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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11064 |
DMT1 blocker 2
|
Others | Others |
DMT1 blocker 2 是一种二价金属转运蛋白 1 的直接抑制剂(IC50:0.83 μM)。它可以阻断体内肠细胞的铁摄取。 | |||
T2096 |
Framycetin sulfate
Neomycin Sulphate B,硫酸新霉素B,Framycetin sulphate |
Antibacterial; Antibiotic | Microbiology/Virology |
Framycetin sulfate (Neomycin Sulphate B) 是一种氨基糖苷类抗生素,是 RNase P 裂解活性抑制剂,Ki 为 35 μM。它抑制锤头状核酶,Ki 值为 13.5 μM,可用于肝性脑病和肠致病性大肠杆菌感染的研究。 | |||
T11063 |
DMT1 blocker 1
|
Others | Others |
DMT1 blocker 1 是二价金属转运蛋白1 (DMT1) 的阻断剂,IC50 为 0.64 μM,可以阻断体内肠细胞的铁摄取。 | |||
T20470 |
Edetic acid
Ethylenediaminetetraacetic acid,乙二胺四乙酸,EDTA |
Others | Others |
Edetic acid (Ethylenediaminetetraacetic acid) 是 Edetate 的酸形式,是一种具有抗高钙血症和抗凝血特性的螯合剂。它与钙和重金属离子结合后,会形成可溶的稳定复合体,使血清钙水平降低。它也可用作血液样本的抗凝剂,并用于治疗铅中毒。 | |||
T20841 |
Nitrilotriacetic acid
Triglycollamic acid,Nitrilotriacetate,Nitriloacetate |
Others | Others |
Nitrilotriacetic acid (Nitriloacetate) 是一种螯合剂,可与二价金属离子介导的6His标签反应来跟踪和富集活细胞中的His标签蛋白。 | |||
T22353 |
Lanthanum(III) chloride heptahydrate
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Lanthanum(III) chloride heptahydrate 是一种无机化合物,用于生化研究,阻断二价阳离子通道,尤其是钙通道的活性。 | |||
T66932 |
Ferrozine monosodium salt
|
Autophagy | Autophagy |
Ferrozine monosodium salt 是一种染料,可与二价铁反应形成稳定的品红络合物,可用于分光光度法测定铁。 | |||
T13041 |
Surfactin
|
HSV | Microbiology/Virology |
Surfactin 是一种有效的环状脂肽生物表面活性剂,可介导单价和二价阳离子(如钙)穿过脂质双层膜的通量,具有抗菌、抗真菌、抗支原体和溶血作用。 | |||
T7295 |
Miridesap
Ro63-8695,CPHPC,GSK2315698 |
Others | Others |
Miridesap (GSK2315698) 是一种血清淀粉样蛋白 P 组分 (SAP) 的配体,能够利用肝脏清除导致循环 SAP 的快速消耗。 它也可以明显减少脑脊液和内脏淀粉样蛋白沉积物中的 SAP。 | |||
T37550 |
Bacitracin Complex
|
Others | Others |
Bacitracin complex is a bacitracin antibiotic complex composed of cyclic dipeptides that has been found inBacillus.1It is metal-dependent and is complexed to a divalent metal cation, such as Cu2+, Ni2+, Co2+, Zn2+, or Mn2+, for its activity.1,2Bacitracin complex is a mixture of bacitracin polypeptides in complex with copper. 1.Piacham, T., Isarankura-Na-Ayudhya, C., Nantasenamat, C., et al.Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutaseBiochem. Biophys. Res. ... | |||
T76140 |
Acetate kinase (ACK)
|
Others | Others |
Acetate kinase (ACK)是细菌和古菌中普遍存在的酶,能在ATP和二价阳离子的作用下,催化乙酸的磷酸化,从而促进乙酰辅酶A的生成,常应用于生化研究领域。 | |||
T75656 |
Calcimycin hemimagnesium
|
Others | Others |
Calcimycin (A-23187) hemimagnesium,一种具有抗生素功能的独特二价阳离子离子载体(例如钙离子和镁离子),通过提高细胞内钙浓度而诱导Ca2+依赖性细胞死亡。该化合物还能抑制革兰氏阳性细菌和部分真菌生长,同时抑制ATP酶活性并解耦哺乳动物细胞的氧化磷酸化(OXPHOS),触发细胞凋亡(apoptosis)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10662L |
Calcimycin
Antibiotic A-23187,离子载体(钙镁盐混合物),A-23187 |
Apoptosis; Antibacterial; Antibiotic; Autophagy; Antifungal | Apoptosis; Autophagy; Microbiology/Virology |
Calcimycin (A-23187) 是抗生素和二价阳离子离子载体。它抑制革兰氏阳性细菌和一些真菌生长,也抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化。它通过增加细胞内钙浓度诱导 Ca2+依赖性细胞死亡。 | |||
T5584 |
Phytic acid sodium salt
Sodium phytate hydrate,玉米 |
Others | Others |
Phytic acid sodium salt (Sodium phytate hydrate) 源于豆类种子中,具有抗营养活性。它是 [PO4]3-储藏库,是其他肌醇磷酸酯和焦磷酸酯的前体,在植物中被植酸酶逐步水解。 | |||
T11665 |
Ionomycin calcium
SQ23377 calcium,罗红霉素钙盐(链霉菌属载体) |
Apoptosis; Calcium Channel; Antibacterial; Antibiotic; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Ionomycin calcium (SQ23377 calcium) 是选择性钙离子载体,也是一种由 Streptomyces conglobatus 产生的抗生素。它对二价阳离子具有高度特异性,还诱导蛋白激酶 C 激活。Ionomycin 促进细胞凋亡。 | |||
T10662 |
Calcimycin hemicalcium salt
Antibiotic A-23187 hemicalcium salt,A-23187 hemicalcium salt |
Others | Others |
Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death by increasing intracellular calcium concentration. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01069 |
CTGF/CCN2 Protein, Human, Recombinant (His)
Hypertrophic chondrocyte-specific protein 24,CCN family memb... |
Human | E. coli |
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. CTGF/CCN2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 15.1 kDa and... | |||
TMPH-02568 |
CTGF/CCN2 Protein, Mouse, Recombinant (GST)
betaIG-M2,Connective tissue growth factor,Protein FISP-12,Fi... |
Mouse | E. coli |
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. | |||
TMPJ-00695 |
CuTA Protein, Human, Recombinant (His)
C6orf82,Brain Acetylcholinesterase Putative Membrane Anchor,... |
Human | E. coli |
Protein CutA (CUTA) posseses a signal peptide and is widely expressed in brain. CUTA mayforms part of a complex of membrane proteins attached to acetylcholinesterase (AChE). CUTA takes part in cellular tolerance to a broad range of divalent cations other than copper. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found. | |||
TMPY-01344 |
MAP1D Protein, Human, Recombinant (His)
MetAP 1D,Metap1l,MAP 1D,methionyl aminopeptidase type 1D (mi... |
Human | Baculovirus Insect Cells |
Methionine aminopeptidase 1D, also known as MAP1D, is a member of the peptidase M24A family. N-terminal methionine removal is an important cellular process required for proper biological activity, subcellular localization, and eventual degradation of many proteins. The enzymes that catalyze this reaction are called Methionine aminopeptidases (MAPs). MAP1D is overexpressed in colon cancer cell lines and colon tumors as compared to normal tissues (at protein level). Downregulation of MAP1D express... | |||
TMPY-01819 |
PDE1B Protein, Human, Recombinant (His & GST)
PDES1B,phosphodiesterase 1B, calmodulin-dependent,PDE1B1 |
Human | Baculovirus Insect Cells |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Phosphodiesterase-1A (PDE1A), Phosphodiesterase-1B (PDE1B), Phosphodiesterase-4B (PDE4B), and Phosphodiesterase-4A (PDE4A) are important regulators of signal transduction in striatum due to their catalysis of cyclic AMP and cyclic GMP. PDE1B is highly expressed in the striatum. It b... | |||
TMPY-00725 |
COMP Protein, Human, Recombinant (His)
THBS5,MED,EPD1,PSACH,cartilage oligomeric matrix protein,EDM... |
Human | HEK293 Cells |
Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and functio... |