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Targets Recommended: ATPase Hedgehog/Smoothened

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抑制剂 & 化合物

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同位素标记化合物

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Cat. No. Product Name
L3200 自噬库

1248 compounds
1248 种细胞自噬相关的生物活性小分子化合物的特有集合,用于自噬相关的研究,用于高通量、高内涵筛选;

化合物库

自噬库
Cat.No: L3200
Compounds: 1248
Cat. No. Product Name Target Signaling Pathways
T14965 Ciliobrevin D

ATPase; Hedgehog/Smoothened GPCR/G Protein; Membrane transporter/Ion channel; Stem Cells
Ciliobrevin D 是细胞渗透性,可逆和特异性的 AAA + ATPase 运动细胞质动力蛋白抑制剂。它在体外抑制依赖于动力蛋白的微管滑动和 ATPase 活性。它抑制Hedgehog 信号和初级纤毛形成。
TP1563 Gap19

Gap Junction Protein Cytoskeletal Signaling
Gap19 是一种衍生自 Cx43 细胞质环九个氨基酸的肽,是选择性连接蛋白 43 半通道阻滞剂。它可以防止 C 末端与 CL 的分子内相互作用,具有保护心肌作用。
T4074 GSK-872

GSK872,GSK'872,GSK2399872A

RIP kinase Apoptosis; NF-κB
GSK-872 (GSK2399872A) 是一种有效且特异性的 RIP3 激酶抑制剂,降低 RIPK3 介导的坏死和随后的 HMGB1 的细胞质易位和表达,可改善早期脑损伤中的脑水肿和神经功能缺损。它以高亲和力结合 RIP3 激酶结构域,IC50为1.8 nM,并抑制激酶活性,IC50为1.3 nM。
T77349 CCR1/5/8 activator 1

Phospholipase Metabolism
CCR1/5/8 activator 1 是胞质磷脂酶 A 抑制剂,具有抗真菌活性。
T20913 Light Green SF Yellowish

Acid Green 5,C.I. Acid Green 5,C.I. 42095

Light Green SF Yellowish (Acid Green 5) 是一种碱性染色剂,可用于动物组织染色,可用于植物组织学中作细胞质和纤维染色。
T2274 SC79

SC 79,2-氨基-6-氯-alpha-氰基-3-(乙氧羰基)-4H-1-苯并吡喃-4-乙酸乙酯

Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
SC79 是一个 AKT 激动剂,具有特异性和血脑屏障渗透性。SC79 可以特异性结合 AKT 的 PH 结构域,激活胞质中 AKT,并抑制 AKT 膜转位。SC79 具有神经保护活性。
T25214 CCR-11

CCR11,CCR 11

Antibiotic Microbiology/Virology
CCR-11 是一种具有抗菌活性的绕丹宁衍生物。 CCR-11 可以抑制 B. subtilis细胞和 HeLa 细胞增殖。 CCR-11 通过抑制 FtsZ 的组装和 GTPase 活性来抑制细菌增殖和细菌胞质分裂。 CCR-11 具有潜在的抗肿瘤活性,可用于研究乳腺癌和小儿骨髓增生异常。
T38722 (Z)-PUGNAc

Others Others
(Z)-PUGNAc是一种强效的O-GlcNAcase抑制剂,它比(E)-PUGNAc更有活性,能清除蛋白质上的O-GlcNAc(肽O-GlcNAc-β-N-乙酰氨基葡萄糖苷酶),并可用于增加体内核蛋白和细胞质蛋白上的O-GlcNAc水平。
T0187 Amorolfine hydrochloride

Amorolfin,盐酸阿莫洛芬,Amorolfine HCl,盐酸阿莫罗芬,Ro 14-4767/002

Antibiotic; Antifungal Microbiology/Virology
Amorolfine hydrochloride (Amorolfine HCl) 是一种抗真菌剂。
T15183 Dynarrestin

Hedgehog/Smoothened GPCR/G Protein; Stem Cells
Dynarrestin 是一种细胞质动力蛋白 1 和 2的氨基噻唑抑制剂。它能够快速的、可逆的抑制动力蛋白 1 驱动的微管在体外滑动和细胞内动力蛋白 1 和 2 依赖性过程,且不影响 ATP 水解和干扰纤毛发生。它可抑制神经元前体和肿瘤细胞的刺猬因子依赖性增殖。
T61428 4-PQBH

Others Others
4-PQBH 是一种有效的 Nur77 结合剂,具有抗肿瘤活性。4-PQBH通过 Nur77 介导的内质应激和自噬广泛诱导半胱天冬酶非依赖性细胞质空泡化和旁睑下垂,抑制异种移植肿瘤。4-PQBH 可用于研究肝癌。
T6529 Halobetasol propionate

卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458

Phospholipase Metabolism
Halobetasol propionate (BMY-30056) 是一种在皮肤外使用的合成类固醇,具有抗炎,止痒和收缩血管的活性。
T1561 Clobetasol propionate

Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,丙酸氯倍他索,CCl 4725

Glucocorticoid Receptor; P450 Endocrinology/Hormones; Metabolism
Clobetasol propionate (CGP9555) 是CYP3A5的选择性抑制剂(IC50:0.206 μM),而对 CYP3A4 或其他主要 CYP 无抑制作用。它是皮质类固醇,对于牛皮癣和其他皮肤病具有潜在的研究价值。
TP1565L1 Foxy-5 Ammonium Salt

Foxy-5 Ammonium Salt(881188-51-8 Free base)

Wnt/beta-catenin Cytoskeletal Signaling; Stem Cells
Foxy-5 Ammonium Salt是 WNT5A 激动剂,是 WNT5A 的一个模拟肽,是 Wnt 家族的非经典成员。Foxy-5 Ammonium Salt可在不影响 β-catenin 激活的情况下触发胞浆游离钙信号传导,并可抑制上皮癌细胞的迁移和侵袭。Foxy-5 Ammonium Salt在原位小鼠模型中能有效降低 WNT5A 低表达的前列腺癌细胞的转移扩散。
T1666 Fludrocortisone acetate

9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,醋酸氟氢可的松,9α-fluorocortisol acetate

Glucocorticoid Receptor; Autophagy Autophagy; Endocrinology/Hormones
Fludrocortisone acetate (9α-Fludrocortisone acetate) 是一种合成的盐皮质激素,可减少尿液中钠丢失量,也用于增加血压,有用于阿狄森氏病的研究潜力。
T3626 Acalabrutinib

ACP-196,阿可替尼

BTK Angiogenesis; Tyrosine Kinase/Adaptors
Acalabrutinib (ACP-196) 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK 抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。
T37739 N-decanoyl-L-Homoserine lactone

C10-HSL,N-decanoyl-L-Homoserine lactone

Reactive Oxygen Species; Antibacterial Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
N-decanoyl-L-Homoserine lactone (C10-HSL) 是一种由克雷莫里色假单胞菌菌株 ND07产生的 N-acyl-homoserine lactone (AHL)。N-decanoyl-L-homoserine lactone 可抑制拟南芥的主根生长。N-decanoyl-L-homoserine lactone 处理可引起拟南芥根胞质游离 Ca2+ 和活性氧 (ROS) 浓度短暂和和立即升高,增加丝裂原激活蛋白激酶 6 (MPK6) 的活性,并促使一氧化氮 (NO) 的产生。
T30507 BMS-229724

LS-46643,42AD6D8ECA,BMS229724,SCHEMBL3304414,BMS 229724

Others Others
BMS-229724 is a tightly bound inhibitor of cytoplasmic phospholipase A2 with anti-inflammatory activity.
TP2278 NTR 368

Others Others
cytoplasmic peptide of the neurotrophin receptor p75NTR
T30745 Carboxy-pyridostatin

Others Others
Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.
T13881 Dicirenone

SC26304

ATPase; Glucocorticoid Receptor Endocrinology/Hormones; Membrane transporter/Ion channel
Dicirenone (SC26304) 对盐皮质激素受体 (MR)有抑制作用,对醛固酮对尿 K+:Na+ 比例的调节和 醛固酮与肾细胞质和核受体结合有抑制作用。
TP1498 FFAGLDD TFA

FFAGLDD TFA is an MMP9 selective cleavage peptide, which is used for the cytoplasmic transfer of doxorubicin (DOX) to realize the controlled slow drug delivery and release.
T28891 SW106

Others Others
SW106 is a selective antagonist of PTHR1-mediated cAMP signaling, not functioning as an inverse agonist on either PTHR1-T410P or PTHR1-H223R, which have activating mutations at the cytoplasmic ends of TMD helices-2 and -6, respectively.
T75747 Indolicidin acetate

Indolicidin acetate 是一种从牛中性粒细胞的细胞质颗粒中纯化的强效抗菌肽。
T38773 LeuRS-IN-1 hydrochloride

Others Others
LeuRS-IN-1 hydrochloride is a potent and orally active inhibitor of M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS). It has IC 50 and Kd values of 0.06 μM and 0.075 μM, respectively, for M.tb LeuRS. Additionally, LeuRS-IN-1 hydrochloride inhibits human cytoplasmic LeuRS with an IC 50 of 38.8 μM and HepG2 protein synthesis with an EC 50 of 19.6 μM.
T75748 Indolicidin TFA

Indolicidin TFA 是一种从牛中性粒细胞的细胞质颗粒中纯化的强效抗菌肽。
T64237 ASB14780

Others Others
ASB14780 是一种 4-苯氧衍生物,是一种胞质磷脂酶 cPLA2α 抑制剂 (IC50: 20 nM)。
TP1511 Gap19 TFA (1507930-57-5 free base)

Gap19 TFA

Gap19 TFA is a peptide derived from nine amino acids of Cx43 cytoplasmic ring (CL), an effective, selective connexin 43 (Cx43) half-channel blocker.
TP2149L NP213

Epigenetic Reader Domain Chromatin/Epigenetic
NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption.
T38775 LeuRS-IN-1

Others Others
LeuRS-IN-1 is a highly potent and orally active inhibitor of the leucyl-tRNA synthetase enzyme derived from Mycobacterium tuberculosis (M.tb LeuRS). It exhibits significant inhibitory activity against M.tb LeuRS with IC 50 and Kd values of 0.06 μM and 0.075 μM, respectively. Additionally, LeuRS-IN-1 effectively inhibits human cytoplasmic LeuRS with an IC 50 value of 38.8 μM and suppresses protein synthesis in HepG2 cells with an EC 50 value of 19.6 μM.
TP2149 NP213 TFA (942577-31-3 free base)

NP213 TFA

Others Others
NP213 TFA is a rapidly acting and first-in-class synthetic antimicrobial peptide (AMP) with anti-fungal activity. It targets the fungal cytoplasmic membrane via membrane perturbation and disruption.
T82176 HR1

HR1是一种乳突蛋白酶,可增加人红细胞膜渗透性,并能诱导细菌细胞质膜和肥大细胞质膜透化。
T63631 hCAII-IN-2

Others Others
hCAII-IN-2 是胞质型人碳酸酐酶 (hCA) 抑制剂,能够作用于 hCA I (Ki: 261.4 nM)、hCA II (Ki: 3.8 nM)、hCA IX (Ki: 19.6 nM)和 hCA XII (Ki: 45.2 nM)。
T76456 Protein Kinase C (19-35) Peptide

Protein Kinase C (19-35) Peptide 是PKC 假底物抑制剂/区域。Protein Kinase C (19-35) Peptide 阻断PKC 激酶结构域的底物结合位点,使PKC 的细胞质形式失活。
T79668 PIK5-12d

Autophagy; PROTACs Autophagy; PROTAC
PIK5-12d为一种高效的PROTAC PIKfyve降解剂,具有显著的DC50值为1.48 nM。该化合物在多种前列腺癌细胞系中有效诱导细胞质空泡化,同时阻碍自噬流的进行,有效抑制前列腺癌细胞的增殖,并展现出抗肿瘤活性。
T78752 Antibacterial agent 145

Others Others
Antibacterialagent 145 (compound 1b)为依赖于细菌铁摄取途径的抗菌剂,能破坏细胞质膜完整性并抑制细菌细胞代谢,同时对正常细胞具有低细胞毒性。
T61721 RAGE 229

Others Others
RAGE 229, N-(4-(7-cyano-4-(morpholin-4ylmethyl) quinolin-2-yl)phenyl)acetamide 是一种小分子 ctRAGE-DIAPH1抑制剂,具有口服活性。RAGE 229 可通过抑制 ctRAGE 与 DIAPH1 的相互作用来抑制细胞内 RAGE 信号。
T73916 NP213 TFA

NP213 TFA是一种具有抗真菌(anti-fungal)活性的快速、新颖的合成抗菌肽(AMP)。该化合物通过瞄准真菌胞质膜并扰乱及破坏其结构来发挥作用,对甲真菌感染显示出高效与良好耐受性。
T8812 Amorolfine HCL

Antibiotic Microbiology/Virology
Amorolfine HCL 是一种抗真菌试剂。它通过选择性地中断麦角甾醇合成途径中的两个步骤并随后破坏真菌细胞膜的功能和结构来发挥抗真菌活性。阿莫罗芬是一种吗啉类抗真菌药物,可抑制 D14 还原酶和 D7-D8 异构酶。这些酶可以消耗麦角甾醇并导致木甾醇在真菌细胞质细胞膜中积累。
TP1910 CALP1

Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibit
T81837 MCaE12A

MCaE12A作为RyR2的高亲和调节剂,提高了RyR2对细胞质Ca2+浓度的敏感性,并促使通道开启。该化合物是在RyR2从结构到功能研究中的关键工具,同时用于控制心肌细胞Ca2+的稳态和动态。
T69873 Cefdinir monohydrate

Others Others
Cefdinir monohydrate is the salt form of Cefdinir (free base), a semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefdinir's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidog...
T82086 ICMT-IN-7

Others Others
ICMT-IN-7(化合物74)是一种高效的ICMT抑制剂,其IC50值为0.015 μM。该化合物能剂量依赖性地在HCT-116细胞中诱导ICMT蛋白在胞质的积累,并能抑制表达K-Ras和N-Ras的多种癌细胞系的增殖。
T80261 Retro-indolicidin

Retro-indolicidin为一具有生物活性的肽,由13个氨基酸残基组成,依据indolicidin序列设计而成。Indolicidin属于cathelicidin蛋白家族,为从牛中性粒细胞细胞质颗粒分离得到的阳离子抗菌肽酰胺。该合成肽(Rev4)已证实显示出显著的体外抗菌和蛋白酶抑制活性。
T36871 5-Octyl-α-ketoglutarate

Others Others
In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate, also known as α-ketoglutarate octyl ester, is a stable, cell-permeable molecule that generates free α-ketoglutarate upon hydrolysis of the ester bond by cytoplasmic esterases. It is used in experiments to increase levels of intracellular α-ketoglutarate. 5-Octyl-α-ketoglutarate has been shown to modulate a variety of enzymes and signaling pathway...
T80106 Z-Pro-Pro-aldehyde-dimethyl acetal

Prolyl Endopeptidase (PREP) Metabolism; Proteases/Proteasome
Z-Pro-Pro-aldehyde-dimethyl acetal 是一种高效的脯氨酸内肽酶(PRE P)抑制剂,其IC50值为12 nM。该化合物在衰老过程和神经退行性疾病,诸如阿尔茨海默病中认知功能障碍的研究中具有重要作用。
T82136 ICMT-IN-1

Others Others
ICMT-IN-1 (化合物75) 作为一种高效的ICMT抑制剂展现出显著活性(IC50=0.0013 μM),能够剂量依赖性地在HCT-116细胞中导致ICMT的胞质内积累,进而有效抑制携带K-Ras和N-Ras变异的多个癌细胞系的增殖。
T79703 RyRs activator 3

Parasite Microbiology/Virology
RyRs activator 3 (compound A4) 作为有效杀虫剂,针对斑小菜蛾 (M. separata) 及小菜蛾 (P. xylostella) 显示出较高效力,其对斑小菜蛾的 LC50 值达到 3.27 mg/L。通过与兰尼碱受体 (ryanodine receptor) 结合,RyRs activator 3 能增加细胞质中 Ca2+ 的浓度,从而产生生物毒性。
T75820 Gap19 TFA

Gap19 TFA,源自Cx43胞浆环(CL)的九个氨基酸肽,是高效且选择性的连接蛋白43 (Cx43) 半通道阻滞剂。该肽阻止C末端(CT)与CL之间的分子内相互作用,但不影响GJ通道或Cx40/pannexin-1半通道。此外,Gap19 TFA对心肌有保护作用。
T32091 Hofman's Violet

Hoffman's violet is specific stains for animal chromosomes. Iodinated alcohol after staining can be substituted with various acids, both organic as well as inorganic, all of which act as trapping agent preventing leaching of the dye that binds with the ch

化合物

Ciliobrevin D
Cat.No: T14965
Synonym:
Target: ATPase, Hedgehog/Smoothened
Gap19
Cat.No: TP1563
Synonym:
Target: Gap Junction Protein
GSK-872
Cat.No: T4074
Synonym: GSK872,GSK'872,GSK2399872A
Target: RIP kinase
CCR1/5/8 activator 1
Cat.No: T77349
Synonym:
Target: Phospholipase
Light Green SF Yellowish
Cat.No: T20913
Synonym: Acid Green 5,C.I. Acid Green 5,C.I. 42095
Target:
SC79
Cat.No: T2274
Synonym: SC 79,2-氨基-6-氯-alpha-氰基-3-(乙氧羰基)-4H-1-苯并吡喃-4-乙酸乙酯
Target: Akt
CCR-11
Cat.No: T25214
Synonym: CCR11,CCR 11
Target: Antibiotic
(Z)-PUGNAc
Cat.No: T38722
Synonym:
Target: Others
Amorolfine hydrochloride
Cat.No: T0187
Synonym: Amorolfin,盐酸阿莫洛芬,Amorolfine HCl,盐酸阿莫罗芬,Ro 14-4767/002
Target: Antibiotic, Antifungal
Dynarrestin
Cat.No: T15183
Synonym:
Target: Hedgehog/Smoothened
4-PQBH
Cat.No: T61428
Synonym:
Target: Others
Halobetasol propionate
Cat.No: T6529
Synonym: 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458
Target: Phospholipase
Clobetasol propionate
Cat.No: T1561
Synonym: Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,丙酸氯倍他索,CCl 4725
Target: Glucocorticoid Receptor, P450
Foxy-5 Ammonium Salt
Cat.No: TP1565L1
Synonym: Foxy-5 Ammonium Salt(881188-51-8 Free base)
Target: Wnt/beta-catenin
Fludrocortisone acetate
Cat.No: T1666
Synonym: 9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,醋酸氟氢可的松,9α-fluorocortisol acetate
Target: Glucocorticoid Receptor, Autophagy
Acalabrutinib
Cat.No: T3626
Synonym: ACP-196,阿可替尼
Target: BTK
N-decanoyl-L-Homoserine lactone
Cat.No: T37739
Synonym: C10-HSL,N-decanoyl-L-Homoserine lactone
Target: Reactive Oxygen Species, Antibacterial
BMS-229724
Cat.No: T30507
Synonym: LS-46643,42AD6D8ECA,BMS229724,SCHEMBL3304414,BMS 229724
Target: Others
NTR 368
Cat.No: TP2278
Synonym:
Target: Others
Carboxy-pyridostatin
Cat.No: T30745
Synonym:
Target: Others
Dicirenone
Cat.No: T13881
Synonym: SC26304
Target: ATPase, Glucocorticoid Receptor
FFAGLDD TFA
Cat.No: TP1498
Synonym:
Target:
SW106
Cat.No: T28891
Synonym:
Target: Others
Indolicidin acetate
Cat.No: T75747
Synonym:
Target:
LeuRS-IN-1 hydrochloride
Cat.No: T38773
Synonym:
Target: Others
Indolicidin TFA
Cat.No: T75748
Synonym:
Target:
ASB14780
Cat.No: T64237
Synonym:
Target: Others
Gap19 TFA (1507930-57-5 free base)
Cat.No: TP1511
Synonym: Gap19 TFA
Target:
NP213
Cat.No: TP2149L
Synonym:
Target: Epigenetic Reader Domain
LeuRS-IN-1
Cat.No: T38775
Synonym:
Target: Others
NP213 TFA (942577-31-3 free base)
Cat.No: TP2149
Synonym: NP213 TFA
Target: Others
HR1
Cat.No: T82176
Synonym:
Target:
hCAII-IN-2
Cat.No: T63631
Synonym:
Target: Others
Protein Kinase C (19-35) Peptide
Cat.No: T76456
Synonym:
Target:
PIK5-12d
Cat.No: T79668
Synonym:
Target: Autophagy, PROTACs
Antibacterial agent 145
Cat.No: T78752
Synonym:
Target: Others
RAGE 229
Cat.No: T61721
Synonym:
Target: Others
NP213 TFA
Cat.No: T73916
Synonym:
Target:
Amorolfine HCL
Cat.No: T8812
Synonym:
Target: Antibiotic
CALP1
Cat.No: TP1910
Synonym:
Target:
MCaE12A
Cat.No: T81837
Synonym:
Target:
Cefdinir monohydrate
Cat.No: T69873
Synonym:
Target: Others
ICMT-IN-7
Cat.No: T82086
Synonym:
Target: Others
Retro-indolicidin
Cat.No: T80261
Synonym:
Target:
5-Octyl-α-ketoglutarate
Cat.No: T36871
Synonym:
Target: Others
Z-Pro-Pro-aldehyde-dimethyl acetal
Cat.No: T80106
Synonym:
Target: Prolyl Endopeptidase (PREP)
ICMT-IN-1
Cat.No: T82136
Synonym:
Target: Others
RyRs activator 3
Cat.No: T79703
Synonym:
Target: Parasite
Gap19 TFA
Cat.No: T75820
Synonym:
Target:
Hofman's Violet
Cat.No: T32091
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T1429 17α-Hydroxyprogesterone

Hydroxyprogesterone,17-OHP,羟孕酮,17-Hydroxyprogesterone,17α-羟孕酮

Estrogen/progestogen Receptor; Progesterone Receptor; Endogenous Metabolite Endocrinology/Hormones; Metabolism; Others
17α-Hydroxyprogesterone (17-OHP) 是一种内源性孕激素,其他类固醇激素(包括糖皮质激素,雌激素,和雄激素)生物合成的化学中间体。
TQ0302 Thapsigargin

毒胡萝卜素

Apoptosis; SARS-CoV; Calcium Channel Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
Thapsigargin 属于天然产物,是一种肌/内质网 Ca2+ ATP 酶 (SERCA) 的抑制剂,也是一种内质网应激诱导剂。Thapsigargin 通过阻断细胞将钙泵入肌浆和内质网的能力来提高胞浆钙浓度。
T40600 Iturin A

Others Others
Iturin A is a chemical compound with potent antifungal properties against pathogenic yeast and fungi. It interacts with the cytoplasmic membrane of the target cell, leading to the formation of ion conducting pores.
T19343 sn-Glycerol 3-phosphate

Glycerol 3-phosphate,SN-甘油3-磷酸 锂盐,sn-Glycerol 3-phosphate lithium salt

Endogenous Metabolite Metabolism
sn-Glycerol 3-phosphate 是一种人内源性化合物,由NADH 还原磷酸二羟基丙酮而产生。
T37972 12-OxoETE

Others Others
12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid. Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE. 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via a leukotriene B4 receptor or a common activation sequence.
T80998 Thapsigargicin

Thapsigargicine

Thapsigargicin(Thapsigargicine)作为肥大细胞和白细胞的激活剂,能诱导大鼠腹膜肥大细胞及人嗜碱性粒细胞释放组胺,并提升完整人血小板中的细胞质游离钙水平。
T13606L cGAMP disodium

Others Others
cGAMP disodium 是在细菌中发现的一种环二核苷酸 (CDN) ,可作为内源性第二信使,影响干扰素的产生以响应胞浆 DNA。cGAMP disodium 通过激活干扰素基因刺激因子 (STING)使 I 型干扰素和其他免疫介质的信号产生级联现象。cGAMP disodium 是一种有效的舌下免疫佐剂,能使免疫功能(血清抗 PA 中和和气道分泌物抗 PA SIgA 反应) 更好的发挥作用。
T35751 Violacein

Others Others
Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.[1] [2] It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserine lactone , a property that has been modified to create a strain of C. violaceum used in detecting quorum-sensing molecules.[3] Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 &#181M, respectively). It is also active aga...

天然产物

17α-Hydroxyprogesterone
Cat.No: T1429
Synonym: Hydroxyprogesterone,17-OHP,羟孕酮,17-Hydroxyprogesterone,17α-羟孕酮
Target: Estrogen/progestogen Receptor, Progesterone Receptor, Endogenous Metabolite
Thapsigargin
Cat.No: TQ0302
Synonym: 毒胡萝卜素
Target: Apoptosis, SARS-CoV, Calcium Channel
Iturin A
Cat.No: T40600
Synonym:
Target: Others
sn-Glycerol 3-phosphate
Cat.No: T19343
Synonym: Glycerol 3-phosphate,SN-甘油3-磷酸 锂盐,sn-Glycerol 3-phosphate lithium salt
Target: Endogenous Metabolite
12-OxoETE
Cat.No: T37972
Synonym:
Target: Others
Thapsigargicin
Cat.No: T80998
Synonym: Thapsigargicine
Target:
cGAMP disodium
Cat.No: T13606L
Synonym:
Target: Others
Violacein
Cat.No: T35751
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPY-00217 KIR3DL3 Protein, Human, Recombinant (His)

KIR44,KIR3DL7,CD158Z,KIRC1,killer cell immunoglobulin like r...

Human HEK293 Cells
KIR3DL3 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 3) is a Protein Coding gene. KIR3DL3 is a framework gene of the Leukocyte Receptor Complex, present in all individuals and haplotypes analyzed to date.KIR3DL3 alleles were characterized by two families and one unrelated individual. The most centromeric gene in the human KIR cluster is KIR3DL3. The encoded protein belongs to the immunoglobulin superfamily. KIR3DL3 has only one immunoreceptor tyrosine-bas...
TMPY-02629 KIR2DL1 Protein, Human, Recombinant (His)

NKAT-1,KIR-K64,XXbac-BPG184J6.7,NKAT1,p58.1,killer cell immu...

Human HEK293 Cells
KIR2DL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is Q6H2H3.
TMPH-00435 Beta-Actin Protein, Cricetulus griseus, Recombinant (His)

ACTB,Actin, cytoplasmic 1,Beta-actin

Chinese hamster E. coli
Beta-Actin Protein, Cricetulus griseus, Recombinant (His) is expressed in E. coli.
TMPY-00410 EPHX2 Protein, Human, Recombinant (His)

SEH,CEH,epoxide hydrolase 2, cytoplasmic

Human Baculovirus Insect Cells
Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the human EPHX2 gene had been implicated in susceptibility to cardiovascular disease, including stroke. The human EPHX2 mutations may in part explain the genetic variability in sensitivity to ischemic brain injury and stroke outcome. Epoxide hydrolase is involved in metabolism of vas...
TMPH-01565 IARS Protein, Human, Recombinant (His & Myc)

Isoleucine--tRNA ligase, cytoplasmic,Isoleucyl-tRNA...

Human E. coli
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
TMPH-02741 IARS1 Protein, Mouse, Recombinant (His & Myc)

Isoleucyl-tRNA synthetase,Iars1,Isoleucine--tRNA ligase,

Mouse E. coli
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. IARS1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 16.8 kDa and the accession number is Q8BU30.
TMPJ-00955 MDH1 Protein, Human, Recombinant (His)

Cytosolic Malate Dehydrogenase,MDH1,MDHA,Diiodophenylpyruvat...

Human E. coli
Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate (using NAD+) and vice versa. MDH1 should not be confused with Malic Enzyme, which catalyzes the conversion of Malate to Pyruvate, producing NADPH. MDH1 also participates in Gluconeogenesis, the synthesis of Glucose from smaller molecules. Pyruvate in the mitochondria is acted up...
TMPH-02101 Serpin B9 Protein, Human, Recombinant (GST)

SERPINB9,Peptidase inhibitor 9,Cytoplasmic antiprot...

Human E. coli
Serpin B9 Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPY-02237 KIR2DL3 Protein, Human, Recombinant (His)

NKAT2,MGC129943,KIR-K7c,NKAT2B,CU464054.1,NKAT,KIR-023GB,p58...

Human HEK293 Cells
KIR2DL3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.9 kDa and the accession number is Q32WE4.
TMPJ-01036 Beta-Actin Protein, Human, Recombinant (His)

Actin Cytoplasmic 1,β-Actin,Beta-Actin,ACTB,β-Actin...

Human E. coli
Actins are ubiquitous globular and highly conserved proteins that are involved in various types of cell motility, structure, and integrity. Three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. ACTB is a major constituent of the contract...
TMPH-02279 YARS1 Protein, Human, Recombinant (GST)

Tyrosine--tRNA ligase, cytoplasmic,Tyrosyl-tRNA syn...

Human E. coli
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). YARS1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 86.0 kDa and the accession number is P54577.
TMPH-02717 HMGCS1 Protein, Mouse, Recombinant (His & SUMO)

Hmgcs1,3-hydroxy-3-methylglutaryl coenzyme A synthase,Hydrox...

Mouse E. coli
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. HMGCS1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 73.6 kDa and the accession number is Q8JZK9.
TMPY-05442 KIR2DL3 Protein, Human, Recombinant (hFc)

KIR-K7b,CU464054.1,killer cell immunoglobulin like receptor,...

Human HEK293 Cells
KIR2DL3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.6 kDa and the accession number is Q32WE4.
TMPJ-00696 NOL3 Protein, Human, Recombinant

Apoptosis Repressor With CARD,Nucleolar Protein of 30 kDa,Nu...

Human E. coli
Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex ...
TMPY-05086 KIR2DL5 Protein, Human, Recombinant (hFc)

KIR2DL5.1,CD158F,KIR2DL5.3,killer cell immunoglobulin like r...

Human HEK293 Cells
KIR2DL5A (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 5A) is a Protein Coding gene. The encoded protein belongs to the immunoglobulin superfamily. The most recently described member of the KIR family, KIR2DL5, is represented in human populations by at least four gene variants, whose exons differ by two to eight nucleotides. KIR2DL5 (CD158f) is the most recently identified inhibitory member of human killer-cell Ig-like receptors (KIRs), which enable NK cells...
TMPH-01196 DYNC1I1 Protein, Human, Recombinant (His)

DH IC-1,DNCIC1,Cytoplasmic dynein 1 intermediate ch...

Human Baculovirus Insect Cells
DYNC1I1 Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPJ-00243 Serpin B6 Protein, Human, Recombinant (E. coli, His)

CAP,PI6,SERPINB6,Placental Thrombin Inhibitor,Cytoplasmi...

Human E. coli
Serpin B6 belongs to the serpin family. Serpin B6 localizes to the cytoplasm. Serpin B6 is expressed in many tissues, abundantly by mast cells in different tissues and mastocytoma lesions. Serpin B6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. In addition, Serpin B6 may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and se...
TMPY-01843 SEMA6A Protein, Human, Recombinant (His)

HT018,VIA,sema domain, transmembrane domain (TM), and cy...

Human HEK293 Cells
SEMA6A, the first identified class 6 semaphorin, is contributed to regulate vascular development and adult angiogenesis. SEMA6A could inhibit proliferation, migration, and invasion in different glioma cell lines. That SEMA6A may be a potential prognostic biomarker in the treatment of GBM. Among different semaphorins tested by reverse transcriptase-polymerase chain reaction in human immune cells, the expression of class 6 transmembrane semaphorin SEMA6A was restricted to dendritic cells (DCs).
TMPJ-00870 NCK1 Protein, Human, Recombinant (His)

SH2/SH3 Adaptor Protein NCK-α,SH2/SH3 Adaptor Protein NCK-Al...

Human E. coli
Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. NCK1 plays a role in the DNA damage response, but not in the detection of the damage by ATM/ATR. It is also involved in transducing...
TMPJ-00697 NOL3 Protein, Human, Recombinant (GST)

Nop30,Myp,NOP,Apoptosis Repressor With CARD,Nucleolar Protei...

Human E. coli
Nucleolar Protein 3 is encoded by NOL3 gene; multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing.Isoform 2 may inhibit apoptosis.It has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53.
TMPY-03652 KIR2DL4 Protein, Human, Recombinant

KIR2DL4,KIR103,G9P,CD158D,KIR,KIR-2DL4,KIR-103AS,killer cell...

Human CHO Cells
KIR2DL4 Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 50.3 kDa and the accession number is ADY38409.1.
TMPH-02648 PKDCC Protein, Mouse, Recombinant (His & Myc)

Extracellular tyrosine-protein kinase PKDCC,Vertebrate lones...

Mouse Baculovirus Insect Cells
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29. May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membr...
TMPY-03651 KIR2DL4 Protein, Human, Recombinant (hFc)

KIR,G9P,KIR-2DL4,KIR2DL4,KIR103,killer cell immunoglobulin l...

Human CHO Cells
KIR2DL4 Protein, Human, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 54.4 kDa and the accession number is ADY38409.1.
TMPH-02488 ACSS2 Protein, Mouse, Recombinant (His)

Propionate--CoA ligase,AceCS1,Acyl-activating enzyme,Acetyl-...

Mouse E. coli
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity. ACSS2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82.9 kDa and the accession number is Q9QXG4.
TMPY-02517 KIR2DL1 Protein, Human, Recombinant (hFc)

KIR-K64,KIR221,killer cell immunoglobulin like receptor, two...

Human HEK293 Cells
KIR2DL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.7 kDa and the accession number is Q6H2H3.
TMPJ-01052 DYNLL1 Protein, Human, Recombinant (His)

DNCL1,PIN,DLC8,Protein Inhibitor of Neuronal Nitric Oxide Sy...

Human E. coli
Human Dynein Cytoplasmic Light Chain 1 (DYNLL1) has been identified as a protein that interacts with NOS1, leading to NOS1 inhibition. NOS1 dimer is destabilized after binding DYNLL1 a conformation necessary activity, and it regulate numerous biologic processes throughits effects on nitric oxide synthase activity. DYNLL1 is widely expressed, with higher expression in testis and moderate expression in brain.
TMPH-01036 Caprin-1/CAPRIN1 Protein, Human, Recombinant (His)

GPI-anchored membrane protein 1,CAPRIN1,GPIP137,M11S1,GPI-an...

Human Baculovirus Insect Cells
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs. Caprin-1/CAPRIN1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells ...
TMPY-05822 Hepatitis B Virus (HBV)(ayw/France/Tiollais/1979) Capsid protein (His)

HBV-D E. coli
Hepatitis B virus (HBV) capsid assembly is a critical step in the propagation of the virus and is mediated by the core protein. The first cytoplasmic step in the formation of an infectious HBV virion is the formation of a capsid containing pregenomic RNA (pgRNA) and the viral polymerase (Pol). HBV capsid assembly is an attractive target for new antiviral therapies.
TMPK-00887 KIR3DL2 Protein, Human, Recombinant (His & Avi)

KIR3DL2,p140,NKAT4,NKAT4A,NKAT4B,CL-5,CD158k,NKAT-4

Human HEK293 Cells
KIR3DL2 is a member of the killer cell immunoglobulin-like receptor (KIR) family that was initially identified at the surface of natural killer (NK) cells. KIR3DL2, also known as CD158k, is expressed as a disulfide-linked homodimer. Each chain is composed of three immunoglobulin-like domains and a long cytoplasmic tail containing two immunoreceptor tyrosine-based inhibitory motifs. KIR3DL2 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The pred...
TMPJ-00651 CD155/PVR Protein, Human, Recombinant (aa 21-343, His)

Poliovirus Receptor,PVS,Nectin-Like Protein 5,NECL-5,CD155,P...

Human HEK293 Cells
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension be...
TMPJ-00059 IL-7 Protein, Human, Recombinant (His)

Interleukin-7,IL7,白细胞介素,IL-7,白介素

Human HEK293 Cells
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-spe...
TMPY-05717 Integrin alpha V beta 8 Protein, Human, Recombinant (His)

Integrin alpha V β8,Integrin α V β 8

Human HEK293 Cells
Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif; including vitronectin; fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP; which releases active TGF-beta. This m...
TMPY-04125 PTP1B Protein, Human, Recombinant (His)

protein tyrosine phosphatase, non-receptor type 1,PTP1B,PTPN...

Human E. coli
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein p...
TMPY-01850 CEACAM3 Protein, Human, Recombinant (His)

W282,W264,CEA,CD66D,CGM1,MGC119875,carcinoembryonic antigen ...

Human HEK293 Cells
CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexp...
TMPY-03407 NQO1 Protein, Human, Recombinant (His)

NAD(P)H dehydrogenase, quinone 1,NMORI,DIA4,QR1,NMOR1,DTD,DH...

Human E. coli
NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered ex...
TMPH-01561 ISCU Protein, Human, Recombinant (His & Myc)

NifU-like protein,ISCU,Iron-sulfur cluster assembly enzyme I...

Human Baculovirus Insect Cells
Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic Functions as a cytoplasmic scaffold protein for the de novo synthesis of iron-sulfur clusters in the cytoplasm.
TMPJ-00233 CD200R1/CRTR2 Protein, Human, Recombinant (His)

Cell Surface Glycoprotein CD200 Receptor 1,OX2R,MOX2R,CD200 ...

Human HEK293 Cells
Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. CD200R1 and CD200 associate via their respective N-terminal Ig-like domains. CD200R1 is restricted primarily to mast cells, basophils, macrophages, and dendritic cells. It propagates inhibitory signals despite its lacking a cytopla...
TMPJ-01443 HChFc2 Protein, Mouse, Recombinant (His)

C2 factor,HCF-2,Host cell factor 2,Hcfc2

Mouse E. coli
Host cell factor 2(HCFC2) is a cytoplasmic protein. It contains 2 fibronectin type-III domains.HCFC2 binds KMT2A/MLL1, as component of the MLL1/MLL complex.Hcfc2 negative regulation of transcription from RNA polymerase II promoter.
TMPH-00596 Colicin-E1 Protein, E. coli, Recombinant (Cell-Free, His & Myc)

Colicin-E1,cea

E. coli E. coli
This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane, leading to dissipation of cellular energy.; Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
TMPH-00597 Colicin-E1 Protein, E. coli, Recombinant (His & Myc)

cea,Colicin-E1

E. coli E. coli
This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane, leading to dissipation of cellular energy.; Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
TMPJ-00219 BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated

BTF3,BTN3A2,Butyrophilin subfamily 3 member A2,BTF4,BT3.2

Human HEK293 Cells
Butyrophilin subfamily 3 member A2, also known as BT3.2, BTF3, BTF4 and BTN3A2, is a single-pass type I membrane protein. It is a member of the butyrophilin (BTN) family and the immunoglobulin (IG) superfamily. Mature human BTN3A2 is a 305 amino acid (aa) glycoprotein. It contains a 219 aa extracellular region with one V-type Ig-like domain, and a 65 aa cytoplasmic tail. The cytoplasmic region undergoes phosphorylation on two serines. There are three potential splice forms. BTN3A2 is postulated ...
TMPH-03641 TroA Protein, Treponema pallidum, Recombinant (His & Myc)

Zinc-binding protein TroA,troA,Tromp-1

Treponema pallidum E. coli
Part of an ATP-driven transport system TroABCD for zinc. Substrate-binding protein involved in the transport of zinc across the cytoplasmic membrane. TroA Protein, Treponema pallidum, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 38.2 kDa and the accession number is P96116.
TMPK-00144 CEACAM3 Protein, Human, Recombinant (hFc)

CEACAM3,CGM1,CEA,CD66d

Human HEK293 Cells
The human granulocyte-specific receptor carcinoembryonic antigen-related cell adhesion molecule (CEACAM)3 is critically involved in the opsonin-independent recognition of several bacterial pathogens. CEACAM3-mediated phagocytosis depends on the integrity of an ITAM-like sequence within the cytoplasmic domain of CEACAM3 and is characterized by rapid stimulation of the GTPase Rac.
TMPJ-01206 Sting Protein, Human, Recombinant (Sumo & His)

TMEM173,Mediator of IRF3 activation,Stimulator of interferon...

Human E. coli
Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). It ubiquitously expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophagesand. Its subunit structure associated with the MHC-II complex and Interacts with DDX58/RIG-I, MAVS and SSR2,...
TMPH-01816 OX1R Protein, Human, Recombinant (His & SUMOstar)

Hypocretin receptor type 1,Orexin receptor type 1,Orexin/Hyp...

Human P. pastoris (Yeast)
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. OX1R Protein, Human, Recombinant (His & SUMOstar) is expressed in yeast with N-6xHis-sumostar tag. The predicted molecular weight is 21.4 kDa and the accession number is O43613.
TMPH-01461 HNRNPA3 Protein, Human, Recombinant (His & Myc)

Heterogeneous nuclear ribonucleoprotein A3,HNRNPA3

Human E. coli
Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. HNRNPA3 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 46.6 kDa and the accession number is P51991.
TMPH-01704 RAE1 Protein, Human, Recombinant (GST)

Rae1 protein homolog,mRNA-associated protein mrnp 41,mRNA ex...

Human E. coli
Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. RAE1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 68.0 kDa and the accession number is P78406.
TMPJ-01302 ACAT2 Protein, Human, Recombinant (His)

ACTL,Acetyl-CoA transferase-like protein,Acetyl-CoA acetyltr...

Human E. coli
ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB. ACAT2 deficiency contributes to severe mental retardation and hypotonus.
TMPK-00709 Tulp1 Protein, Human, Recombinant (His)

LCA15,TUBL1,TULP1,RP14,Tubby-related protein 1,Tubby-like pr...

Human E. coli
The tubby-like protein 1 (tulp1) gene is a member of the tubby multigene family which includes tub, tulp1, tulp2 and tulp3.TULP1 is a cytoplasmic, membrane-associated protein shown to be involved in transportation of newly synthesized proteins destined for the outer segment compartment of photoreceptor cells.
TMPJ-00552 LILRB2/CD85d/ILT4 Protein, Human, Recombinant (Avi & His), Biotinylated

Leukocyte Immunoglobulin-Like Receptor 2,Monocyte/Macrophage...

Human HEK293 Cells
Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa...
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重组蛋白

KIR3DL3 Protein, Human, Recombinant (His)
Cat.No: TMPY-00217
Species: Human
Expression System: HEK293 Cells
KIR2DL1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02629
Species: Human
Expression System: HEK293 Cells
Beta-Actin Protein, Cricetulus griseus, Recombinant (His)
Cat.No: TMPH-00435
Species: Chinese hamster
Expression System: E. coli
EPHX2 Protein, Human, Recombinant (His)
Cat.No: TMPY-00410
Species: Human
Expression System: Baculovirus Insect Cells
IARS Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01565
Species: Human
Expression System: E. coli
IARS1 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02741
Species: Mouse
Expression System: E. coli
MDH1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00955
Species: Human
Expression System: E. coli
Serpin B9 Protein, Human, Recombinant (GST)
Cat.No: TMPH-02101
Species: Human
Expression System: E. coli
KIR2DL3 Protein, Human, Recombinant (His)
Cat.No: TMPY-02237
Species: Human
Expression System: HEK293 Cells
Beta-Actin Protein, Human, Recombinant (His)
Cat.No: TMPJ-01036
Species: Human
Expression System: E. coli
YARS1 Protein, Human, Recombinant (GST)
Cat.No: TMPH-02279
Species: Human
Expression System: E. coli
HMGCS1 Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02717
Species: Mouse
Expression System: E. coli
KIR2DL3 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05442
Species: Human
Expression System: HEK293 Cells
NOL3 Protein, Human, Recombinant
Cat.No: TMPJ-00696
Species: Human
Expression System: E. coli
KIR2DL5 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05086
Species: Human
Expression System: HEK293 Cells
DYNC1I1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01196
Species: Human
Expression System: Baculovirus Insect Cells
Serpin B6 Protein, Human, Recombinant (E. coli, His)
Cat.No: TMPJ-00243
Species: Human
Expression System: E. coli
SEMA6A Protein, Human, Recombinant (His)
Cat.No: TMPY-01843
Species: Human
Expression System: HEK293 Cells
NCK1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00870
Species: Human
Expression System: E. coli
NOL3 Protein, Human, Recombinant (GST)
Cat.No: TMPJ-00697
Species: Human
Expression System: E. coli
KIR2DL4 Protein, Human, Recombinant
Cat.No: TMPY-03652
Species: Human
Expression System: CHO Cells
PKDCC Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02648
Species: Mouse
Expression System: Baculovirus Insect Cells
KIR2DL4 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-03651
Species: Human
Expression System: CHO Cells
ACSS2 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02488
Species: Mouse
Expression System: E. coli
KIR2DL1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-02517
Species: Human
Expression System: HEK293 Cells
DYNLL1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01052
Species: Human
Expression System: E. coli
Caprin-1/CAPRIN1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01036
Species: Human
Expression System: Baculovirus Insect Cells
Hepatitis B Virus (HBV)(ayw/France/Tiollais/1979) Capsid protein (His)
Cat.No: TMPY-05822
Species: HBV-D
Expression System: E. coli
KIR3DL2 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00887
Species: Human
Expression System: HEK293 Cells
CD155/PVR Protein, Human, Recombinant (aa 21-343, His)
Cat.No: TMPJ-00651
Species: Human
Expression System: HEK293 Cells
IL-7 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00059
Species: Human
Expression System: HEK293 Cells
Integrin alpha V beta 8 Protein, Human, Recombinant (His)
Cat.No: TMPY-05717
Species: Human
Expression System: HEK293 Cells
PTP1B Protein, Human, Recombinant (His)
Cat.No: TMPY-04125
Species: Human
Expression System: E. coli
CEACAM3 Protein, Human, Recombinant (His)
Cat.No: TMPY-01850
Species: Human
Expression System: HEK293 Cells
NQO1 Protein, Human, Recombinant (His)
Cat.No: TMPY-03407
Species: Human
Expression System: E. coli
ISCU Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01561
Species: Human
Expression System: Baculovirus Insect Cells
CD200R1/CRTR2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00233
Species: Human
Expression System: HEK293 Cells
HChFc2 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-01443
Species: Mouse
Expression System: E. coli
Colicin-E1 Protein, E. coli, Recombinant (Cell-Free, His & Myc)
Cat.No: TMPH-00596
Species: E. coli
Expression System: E. coli
Colicin-E1 Protein, E. coli, Recombinant (His & Myc)
Cat.No: TMPH-00597
Species: E. coli
Expression System: E. coli
BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPJ-00219
Species: Human
Expression System: HEK293 Cells
TroA Protein, Treponema pallidum, Recombinant (His & Myc)
Cat.No: TMPH-03641
Species: Treponema pallidum
Expression System: E. coli
CEACAM3 Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00144
Species: Human
Expression System: HEK293 Cells
Sting Protein, Human, Recombinant (Sumo & His)
Cat.No: TMPJ-01206
Species: Human
Expression System: E. coli
OX1R Protein, Human, Recombinant (His & SUMOstar)
Cat.No: TMPH-01816
Species: Human
Expression System: P. pastoris (Yeast)
HNRNPA3 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01461
Species: Human
Expression System: E. coli
RAE1 Protein, Human, Recombinant (GST)
Cat.No: TMPH-01704
Species: Human
Expression System: E. coli
ACAT2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01302
Species: Human
Expression System: E. coli
Tulp1 Protein, Human, Recombinant (His)
Cat.No: TMPK-00709
Species: Human
Expression System: E. coli
LILRB2/CD85d/ILT4 Protein, Human, Recombinant (Avi & His), Biotinylated
Cat.No: TMPJ-00552
Species: Human
Expression System: HEK293 Cells
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Cat. No. Product Name Target Signaling Pathways
TMIH-0065 Acalabrutinib-d4

Acalabrutinib-d4 是 Acalabrutinib 的氘代化合物。Acalabrutinib 的 CAS 号为 1420477-60-6。Acalabrutinib 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。

同位素标记化合物

Acalabrutinib-d4
Cat.No: TMIH-0065
Synonym:
Target:
TargetMol Loading
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