KIR2DL4 Protein, Human, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 54.4 kDa and the accession number is ADY38409.1.

Human

CHO Cells

KIR-2DL4,KIR2DL4,KIR-103AS,KIR103AS,KIR103,KIR,killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4,G9P,CD158D

A DNA sequence encoding the human KIR2DL4 (ADY38409.1)(Met1-His242) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Trp 24

> 95 % as determined by SDS-PAGE

A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.