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Search Results for " less-active "

Targets Recommended: HBV

112

抑制剂 & 化合物

7

天然产物

4

化合物库

3

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L1580	GPCR库Plus		338 compounds
	338 种GPCR 靶向、结构新颖的化合物；
L6810	中药单体化合物库		2755 compounds
	2755 种中药来源的单体化合物，是药物开发、药理研究等领域的有力工具；
L6800	中国药典收录天然产物库		2051 compounds
	2051 种中国药典收录的天然产物，是药物开发、药理研究等领域的有力工具；
L9900	药用辅料化合物库		182 compounds
	182 种 FDA 批准药品中的非活性成分集合

化合物库

Cat.No: L1580

Compounds: 338

中药单体化合物库

Cat.No: L6810

Compounds: 2755

中国药典收录天然产物库

Cat.No: L6800

Compounds: 2051

药用辅料化合物库

Cat.No: L9900

Compounds: 182

Cat. No.	Product Name	Target	Signaling Pathways
T10480	Bay 41-4109 (less active enantiomer)	HBV	Microbiology/Virology
	Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM).
T6352	(-)-Dizocilpine maleate C13737,(-)-MK 801 (Maleate),(-)-MK 801马来酸,(-)-MK 801 Maleate	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	(-)-Dizocilpine maleate ((-)-MK 801 (Maleate)) 是一种选择性且非竞争性的 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂，Ki 为 211.7 nM。它是一种 Dizocilpine 的活性较低的 (-)-对映体，具有抗抑郁作用。
T12814	(S)-Tenofovir (S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF	Others	Others
	(S)-Tenofovir ((S)-PMPA) 是Tenofovir 的活性较低的S-对映体，Tenofovir 是一种核苷酸逆转录酶抑制剂。
T12664	(Rac)-BRD0705	Others	Others
	(Rac)-BRD0705 是 BRD0705 的活性较低的外消旋体。 BRD0705 是一种有效的特异性 GSK3α 抑制剂。
T12831	SAR405 R enantiomer	Others	Others
	SAR405 R enantiomer 是一种 PIK3C3/Vps34 抑制剂，也是活性低于 SAR405 的对映体。
T10376	ARS-1630	Ras	GPCR/G Protein; MAPK
	ARS-1630 是一种突变型 K-ras G12C 抑制剂。它是 ARS-1620 的活性较低的对映异构体。
T68051L	RS 15385-198	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	RS 15385-198 是 Delequamine 的低活性异构体。Delequamine 是一种选择性 α2-肾上腺素受体拮抗剂。
T7080	CCT245737 SRA737	Chk	Cell Cycle/Checkpoint
	CCT245737 (SRA737) 是一种具有口服活性的选择性 Chk1 抑制剂，IC50值为 1.3 nM。
T9554	SN-008	STING	Immunology/Inflammation
	SN-008 是 SN-011 的低活性类似物，可作为阴性对照。
T11129L	Duvelisib (R enantiomer) hydrochloride IPI-145 R enantiomer HCl,Duvelisib (R enantiomer) hydrochloride(1261590-48-0 Free base),INK1197 R enantiomer HCl	PI3K	PI3K/Akt/mTOR signaling
	Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) 是 PI3K 抑制剂。Duvelisib (R enantiomer) hydrochloride 是 Duvelisib 的活性较低的对映体。
T22818	GSK9027 GR agonist 23a,GSK 9027,GSK-9027	Glucocorticoid Receptor	Endocrinology/Hormones
	GSK9027 (GR agonist 23a) 是一种非甾体糖皮质激素受体 (GR) 激动剂。GSK9027 (GR agonist 23a) 在2×GRE报告基因上对比地塞米松的活性属于部分激动剂，活性较地塞米松活性较弱。
T9042	Teriflunomide impurity 3 4-Amino-N-(4-trifluoromethylphenyl)benzamide	COX	Immunology/Inflammation; Neuroscience
	Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) 是一种选择性COX-1抑制剂，IC50为 30 µM。
T22450	Tyrphostin B44, (+) enantiomer 酪氨酸磷酸化抑制剂AG 835	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin B44, (+) enantiomer 是一种表皮生长因子受体 (EGFR) 激酶抑制剂，IC50 为 0.86 μM，活性低于 (-) 对映体。
T6205	AT7519	Apoptosis; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	AT7519 是一种CDK 抑制剂，对 CDK1，CDK2，CDK4-CDK6 以及 CDK9 的IC50值分别为 210，47，100，13，170 和 <10 nM。
T67905	GS-829845	JAK; Drug Metabolite	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Metabolism; Stem Cells
	GS-829845 是一种 JAK1 抑制剂，是 Filgotinib 活性代谢物的主要成分，其效力比母体低约 10 倍且半衰期更长。
T16759	Ritanserin 利坦丝林,R 55667	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Ritanserin (R 55667) 是一种长效、高效、相对选择性、可口服的5-HT2受体拮抗剂，IC50值为 0.9 nM。
T12146	N-Desmethyl-Apalutamide N-Desmethyl Apalutamide,N-去甲基阿帕鲁胺杂质	P450; Androgen Receptor	Endocrinology/Hormones; Metabolism
	N-Desmethyl-Apalutamide 是一种 Apalutamide 的活性代谢产物，主要由 CYP2C8 和 CYP3A4 介导形成。它是一种低活性的雄激素受体拮抗剂，其作用力是 Apalutamide 活性的三分之一。它是中等至强的CYP3A4和CYP2B6诱导剂，并具有优异的血浆蛋白结合浓度。
T6104	Cerdulatinib hydrochloride Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride	MLK; c-Fms; Tyrosine Kinases; Hippo pathway; JAK; Syk	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors
	Cerdulatinib hydrochloride (PRT2070 hydrochloride) 是一种选择性可逆，具有口服活性、 ATP 竞争性的 SYK 和 JAK 的双重抑制剂，抑制 JAK1、2、3、SYK 和 Tyk2的 IC50值分别为12、6、8、32 和 0.5 nM。它可用于研究自身免疫性疾病和B 细胞恶性肿瘤。
T12695	RBN-2397	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	RBN-2397 是一种有效的、选择性的、具有口服活性的跨物种 NAD+ 竞争性 PARP7 抑制剂，IC50 小于 3 nM。它选择性结合 PARP7 ，Kd 为0.001 μM，可恢复干扰素 I 型信号转导，有用于晚期或转移性实体肿瘤的研究潜力。
T15545	ICA-27243	Potassium Channel	Membrane transporter/Ion channel
	ICA-27243 是选择性的，口服有效的 KCNQ2/Q3钾通道开放剂，EC50为 0.38 μM。对 KCNQ4 和 KCNQ3/Q5 的激活效果较差。它具有抗惊厥和抗癫痫作用。
T6458	CYC-116 噻氯匹定	VEGFR; FLT; CDK; S6 Kinase; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	CYC116是一种有效的极光激酶 A 和 B 的抑制剂，Ki 值分别为8和9 nM。
T21938	AS-041164	PI3K	PI3K/Akt/mTOR signaling
	AS-041164 是选择性的，具有口服活性的PI3Kγ亚型抑制剂，IC50=70 nM。它对 PI3Kα (IC50:240 μM)，PI3Kβ (IC50:1.45 μM) 和 PI3Kδ (IC50:1.70 μM) 的活性较低。它具有抗炎活性。
T11991	Mefentrifluconazole	P450; Antifungal	Metabolism; Microbiology/Virology
	Mefentrifluconazole 是一种有效的、选择性的和具有口服活性的真菌 CYP51 (Kd= 0.5 nM) 抑制剂，但对人芳香酶的抑制活性较低，IC50值为0.92 μM。它是一种新型唑类衍生物，用作农用广谱抗真菌剂。
T13140	Umbralisib R-enantiomer TGR-1202 R-enantiomer,RP5264 R-enantiomer	PI3K	PI3K/Akt/mTOR signaling
	Umbralisib R-enantiomer (RP5264 R-enantiomer) 是 PI3K 的δ型抑制剂，是 TGR-1202 活性较低的对映体。Umbralisib R-enantiomer 对δ型 pi3激酶的 IC50，至少比抑制剂对其他 PI3K 亚型(A， β和γ)的 IC50低20倍。
T0932	Cefixime FK-027,头孢克肟,Cefspan,Cefiximum,Cephoral,FR-17027,CL-284635	Antibacterial; Antibiotic	Microbiology/Virology
	Cefixime (FR-17027) 是一种头孢菌素类抗生素, 可研究一些细菌感染。
T20898	(R)-Propranolol hydrochloride Dexpropranolol hydrochloride,(R)-(+)-Propranolol,盐酸普奈洛尔	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) 是一种抗肾上腺素受体拮抗剂，是一种普萘洛尔的活性较低的对映体。Dexpropranolol 是一种非选择性的β-adrenergic receptor 拮抗剂，对 β1AR 和 β2AR 具有高亲和力。
T35528L	TD52 dihydrochloride TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl	Others	Others
	TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signaling pathway, resulting in the induction of apoptosis in triple-negative breast cancer (TNBC) cells. Mechanistically, TD52 dihydrochloride disrupts the binding of Elk1 to the CIP2A promoter, effectively reducing CIP2A levels. Notably, TD52 dihydrochloride demonstrates powerful anti...
T15199	Edicotinib JNJ-527,JNJ-40346527	c-Fms; FLT; CSF-1R; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Edicotinib (JNJ-527) 是能够透过血脑屏障的、口服具有活性的、选择性的CSF-1R 抑制剂 (IC50:3.2 nM)。它对 KIT (IC50:20 nM) 和 FLT3 (IC50:190 nM) 的抑制作用较小。它抑制小胶质细胞的扩张，减弱小胶质细胞的增殖和神经退行性变。它可用于研究阿尔茨海默病和类风湿性关节炎。
T4481	Tucidinostat HBI-8000,Chidamide,西达本胺,CS 055	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Tucidinostat (Chidamide) 是一种 HDAC 抑制剂，对 HDAC1、HDAC2、HDAC3、HDAC10 有抑制活性 (IC50=95/160/67/78 nM)。Tucidinostat 具有抗肿瘤活性，可以用于治疗 T 细胞白血病-淋巴瘤。
T6446	Clevudine L-FMAU,克拉夫定,Levovir	HBV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Clevudine (Levovir) 是一种非自然 L-构型的核苷类似物，是一种与聚合酶结合的非竞争性抑制剂，具有较强的抗 HBV 活性，半衰期长，毒性低的特点。
T1995	Fedratinib TG-101348,SAR 302503	Apoptosis; FLT; c-RET; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Fedratinib (TG-101348) 是一种 JAK2 抑制剂，具有选择性、ATP 竞争性和具有口服活性，抑制 JAK2 和 JAK2V617F 激酶 (IC50=3 nM)。Fedratinib 可诱导肿瘤细胞凋亡，并可用于骨髓增生性疾病的研究。
T60336	CCR4 antagonist 3-1	CCR	Immunology/Inflammation; Microbiology/Virology
	CCR4 antagonist 3-1 是一种具有较低活性的趋化因子受体 4 (CCR4) 拮抗剂，对 [125I]TARC (胸腺和活化调节趋化因子) 具有抑制作用，IC50 值为 1.7 μM。CCR4 antagonist 3-1 对放射标记的[125I]TARC和巨噬细胞来源的趋化因子(MDC) 与 CEM 细胞表面的CCR4 受体的结合有抑制作用，并对 TARC 介导的 CEM 细胞的体外迁移有抑制作用，IC50 值为 6.4 μM。
T13438	(R,S)-Ivosidenib (R,S)-AG-120	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	(R,S)-Ivosidenib is the less active enantiomer of Ivosidenib .
T26371	(2S,3R)-LP99	Others	Others
	(2S,3R)-LP99 is a less active enantiomer of LP99.
T13426L	(3S,4S)-Tofacitinib (3S,4S)-托法替尼	Others	Others
	(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.
T13450	(S)-GNE-140	Others	Others
	(S)-GNE-140 is the less active enantiomer of GNE-140.
T13451	(S)-Mapracorat (S)-ZK-245186,(S)-BOL-303242X	Others	Others
	(S)-Mapracorat is a selective and less active agonist of glucocorticoid receptor.
T11801	l-Atabrine dihydrochloride	Others	Others
	l-Atabrine dihydrochloride displays antiprion activity. l-Atabrine dihydrochloride is a less active enantiomer of quinacrine.
T10564	(8R,9S)-Talazoparib (8R,9S)-BMN-673,他拉唑帕利 (8R,9S)	Others	Others
	(8R,9S)-Talazoparib is Talazoparib enantiomer , less active than Talazoparib on the inhibition of PARP1 (IC50: 144 nM).
T26163	Rubradirin B	Others	Others
	Rubradirin B has an antibacterial activity similar to rubradirin, but the antibiotic is less active.
T19549	Ro18-5362	Others	Others
	Ro18-5362 is the less active prodrug of Ro 18-5364.
T12635	(R)-Plevitrexed (R)-ZD 9331,(R)-BGC9331,(R)-普来曲塞	Others	Others
	(R)-Plevitrexed is a less active enantiomer of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).
T13427	(3S,4R)-Tofacitinib	Others	Others
	(3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).
T11156	Nazartinib S-enantiomer EGF816 (S-enantiomer)	Others	Others
	Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.
T6493L	(R)-Citalopram oxalate	Others	Others
	(R)-Citalopram oxalate is a less active enantiomer of Escitalopram Oxalate. Escitalopram Oxalate is a potent and selective serotonin reuptake inhibitor.
T12636	(R)-(+)-Anatabine	Others	Others
	(R)-(+)-Anatabine is an less active R-enantiomer of Anatabine. Anatabine is a potent agonist of α4β2 nAChR.
T10856	Cobimetinib (R-enantiomer) 考比替尼 (R 型对映体),XL-518 R-enantiomer,Cobimetinib R-enantiomer,GDC-0973 R-enantiomer	Others	Others
	Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.
T12641	(R)-SCH 42495	Others	Others
	(R)-SCH 42495 is the less active enantiomer of SCH 42495. SCH 42495 is an orally active inhibitor of neutral metalloendopeptidase (NEP), with antihypertensive effect.
T15186	(E)-4-Hydroxytamoxifen	Others	Others
	(E)-4-Hydroxytamoxifen is a less active isomer of (Z)-4-hydroxytamoxifen and also is an estrogen receptor modulator.
T11335	Fulvestrant (S enantiomer) ZM 182780 S enantiomer,ICI 182780 S enantiomer,Fulvestrant S enantiomer,ZD 9238 S enantiomer	Others	Others
	Fulvestrant S enantiomer is the less active S enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM.

化合物

Bay 41-4109 (less active enantiomer)

Cat.No: T10480

Target: HBV

(-)-Dizocilpine maleate

Cat.No: T6352

Synonym: C13737,(-)-MK 801 (Maleate),(-)-MK 801马来酸,(-)-MK 801 Maleate

Target: NMDAR, iGluR

Cat.No: T12814

Synonym: (S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF

Target: Others

Cat.No: T12664

Target: Others

SAR405 R enantiomer

Cat.No: T12831

Target: Others

Cat.No: T10376

Target: Ras

Cat.No: T68051L

Target: Adrenergic Receptor

Cat.No: T7080

Synonym: SRA737

Target: Chk

Cat.No: T9554

Target: STING

Duvelisib (R enantiomer) hydrochloride

Cat.No: T11129L

Synonym: IPI-145 R enantiomer HCl,Duvelisib (R enantiomer) hydrochloride(1261590-48-0 Free base),INK1197 R enantiomer HCl

Target: PI3K

Cat.No: T22818

Synonym: GR agonist 23a,GSK 9027,GSK-9027

Target: Glucocorticoid Receptor

Teriflunomide impurity 3

Cat.No: T9042

Synonym: 4-Amino-N-(4-trifluoromethylphenyl)benzamide

Target: COX

Tyrphostin B44, (+) enantiomer

Cat.No: T22450

Synonym: 酪氨酸磷酸化抑制剂AG 835

Target: EGFR

Cat.No: T6205

Target: Apoptosis, GSK-3, CDK

Cat.No: T67905

Target: JAK, Drug Metabolite

Cat.No: T16759

Synonym: 利坦丝林,R 55667

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

N-Desmethyl-Apalutamide

Cat.No: T12146

Synonym: N-Desmethyl Apalutamide,N-去甲基阿帕鲁胺杂质

Target: P450, Androgen Receptor

Cerdulatinib hydrochloride

Cat.No: T6104

Synonym: Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride

Target: MLK, c-Fms, Tyrosine Kinases, Hippo pathway, JAK, Syk

Cat.No: T12695

Target: PARP

Cat.No: T15545

Target: Potassium Channel

Cat.No: T6458

Synonym: 噻氯匹定

Target: VEGFR, FLT, CDK, S6 Kinase, Aurora Kinase

Cat.No: T21938

Target: PI3K

Mefentrifluconazole

Cat.No: T11991

Target: P450, Antifungal

Umbralisib R-enantiomer

Cat.No: T13140

Synonym: TGR-1202 R-enantiomer,RP5264 R-enantiomer

Target: PI3K

Cat.No: T0932

Synonym: FK-027,头孢克肟,Cefspan,Cefiximum,Cephoral,FR-17027,CL-284635

Target: Antibacterial, Antibiotic

(R)-Propranolol hydrochloride

Cat.No: T20898

Synonym: Dexpropranolol hydrochloride,(R)-(+)-Propranolol,盐酸普奈洛尔

Target: Adrenergic Receptor

TD52 dihydrochloride

Cat.No: T35528L

Synonym: TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl

Target: Others

Cat.No: T15199

Synonym: JNJ-527,JNJ-40346527

Target: c-Fms, FLT, CSF-1R, c-Kit

Cat.No: T4481

Synonym: HBI-8000,Chidamide,西达本胺,CS 055

Target: HDAC

Cat.No: T6446

Synonym: L-FMAU,克拉夫定,Levovir

Target: HBV, DNA/RNA Synthesis

Cat.No: T1995

Synonym: TG-101348,SAR 302503

Target: Apoptosis, FLT, c-RET, JAK

CCR4 antagonist 3-1

Cat.No: T60336

Target: CCR

(R,S)-Ivosidenib

Cat.No: T13438

Synonym: (R,S)-AG-120

Target: Opioid Receptor

Cat.No: T26371

Target: Others

(3S,4S)-Tofacitinib

Cat.No: T13426L

Synonym: (3S,4S)-托法替尼

Target: Others

Cat.No: T13450

Target: Others

Cat.No: T13451

Synonym: (S)-ZK-245186,(S)-BOL-303242X

Target: Others

l-Atabrine dihydrochloride

Cat.No: T11801

Target: Others

(8R,9S)-Talazoparib

Cat.No: T10564

Synonym: (8R,9S)-BMN-673,他拉唑帕利 (8R,9S)

Target: Others

Cat.No: T26163

Target: Others

Cat.No: T19549

Target: Others

(R)-Plevitrexed

Cat.No: T12635

Synonym: (R)-ZD 9331,(R)-BGC9331,(R)-普来曲塞

Target: Others

(3S,4R)-Tofacitinib

Cat.No: T13427

Target: Others

Nazartinib S-enantiomer

Cat.No: T11156

Synonym: EGF816 (S-enantiomer)

Target: Others

(R)-Citalopram oxalate

Cat.No: T6493L

Target: Others

(R)-(+)-Anatabine

Cat.No: T12636

Target: Others

Cobimetinib (R-enantiomer)

Cat.No: T10856

Synonym: 考比替尼 (R 型对映体),XL-518 R-enantiomer,Cobimetinib R-enantiomer,GDC-0973 R-enantiomer

Target: Others

Cat.No: T12641

Target: Others

(E)-4-Hydroxytamoxifen

Cat.No: T15186

Target: Others

Fulvestrant (S enantiomer)

Cat.No: T11335

Synonym: ZM 182780 S enantiomer,ICI 182780 S enantiomer,Fulvestrant S enantiomer,ZD 9238 S enantiomer

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T20191	(-)-Camphoric acid (-)-樟脑酸,L-Camphoric acid,Camphoric acid, (-)-	GluR	Neuroscience
	(-)-Camphoric acid (L-Camphoric acid) 是一种活性较低的樟脑酸对映异构体，樟脑酸可诱导 GluR 表达。
T13669	(E)-Cinnamamide trans-Cinnamamide,肉桂酰胺	Others	Others
	(E)-Cinnamamide (trans-Cinnamamide) 是 Cinnamamide 的活性较低的异构体，Cinnamamide 是一种有效的非致命化学驱虫剂，适用于减少鸟类害虫的损害。
TN1448	(-)-Bornyl acetate L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯	p38 MAPK; NF-κB; JNK; Antifungal	MAPK; Microbiology/Virology; NF-κB
	(-)-Bornyl acetate (L-(-)-Bornyl acetate) 是存在于牛膝草油中的一种具有抗真菌活性的 (+)-Bornyl acetate 低活性异构体。
T36585	Isodeoxycholic Acid isoDCA	Chloride channel; Antibacterial	Membrane transporter/Ion channel; Microbiology/Virology
	Isodeoxycholic Acid 是一种胆汁酸，由肠道细菌通过脱氧胆酸的表聚作用形成。Isodeoxycholic acid 的临界胶束浓度高于二氯苯甲醚，这表明它的去污活性降低了，而且在抑制七种肠道共生细菌生长方面的活性低于二氯苯甲醚。Isodeoxycholic Acid（0.1%）能抑制几种艰难梭菌菌株在牛磺胆酸诱导下的孢子萌发，并能降低艰难梭菌培养上清对 Vero 细胞的细胞毒性。在高脂饮食诱发肥胖的大鼠模型中，血浆中的Isodeoxycholic acid 水平比正常饮食的大鼠低。
TN2931	3-Epikatonic acid	Antifection	Microbiology/Virology
	Epikatonic acid shows less active against T. (S.) cruzi trypanosome.
T38497	(-)-Taxifolin (-)-二氢槲皮素,(-)-Dihydroquercetin	Others	Others
	(-)-Taxifolin is the less active enantiomer of Taxifolin, demonstrating vital anti-tyrosinase activity and notable inhibition against collagenase (IC50 = 193.3 μM). It is valued as an essential natural compound showing antifibrotic potential, while also acting as a capable free radical scavenger and possessing antioxidant capacity.
TN4471	Lysicamine	IL Receptor; Antifection	Immunology/Inflammation; Microbiology/Virology
	Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1). Lysicamine has antimicrobial and anti-inflammation activity, the mini

天然产物

(-)-Camphoric acid

Cat.No: T20191

Synonym: (-)-樟脑酸,L-Camphoric acid,Camphoric acid, (-)-

Target: GluR

(E)-Cinnamamide

Cat.No: T13669

Synonym: trans-Cinnamamide,肉桂酰胺

Target: Others

(-)-Bornyl acetate

Cat.No: TN1448

Synonym: L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯

Target: p38 MAPK, NF-κB, JNK, Antifungal

Isodeoxycholic Acid

Cat.No: T36585

Synonym: isoDCA

Target: Chloride channel, Antibacterial

3-Epikatonic acid

Cat.No: TN2931

Target: Antifection

Cat.No: T38497

Synonym: (-)-二氢槲皮素,(-)-Dihydroquercetin

Target: Others

Cat.No: TN4471

Target: IL Receptor, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02778	Mcpt4 Protein, Mouse, Recombinant (E. coli, His) MSMCP,Mast cell protease 4,Myonase,Serosal mast cell proteas...	Mouse	E. coli
	Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-\|-Ile-5' bond of angiotensin I and the 'Phe-20-\|-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-\|-His-9' bond of angiotensin I and the 'Phe-4-\|-Ala-5' and 'Tyr-10-\|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing. Mcpt4 Protein, Mouse, Recombinant (E. c...
TMPJ-01320	BSSP-4 Protein, Human, Recombinant (His) BSSP4,Tryptase ε,Serine Protease 26,BSSP-4,Serine Protease 2...	Human	HEK293 Cells
	Brain-Specific Serine Protease 4 (BSSP-4) is a serine protease that preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. BSSP-4 is expressed abundantly in the epithelial cells of the airways, including trachea, esophagus and fetal lung, but scarce in adult lung and expressed at low levels in placenta, pancreas, prostate and thyroid gland. BSSP-4 belongs to the peptidase S1 family and related to trypsin, referentially hydrolyzing substrates after a...
TMPJ-00052	Leptin Protein, Mouse, Recombinant OB,Obesity Factor,OBS,LEP,Obese Protein,Leptin	Mouse	E. coli
	Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin defici...

重组蛋白

Mcpt4 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02778

Species: Mouse

Expression System: E. coli

BSSP-4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01320

Species: Human

Expression System: HEK293 Cells

Leptin Protein, Mouse, Recombinant

Cat.No: TMPJ-00052

Species: Mouse

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0372	N-desmethyl Apalutamide-d4
	N-desmethyl Apalutamide-d4 是 N-desmethyl Apalutamide 的氘代化合物。N-desmethyl Apalutamide 的 CAS 号为 1332391-11-3。N-Desmethyl Apalutamide 是一种 Apalutamide 的活性代谢产物，主要由 CYP2C8 和 CYP3A4 介导形成。它是一种低活性的雄激素受体拮抗剂，其作用力是 Apalutamide 活性的三分之一。它是中等至强的CYP3A4和CYP2B6诱导剂，并具有优异的血浆蛋白结合浓度。

同位素标记化合物

N-desmethyl Apalutamide-d4

Cat.No: TMIH-0372

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