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Search Results for " senescence "

Targets Recommended: Ferroptosis TRP/TRPV Channel PPAR Autophagy

31

抑制剂 & 化合物

9

天然产物

2

化合物库

14

重组蛋白

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Cat. No.	Product Name
L3200	自噬库		1248 compounds
	1248 种细胞自噬相关的生物活性小分子化合物的特有集合，用于自噬相关的研究，用于高通量、高内涵筛选；
L8200	抗衰老化合物库		3279 compounds
	3279 个抗衰老化合物的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

Cat.No: L3200

Compounds: 1248

抗衰老化合物库

Cat.No: L8200

Compounds: 3279

Cat. No.	Product Name	Target	Signaling Pathways
T0334	Rosiglitazone BRL49653,罗格列酮	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone (BRL49653) 是一种 PPARγ 激动剂、TRPC5 激活剂和 TRPM3 抑制剂，具有口服活性。Rosiglitazone 也是一种降糖剂，是噻唑烷二酮类胰岛素增敏剂。
T12854	SBI-797812	NAMPT	Metabolism
	SBI-797812 是在结构上类似于活性位点定向的 NAMPT 抑制剂的化合物，能够阻断这些抑制剂与 NAMPT 的结合。它将 NAMPT 反应平衡转向 NMN 形成，提高 NAMPT 对 ATP 的亲和力，稳定 His247 处的磷酸化 NAMPT，增加焦磷酸盐副产物的消耗，并通过 NAD+钝化反馈抑制。
T6646	Rosiglitazone hydrochloride 盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone hydrochloride (BRL-49653 HCl) 是一种降血糖药物，通过与脂肪细胞中的 PPAR 受体结合来刺激胰岛素分泌。它对 PPARγ1、PPARγ2 和 PPARγ 的EC50值分别为 30 nM、100 nM 和 60 nM。它也是TRPC5的激活剂和TRPM3的抑制剂。
T11383	GDP366	Survivin	Apoptosis
	GDP366 有效且特异性地抑制 survivin 和 Op18 的表达。 GDP366 增加染色体不稳定性，并通过抑制端粒酶活性诱导细胞衰老。
T36010	p38 MAPK Inhibitor	p38 MAPK	MAPK
	p38 MAPK Inhibitor 是p38 MAPK 激酶的有效抑制剂（IC50＝ 35 nM）。p38 MAPK Inhibitor 抑制癌基因RAS 诱导的衰老。
T40351	MHY-1685	mTOR	PI3K/Akt/mTOR signaling
	MHY-1685是一种哺乳动物雷帕霉素靶蛋白(mTOR)抑制剂及衰老抑制剂，通过调节自噬作用能够使衰老的hCSCs恢复活力。
T16740	RH1 NSC 697726	Apoptosis	Apoptosis
	RH1 (NSC 697726) 是一种生物还原性抗癌化合物，在体外表现出剂量依赖性双相效应，在较高剂量下诱导细胞凋亡，在较低剂量下诱导衰老。
T71832	CTX-0124143	Histone Acetyltransferase	Chromatin/Epigenetic
	CTX-0124143 是一种组蛋白乙酰转移酶抑制剂，对 KAT6A 的 IC50 值为 1.0μM。CTX-0124143 可用于研究细胞衰老。
T1923	BRD4770	Histone Methyltransferase	Chromatin/Epigenetic
	BRD4770 是组蛋白甲基转移酶G9a 抑制剂，可激活共济失调毛细血管扩张突变途径并诱导细胞衰老。它可抑制H3K9的二甲基和三甲基化，EC50为 5 µM。
T79903	Sirtuin-1 inhibitor 1	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Sirtuin-1 inhibitor 1 是一种针对去乙酰化酶-1（Sirtuin-1）的抑制剂，可用于研究机体的衰老和细胞的死亡。
T78393	C12FDG 5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside
	C12FDG (5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside) 作为一种亲脂性用于检测β-半乳糖活性的绿色荧光底物，是一种衰老标志物，常与流式细胞仪连用。
T12040	Milademetan RAIN-32,DS-3032,DS3032b	Mdm2; Others	Apoptosis; Others
	Milademetan (DS-3032) 是一种具有口服活性和有效性的 MDM2 抑制剂，具有抗肿瘤活性，诱导 G1 细胞周期阻滞、衰老和凋亡。Milademetan 可用于研究急性髓系白血病和实体肿瘤。
T3317	SZL P1-41	Apoptosis; Others; E1/E2/E3 Enzyme	Apoptosis; Others; Ubiquitination
	SZL P1-41 是 Skp2 抑制剂，可以阻止 Skp2-Skp1 复合物的组装。它选择性地抑制 Skp2 SCF E3 连接酶活性，还在体内外抑制 Skp2 介导的 p27 和 Akt 泛素化。它通过触发细胞衰老和抑制糖酵解来抑制 Y 细胞和 Y 干细胞的存活，有抗肿瘤作用。
T26872	BMVC4 BMVC 4,BMVC-4	Others	Others
	BMVC4 is a G-quadruplex stabilizer. BMVC4 induces senescence by activation of pathways of response to DNA damage that was independent of its telomerase inhibitory activity.
T41151	K34c	Others	Others
	K34c is a potent and selective α5β1 integrin inhibitor (IC50 = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide or Ellipticine and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltrationin vivoand reduces cell adhesion on fibronectin.
T61848	Rosiglitazone potassium	Others	Others
	Rosiglitazone (BRL 49653) potassium is a potent and selective PPARγ agonist (EC 50: 60 nM, Kd: 40 nM), administered orally. It also serves as an activator of TRPC5 (EC 50: 30 μM) and an inhibitor of TRPM3. This compound, widely used in research, has shown promise in investigating obesity, diabetes, senescence, and ovarian cancer [1] [2] [4] [7].
T83432	1-DCP	Others	Others
	1-DCP 是一种抑制果实成熟和衰老作用中乙烯功能的有效乙烯拮抗剂。
T74590	Boanmycin	Others	Others
	Boanmycin 是一种具有抗肿瘤活性的抗生素，可以诱导细胞衰老、凋亡 (apoptosis)。
T84495	dinor-12-oxo Phytodienoic Acid dinor-OPDA	Others	Others
	1dinor-12-oxo-Phytodienoic acid (dinor-OPDA) serves as an intermediate in the biosynthesis of jasmonic acid from hexadecatrienoic acid, playing a crucial role in the jasmonate pathway in plants. This pathway oxygenates and modifies certain unsaturated fatty acids to produce plant hormones critical for processes such as senescence, flower development, mechanotransduction, and response to herbivory. Additionally, dinor-OPDA can be incorporated into glycerolipids and galactolipids, including specif...
T71034	Bizelesin	Others	Others
	Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis.
T37865	9(S)-HOTrE	Others	Others
	9(S)-HOTrE is a monohydroxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase on α-linolenic acid. 9(S)-HOTrE is predominantly localized in cellular ester lipids of Glechoma hederacea leaves and is partially released during artificial dehydration. The biological role of 9(S)-HOTrE in G. hederacea leaves is still undetermined, but it may play a role in natural senescence. 9(S)-HOTrE is an inhibitor of spore germination and germ tube elongation of rice blast fungus with ED50 valu...
T75714	Decapeptide-12
	Decapeptide-12，一个小型寡肽，作为tyrosinase的抑制剂，通过与tyrosinase的C末端残基相互作用(Kd: 61.1 μM)发挥作用。作为mushroom tyrosinase的竞争性抑制剂(IC50: 40 µM)，Decapeptide-12有效上调SIRT的转录水平，并能减少黑色素细胞中的黑色素含量，适用于黑色素生成、衰老和炎症的研究。
T77767	GLF16
	GLF16 是一种亲水性荧光 SBB 类似物，可有效识别衰老。它可以使用流式细胞术和活细胞分选来快速检测衰老细胞。 GLF16 适用于各种生物材料中单细胞水平的衰老细胞群的体内鉴定、分离和下游表征。
T73634	Milademetan tosylate hydrate	Others	Others
	Milademetan (DS-3032) tosylate hydrate，一种特异性、具口服活性的MDM2抑制剂，主要研究用途包括急性髓系白血病和实体肿瘤。它能诱导G1细胞周期阻滞、衰老和凋亡。
T31573	DPX-3778	Others	Others
	DPX-3778 is the triethanolamine salt of 3-(p-chlorophenyl)-6-methoxy-s-triazine-2,4(1H,3H) dione, at concentrations of 0.124-2.48 μM enhanced ca. 4-5-fold the proliferation of tobacco (Nicotiana tabacum L. cv. Wisconsin 38) callus cultured in the presence
T78344	Pectinase	Others	Others
	果胶酶(Pectinase)为水解果胶的酶混合物，广泛存在于微生物与高等植物中。该酶涉及细胞壁代谢，并影响细胞生长、衰老、果实成熟及发病与脱落过程。
T82420	FAK-IN-12	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	FAK-IN-12（Compound 12S）为FAK抑制剂，具有47 nM的IC50值。该化合物对MGC-803、HCT-116及KYSE30细胞系的增殖具有抑制作用（IC50值分别为0.24、0.45、0.44 μM），并可诱导细胞凋亡和细胞衰老。
T84891	TM5441 sodium	Others	Others
	TM5441是一种口服生物可利用的PAI-1(纤溶酶原激活物抑制剂-1)抑制剂，其对多种癌症细胞系的IC50值介于13.9到51.1μM之间，能诱导人类癌症细胞的内在凋亡(apoptosis)。此外，TM5441还可减轻Nω-硝基-1-精氨酸甲酯引发的心脏高血压和血管老化。
T81154	SIRT1 activator 1	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SIRT1 activator1(compound 3)，作为海洋化合物xyloallenoide a的衍生物，最初从红树林真菌Xylaria sp中分离获得。该化合物在斑马鱼模型中展现了促进血管生成的活性，并且能够通过提升SIRT1的表达水平以及调节AMPK/Akt信号通路，来防护人类内皮祖细胞(hEPC)免受血管老化的影响。
T85018	Sphynolactone-7 SPL7	Others	Others
	Sphynolactone-7 (SPL7) acts as an agonist for the Striga hyposensitive to light receptor 7 (ShHTL7) found in the parasitic plant Striga hermonthica. SPL7 selectively targets ShHTL7 with an IC50 of 0.31 µM, demonstrating higher specificity compared to ShHTL2-6, ShHTL9-10, and the strigolactone receptor AtD14 at a concentration of 10 µM, though it still inhibits ShHTL8 and ShHTL11 with IC50s of 1.2 and 7.8 µM, respectively. This compound triggers fatal germination of Striga hermonthica seeds in th...
T36618	Rupatadine	Others	Others
	Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited histamine-induced guinea pig ileum contraction (pA2 = 9.29 +/- 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4). It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in hu...

化合物

Cat.No: T0334

Synonym: BRL49653,罗格列酮

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Cat.No: T12854

Target: NAMPT

Rosiglitazone hydrochloride

Cat.No: T6646

Synonym: 盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Cat.No: T11383

Target: Survivin

p38 MAPK Inhibitor

Cat.No: T36010

Target: p38 MAPK

Cat.No: T40351

Target: mTOR

Cat.No: T16740

Synonym: NSC 697726

Target: Apoptosis

Cat.No: T71832

Target: Histone Acetyltransferase

Cat.No: T1923

Target: Histone Methyltransferase

Sirtuin-1 inhibitor 1

Cat.No: T79903

Target: Sirtuin

Cat.No: T78393

Synonym: 5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside

Cat.No: T12040

Synonym: RAIN-32,DS-3032,DS3032b

Target: Mdm2, Others

Cat.No: T3317

Target: Apoptosis, Others, E1/E2/E3 Enzyme

Cat.No: T26872

Synonym: BMVC 4,BMVC-4

Target: Others

Cat.No: T41151

Target: Others

Rosiglitazone potassium

Cat.No: T61848

Target: Others

Cat.No: T83432

Target: Others

Cat.No: T74590

Target: Others

dinor-12-oxo Phytodienoic Acid

Cat.No: T84495

Synonym: dinor-OPDA

Target: Others

Cat.No: T71034

Target: Others

Cat.No: T37865

Target: Others

Cat.No: T75714

Cat.No: T77767

Milademetan tosylate hydrate

Cat.No: T73634

Target: Others

Cat.No: T31573

Target: Others

Cat.No: T78344

Target: Others

Cat.No: T82420

Target: FAK

Cat.No: T84891

Target: Others

SIRT1 activator 1

Cat.No: T81154

Target: Sirtuin

Sphynolactone-7

Cat.No: T85018

Synonym: SPL7

Target: Others

Cat.No: T36618

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3768	Epifriedelanol 表木栓醇,Epifriedelinol	Others	Others
	Epifriedelanol (Epifriedelinol) 是一种分离自 Ulmus davidiana 根皮中的三萜类化合物，具有抗肿瘤作用，可以减缓人原始细胞的衰老。
T0591	D-Galactose D-(+)-Galactose,alpha-D-半乳糖,D-半乳糖,D-Galactopyranose,Alpha-D-galactose	Endogenous Metabolite	Metabolism
	D-Galactose (Alpha-D-galactose) 属于天然己糖，与葡萄糖结合构成乳糖。D-Galactose 常被用于构建动物衰老模型。
TL0005	3,5-O-Dicaffeoylquinic acid Isochlorogenic Acid A,(-)-3,5-二咖啡酰奎宁酸,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid	Others	Others
	3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) 能够改善由三甲基锡诱导的学习和记忆缺陷。
T4752	1-Aminocyclopropane-1-carboxylic acid 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite; NMDAR	Metabolism; Neuroscience
	1-Aminocyclopropane-1-carboxylic acid (ACC) 是内源性代谢产物的一种。
T19320	FAPy-adenine	Others	Others
	FAPy-adenine is an oxidized DNA base.Adenine is on the rise in the brains of people with Alzheimer's disease.Nucleoside oxidation is a biochemical marker for tumors, senescence and neurodegenerative diseases.
T64533	Ceramide (Egg, Chicken)	Apoptosis	Apoptosis
	Ceramide (Egg, Chicken)在鞘脂的合成代谢和分解代谢途径中起主要作用。Ceramide (Egg, Chicken)刺激许多细胞分化，生长抑制，细胞衰老和凋亡。
T79991	Condurango glycoside A	Others	Others
	Condurango glycoside A 作为p53激活剂，能够促进ROS的生成并且上调p53的表达。此外，Condurango glycoside A 还能够诱导HeLa细胞发生与DNA损伤相关的凋亡及过早老化。
TN3719	Cristacarpin	p38 MAPK; ROS; CDK; Antifection; p53	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; Microbiology/Virology
	Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering s
TN3968	Epifriedelanol acetate	Others	Others
	Epifriedelanol exhibits antibacterial activities. It also can reduce cellular senescence in human primary cells and may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases. Epifriedelanol and friedel

天然产物

Cat.No: T3768

Synonym: 表木栓醇,Epifriedelinol

Target: Others

Cat.No: T0591

Synonym: D-(+)-Galactose,alpha-D-半乳糖,D-半乳糖,D-Galactopyranose,Alpha-D-galactose

Target: Endogenous Metabolite

3,5-O-Dicaffeoylquinic acid

Cat.No: TL0005

Synonym: Isochlorogenic Acid A,(-)-3,5-二咖啡酰奎宁酸,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid

Target: Others

1-Aminocyclopropane-1-carboxylic acid

Cat.No: T4752

Synonym: 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC

Target: Endogenous Metabolite, NMDAR

Cat.No: T19320

Target: Others

Ceramide (Egg, Chicken)

Cat.No: T64533

Target: Apoptosis

Condurango glycoside A

Cat.No: T79991

Target: Others

Cat.No: TN3719

Target: p38 MAPK, ROS, CDK, Antifection, p53

Epifriedelanol acetate

Cat.No: TN3968

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02241	TMEM158 Protein, Human, Recombinant (His) TMEM158,Ras-induced senescence protein 1,40 kDa BIN...	Human	E. coli
	Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.
TMPH-02234	TMPRSS11A Protein, Human, Recombinant (His) Epidermal type-II transmembrane serine protease,Transmembran...	Human	E. coli
	Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
TMPJ-01399	ASF1A Protein, Human, Recombinant (His, T7) CIA,Anti-Silencing Function Protein 1 Homolog A,ASF1A,Histon...	Human	E. coli
	Human Histone Chaperone ASF1A (ASF1A) belongs to the H3/H4 family of histone chaperone proteins. ASF1A is ubiquitously expressed in many cells and tissues, interacting with histones H3 and H4. ASF1A cooperates with Chromatin Assembly Factor 1 to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. In addition, ASF1A is necessary for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associat...
TMPH-02306	VTI1B Protein, Human, Recombinant (His & SUMO) Vti1-rp1,VTI1B,Vesicle transport through interaction with t-...	Human	E. coli
	V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.
TMPH-02875	ROMO1 Protein, Mouse, Recombinant (His) Protein MGR2 homolog,Romo1,Reactive oxygen species modulator...	Mouse	E. coli
	Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.; Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
TMPH-02834	PAI-1 Protein, Mouse, Recombinant (His & SUMO) Endothelial plasminogen activator inhibitor,Serpine1,Serpin ...	Mouse	E. coli
	Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of ...
TMPJ-01121	MORF4L2 Protein, Human, Recombinant (His) MORF4L2,Transcription Factor-Like Protein MRGX,Protein MSL3-...	Human	E. coli
	Mortality Factor 4-Like Protein 2 (MORF4L2) is a member of the mortality factor (MORF) family. MORF4L2 localizes in the nucleus, possessing a protein kinase C phosphorylation site and a tyrosine phosphorylation site. MORF4L2 interacts with the Rb tumor suppressor and it has histone deacetylase activity which can either repress or promote the activity of the B-Myb promoter depending on the tissue. In addition, MORF4L2 is involved in cell growth, regulation, and senescence.
TMPH-02526	Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO) Arginase II,Kidney-type arginase,Type II arginase,Arg2,Argin...	Mouse	E. coli
	May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium....
TMPH-00545	Epstein-Barr virus (strain GD1) BRLF1 Protein (His & Myc) Immediate-early protein Rta,Protein R,Replication and transc...	EBV	E. coli
	Immediate-early transcription factor that controls the initiation of viral lytic gene expression and lytic reactivation from latency. Triggers lytic replication, and initiates a cellular senescence program in epithelial cells. Upregulates human DCR3/TNFRSF6B by directly binding to its receptor. Epstein-Barr virus (strain GD1) BRLF1 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.9 kDa and the accession number is Q3KS...
TMPJ-00854	ETS1 Protein, Human, Recombinant (His) V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),...	Human	E. coli
	ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As...
TMPY-02810	Ninjurin-1 Protein, Rat, Recombinant (hFc) ninjurin 1	Rat	HEK293 Cells
	Ninjurin-1, also known as NINJ1, is a member of the Ninjurin family of transmembrane (TM) proteins. It is expressed in CD19(+) CD10(+) B-cell progenitor cells and higher levels in B-lineage acute lymphoblastic leukemia cells. Ninjurin-1 is expressed also in some other adult and embryonic tissues, predominantly in epithelial cells. Its expression is upregulated after axotomy in neurons and Schwann cells surrounding the distal nerve segment. Upregulated expression of ninjurin-1 has been identified...
TMPY-01869	SIRT1 Protein, Human, Recombinant (His) SIR2L1,sirtuin 1	Human	E. coli
	SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent protein deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. It deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. SIRT1 also deacetylates TAF1B and there...
TMPH-02855	PML Protein, Mouse, Recombinant (His & Myc) Protein PML,Pml	Mouse	E. coli
	Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosp...
TMPY-02228	p53 Protein, Cynomolgus, Recombinant tumor protein p53,p53,TP53	Cynomolgus	E. coli
	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damag...

重组蛋白

TMEM158 Protein, Human, Recombinant (His)

Cat.No: TMPH-02241

Species: Human

Expression System: E. coli

TMPRSS11A Protein, Human, Recombinant (His)

Cat.No: TMPH-02234

Species: Human

Expression System: E. coli

ASF1A Protein, Human, Recombinant (His, T7)

Cat.No: TMPJ-01399

Species: Human

Expression System: E. coli

VTI1B Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02306

Species: Human

Expression System: E. coli

ROMO1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02875

Species: Mouse

Expression System: E. coli

PAI-1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02834

Species: Mouse

Expression System: E. coli

MORF4L2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01121

Species: Human

Expression System: E. coli

Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02526

Species: Mouse

Expression System: E. coli

Epstein-Barr virus (strain GD1) BRLF1 Protein (His & Myc)

Cat.No: TMPH-00545

Species: EBV

Expression System: E. coli

ETS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00854

Species: Human

Expression System: E. coli

Ninjurin-1 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-02810

Species: Rat

Expression System: HEK293 Cells

SIRT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01869

Species: Human

Expression System: E. coli

PML Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02855

Species: Mouse

Expression System: E. coli

p53 Protein, Cynomolgus, Recombinant

Cat.No: TMPY-02228

Species: Cynomolgus

Expression System: E. coli

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