购物车
- 全部删除
- 您的购物车当前为空
JNJ-5207852 dihydrochloride 是一种新型的非咪唑组胺 H3 受体拮抗剂,对大鼠和人类 H3受体的 pKi 值分别为 8.9 和 9.24。
JNJ-5207852 dihydrochloride 是一种新型的非咪唑组胺 H3 受体拮抗剂,对大鼠和人类 H3受体的 pKi 值分别为 8.9 和 9.24。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 289 | 现货 | |
5 mg | ¥ 598 | 现货 | |
10 mg | ¥ 1,050 | 现货 | |
25 mg | ¥ 2,110 | 现货 | |
50 mg | ¥ 2,980 | 现货 | |
100 mg | ¥ 4,330 | 现货 | |
200 mg | ¥ 5,790 | 现货 |
产品描述 | JNJ-5207852 dihydrochloride is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor. |
体内活性 | JNJ-5207852 is a potent dibasic amine antagonist that binds potently to rat H3 receptors (Ki=1.2?nm), and has good brain penetration. In ex vivo binding studies in mice, the compound had an ED50 of 0.13?mg?kg?1, subcutaneously. It promotes wakefulness in rodents at 10?mg?kg?1 s.c. but not at 1?mg?kg?1, and significantly, this effect was absent in H3 receptor KO mice. JNJ-10181457 is also a dibasic amine antagonist that exhibits high-affinity binding for the rat H3 receptor (Ki=7.1?nm), promoting wakefulness in rodents and reducing cataplectic attacks in narcoleptic dogs . JNJ-10181457 improved cognitive performance in SHR pups at 10?mg?kg?1[1]. |
分子量 | 389.4 |
分子式 | C20H34Cl2N2O |
CAS No. | 1782228-76-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | DMSO: Slightly soluble |
版权所有©2015-2024 TargetMol Chemicals Inc.保留所有权利.