PF-04634817

Name: PF-04634817
Brand: TargetMol
SKU: T12419L
Price: 189 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T12419LCas号 1228111-63-4

PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 antagonist. It also has comparable human and rodent CCR2 potency (rat IC50=20.8 nM). PF-0463481 shows 10-20 fold less rodent CCR5 potency (rat IC50=470 nM).

PF-04634817

纯度: 无数据

产品编号 T12419LCas号 1228111-63-4

规格	价格	库存
25 mg	¥ 12,800	8-10周
50 mg	¥ 16,800	8-10周
100 mg	¥ 21,500	8-10周

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产品介绍

生物活性

产品描述	PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 antagonist. It also has comparable human and rodent CCR2 potency (rat IC50=20.8 nM). PF-0463481 shows 10-20 fold less rodent CCR5 potency (rat IC50=470 nM).
靶点活性	CCR5:470 nM, CCR2 (rat):20.8 nM
体内活性	PF-04634817 (p.o.; 30 mg/kg; once daily; 31 days intervention (weeks 2-15 after Streptozotocin)) intervention at the onset of diabetes (week 2) has no impact on the fasting blood glucose levels in diabetic Nos3-/- 221 mice. Early intervention with PF-04634817 induces an additional increase in glycated hemoglobin (HbA1c) levels. The development of diabetes causes a marked increase in the levels of glycated haemoglobin (HbA1c) in Nos3-/- mice [1].

化学信息

分子量	511.58
分子式	C₂₅H₃₆F₃N₅O₃
CAS No.	1228111-63-4

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 50 mg/mL (97.74 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9547 mL	9.7736 mL	19.5473 mL	97.7364 mL
5 mM	0.3909 mL	1.9547 mL	3.9095 mL	19.5473 mL
10 mM	0.1955 mL	0.9774 mL	1.9547 mL	9.7736 mL
20 mM	0.0977 mL	0.4887 mL	0.9774 mL	4.8868 mL
50 mM	0.0391 mL	0.1955 mL	0.3909 mL	1.9547 mL