购物车
  • 全部删除
  • TargetMol
    您的购物车当前为空

TAME hydrochloride

Rating icon 很棒
产品编号 T1731Cas号 1784-03-8
别名 TOS-ARG-OME hydrochloride, Tos-Arg-OMe HCl, NA-P-甲苯磺酰-L-精氨酸甲酯盐酸盐

TAME hydrochloride (Tos-Arg-OMe HCl) 是后期促进复合体(APC/C 或 APC)的抑制剂,可与 APC/C 结合并阻止其通过 Cdc20 和 Cdh1 活化,产生有丝分裂阻滞。它是一种 od 氨基酸衍生物。

TAME hydrochloride

TAME hydrochloride

Rating icon 很棒
纯度: 99.11%
产品编号 T1731 别名 TOS-ARG-OME hydrochloride, Tos-Arg-OMe HCl, NA-P-甲苯磺酰-L-精氨酸甲酯盐酸盐Cas号 1784-03-8

TAME hydrochloride (Tos-Arg-OMe HCl) 是后期促进复合体(APC/C 或 APC)的抑制剂,可与 APC/C 结合并阻止其通过 Cdc20 和 Cdh1 活化,产生有丝分裂阻滞。它是一种 od 氨基酸衍生物。

规格价格库存数量
1 mg
¥ 128
现货
5 mg
¥ 268
现货
10 mg
¥ 372
现货
25 mg
¥ 538
现货
50 mg
¥ 793
现货
100 mg
¥ 1,360
现货
200 mg
¥ 1,980
现货
1 mL x 10 mM (in DMSO)
¥ 293
现货
大包装 & 定制
加入购物车
TargetMol 的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服务。请您遵守承诺用途,不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多

"TAME hydrochloride"的相关化合物库

选择批次:
纯度:99.11%
联系我们获取更多批次信息

产品介绍

生物活性
产品描述
TAME hydrochloride (Tos-Arg-OMe HCl) is a kind od amino acid derivatives.
激酶实验
This clonal cell line, referred to as HEK 293 4.0-7 cells, are used in a high-throughput screening format to detect agonists and allosteric activators of the Ca2+?receptor. Changes in the concentration of cytoplasmic [Ca2+]i provide a quantitative and functional assessment of Ca2+ receptor activity in these cells and the results using this assay parallel those obtained using a homologous expression system of bovine parathyroid cells. On-line continuous measurements of fluorescence in fluo-3- or fura-2-loaded HEK 293 4.0-7 cells are obtained using a custom-built spectrofluorimeter or a fluorescence imaging plate reader instrument. NPS-2143 is incubated with cells for 1 minute before increasing the concentration of extracellular Ca2+?from 1.0 mM to 1.75 mM. NPS-2143 is tested individually at a concentration of 100 μg/mL (20 μM-80 μM) and those causing more than a 40% inhibition of the control response are considered to be biologically active. To determine the potencies (IC50) of NPS-2143 with biological activity, concentration-response curves are obtained and then, as an initial assessment of selectivity, the effects of NPS-2143 on [Ca2+]i evoked by other G protein-coupled receptors are examined at a concentration several times their IC50. Wild-type HEK 293 cells (and HEK 293 4.0-7 cells) express receptors for thrombin, bradykinin, and ATP, which couple to the mobilization of intracellular Ca2+. These responses can be studied to quickly assess any nonselective action of compounds on G protein-coupled receptors. Additional assays for selectivity include HEK 293 cells engineered to express receptors most homologous in sequence and topology to the Ca2+ receptor. These include native or chimeric receptors for various metabotropic glutamate and γ-aminobutyric acid type B receptors (GABABRs).Chimeric receptors are created using partial sequences of metabotropic glutamate receptors and Ca2+?receptors, engineered to couple to activation of phospholipase C and release of intracellular Ca2+?in HEK 293 cells. NPS-2143 lacking pan-activity are then subjected to structural modifications and their potencies and selectivities monitored using these HEK 293 4.0-7 cell assays in an iterative process.
别名TOS-ARG-OME hydrochloride, Tos-Arg-OMe HCl, NA-P-甲苯磺酰-L-精氨酸甲酯盐酸盐
化学信息
分子量378.87
分子式C14H23ClN4O4S
CAS No.1784-03-8
SmilesCl.COC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccc(C)cc1
密度no data available
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 60 mg/mL (158.37 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM2.6394 mL13.1971 mL26.3943 mL131.9714 mL
5 mM0.5279 mL2.6394 mL5.2789 mL26.3943 mL
10 mM0.2639 mL1.3197 mL2.6394 mL13.1971 mL
20 mM0.1320 mL0.6599 mL1.3197 mL6.5986 mL
50 mM0.0528 mL0.2639 mL0.5279 mL2.6394 mL
100 mM0.0264 mL0.1320 mL0.2639 mL1.3197 mL

SCI 文献

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

对于不同动物的给药剂量换算,您也可以参考 更多

关键词

评论列表

4个月前
5.0
Rating icon 很棒

评论内容

Related Tags: buy TAME hydrochloride | purchase TAME hydrochloride | TAME hydrochloride cost | order TAME hydrochloride | TAME hydrochloride chemical structure | TAME hydrochloride formula | TAME hydrochloride molecular weight