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Search Results for " topology "

Targets Recommended: Others

4

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9423	Alkyne tyramide	Others	Others
	Alkyne tyramide 是抗坏血酸过氧化物酶 2 探针。它有助于鉴定 APEX 标记位点，明确线粒体蛋白的膜拓扑的分配。它显著提高了完整酵母细胞的 APEX 标记效率，比 APEX2 底物生物素苯酚具有更大的细胞壁渗透性。
T65012	Bis(4-nitrophenyl) phosphate BNPP	Others	Others
	Bis(4-nitrophenyl) phosphate （BNPP) 抑制UDP-半乳糖，可用于研究糖基转移酶膜拓扑结构。
T69374	NGD 98-2	Others	Others
	NGD 98-2 is a new generation, topology 2 selective orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.
T25864	NGD9002 NGD-9002,NGD 9002	Others	Others
	NGD9002 is a novel generation, topology 2 selective corticotropin releasing factor-1 (CRF-1) receptor antagonist agent.

化合物

Alkyne tyramide

Cat.No: T9423

Target: Others

Bis(4-nitrophenyl) phosphate

Cat.No: T65012

Synonym: BNPP

Target: Others

Cat.No: T69374

Target: Others

Cat.No: T25864

Synonym: NGD-9002,NGD 9002

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05058	TMX1 Protein, Human, Recombinant (mFc) thioredoxin-related transmembrane protein 1,PDIA11,TXNDC,TXN...	Human	HEK293 Cells
	As a thiol-based tumor suppressor, TMX1 increases mitochondrial ATP production and apoptosis progression. TMX1 is the first example of a topology-specific client protein redox catalyst acting both in the folding and in the degradative pathways.
TMPH-01299	EMC4 Protein, Human, Recombinant (His) TMEM85,EMC4,ER membrane protein complex subunit 4,Transmembr...	Human	E. coli
	Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spann...
TMPY-04964	Recombinant Protein A, HRP conjugate
	Protein A is surface protein originally found in the cell wall of the bacteria Staphylococcusaureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two component system called ArlS-ArlR. Protein A binds the Fc region of various mammalian IgG subclasses including: Human IgG1, IgG2, IgG3 (weakly), IgG4 Mouse IgG1 (weakly), IgG2a, IgG2b, IgG3 SPA also binds IgG from monkey, rabbit, pig, guinea pig, dog, rat and cat. It also weakly binds to...
TMPY-04137	ATP6V1F Protein, Human, Recombinant (GST) Vma7,ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F,...	Human	E. coli
	ATP6V1F encodes a component of vacuolar ATPase mediating acidification. The cDNA and the genomic sequences of ATP6V1F were cloned successfully for the first time from the Giant Panda (Ailuropoda melanoleuca) using reverse transcription polymerase chain reaction and touchdown-polymerase chain reaction, respectively. Topology prediction showed that there is one protein kinase C phosphorylation site, two Casein kinase II phosphorylation sites, and one N-myristoylation site in the ATP6V1F protein. U...
TMPJ-01081	Dtk Protein, Human, Recombinant (His) RSE,SKY,DTK,Tyrosine-protein kinase DTK,Tyrosine-protein kin...	Human	HEK293 Cells
	Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to th...
TMPY-02522	OTUB2 Protein, Human, Recombinant (His) OTU deubiquitinase, ubiquitin aldehyde binding 2,OTU2,OTB2,C...	Human	E. coli
	Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1 and α2, and a large helical region comprised of α3-α10. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2)'s active-site cleft is sterically occluded by a nov...
TMPY-02050	DDOST Protein, Human, Recombinant CDG1R,OST48,OKSWcl45,AGER1,OST,dolichyl-diphosphooligosaccha...	Human	E. coli
	The enzyme oligosaccharyltransferase (dolichyl-diphosphooligosaccharide-protein glycosyltransferase) (DDOST), or 48-kDa subunit (OST48) is one of the catalytic subunits in this complex, exerts a typical type I membrane topology, containing a large luminal domain, a hydrophobic transmembrane domain and a short cytosolic peptide tail. DDOST/OST48 catalyzes the transfer of a high-mannose oligosaccharide (GlcNac2Man9Glc3) from a dolichol-linked oligosaccharide donor (dolichol-P-GlcNac2Man9Glc3) onto...
TMPH-02217	SMARCA4 Protein, Human, Recombinant (His) Transcription activator BRG1,Protein brahma homolog 1,SWI/SN...	Human	P. pastoris (Yeast)
	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor compl...

重组蛋白

TMX1 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05058

Species: Human

Expression System: HEK293 Cells

EMC4 Protein, Human, Recombinant (His)

Cat.No: TMPH-01299

Species: Human

Expression System: E. coli

Recombinant Protein A, HRP conjugate

Cat.No: TMPY-04964

Expression System:

ATP6V1F Protein, Human, Recombinant (GST)

Cat.No: TMPY-04137

Species: Human

Expression System: E. coli

Dtk Protein, Human, Recombinant (His)

Cat.No: TMPJ-01081

Species: Human

Expression System: HEK293 Cells

OTUB2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02522

Species: Human

Expression System: E. coli

DDOST Protein, Human, Recombinant

Cat.No: TMPY-02050

Species: Human

Expression System: E. coli

SMARCA4 Protein, Human, Recombinant (His)

Cat.No: TMPH-02217

Species: Human

Expression System: P. pastoris (Yeast)

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