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Search Results for " myeloproliferative "

Targets Recommended: PDE

12

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T0160	Anagrelide Anagrelida,Xagrid,Anagrelidum,阿那格雷	PDE	Metabolism
	Anagrelide (Xagrid) 是III 型磷酸二酯酶(PDEIII)抑制剂 (IC50=36 nM)，是咪唑喹唑啉衍生物。它能够抑制血小板生成，以及抗血栓形成作用，可用作血小板聚集抑制剂。
T4570	Pipobroman Vercyte,A-8103,Amedel,哌泊溴烷	Others; DNA Alkylator/Crosslinker	DNA Damage/DNA Repair; Others
	Pipobroman (Vercyte) 是一种烷基化剂，是哌嗪的溴化衍生物。它通过抑制 DNA 和 RNA 聚合酶或减少嘧啶核苷酸掺入 DNA 发挥其作用。它在真性红细胞增多症和原发性血小板增多症中具有良好的临床活性，可用于癌症研究。
T1995	Fedratinib TG-101348,SAR 302503	Apoptosis; FLT; c-RET; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Fedratinib (TG-101348) 是一种 JAK2 抑制剂，具有选择性、ATP 竞争性和具有口服活性，抑制 JAK2 和 JAK2V617F 激酶 (IC50=3 nM)。Fedratinib 可诱导肿瘤细胞凋亡，并可用于骨髓增生性疾病的研究。
T9251	Fedratinib hydrochloride hydrate TG-101348 hydrochloride hydrate,SAR 302503 hydrochloride hydrate	Apoptosis; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) 是一种选择性的，ATP 竞争性和具有口服活性的JAK2抑制剂，对于JAK2和JAK2V617F 激酶的IC50均为 3 nM。它可诱导癌细胞凋亡，可研究骨髓增生性疾病。
T70008	Bomedemstat ditosylate MK-3543 ditosylate,IMG-7289 ditosylate	Apoptosis; Histone Demethylase	Apoptosis; Chromatin/Epigenetic
	Bomedemstat ditosylate (IMG-7289 ditosylate) 是一种具有口服活性的 lysine-specific demethylase 1 (LSD1) 抑制剂，具有抗肿瘤活性，增强 SCLC 同基因模型中对 PD-1 抑制的反应，抑制癌细胞增殖，诱导细胞凋亡。Bomedemstat ditosylate 可用于研究骨髓增生性肿瘤和骨髓纤维化。
T71313	BVB-808	Others	Others
	BVB-808 is a selective Jak2 type 1 inhibitor. Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative myeloproliferative neoplasms. Preclinical results support that JAK2 inhibitors could show efficacy in treating chronic myeloproliferative neoplasms. JAK2 has also been postulated to play a role in BCR-ABL signal transduction. Therefore, inhibitors of JAK2 kinases are turning int...
T10009	JAK3-IN-7	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK3-IN-7 是一种有效的选择性 JAK3 抑制剂（IC50<0.01 μM），可用于治疗器官移植中的排斥反应、器官移植后的移植物抗宿主反应、自身免疫性疾病、过敏性疾病和慢性骨髓增生性疾病。
T76853	Ropeginterferon alfa-2b
	Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) 为单聚乙二醇化IFN-α类化合物，主要应用于骨髓增性肿瘤研究领域。
T64227	JAK2 JH2 binder-1	Others	Others
	JAK2 JH2 binder-1 是一种有效的、选择性的 JAK2 JH2 结合剂 (Ki: 37.1 nM)。JAK2 JH2 binder-1 具有用于研究各种骨髓增生性肿瘤的潜力。
T9634	Bomedemstat	Others	Others
	Bomedemstat (IMG-7289) 是一种有效的，具有口服活性的且不可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂，具有表观遗传活性。Bomedemstat 具有抗癌活性，可用于急性髓性白血病 (AML) 和骨髓纤维化 (MF) 的研究。
T79581	JAK2-IN-9	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK2-IN-9（Compound A8）是一款选择性JAK2抑制剂（IC50：5 nM），能够抑制JAK2、STAT3和STAT5的磷酸化，并显示出代谢稳定性。此外，JAK2-IN-9能够诱导细胞凋亡（apoptosis），适用于骨髓增生性肿瘤（MPN）的研究。
T73567	ZT55	Others	Others
	ZT55 是一种口服有效并具有高选择性的JAK2抑制剂，其IC50值为 0.031 μM。ZT55 能抑制表达JAK2V617F 的 HEL 细胞系的增殖，并诱导细胞凋亡和周期停滞。ZT-55 还可有效抑制小鼠模型体内 HEL 异种移植肿瘤的生长。ZT-55 可用于骨髓增生性肿瘤、多血症以及原发性血小板增多症的研究。

化合物

Cat.No: T0160

Synonym: Anagrelida,Xagrid,Anagrelidum,阿那格雷

Target: PDE

Cat.No: T4570

Synonym: Vercyte,A-8103,Amedel,哌泊溴烷

Target: Others, DNA Alkylator/Crosslinker

Cat.No: T1995

Synonym: TG-101348,SAR 302503

Target: Apoptosis, FLT, c-RET, JAK

Fedratinib hydrochloride hydrate

Cat.No: T9251

Synonym: TG-101348 hydrochloride hydrate,SAR 302503 hydrochloride hydrate

Target: Apoptosis, JAK

Bomedemstat ditosylate

Cat.No: T70008

Synonym: MK-3543 ditosylate,IMG-7289 ditosylate

Target: Apoptosis, Histone Demethylase

Cat.No: T71313

Target: Others

Cat.No: T10009

Target: JAK

Ropeginterferon alfa-2b

Cat.No: T76853

JAK2 JH2 binder-1

Cat.No: T64227

Target: Others

Cat.No: T9634

Target: Others

Cat.No: T79581

Target: JAK

Cat.No: T73567

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00235	TPO Protein, Human, Recombinant (His) Megakaryocyte growth and development factor,C-mpl ligand,Thr...	Human	HEK293 Cells
	Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physi...
TMPY-03455	FGFR1OP Protein, Human, Recombinant (His & GST) FGFR1 oncogene partner,FOP	Human	Baculovirus Insect Cells
	FOP( fibroblast growth factor receptor 1 oncogene partner) is a largely hydrophilic protein postulated to be a leucine-rich protein family member. FOP contains 1 LisH domain. A t(6;8)(q27;p11) chromosomal translocation, fusing FOP gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. FOP g...
TMPJ-00541	CD177 Protein, Human, Recombinant (His) PRV-1,HNA-2a,Human Neutrophil Alloantigen 2a,CD177,Polycythe...	Human	HEK293 Cells
	CD177 is polymorphic and has at least two alleles: PRV1 and NB1. Human PRV1 is a Glycosyl-Phosphatidylinositol (GPI)-linked cell surface glycoprotein that belongs to the uPAR/CD59/Ly6 family of receptors. PRV1 is expressed by neutrophils and neutrophil precursors,and changes in expression serve as diagnostic markers for myeloproliferative disorders such as polycythemia vera and essential thrombocythemia. PRV1 may also be expressed by Erythroblasts, B cells, and Monocytes. NB1, a Glycosyl-Phospha...

重组蛋白

TPO Protein, Human, Recombinant (His)

Cat.No: TMPJ-00235

Species: Human

Expression System: HEK293 Cells

FGFR1OP Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03455

Species: Human

Expression System: Baculovirus Insect Cells

CD177 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00541

Species: Human

Expression System: HEK293 Cells

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