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Search Results for " hypotension "
Targets Recommended: Adrenergic Receptor

36

抑制剂 & 化合物

3

天然产物

7

重组蛋白

1

同位素标记化合物

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Cat. No. Product Name Target Signaling Pathways
T2150 Guanfacine hydrochloride

盐酸胍法辛,Tenex,Intuniv,Guanfacine

Adrenergic Receptor GPCR/G Protein; Neuroscience
Guanfacine hydrochloride (Intuniv) 是一种 α2A 肾上腺素受体激动剂,Kd=31 nM,具有抗高血压作用。
T1180 Blonanserin

布南色林,AD-5423

Dopamine Receptor; Sigma receptor; 5-HT Receptor; Adrenergic Receptor GPCR/G Protein; Neuroscience
Blonanserin (AD-5423) 是一种有效的5-HT2A 和多巴胺 D2 受体拮抗剂,Ki 为 0.812 和 0.142 nM,是一种非典型的抗精神病试剂。
T2547 Droxidopa

屈昔多巴,屈西多巴,SM5688,DOPS,L-DOPS

Adrenergic Receptor GPCR/G Protein; Neuroscience
Droxidopa (L-DOPS) 是 Droxidopa (w/w80%) 和 Pharmaceutical starch (w/w20%) 的混合物,能透过血脑屏障,可作为神经递质去甲肾上腺素和肾上腺素的原药。
T8171 Glycyl-glutamine

Glycyl-L-glutamine monohydrate,甘氨酰-L-谷氨酰胺一水合物,Glycyl-L-glutamine,Glycylglutamine

Others Others
Glycyl-glutamine (Glycyl-L-glutamine monohydrate) 是 β-内啡肽(1-31) 的内源拮抗剂,是β-endorphin 的酶裂解产品。它是一种比谷氨酰胺 (Gln) 稳定的活性神经肽。
T22419 S-Methylisothiourea sulfate

(S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐

NOS; NO Synthase; HSV Immunology/Inflammation; Microbiology/Virology
S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂,在感染性休克的啮齿动物模型中发挥有益作用。
T0045 Heptaminol hydrochloride

盐酸庚胺醇,RP-2831 hydrochloride

Others Others
Heptaminol hydrochloride (RP-2831 hydrochloride) 是一种血管收缩剂,有用于低血压(特别是体位性低血压)的研究潜力。
T27102 CV-6209

CV6209,CV 6209

PAFR; AChE GPCR/G Protein; Neuroscience
CV-6209 是一种具有选择性和高效性的血小板活化因子 (PAF) 拮抗剂,具有抗增殖作用,部分抑制乙酰胆碱诱导的低血压,抑制 Paf 诱导的 PMN 或血小板聚集。CV-6209 具有抗幽门螺杆菌作用,可以抑制 PAF 引起的大鼠低血压。
T30686 Cafedrine

l-Cafedrine,Cafedrin

Others Others
Cafedrine (Cafedrin) 存在于茶叶和咖啡中,对中枢神经的兴奋作用。Cafedrine 常与可肾上腺素固定 20:1 组合来研究急性低血压。
T13142L Theodrenaline hydrochloride

Theodrenaline hydrochloride(13460-98-5 Free base)

SARS-CoV Microbiology/Virology
Theodrenaline hydrochloride 是一种靶向 SARS-CoV-2 的抑制剂,可用于研究由脊髓麻醉引起的低血压。
T70722 N 0861

Adenosine Receptor GPCR/G Protein; Neuroscience
N 0861 是选择性腺苷A1受体拮抗剂,减轻大鼠腺苷控制低血压期间肾功能不全。
T3126 Bethanechol chloride

(±)-Bethanechol,Urecholine,Myocholine,氯贝胆碱,Carbamyl-β-methylcholine chloride

AChR Neuroscience
Bethanechol chloride (Carbamyl-β-methylcholine chloride) 是一种拟副交感神经剂,是毒蕈碱型受体 (mAChR) 激动剂,通过直接刺激副交感神经系统的 mAChR 发挥作用。
TP1898 HS024

HS 024

Melanocortin Receptor GPCR/G Protein; Neuroscience
HS024 是一种选择性的MC4受体拮抗剂,可增加食物摄入,对 MC4、MC5、MC3 和 MC1 的Ki 分别为 0.29、3.29、5.45 和 18.6 nM。
T0279 Metaraminol tartrate

重酒石酸间羟胺,Metaradrine tartrate,Metaraminol bitartrate

Adrenergic Receptor GPCR/G Protein; Neuroscience
Metaraminol tartrate (Metaradrine tartrate) 是一种 α-肾上腺素能 (α-adrenergic) 激动剂,是一种直接或间接影响肾上腺素受体的拟交感神经胺,其中 α 效应占主导地位,可作为血管加压剂。
T33384 Midodrine (R-isomer HCl)

ProAmatine,Midodrine,ST-1085,Gutron,Amatine

Others Others
Midodrine is a vasopressor/antihypertensive agent for the treatment of symptomatic postural hypotension.
T0279L2 Metaraminol hydrochloride

Metaraminol HCl

Others Others
Metaraminol hydrochloride, used primarily as a vasoconstrictor in the treatment of HYPOTENSION, is a sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors.
T69000 Prenalterol hydrochloride

Others Others
Prenalterol hydrochloride is a partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute cardiac failure, postmyocardial infarction low-output syndrome, shock, and reducing orthostatic hypotension in the Shy-Drager syndrome.
T38945 Carboxy-PTIO

Others Others
Carboxy-PTIO is a highly effective nitric oxide (NO) scavenger known for its rapid reaction rate with NO, resulting in the formation of nitric dioxide (NO2). Its direct scavenging action against NO plays a crucial role in preventing hypotension and endotoxic shock, particularly in lipopolysaccharide-stimulated rat models.
T60369 Droxidopa hydrochloride

Others Others
Droxidopa (L-DOPS) hydrochloride 是一种有效的、具有口服活性的去甲肾上腺素前体。Droxidopa hydrochloride 可增加站立血压,改善直立性低血压症状并提高站立能力。Droxidopa hydrochloride 具有研究神经源性直立性低血压(nOH)和替代性多动症 (注意缺陷多动障碍) 的潜力[3]。
T40850 [D-Trp11]-Neurotensin

[D-Trp11]-Neurotensin

[D-Trp11]-Neurotensin is a compound that functions as a selective antagonist of Neurotensin (NT) in perfused rat hearts, while exhibiting full agonist properties in guinea pig atria and rat stomach strips. Additionally, this compound can inhibit hypotension induced by NT.
T36545 Prostaglandin D2 methyl ester

Prostaglandin D2 methyl ester

Others Others
Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypotension, and is an inhibitor of platelet aggregation. Prostaglandin D2 methyl ester (PGD2 methyl ester) is a more lipid-soluble, cell-permeable prodrug form of PGD2. It binds to the human and mouse PGD2 receptors (DP1 and CRTH2/DP2) with 5-10 fold lower affinity than PGD2.
T34072 Pipotiazine

19366 RP,Pipotiazina,Pipotiazinum,Piportil L4,Pipothiazine

Others Others
Pipotiazine has less sedating and a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics among the different phenothiazine derivatives. However, it produces a high incidence of extra pyramidal reactions. I
T78027 PAMP-12 (unmodified)

PAMP-12 (unmodified)为有效的MRGPRX2 (MrgX2)激动剂,其EC50值为20-50 nM。作为内源性肽,它能够通过抑制交感神经末梢和肾上腺嗜铬细胞的儿茶酚胺分泌来引发低血压。
T36732 Ciprostene (calcium salt)

Others Others
Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 μg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 μg/kg/min and 60 ng/ml, respectively.
TP1999 MEN 11270

Peptide antagonist of the B2 bradykinin receptor (pKi = 10.3); conformationally constrained cyclized analog of HOE 140. Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other receptors and ion channels (pIC50 < 5.5).
T80080 PAMP-12 (unmodified) (TFA)

PAMP-12 (unmodified) TFA 作为MRGPRX2 (MrgX2)激动剂,展现出高效性(EC50=20-50 nM)。该化合物为内源性肽,能够通过抑制交感神经末梢及肾上腺嗜铬细胞中的儿茶酚胺释放来诱发低血压。
T83121 Anatumomab mafenatox

ABR-214936

Anatumomab mafenatox (ABR-214936)是一种73 KDa的重组蛋白,针对广泛表达于恶性肿瘤中的肿瘤相关抗原5T4。该分子构建于修饰后的SEA和小鼠Fab片段之间。Anatumomab mafenatox的主要副作用包括发烧、低血压、疼痛、恶心和嗜睡。
T25912 Oxypyrronium bromide

L.D. 3055,Immetropan,LD 3055,LD3055,LD-3055

Others Others
Oxypyrronium bromide 一种含有季铵的抗胆碱能和解痉剂。在动物模型中,它抑制胃运动、迷走神经刺激或乙酰胆碱静脉注射引起的低血压;鼓索神经刺激引起的流涎和节前颈交感神经刺激引起收缩。
T68639 Ciprostene (free base)

Others Others
Ciprostene (free base) is a synthetic, chemically stable analog of prostacyclin (PGI2). In animal models, administration of ciprostene resulted in dose-dependent hypotension, tachycardia, and inhibition of ex vivo ADP-induced platelet aggregation. Ciprostene was evaluated in clinical trials in patients with peripheral vascular disease. It was found to reduce restenosis in patients with coronary artery disease undergoing therapeutic percutaneous transluminal coronary angioplasty.
T75804 K41498 TFA

K41498 TFA 是一种强选择性的CRF2 receptor 拮抗剂,其对人 CRF2α、CRF2β和 CRF1受体的Ki 值分别为 0.66 nM、0.62 nM 和425 nM。K41498 TFA 是 antisauvagine-30 (aSvg-30) 的类似物,可抑制 sauvagine 刺激的 cAMP 在 hCRF2α/hCRF2β表达细胞中的积累。K41498 可用于低血压研究。
TP2009 K41498

K 41498

Potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats in vivo, blo
T85181 Urocortin II (human) TFA

Others Others
Urocortin II, a neuropeptide hormone within the corticotropin-releasing factor (CRF) family—which comprises mammalian CRF, urocortin I, urocortin III, frog sauvagine, and piscine urotensin I—displays 34, 43, and 37-40% sequence homology with rat and human CRF, human urocortin I, and human urocortin III, respectively. This compound enhances rabbit ventricular myocyte shortening and relaxation in both a time- and concentration-dependent manner. In vivo studies reveal that urocortin II lowers arter...
T83905 Brain Natriuretic Peptide-32 (rat) acetate

BNP (14-45),B-type Natriuretic Peptide-32,Brain Natriuretic Polypeptide-32,BNP-32

BNP-32(Brain natriuretic peptide-32)是心血管激素前体proBNP的肽段,能够结合大鼠血管平滑肌上的利钠肽受体(IC50 = 7.3 nM),并在同样的细胞中促进cGMP积累(EC50 = 170 nM)。BNP-32还能使经去甲肾上腺素预收缩的孤立大鼠主动脉条带松弛(EC50 = 6.7 nM),当以3 µg/kg的剂量给药时,能增加大鼠的尿量和尿液电解质排泄,并诱导低血压。
T70456 Nolpitantium Free Base

Others Others
Nolpitantium Free Base is a highly selective nonpeptide antagonist of neurokinin-1 (NK1) receptor. Nolpitantium potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal species, including humans. In vitro, it was a potent antagonist in functional assays for NK1 receptors such as [Sar9, Met(O2)11]substance P-induced endothelium-dependent relaxation of rabbit pulmonary artery and contraction of guinea-pig ileum. Up to 1 mkM, Nolpitantium had no eff...
T83674 K 41498 TFA

K 41498 是一种针对皮质酮释放因子受体2α(CRF2α)和CRF2β的肽拮抗剂,其在表达人类受体的HEK293细胞中的Ki值分别为0.66和0.62 nM。它对CRF2α和CRF2β具有选择性,与CRF1相比(在表达人类受体的HEK293细胞中Ki值为425 nM)。K 41498 (1.84 µg/动物, 静脉注射) 能够阻止大鼠由于尿催肾上腺皮质激素引发的低血压。通过脊髓内给药,K 41498 (0.075-0.5 µmol/动物) 能降低完全弗氏佐剂引起的大鼠模型中机械性爪撤回阈值。
T83697 PAMP-12 (human, mouse, rat, porcine, bovine) TFA

Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)

Proadrenomedullin N-terminal 12 peptide (PAMP-12) 是一种内源性肽段,源自人体肾上腺髓质,对应人类PAMP-20的9-20氨基酸,涉及降低血压。它是MAS相关G蛋白偶联受体家族成员X2 (MRGPRX2) 的激动剂。在表达人MRGPRX2的CHO细胞中,PAMP-12抑制forskolin诱导的cAMP积累(EC50 = 57.2 nM),特异性诱导表达MRGPRX2的CHO细胞的钙离子动员(EC50 = 41 nM),而在表达MRGPRX1、MRGPRX3或MRGPRX4的细胞中则无此效应(在1 µM浓度下)。PAMP-12还能作为烟碱型乙酰胆碱受体(nAChRs)的拮抗剂,抑制carbachol诱导的儿茶酚胺释放(IC50 = 1.3 µM)及钙和钠的流入(IC50分别为0.39 µM和0.87 µM),但不抑制组胺诱导的儿茶酚胺释放或钙和钠的流入(IC50 >1 µM),在初级牛肾上腺嗜铬细胞中有此表现。当以10至50 nmol/kg剂量给予正常血压大鼠时,PAMP-12能降低平均动脉血压。
T36618 Rupatadine

Others Others
Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited histamine-induced guinea pig ileum contraction (pA2 = 9.29 +/- 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4). It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in hu...

化合物

Guanfacine hydrochloride
Cat.No: T2150
Synonym: 盐酸胍法辛,Tenex,Intuniv,Guanfacine
Target: Adrenergic Receptor
Blonanserin
Cat.No: T1180
Synonym: 布南色林,AD-5423
Target: Dopamine Receptor, Sigma receptor, 5-HT Receptor, Adrenergic Receptor
Droxidopa
Cat.No: T2547
Synonym: 屈昔多巴,屈西多巴,SM5688,DOPS,L-DOPS
Target: Adrenergic Receptor
Glycyl-glutamine
Cat.No: T8171
Synonym: Glycyl-L-glutamine monohydrate,甘氨酰-L-谷氨酰胺一水合物,Glycyl-L-glutamine,Glycylglutamine
Target: Others
S-Methylisothiourea sulfate
Cat.No: T22419
Synonym: (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐
Target: NOS, NO Synthase, HSV
Heptaminol hydrochloride
Cat.No: T0045
Synonym: 盐酸庚胺醇,RP-2831 hydrochloride
Target: Others
CV-6209
Cat.No: T27102
Synonym: CV6209,CV 6209
Target: PAFR, AChE
Cafedrine
Cat.No: T30686
Synonym: l-Cafedrine,Cafedrin
Target: Others
Theodrenaline hydrochloride
Cat.No: T13142L
Synonym: Theodrenaline hydrochloride(13460-98-5 Free base)
Target: SARS-CoV
N 0861
Cat.No: T70722
Synonym:
Target: Adenosine Receptor
Bethanechol chloride
Cat.No: T3126
Synonym: (±)-Bethanechol,Urecholine,Myocholine,氯贝胆碱,Carbamyl-β-methylcholine chloride
Target: AChR
HS024
Cat.No: TP1898
Synonym: HS 024
Target: Melanocortin Receptor
Metaraminol tartrate
Cat.No: T0279
Synonym: 重酒石酸间羟胺,Metaradrine tartrate,Metaraminol bitartrate
Target: Adrenergic Receptor
Midodrine (R-isomer HCl)
Cat.No: T33384
Synonym: ProAmatine,Midodrine,ST-1085,Gutron,Amatine
Target: Others
Metaraminol hydrochloride
Cat.No: T0279L2
Synonym: Metaraminol HCl
Target: Others
Prenalterol hydrochloride
Cat.No: T69000
Synonym:
Target: Others
Carboxy-PTIO
Cat.No: T38945
Synonym:
Target: Others
Droxidopa hydrochloride
Cat.No: T60369
Synonym:
Target: Others
[D-Trp11]-Neurotensin
Cat.No: T40850
Synonym: [D-Trp11]-Neurotensin
Target:
Prostaglandin D2 methyl ester
Cat.No: T36545
Synonym: Prostaglandin D2 methyl ester
Target: Others
Pipotiazine
Cat.No: T34072
Synonym: 19366 RP,Pipotiazina,Pipotiazinum,Piportil L4,Pipothiazine
Target: Others
PAMP-12 (unmodified)
Cat.No: T78027
Synonym:
Target:
Ciprostene (calcium salt)
Cat.No: T36732
Synonym:
Target: Others
MEN 11270
Cat.No: TP1999
Synonym:
Target:
PAMP-12 (unmodified) (TFA)
Cat.No: T80080
Synonym:
Target:
Anatumomab mafenatox
Cat.No: T83121
Synonym: ABR-214936
Target:
Oxypyrronium bromide
Cat.No: T25912
Synonym: L.D. 3055,Immetropan,LD 3055,LD3055,LD-3055
Target: Others
Ciprostene (free base)
Cat.No: T68639
Synonym:
Target: Others
K41498 TFA
Cat.No: T75804
Synonym:
Target:
K41498
Cat.No: TP2009
Synonym: K 41498
Target:
Urocortin II (human) TFA
Cat.No: T85181
Synonym:
Target: Others
Brain Natriuretic Peptide-32 (rat) acetate
Cat.No: T83905
Synonym: BNP (14-45),B-type Natriuretic Peptide-32,Brain Natriuretic Polypeptide-32,BNP-32
Target:
Nolpitantium Free Base
Cat.No: T70456
Synonym:
Target: Others
K 41498 TFA
Cat.No: T83674
Synonym:
Target:
PAMP-12 (human, mouse, rat, porcine, bovine) TFA
Cat.No: T83697
Synonym: Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)
Target:
Rupatadine
Cat.No: T36618
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
TCS1704 Artemitin

艾黄素,Artemetin,Artemisetin,Erianthin

Antioxidant oxidation-reduction
Artemitin (Erianthin) 是一种存在于翼齿六棱菊中的天然黄酮,具有抗氧化、抗炎、抗病毒活性。
T3S2259 Methyl eugenol

4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物,存在于植物叶子、果实、根茎中,当植物相应的部位因食草动物进食而受损时,就会释放。它可用于消灭雄性东方果蝇。
TL0014 Pinusolide

ERK; p38 MAPK; Calcium Channel; Lipoxygenase; PAFR; Caspase; JNK; AMPK Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.

天然产物

Artemitin
Cat.No: TCS1704
Synonym: 艾黄素,Artemetin,Artemisetin,Erianthin
Target: Antioxidant
Methyl eugenol
Cat.No: T3S2259
Synonym: 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚
Target: GABA Receptor
Pinusolide
Cat.No: TL0014
Synonym:
Target: ERK, p38 MAPK, Calcium Channel, Lipoxygenase, PAFR, Caspase, JNK, AMPK
Cat. No. Product Name Species Expression System
TMPH-03548 Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His)

entG,Enterotoxin type G,SEG

Staphylococcus aureus P. pastoris (Yeast)
Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.0 kDa and the accession number is P0A0L7.
TMPH-03546 Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His & SUMO)

Enterotoxin type G,entG,SEG

Staphylococcus aureus E. coli
Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.0 kDa and the accession number is P0A0L7.
TMPJ-00932 PBLD Protein, Human, Recombinant (His)

MAWBP,MAWD-Binding Protein,PBLD,MAWDBP,Unknown Protein 32 Fr...

Human E. coli
Phenazine Biosynthesis-Like Domain-Containing protein (PBLD) belongs to the phenazine biosynthesis-like protein (PhzF) family, which is expressed in most tissues. PBLD takes part in the MAPK signaling pathway, and is involved in multiple basic cellular functions. The expression of PBLD can be increased in several disease processes, including insulin resistance, folate deficiency and hypotension.
TMPH-03701 Vespakinin-M Protein, Vespa mandarinia, Recombinant (His & KSI)

Vespakinin-M,Bradykinin-related peptide

Vespa mandarinia E. coli
Bradykinins are a potent but short-lived agent of arteriolar dilation and increased capillary permeability. May target bradykinin receptors (BDKRB). May cause hypotension. Vespakinin-M Protein, Vespa mandarinia, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 16.7 kDa and the accession number is Q7M3T3.
TMPH-03547 Enterotoxin type G Protein, S. aureus (strain Mu50/ATCC 700699), Recombinant (His & SUMO)

SEG,Enterotoxin type G,entG

Staphylococcus aureus E. coli
Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Enterotoxin type G Protein, S. aureus (strain Mu50/ATCC 700699), Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.0 kDa and the accession number is P0A0L6.
TMPH-00227 Beta-casein Protein, Bovine, Recombinant (His & Myc)

CSN2,Beta-casein

Bovine E. coli
Important role in determination of the surface properties of the casein micelles.; Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide.; Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A.; Antioxidant peptide has antioxidant activity. Beta-casein Protein, Bovine, Recomb...
TMPJ-00734 KNG1 Protein, Human, Recombinant (His)

KNG1,High Molecular Weight Kininogen,BDK,HMWK,KNG,Williams-F...

Human HEK293 Cells
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation...

重组蛋白

Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His)
Cat.No: TMPH-03548
Species: Staphylococcus aureus
Expression System: P. pastoris (Yeast)
Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His & SUMO)
Cat.No: TMPH-03546
Species: Staphylococcus aureus
Expression System: E. coli
PBLD Protein, Human, Recombinant (His)
Cat.No: TMPJ-00932
Species: Human
Expression System: E. coli
Vespakinin-M Protein, Vespa mandarinia, Recombinant (His & KSI)
Cat.No: TMPH-03701
Species: Vespa mandarinia
Expression System: E. coli
Enterotoxin type G Protein, S. aureus (strain Mu50/ATCC 700699), Recombinant (His & SUMO)
Cat.No: TMPH-03547
Species: Staphylococcus aureus
Expression System: E. coli
Beta-casein Protein, Bovine, Recombinant (His & Myc)
Cat.No: TMPH-00227
Species: Bovine
Expression System: E. coli
KNG1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00734
Species: Human
Expression System: HEK293 Cells
Cat. No. Product Name Target Signaling Pathways
TMIJ-0145 Blonanserin-d5

Blonanserin-d5 是 Blonanserin 的氘代化合物。Blonanserin 的 CAS 号为 132810-10-7。Blonanserin 是一种有效的5-HT2A和多巴胺 D2 受体拮抗剂,Ki为 0.812 和 0.142 nM,是一种非典型的抗精神病试剂。

同位素标记化合物

Blonanserin-d5
Cat.No: TMIJ-0145
Synonym:
Target:
TargetMol Loading
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