Ro 41-1049 hydrochloride

Name: Ro 41-1049 hydrochloride
Brand: TargetMol
SKU: T16770
Price: -1 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T16770Cas号 127917-66-2

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).

Ro 41-1049 hydrochloride

还可以

产品编号 T16770Cas号 127917-66-2

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).

规格	价格	库存
2 mg	¥ 330	5日内发货
5 mg	¥ 547	5日内发货
10 mg	¥ 822	5日内发货
1 mL x 10 mM (in DMSO)	¥ 589	5日内发货

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产品介绍

生物活性

产品描述

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).

体内活性

Ro 41-1049 (20 mg/kg) pretreatment significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing the formation of 3,4-dihydroxyphenylacetic acid and homovanillic acid. Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion [2].

化学信息

分子量	301.77
分子式	C₁₂H₁₃ClFN₃OS
CAS No.	127917-66-2
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 32 mg/mL (106.04 mM)

H2O: 25 mg/mL (82.84 mM), Sonication is recommended.

溶液配制表

	1mg	5mg	10mg	50mg
1 mM	3.3138 mL	16.5689 mL	33.1378 mL	165.6891 mL
5 mM	0.6628 mL	3.3138 mL	6.6276 mL	33.1378 mL
10 mM	0.3314 mL	1.6569 mL	3.3138 mL	16.5689 mL
20 mM	0.1657 mL	0.8284 mL	1.6569 mL	8.2845 mL
50 mM	0.0663 mL	0.3314 mL	0.6628 mL	3.3138 mL