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Search Results for " pb1 "

Targets Recommended: Others

9

抑制剂 & 化合物

1

天然产物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T35888	PB1	Others	Others
	PB1 is a highly-effective intracellular disulfide reducing agent with notable attributes such as excellent cell permeability, the capacity to generate a substantial intracellular concentration gradient, and remarkable stability. It serves as a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogue. PB1 demonstrates the potential to enhance the survival of retinal ganglion cells following axotomy in vitro at concentrations in the nanomolar and picomolar range. Consequently, PB1 has proven...
T9568	SGC-SMARCA-BRDVIII	Epigenetic Reader Domain	Chromatin/Epigenetic
	SGC-SMARCA-BRDVIII 是SMARCA2/4和PB1(5)选择性抑制剂，其Kd 值分别为 35 nM，36 nM 和 13 nM。它还抑制PB1(2)和PB1(3)，Kd 值分别为 3.7 和 2.0 μM。它可阻断 3T3-L1 鼠成纤维细胞的脂肪生成。
T32287	Jegosapogenol A Jegosapogenol,Giganteumgenin M,Proschiwalligenin PB1,Careyagenol A,Saniculagenin D	Others	Others
	Jegosapogenol A is a type of triterpenoid. Triterpenoids are terpene molecules containing six isoprene units. Barringtogenol C is a very weakly acidic compound (based on its pKa) and practically insoluble (in water). Barringtogenol C exists in tea. It can
T78552	PB118	Others	Others
	PB118是一种新型组蛋白去乙酰化酶 6（HDAC6）抑制剂，具备穿越血脑屏障的能力，可用于AD治疗。PB118 对 HDAC6 的 IC50 为 5.6 nM。
T78969	PB131	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PB131为选择性HDAC6抑制剂，能穿透血脑屏障且显示出高结合亲和性（IC50: 1.8 nM）。该化合物展现出显著的抗炎活性，适用于炎症特别是神经炎症的研究领域。
T62772	TPB15	Others	Others
	TPB15 是一种口服具有活力的 Hh(Hedgehog) 信号抑制剂。TPB15 可以明显阻滞 MDA-MB-468 细胞周期，并诱导其凋亡。TPB15 阻断 Smo(Smoothened) 转位到纤毛中，减少 Smo 蛋白和 mRNA 表达。TPB15 对下游调控因子胶质瘤相关癌基因1 (Gli1) 的表达表现出抑制作用。TPB15 具有较好的抗肿瘤作用，且毒性较低。
T12526	PP7	Influenza Virus	Microbiology/Virology
	PP7 是一种PB1-PB2互作抑制剂，IC50为 8.6 μM。PB1-PB2 抑制病毒聚合酶的活性，IC50为9.5 μM。它对甲型流感病毒 A 包括 (H1N1)pdm09 (EC50=1.4 μM)，A(H7N9)，A(H9N2) 亚型具有抗病毒活性。
T4178	NSC 80538	Others	Others
	NSC 80538 是多重 HTS 检测中 MEK Kinase PB1 Domains 的抑制剂。
T62812	RdRP-IN-4	Others	Others
	RdRP-IN-4 (compound 11q) 是一种芳基苯甲酰肼类似物，是一种口服具有活力的甲型流感病毒 RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂，能够直接结合 RdRp 的 PB1 亚基。RdRP-IN-4 可有效抑制 H5N1 禽流感病毒株，在 MDCK 细胞的 EC50=18 nM。RdRP-IN-4 对 H1N1 (A/PR/8/34) Flu A 株和 Flu B 株 (B/Lee/1940) 具有抑制作用，其 EC50 值分别为 53 nM 和 20 nM。RdRP-IN-4 以剂量依赖性方式显著抑制病毒核蛋白 (NP) 的表达水平。RdRP-IN-4 在受感染的小鼠中具有明显的抗病毒作用。

化合物

Cat.No: T35888

Target: Others

SGC-SMARCA-BRDVIII

Cat.No: T9568

Target: Epigenetic Reader Domain

Jegosapogenol A

Cat.No: T32287

Synonym: Jegosapogenol,Giganteumgenin M,Proschiwalligenin PB1,Careyagenol A,Saniculagenin D

Target: Others

Cat.No: T78552

Target: Others

Cat.No: T78969

Target: HDAC

Cat.No: T62772

Target: Others

Cat.No: T12526

Target: Influenza Virus

Cat.No: T4178

Target: Others

Cat.No: T62812

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T19125	3-Phenylbutyric acid	Others; Endogenous Metabolite	Metabolism; Others
	3-Phenylbutyric acid 从堆肥土壤中分离出 Rhodococcus rhodochrous PB1，通过苯环的初始氧化和侧链的初始氧化进行代谢。

天然产物

3-Phenylbutyric acid

Cat.No: T19125

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01490	HLA-DPB1 Protein, Human, Recombinant (His) HLA class II histocompatibility antigen, DP(W4) beta chain,H...	Human	E. coli
	HLA-DPB1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPJ-01411	HSPB11 Protein, Human, Recombinant (His) PP25,Placental Protein 25,Heat Shock Protein β-1	Human	E. coli
	Heat Shock Protein β-11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 and is detected in placenta. HSPB11 has beeb shown to form oligomeric complexes and prevent the aggregation of in vitro denaturated aldolase and glyceraldehyde-3-phosphate dehydrogenase in accordance with the chaperone model of HSPB1 and HSPB5. HSPB11 overexpression protected a...
TMPH-00505	RPB1 Protein, Drosophila melanogaster, Recombinant (His) RNA polymerase II subunit A,DNA-directed RNA polymerase II s...	Fruit fly	P. pastoris (Yeast)
	RPB1 Protein, Drosophila melanogaster, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 33.6 kDa and the accession number is P04052.
TMPK-00693	HSP27/HSPB1 Protein, Human, Recombinant (His) Hsp27,SRP27,HMN2B,HSP 27,HSPB1,CMT2F,HSP28	Human	E. coli
	Heat shock protein beta-1 (HSPB1, also known as HSP27) is a small heat shock protein involved in many cellular processes and reportedly protects cells against oxidative stress. This protein is expressed only in insulin-dependent tissues (heart, skeletal muscle, and fat tissue), and expression of HspB7 is regulated by many different factors. HspB7 has an unusual N-terminal sequence, a conservative α-crystallin domain, and very short C-terminal domain lacking conservative IPV tripeptide involved i...
TMPJ-01374	UPB1 Protein, Human, Recombinant (His) β-Ureidopropionase,Beta-Alanine Synthase,β-Alanine Synthase,...	Human	E. coli
	β-Ureidopropionase is a cytoplasmic protein which belongs to the CN hydrolase family of BUP subfamily. β-Ureidopropionase binds one zinc ion per subunit, catalyzes the last step in the pyrimidine degradation pathway. β-Ureidopropionase can convert N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide, respectively. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidi...

重组蛋白

HLA-DPB1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01490

Species: Human

Expression System: E. coli

HSPB11 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01411

Species: Human

Expression System: E. coli

RPB1 Protein, Drosophila melanogaster, Recombinant (His)

Cat.No: TMPH-00505

Species: Fruit fly

Expression System: P. pastoris (Yeast)

HSP27/HSPB1 Protein, Human, Recombinant (His)

Cat.No: TMPK-00693

Species: Human

Expression System: E. coli

UPB1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01374

Species: Human

Expression System: E. coli

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