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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T28865 |
STAT3-IN-B9
STAT3 IN B9,B9 |
STAT | JAK/STAT signaling; Stem Cells |
STAT3-IN-B9 (B9) 是异常 STAT3 激活的抑制剂,可抑制 MDA-MB-468、MDA-MB-231 和 DU145 等肿瘤细胞的增殖。 | |||
T67935 |
Tubulin inhibitor 11
|
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Tubulin inhibitor 11 是一种口服活性的有效微管蛋白抑制剂。它通过靶向秋水仙碱结合位点,抑制tubulin聚合,进而促进有丝分裂阻断和apoptosis。 | |||
TP2128 |
R8-T198wt
|
||
Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells | |||
T70962 |
MHY219
|
Others | Others |
MHY219 is a novel HDAC inhibitor. MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells. MHY219 was shown to enhance the cytotoxicity on DU145 cells (IC50, 0.36 μM) when compared with LNCaP (IC50, 0.97 μM) and PC3 cells (IC50, 5.12 μM). MHY219 showed a potent inhibition of total HDAC activity when compared with SAHA. MHY219 increased histone H3 hyperacetylation and reduced the expression of class I HDACs (1, 2 and 3) in prostate cancer cells. M... | |||
T36969 |
ARN24139
|
Others | Others |
ARN24139 is a topoisomerase II poison (IC50= 7.3 μM in a topoisomerase II decatenation assay).1It inhibits proliferation of DU145, HeLa, and A549 cells (IC50s = 4.7, 3.8, and 3.1 μM, respectively). 1.Arencibia, J.M., Brindani, N., Franco-Ulloa, S., et al.Design, synthesis, dynamic docking, biochemical characterization, and in vivo pharmacokinetics studies of novel topoisomerase II poisons with promising antiproliferative activityJ. Med. Chem.63(7)3508-3521(2020) | |||
T15362 |
FX-11
LDHA Inhibitor FX11 |
Dehydrogenase | Metabolism |
FX-11 (LDHA Inhibitor FX11) 是一种有效的、选择性的和竞争性的乳酸脱氢酶 A (LDHA) 的特异性抑制剂,对LDHA 的Ki 为 8 μM。FX-11 对PKM2 (丙酮酸激酶 M2)具有激活作用。FX-11 可降低 ATP 水平,诱导氧化应激和ROS 生成,可引起细胞死亡。FX-11 在淋巴瘤和胰腺癌异种移植过程中表现出抗肿瘤 活性。 | |||
T36905 |
Nanangenine F
|
Others | Others |
Nanangenine F is a drimane sesquiterpene fungal metabolite that has been found inA. nanangensis.1It is active againstB. subtilis(IC50= 78 μg/ml) and cytotoxic to NS-1, DU145, and MCF-7 cancer and NFF non-cancerous cells (IC50s = 49, 95, 49, and 84 μg/ml, respectively). 1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019) | |||
T40212 |
ATR-IN-4
|
Others | Others |
ATR-IN-4, a potent inhibitor of ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase), restricts the growth of DU145 prostate cancer cells and NCI-H460 lung cancer cells, with IC 50 values of 130.9 nM and 41.33 nM, respectively. | |||
T35940 |
Darinaparsin
Dimethylarsinic glutathione,Darinaparsin |
Others | Others |
Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 µM) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 µM), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 µM, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2,... | |||
T15205 |
EL-102
EL102 |
Microtubule Associated; HIF | Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling |
EL-102 是一种 HIF1α 抑制剂,具有抗癌活性,可抑制微管蛋白聚合,可用于研究前列腺癌。 | |||
T70856 |
3-Oxobetulin Acetate
|
Others | Others |
3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 µg/ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 µg/ml for both). 3-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblasto... | |||
T36968 |
ARN-21934
|
Topoisomerase | DNA Damage/DNA Repair |
ARN-21934 是高选择性的人拓扑异构酶 II α 抑制剂,具有血脑屏障通透性。依托泊苷抑制 DNA 松弛的IC50为120 μM,ARN-21934 抑制 DNA 松弛的IC50为 2 μM。ARN-21934具有良好的体内药代动力学特性。 | |||
T36195 |
CAY10744
|
Others | Others |
CAY10744 is a topoisomerase II-α poison.1 It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 μM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 μM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 μM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 μM. CAY1074... | |||
T35437 |
(-)-Viriditoxin
|
Others | Others |
(-)-Viriditoxin is a mycotoxin originally isolated from A. viridinutans that has antibacterial and antiproliferative activity. It is active against methicillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), tetracycline-sensitive and -resistant Staphylococcus, vancomycin-sensitive and -resistant Enterococcus, and penicillin-sensitive and -resistant S. pneumoniae (MICs = 2-32 μg/ml). (-)-Viriditoxin is also active against fish pathogens, including S. iniae and S. parauberis (MI... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8188 |
Podophyllotoxone
|
Others; Microtubule Associated | Cytoskeletal Signaling; Others |
Podophyllotoxone 是从八角莲根中分离得到的一种天然产物,能抑制微管蛋白聚合,具有抗癌活性。 | |||
T3S1416 |
Decursin
Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素 |
Apoptosis; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling |
Decursin (Decursinol angelate) 是一种细胞毒性剂,是一种来自朝鲜当归根的有效蛋白激酶 C 激活剂。它通过 Hippo/YAP 信号通路抑制 HepG2 细胞的生长。它通过下调 CXCR7 表达来抑制胃癌中的肿瘤生长,迁移和侵袭。 | |||
T4869 |
D-Allose
阿洛糖,β-D-Allopyranose,D-(+)-ALLOSE |
Others; Endogenous Metabolite | Metabolism; Others |
D-Allose (β-D-Allopyranose) 是内源性代谢产物的一种。 | |||
T2795 |
Amygdalin
苦杏仁苷,Laetrile |
Others | Others |
Amygdalin (Laetrile) 是一种植物葡萄糖苷,分离自蔷薇果实的果核中,如杏,桃,杏仁,樱桃和李子。 | |||
T3S0081 |
Oxypeucedanin
(+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin |
Potassium Channel | Membrane transporter/Ion channel |
Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物,分离自Angelica dahurica。它是选择性开放通道阻滞剂,可抑制hKv1.5通道电流,IC50值为 76 nM。它延长心脏动作电位持续时间,是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。 | |||
TN3920 |
Effusanin A
|
Raf; Antifection | MAPK; Microbiology/Virology |
Effusanin A 是一种存在于Isodon rugosus 之中的天然产物。 它具有 DNA 损伤和抗菌作用。 | |||
TN4263 |
Isoangustone A
|
MMP; GSK-3; NF-κB; ROS; Akt; PI3K; CDK; JNK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals. | |||
TN3049 |
4-Methoxycinnamyl alcohol
|
Others | Others |
4-Methoxycinnamyl alcohol 对MCF-7、HeLa 和DU145癌症细胞系显示出毒性,IC50值分别为14.24、7.82和22.10μg/mL。4-methoxycinnamyl alcohol 是从Foeniculum vulgare 中分离出来的。4-Methoxycinnamyl alcohol 没有显示出凋亡作用,却在10μg/mL DNA 碎片研究显示48小时后发生了坏死。 |