hypotension

Blonanserin (AD-5423) 是一种有效的5-HT2A 和多巴胺 D2 受体拮抗剂，Ki 为 0.812 和 0.142 nM，是一种非典型的抗精神病试剂。

Guanfacine hydrochloride (Intuniv) 是一种 α2A 肾上腺素受体激动剂，Kd=31 nM，具有抗高血压作用。

Glycyl-glutamine (Glycyl-L-glutamine monohydrate) 是 β-内啡肽(1-31) 的内源拮抗剂，是β-endorphin 的酶裂解产品。它是一种比谷氨酰胺 (Gln) 稳定的活性神经肽。

S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂，在感染性休克的啮齿动物模型中发挥有益作用。

Droxidopa (L-DOPS) 是 Droxidopa (w w80%) 和 Pharmaceutical starch (w w20%) 的混合物，能透过血脑屏障，可作为神经递质去甲肾上腺素和肾上腺素的原药。

Theodrenaline hydrochloride 是一种靶向 SARS-CoV-2 的抑制剂，可用于研究由脊髓麻醉引起的低血压。

Fludrocortisone （Florinef） 是一种合成皮质类固醇，具有中等的糖皮质激素效力和更大的盐皮质激素效力。Fludrocortisone 可用于治疗低血压的研究。[3]

CV-6209 是一种具有选择性和高效性的血小板活化因子 (PAF) 拮抗剂，具有抗增殖作用，部分抑制乙酰胆碱诱导的低血压，抑制 Paf 诱导的 PMN 或血小板聚集。CV-6209 具有抗幽门螺杆菌作用，可以抑制 PAF 引起的大鼠低血压。

Cafedrine (Cafedrin) 存在于茶叶和咖啡中，对中枢神经的兴奋作用。Cafedrine 常与可肾上腺素固定 20：1 组合来研究急性低血压。

N 0861 是选择性腺苷A1受体拮抗剂,减轻大鼠腺苷控制低血压期间肾功能不全。

Heptaminol hydrochloride (RP-2831 hydrochloride) 是一种血管收缩剂，有用于低血压(特别是体位性低血压)的研究潜力。

Bethanechol chloride (Carbamyl-β-methylcholine chloride) 是一种拟副交感神经剂，是毒蕈碱型受体 (mAChR) 激动剂，通过直接刺激副交感神经系统的 mAChR 发挥作用。

Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物，存在于植物叶子、果实、根茎中，当植物相应的部位因食草动物进食而受损时，就会释放。它可用于消灭雄性东方果蝇。

Rupatadine(UR-12592,卢帕他定)是一种有效和可口服的PAF和组胺H1受体的双重拮抗剂，Ki 值分别为 0.55 μM 和 0.1 μM，能够缓解过敏症状并抗炎，可用于过敏性鼻炎和慢性荨麻疹。

Artemitin (Erianthin) 是一种存在于翼齿六棱菊中的天然黄酮，具有抗氧化、抗炎、抗病毒活性。

Metaraminol tartrate (Metaradrine tartrate) 是一种 α-肾上腺素能 (α-adrenergic) 激动剂，是一种直接或间接影响肾上腺素受体的拟交感神经胺，其中 α 效应占主导地位，可作为血管加压剂。

Metaraminol hydrochloride, used primarily as a vasoconstrictor in the treatment of HYPOTENSION, is a sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors.

Oxypyrronium bromide 一种含有季铵的抗胆碱能和解痉剂。在动物模型中，它抑制胃运动、迷走神经刺激或乙酰胆碱静脉注射引起的低血压；鼓索神经刺激引起的流涎和节前颈交感神经刺激引起收缩。

Midodrine is a vasopressor antihypertensive agent for the treatment of symptomatic postural hypotension.

Pipotiazine has less sedating and a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics among the different phenothiazine derivatives. However, it produces a high incidence of extra pyramidal reactions. I

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypotension, and is an inhibitor of platelet aggregation. Prostaglandin D2 methyl ester (PGD2 methyl ester) is a more lipid-soluble, cell-permeable prodrug form of PGD2. It binds to the human and mouse PGD2 receptors (DP1 and CRTH2 DP2) with 5-10 fold lower affinity than PGD2.

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 μg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 μg/kg/min and 60 ng/ml, respectively.

Carboxy-PTIO is a highly effective nitric oxide (NO) scavenger known for its rapid reaction rate with NO, resulting in the formation of nitric dioxide (NO2). Its direct scavenging action against NO plays a crucial role in preventing hypotension and endotoxic shock, particularly in lipopolysaccharide-stimulated rat models.

[D-Trp11]-Neurotensin is a compound that functions as a selective antagonist of Neurotensin (NT) in perfused rat hearts, while exhibiting full agonist properties in guinea pig atria and rat stomach strips. Additionally, this compound can inhibit hypotension induced by NT.