137
11
2
2
3
Cat. No. | Product Name | ||
---|---|---|---|
L3400 | 临床期小分子药物库 | 3404 compounds | |
3404 个临床期化合物集合,可用于高通量筛选和高内涵筛选; | |||
L6620 | 抗寄生虫天然产物库 | 253 compounds | |
253 个抗寄生虫相关的天然产物集合,是药物开发、药理研究的有效工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35862 |
Cucurbit[8]uril
|
Others | Others |
Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, demonstrating its specificity and versatility. Additionally, Cucurbit[8]uril shows exceptional oral activity and low toxicity, making it a promising candidate for various pharmaceutical and biotechnological applications. | |||
T21246 |
Metsulfuron-methyl
|
Others | Others |
Metsulfuron-methyl 是一种内吸传导选择性麦田高效磺酰脲类除草剂,主要防治麦田大多数阔叶杂草和禾本科杂草。 | |||
T7413 |
JNJ-5207852
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
JNJ-5207852 是一种新型的非咪唑组胺 H3 受体拮抗剂,其对大鼠和人 H3 受体的 pKi 值分别为 8.9 和9.24。 | |||
T8418 |
DCLK1-IN-1
|
Others | Others |
DCLK1-IN-1 是选择性的、体内相容的双皮质素样激酶1DCLK1激酶结构域化学探针。它抑制 DCLK1 和 DCLK2 激酶。它具有低毒性,可以研究 DCLK1 的生物学特性,确定其在肿瘤中的作用,如 DCLK1+胰腺导管腺癌。 | |||
T9193 |
ACH-000143
|
Melatonin Receptor; MT Receptor | GPCR/G Protein; Neuroscience |
ACH-000143 是一种可口服的褪黑素受体激动剂,对 MT1 和 MT2 的EC50值分别为0.06 和0.32 nM。 | |||
T13950 |
UC-514321
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
UC-514321 是NSC370284 的结构类似物,靶向STAT3/5并选择性抑制TET1的表达,且活性更高。它有较低的毒性,在体内外均表现出良好的抗急性髓系白血病活性。 | |||
T8646 |
URB937
|
FAAH | Metabolism; Neuroscience |
URB937 是一种口服具有活性的、外周限制的FAAH 抑制剂,IC50=26.8 nM,可增加 anandamide 水平,但不能影响脑内 FAAH 水平 (无法透过血脑屏障)。 | |||
T9050 |
AG-270
|
Others; Methionine Adenosyltransferase (MAT) | Chromatin/Epigenetic; Others |
AG-270 是一种可逆的、非竞争性的、具有口服活性的MAT2A 变构抑制剂(IC50:14 nM)。 | |||
T13974 |
ZL0580
|
Epigenetic Reader Domain; HIV Protease | Chromatin/Epigenetic; Microbiology/Virology; Proteases/Proteasome |
ZL0580 通过抑制 Tat 反式激活和转录延伸以及通过在 HIV 启动子处诱导抑制性染色质结构来诱导 HIV 抑制。 | |||
T10565 |
BMS-1001 hydrochloride
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS-1001 hydrochloride 是一种人 PD-L1/PD-1免疫检查点的抑制剂,具有口服活性且细胞毒性低。 | |||
T9575 |
MRTX9768
|
Histone Methyltransferase | Chromatin/Epigenetic |
MRTX-9768 是一种有效的、选择性的、具有口服活性的 PRMT5-MTA 复合体抑制剂,可选择性靶向 MTAP/CDKN2A 缺失的肿瘤。 | |||
T7860 |
SM-324405
SM 324405 |
TLR | Immunology/Inflammation |
SM-324405 是TLR7的激动剂,EC50 为 50 nM,对人和大鼠 TLR7 的 pEC50值分别为 7.3 和 6.6,可用于过敏性疾病的免疫治疗研究。 | |||
T2108 |
Andarine
S-4,GTx-007 |
Androgen Receptor | Endocrinology/Hormones |
Andarine (GTx-007) 是一种选择性的、具有口服活性的、非甾体受体雄激素受体(AR)调节剂 (SARM) 和部分激动剂,Ki=4 nM。它是一种具有较强活性的、具有组织选择性的 SARM。 | |||
T9812 |
Tubulin inhibitor 24
|
Microtubule Associated | Cytoskeletal Signaling |
Tubulin inhibitor 24 是一种 tubulin 抑制剂,可以抑制微管蛋白聚合,以浓度依赖性方式诱导细胞周期停滞在 G2/M 期, 具有抗肿瘤活性且无明显毒性。 | |||
T1115 |
Doxylamine succinate
琥珀酸多西拉敏,Decapryn |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Doxylamine succinate (Decapryn) 是一种吡啶衍生物组胺 H1 拮抗剂,具有明显的镇静特性。它竞争性阻断组胺 H1 受体并限制典型的过敏和过敏反应,可防止组胺引起的皮肤和粘膜疼痛和瘙痒。 | |||
T4325 |
COTI-2
COTI 2,COTI2 |
Apoptosis; p53 | Apoptosis |
COTI-2是一种具有口服活性的低毒性抗癌药物,是 p53 突变体激活剂。它通过激活突变型 p53 和抑制PI3K/AKT/mTOR 途径发挥作用,通过 p53 依赖和非依赖机制在 HNSCC 中具有抗肿瘤活性。它诱导多种人肿瘤细胞凋亡,可将突变型 p53 转化为野生型构象。 | |||
T14919 |
CDKI-73
|
Apoptosis; CDK | Apoptosis; Cell Cycle/Checkpoint |
CDKI-73 是一种具有口服活性的 CDK9抑制剂,其对 CDK9、CDK1 和 CDK2 的Ki 值分别为 4 nM、4 nM 和 3 nM。CDKI-73 可下调 RNA 聚合酶 II 的磷酸化。CDKI-73 也是一种 Rab11 的抑制剂。 | |||
T8822 |
JNJ-5207852 dihydrochloride
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
JNJ-5207852 dihydrochloride 是一种新型的非咪唑组胺 H3 受体拮抗剂,对大鼠和人类 H3受体的 pKi 值分别为 8.9 和 9.24。 | |||
T6446 |
Clevudine
L-FMAU,克拉夫定,Levovir |
HBV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Clevudine (Levovir) 是一种非自然 L-构型的核苷类似物,是一种与聚合酶结合的非竞争性抑制剂,具有较强的抗 HBV 活性,半衰期长,毒性低的特点。 | |||
T13692 |
Ferric maltol
Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate,麦芽酚铁 |
Others | Others |
Ferric maltol (Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate) 是一种具有口服活性的单一铁离子 (Fe3+) 复合物,可用于研究炎症性肠病缺铁性贫血。 | |||
T67060 |
1,16-Hexadecanediol
|
Others | Others |
1,16-Hexadecanediol 毒性较低,可用于制作树脂和纳米材料。 | |||
T41116 |
FV-100
Valnivudine HCl |
Others | Others |
FV-100 (Valnivudine HCl)是一种具有口服活性的抗水痘带状疱疹病毒剂,具有有效性和选择性。FV-100是CF-1743的原料药。FV-100在体内显示出很低的毒性。 | |||
T3202 |
Fluensulfone
MCW-2 |
Parasite | Microbiology/Virology |
Fluensulfone (MCW-2) 是一种新型杀线虫剂,可化学防治植物寄生线虫。 | |||
T77550 |
O-Desmethyl Quinidine
|
Others | Others |
O-Desmethyl Quinidine 是一种新型的奎尼丁类似物,具有显着的抗心律失常活性和较低的急性毒性,可能有助于治疗心律失常。 | |||
T23478 |
Trometamol hydrochloride
TRIS hydrochloride,三(羟甲基)氨基甲烷盐酸盐 |
Others | Others |
Trometamol hydrochloride (TRIS hydrochloride) 是低毒性的生物惰性氨基醇,可以在体内、外缓冲二氧化碳和酸,能用于生理范围内控制 pH 值。 | |||
T38970 |
Hematoporphyrin monomethyl ether
|
Others | Others |
Hematoporphyrin monomethyl ether (HMME), a second-generation porphyrin-related photosensitizer, is a highly selective and low-toxicity compound known for its singular form and high yield of singlet oxygen. It finds extensive application in diagnosing and treating various tumors, including lung cancer, bladder cancer, nevus flammeus, and brain glioma. | |||
T0790 |
Carbaryl
1-naphthyl methylcarbamate,甲萘威,Sevin |
AChR | Neuroscience |
Carbaryl (1-naphthyl methylcarbamate) 可作为一种杀虫剂。 | |||
T0880 |
Bronopol
布波尔,BNPK,溴硝醇,BNPD |
Antibacterial | Microbiology/Virology |
Bronopol (BNPD) 是一种抗菌剂,对哺乳动物毒性低和对革兰氏阴性菌活性高。 | |||
T78745 |
Mtb-IN-2
|
Antibiotic | Microbiology/Virology |
Mtb-IN-2 是一种具有抗菌活性和低毒性的结核分枝杆菌(Mtb)的小分子化合物,干预蛋氨酸代谢过程,可用于研究结核病。 | |||
T19914 |
Chlorothalonil
DAC 2787,Daconil,Daconil M,百菌清 |
Antifungal | Microbiology/Virology |
Chlorothalonil (DAC 2787) 是一种高效低毒广谱的杀菌剂,广泛用于防治果树、蔬菜菜叶等多种害虫,对水稻、小麦、棉花等多种病害,也具有较好的防治效果。 | |||
T9548 |
RSM-932A
TCD-717 |
||
RSM-932A (TCD-717) 是一种特异性 ChoKα 抑制剂,对人重组 ChoKα 和 ChoKβ 酶的 IC50 分别为 1 和 33 μM。RSM-932A 具有有效的体内外抗肿瘤活性,并且毒性较低。 | |||
TQ0232 |
UNC0646
UNC 0646 |
Histone Methyltransferase | Chromatin/Epigenetic |
UNC0646 是一种有效的、选择性的同源蛋白赖氨酸甲基转移酶 G9a 和 GLP 抑制剂,IC50分别为 6 和 15 nM,对 G9a/GLP 的选择性比 SETD7、SUV39H2、SETD8 和 PRMT3 高。它降低 MDA-MB-231 细胞中H3K9me2的水平,IC50为 26 nM。 | |||
T25672 |
Lesopitron
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Lesopitron 是一种具有突触前和突触后5-HT1A 激动剂活性的抗焦虑剂,在大鼠社会交往和狨猴焦虑模型中比5-HT1A 激动剂更有效。Lesopitron 能对抗苯二氮卓类药物戒断引起的啮齿动物的焦虑且急性毒性很低,不会增强酒精或巴比妥类药物的作用。 | |||
T0992 |
Carbenoxolone disodium
Biogastrone,Duogastrone,甘珀酸钠,Bioral |
Gap Junction Protein | Cytoskeletal Signaling |
Carbenoxolone disodium (Duogastrone) 是甘草酸的活性代谢物和人11β-HSD 和细菌3α, 20β-HSD 的抑制剂。它是一种缝隙连接的解耦剂,可抑制牛痘病毒生长,用于消化性、食道和口腔溃疡和炎症的相关研究。 | |||
TP1341L |
Polymyxin B nonapeptide acetate
Polymyxin B nonapeptide acetate(86408-36-8 free base) |
Antibacterial; Antibiotic | Microbiology/Virology |
Polymyxin B nonapeptide acetate(86408-36-8 free base) 是一种阳离子环肽。 Polyxin B 九肽是 polyxin B 经酶解产生的衍生物。与 polyxin B 相比,polyxin B 九肽毒性低,缺乏杀菌活性,仍具有破坏革兰氏阴性菌外膜的能力。 | |||
T9172 |
Simufilam dihydrochloride
PTI-125 dihydrochloride |
Others | Others |
Simufilam dihydrochloride (PTI-125 dihydrochloride) 是口服具有活力的、毒性低的 filamin A 激活剂。它可优先结合改变的 FLNA,并恢复其天然构象,恢复受体和突触活性,并减少其与 a7nAChR/TLR4 的关联和下游病理作用。它可用于研究阿尔茨海默症。 | |||
T77575 |
P-gb-IN-1
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
P-gb-IN-1 是一种有效的 P-糖蛋白 (P-gp) 抑制剂,通过抑制 P-gp 外流展现出逆转活性。P-gb-IN-1 通过与残基 Asn 721 和 Met 986 形成氢键相互作用从而显示出对 P-gp 的抑制作用。P-gb-IN-1 在 MCF-7/ADR 细胞中显示出低毒性。 | |||
T9403 |
1,3,5-tris(pyridin-4-ylethynyl)benzene
|
Others | Others |
1,3,5-tris(pyridin-4-ylethynyl)benzene 是一种杂环化合物,具有广泛的性质,如荧光和电化学活性,具有相对较低的毒性。它已被用作合成各种材料的构建块,如聚合物、纳米材料和有机发光二极管(OLED)。它也是开发新型药物递送系统的一种有前途的材料。 | |||
T26690 |
AVN-101
|
5-HT Receptor; Adrenergic Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
AVN-101 是一种非常有效的 5-HT7 受体拮抗剂 (Ki = 153 pM)。 AVN-101 还对组胺 H1 (Ki = 0.58 nM) 和肾上腺素能 α2A、α2B 和 α2C (Ki = 0.41-3.6 nM) 受体表现出相当高的亲和力。 AVN-101在中枢神经系统疾病动物模型中显示出良好的口服生物利用度和促进脑血屏障通透性、低毒性和合理的疗效。 | |||
T13821 |
Pirinixil
BR-931,匹立昔尔 |
Others | Others |
Pirinixil is a hypolipidemic low toxicity agent. | |||
T31064 |
CP-5484
CP 5484,UNII-A53TMV6VUN,CP5484 |
Others | Others |
Cp-5484 is a new kind of Quaternary carbapenem with strong anti MRSA activity and low acute toxicity. | |||
T20831 |
Etrimfos
Ekamet,San197,San 197,Satisfar,San-197 |
Others | Others |
Etrimfos is an organophosphorus insecticide with high efficiency and low toxicity. | |||
T27280 |
Eremomycin
A82846A,A-82846A,A 82846A |
Others | Others |
Eremomycin, an antibiotic, can be used intramuscularly due to low toxicity. | |||
T20588 |
Tetrachlorvinphos
Stirofos |
Others | Others |
Tetrachlorvinphos, an organophosphate cholinesterase inhibitor, is used as an insecticide. It has low toxicity to mammals. | |||
T20748 |
Furametpyr
Limber |
Others | Others |
Furametpyr is a kind of low toxicity pesticides used to control plant diseases caused by various pathogenic microorganisms. | |||
T31528 |
Disodium sebacate
Sebacic Acid Disodium Salt,Decanedioic Acid Disodium Salt,Disodium Decanedioate |
Others | Others |
Disodium sebacate is a 10-carbon-atom dicarboxylic acid, proposed as substrate for parenteral nutrition. It has low toxicity. | |||
T12824 |
S55746 hydrochloride
BLC201 (hydrochloride) |
BCL | Apoptosis |
S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity. | |||
T73417 |
Con B-1
|
Others | Others |
ConB-1是一种对正常细胞低毒的强选择性 ALK 抑制剂。 | |||
T75299 |
Etimicin sulfate
|
Others | Others |
Etimicin (sulfate)是第四代氨基糖苷类抗生素,因其高效、低毒而被广泛应用于临床。 | |||
T39682 |
Gunagratinib
ICP-192 |
Others | Others |
Gunagratinib (ICP-192) is a potent and selective, orally active pan-FGFR (fibroblast growth factor receptors) inhibitor with low toxicity, exhibiting irreversible covalent binding to effectively inhibit FGFR activities. It is particularly suitable for cancer research purposes. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S0803 |
Columbamine
非洲防己碱,Columbamin,Dehydroisocorypalmine |
Others | Others |
Columbamine (Columbamin) 是一种从植物中提取的季异喹啉生物碱。 | |||
T5625 |
Zearalenone
玉米,Mycotoxin F2,玉米烯酮,RAL,F2 toxin,Toxin F2 |
Others | Others |
Zearalenone (F2 toxin) 是真菌毒素,主要由食物和饲料中的 Fusarium 产生。它会引起幼龄母猪乳房发育早熟或其它雌激素效应。它在猪、牛、羊体内具有雌激素活性,急性毒性低。 | |||
T19317 |
Ethyl phenylacetate
|
Others | Others |
Ethyl phenylacetate 是天然香料,其感官阈值接近 73 µg/L。它可使葡萄酒具有强烈的蜂蜜样特性。它是一种毒性较小且对环境更友好的溶剂,是非诱变性的,并且是犹太食品添加剂。 | |||
T5S0053 |
Coptisine
黄连碱,Coptisin |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Coptisine (Coptisin) 是一种从黄连中分离到的生物碱,是非竞争性的IDO 抑制剂,Ki=为 5.8 μM,IC50=6.3 μM。 | |||
TN4724 |
Otosenine
|
Others | Others |
D-Otocenine elicites low toxicity, it shows spasmolytic properties . | |||
TN3010 |
4,5-Di-O-caffeoylquinic acid methyl ester
金银花 |
HSV | Microbiology/Virology |
4,5-Di-O-caffeoylquinic acid methyl ester shows high efficiency and low toxicity with antivirus activity against RSV. | |||
TN2872 |
3,4-Di-O-caffeoylquinic acid methyl ester
金银花 |
HSV | Microbiology/Virology |
3,4-Di-O-caffeoylquinic acid methyl ester shows high efficiency and low toxicity with antivirus activity against RSV; it exhibits cytotoxicity actions against human cervix carcinoma HeLa cells. | |||
TN3080 | 5,6,7-Trimethoxycoumarin | P450; Antifection | Metabolism; Microbiology/Virology |
5,6,7-Trimethoxycoumarin shows moderate inhibitory activity against Micrococcus luteus, it also displays an intermediate cytotoxic effects against brine shrimp larvae. 5,6,7-Trimethoxycoumarin can improve gastroprotective effects, and it has low toxicity | |||
TN2894 |
3,5-Di-O-caffeoylquinic acid methyl ester
金银花 |
HSV | Microbiology/Virology |
3,5-Di-O-caffeoylquinic acid methyl ester exhibits potent inhibitory activities against the formation of advanced glycation end products (AGEs); it exhibits cytotoxicity actions against human cervix carcinoma HeLa cells. 3,5-Di-O-caffeoylquinic acid methyl ester shows high efficiency and low toxicity with antivirus activity against RSV. | |||
TN4699 | Ohchinin | Others | Others |
Ohchinin exhibits potent inhibitory activities with 26 - 66% reduction of melanin content at 100 μm concentration with almost no or low toxicity to the B16 melanoma cells (70 - 99% cell viability at 100 μm). | |||
T83693 |
Magainin 2 TFA
MG2 |
Others | Others |
Magainin 2是一种从非洲爪蟾(X. laevis)皮肤中分离出的阳离子肽,具有宿主防御和抗菌活性。该化合物对细菌E. coli、K. pneumoniae、S. epidermidis、S. aureus及真菌C. albicans表现出活性(MICs分别为5、10、10、50和80 µg/ml)。Magainin 2(20 µM)能降低猕猴桃花粉的萌发率和平均管长。在被单纯疱疹病毒1型(HSV-1)或2型(HSV-2)感染的Vero细胞中,它可减少病毒复制(EC50s分别为22.16和19.8 µM),同时不影响细胞活性,其50%细胞毒性浓度值(CC50)大于100 µM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02404 |
LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO)
Alpha-insect toxin LqhaIT,Lqh-alpha-IT |
Yellow scorpion | E. coli |
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice. LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.5 kDa and ... | |||
TMPY-01099 |
GPT Protein, Rat, Recombinant (His)
Gpt1,ALAT,glutamic-pyruvate transaminase (alanine aminotrans... |
Rat | Baculovirus Insect Cells |
Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (GPT), is a pyridoxal enzyme that belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily. Gpt / Gpt1 / ALT catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and plays a key role in the intermediary metabolism of glucose and amino acids. Gpt / Gpt1 / ALT is expressed in the liver, kidney, heart, and skeletal musc... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0451 |
Malathion-d10
|
||
Malathion-d10 是 Malathion 的氘代化合物。Malathion 的 CAS 号为 121-75-5。Malathion 是一种杀虫剂,是一种有机磷酸酯的副交感神经药物,不可逆地与胆碱酯酶结合,具有相对较低的人体毒性。 | |||
TMIJ-0516 |
Carbaryl-d3
|
||
Carbaryl-d3 是 Carbaryl 的氘代化合物。Carbaryl 的 CAS 号为 63-25-2。Carbaryl 可作为一种杀虫剂。 | |||
TMIJ-0456 |
Malathion-d7
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Malathion-d7 是 Malathion 的氘代化合物。Malathion 的 CAS 号为 121-75-5。Malathion 是一种杀虫剂,是一种有机磷酸酯的副交感神经药物,不可逆地与胆碱酯酶结合,具有相对较低的人体毒性。 |