CLEC3A) is a poorly characterized protein belonging to the superfamily of C-type lectins. Elevated CLEC3A expression may correlate with breast IDC metastatic potential and indicated a poor prognosis in breast IDC. CLEC3A knockdown inhibited BC cell growth and metastasis might be through suppressing PI3K/AKT signaling activity. That CLEC3A is a promising therapeutic target for BC in the future. Matrilysin (MMP-7) plays important roles in tumor progression. ... |
|
TMPJ-00315
|
ACVR2A Protein, Human, Recombinant (hFc & His)
ACTR-IIA,Activin Receptor Type IIA,ACTRIIA,Activin Receptor ...
|
Human
|
HEK293 Cells
|
|
Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors.... |
|
TMPY-04567
|
SRPK1 Protein, Human, Recombinant (His & GST)
SRSF protein kinase 1,SFRSK1,RP3-422H11.1
|
Human
|
Baculovirus Insect Cells
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Serine / threonine-protein kinase SRPK1, also known as SFRS protein kinase 1, Serine/arginine-rich protein-specific kinase 1, SR-protein-specific kinase 1 and SRPK1, is a cytoplasm and nucleus protein that belongs to the protein kinase superfamily and CMGC Ser/Thr protein kinase family. Isoform 2 of SRPK1 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 of SRPK1 is only seen in th... |
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TMPY-04374
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MST4 Protein, Human, Recombinant (GST)
serine/threonine protein kinase 26,MST4,MASK
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Human
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Baculovirus Insect Cells
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MST4, also known as mammalian STE2-like protein kinase 4, is a novel member of the germinal center kinase subfamily of human Ste2-like kinases and is closely related to MST3. The 416 amino acid full-length MST4 contains a C-terminal regulatory domain and an N-terminal kinase domain, both of which are required for full activation of the kinase. MST4 is highly expressed in the placenta, thymus, and peripheral blood leukocytes. MST4 specifically activates ERK but not JNK or p38 MAPK in transiently ... |
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TMPY-01927
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ANP32A Protein, Human, Recombinant (His & GST)
MAPM,PP32,I1PP2A,C15orf1,LANP,HPPCn,PHAPI,acidic (leucine-ri...
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Human
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E. coli
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acidic leucine-rich nuclear phosphoprotein 32 family member A, also known as acidic nuclear phosphoprotein pp32, Leucine-rich acidic nuclear protein, Mapmodulin, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A, Putative HLA-DR-associated protein I, PHAPI and ANP32A, is a nucleus, cytoplasm and endoplasmic reticulum. ANP32A / LANP is expressed in all tissues tested. It is highly expressed in kidney and skeletal muscle, moderate levels of expression is in brain, placenta and panc... |
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TMPY-01953
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CALML5 Protein, Human, Recombinant (His & GST)
calmodulin like 5,CLSP
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Human
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E. coli
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Calmodulin-like protein 5, also known as Calmodulin-like skin protein, CALML5 and CLSP, is a protein which contains fourEF-hand domains. CALML5 / CLSP is particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation.The expression is very low in lung. CALML5 / CLSP binds calcium. It may be involved in terminal differentiation of keratinocytes. Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily a... |
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TMPY-04813
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ACAT2 Protein, Rat, Recombinant (His)
acetyl-CoA acetyltransferase 2
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Rat
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E. coli
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Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two enzymes are involved in storing cholesteryl esters as lipid droplets, in macrophage foam-cell formation, in absorbing dietary cholesterol, and in supplying cholesteryl esters as part of the core lipid for lipoprotein synthesis and assembly. The key difference in tissue distributio... |
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TMPY-02228
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p53 Protein, Cynomolgus, Recombinant
tumor protein p53,p53,TP53
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Cynomolgus
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E. coli
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p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damag... |
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