Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxytetranorProstaglandin F2α isopropylester (16-phenoxytetranor PGF2α isopropylester) is a lipophilic analog of 16-phenoxytetranor PGF2α. Isopropylesters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.
2-hydroxy Stearic acid is a hydroxylated fatty acid methyl ester that broadens phase transition in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugate anti-HIV agents to increase phosphodiester bond cleavage and the amount of liberated intracellular nucleotides.
Cloprostenol isopropylester is a PGF2α agonist and a similar synthetic prostaglandin F2α (PGF2α), which can induce luteal dissolution in mares during the luteal phase without causing clinical side effects or stress responses.
2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF-induced death at a dose of 300 micrograms/mouse.
2-Fluoro palmitic acid methyl ester, a monofluorinated derivative of palmitic acid methyl ester, serves as an intermediate in the synthesis of 2-iodoaldehydes, monofluorinated fatty acids, and polyfluoro ketones [Matreya, LLC. Catalog No. 1718].
PGF2α isopropylester is an ester prodrug of PGF2α with enhanced lipid solubility. Due to better membrane penetration, PGF2α isopropylester is more suitable than PGF2α or PGF2α tromethamine salt for topical application in studies on intraocular pressure. The ester functionality is readily hydrolyzed in vivo to release the active compound PGF2α. When administered topically to the eyes of cynomolgus monkeys, a 5 μg dose reduces intraocular pressure by 68% after the fourth day of treatment.