186
12
5
45
9
Cat. No. | Product Name | ||
---|---|---|---|
L2910 | 抗氧化化合物库 | 1314 compounds | |
氧化应激(Oxidative Stress,OS)是指体内氧化与抗氧化作用失衡的一种状态。氧化应激导致活性氧(ROS)大量积累,氧化程度超出抗氧化物的清除能力,从而引起氧化损伤,氧化应激损伤是许多疾病发生的基础,不同程度的氧化应激造成的细胞效应与心脑血管疾病、神经退行性病变、炎症和肿瘤密切相关。抗氧化剂是一类能够对抗氧化应激,降低氧化损伤的一类化合物。 TargetMol 抗氧化化合物库是1314 种对氧化应激具有抑制作用的小分子特有集合,是研究氧化应激的有用工具,可以用于高通量筛选和高内涵筛选。 | |||
L2151 | 化疗药物库 | 48 compounds | |
48 个肿瘤化疗药物,可以用于高通量和高内涵筛选; | |||
L9810 | 抗纤维化化合物库 | 1180 compounds | |
1180 种潜在的抗纤维化分子,是研究纤维化的有效工具,可以用于高通量筛选和高内涵筛选; | |||
L7900 | 成骨分子库 | 317 compounds | |
317 种成骨相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L5510 | 肝脏毒性化合物库 | 1001 compounds | |
1001 个肝脏毒性化合物的特有集合,可用于高通量、高内涵筛选,是毒理学研究的良好工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7527 |
Frentizole
|
Beta Amyloid | Neuroscience |
Frentizole 是一种 FDA 批准的免疫抑制剂,是一种新型 Aβ-ABAD 相互作用抑制剂。 | |||
T2180 |
Hexythiazox
|
Parasite | Microbiology/Virology |
Hexythiazox 是一种螨类生长调节剂和噻唑烷类杀螨剂,对多种螨类具有长效杀虫作用,适用于植物从萌芽到结果的任何生长阶段。 | |||
T21246 |
Metsulfuron-methyl
|
Others | Others |
Metsulfuron-methyl 是一种内吸传导选择性麦田高效磺酰脲类除草剂,主要防治麦田大多数阔叶杂草和禾本科杂草。 | |||
T19332 |
Gadopentetic acid
gadolinium complex,钆喷酸,Gd-DTPA |
Others | Others |
Gadopentetic acid (gadolinium complex) 是一种顺磁性造影剂,通常通过静脉内注射 (i.v.) 的方式用于 DCE-MRI 研究。 | |||
T8157 |
Centhaquin
PMZ-2010,Centhaquine |
Others | Others |
Centhaquin (Centhaquine)e 是一种具有研究出血性休克的潜力的试剂。在出血模型中,它能够减少全身血管阻力。 | |||
T7683 |
Adenosine amine congener
ADAC |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Adenosine amine congener (ADAC) 是一种选择性的 A1 腺苷受体激动剂,具有神经保护作用,可以改善噪音和顺铂引起的耳蜗损伤。 | |||
T21712 |
BAY 41-8543
|
Others; Guanylate cyclase | GPCR/G Protein; Others |
BAY 41-8543 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶 (sGC) 刺激剂,具有抗血小板作用。它在大鼠的肺和全身血管床中具有血管舒张活性,有用于心血管疾病的研究潜力。 | |||
T16079 |
Mirodenafil
米罗那非,SK3530 |
PDE | Metabolism |
Mirodenafil 是一种磷酸二酯酶5(PDE-5)抑制剂,可用于勃起功能紊乱的研究。 | |||
T14968 |
Cinanserin hydrochloride
SQ 10643 |
Influenza Virus; 5-HT Receptor | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Cinanserin hydrochloride (SQ 10643) 是一种高亲和力拮抗剂,对 5-HT2 受体的Ki 值为 41 nM。它也是严重急性呼吸综合征冠状病毒的 3C 样蛋白酶抑制剂。 | |||
T26745 |
BAY 73-1449
BAY-73-1449,BAY73-1449 |
Others | Others |
BAY 73-1449 是前列环素受体选择性拮抗剂,在人 HEL 细胞和大鼠 DRG 的 cAMP 分析中具有很高的效价,IC50小于 0.1 nM。BAY 73-1449在降血压方面有研究的价值。 | |||
TQ0126 |
Mirodenafil dihydrochloride
SK-3530 dihydrochloride,米罗那非二盐酸盐 |
PDE | Metabolism |
Mirodenafil dihydrochloride 是一种磷酸二酯酶5(PDE-5)抑制剂,可作用于勃起功能紊乱的研究。 | |||
T16099 |
MK8722
|
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
MK8722 是一种全身性泛 AMPK 激活剂。 | |||
T77491 |
Prezalumab
AMG 557 |
Others | Others |
Prezalumab (AMG 557) 是一种针对 ICOSL 和 BAFF 的人源 IgG2 单克隆抗体。Prezalumab 可用于研究干燥综合征皮肤红斑狼疮、银屑病、系统性红斑狼疮关节炎和系统性红斑狼疮 (SLE)。 | |||
T26923 |
Bunazosin Hydrochloride
E 1015,盐酸布那唑嗪,E643,E-1015,E-643,E 643 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Bunazosin Hydrochloride (E 1015) 是一种 α(1)-adrenoceptor 拮抗剂,用作全身性抗高血压药和降眼压药。 | |||
T20137 |
Dimethoate
Rogor,Phosphamid,Lurgo,L395,乐果,L 395,L-395 |
Others | Others |
Dimethoate (L-395) 是一种系统性和接触性杀虫剂,用于控制牛蛴螬和农场动物的某些其他害虫。 | |||
T14219 |
Aminaftone
Aminaphthone |
Endothelin Receptor | GPCR/G Protein |
Aminaftone 是 4-氨基苯甲酸的衍生物,可抑制内皮素-1 (ET-1) 的产生,可用于研究高血压和系统硬化症。 | |||
T6969 |
Imidacloprid
|
Others | Others |
Imidacloprid 是一种新烟碱类农药,广泛用于控制蔬菜,谷物,茶叶和棉花的害虫。 | |||
T7517 |
Tiadinil
3'-氯-4,4'-二甲基-1,2,3-噻二唑-5-甲酰苯胺,噻酰菌胺 |
Others; Antibacterial | Microbiology/Virology; Others |
Tiadinil 是一种系统获得性抗性的植物激活剂,可促进草食动物诱导的植物挥发物的产生。 | |||
T29328 |
21-deacetyldeflazacort
|
Others | Others |
21-deacetyldeflazacort 是 Deflazacort 的代谢物,它是一种全身性皮质类固醇和泼尼松龙的衍生物。 | |||
T8503 |
TLR4-IN-C34
|
TLR | Immunology/Inflammation |
TLR4-IN-C34 是 TLR4 的抑制剂,可减少内毒素血症和坏死性小肠结肠炎模型中的全身炎症 | |||
T8862 |
ML 254
|
GluR | Neuroscience |
是一种化学合成中的砌块 | |||
T1066L |
Ketanserin tartrate
KJK 945 tartrate,KJK-945 tartrate,KJK945 tartrate |
5-HT Receptor; Serotonin Transporter; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Ketanserin tartrate (KJK-945 tartrate) 是 5-HT2A 受体和α1-肾上腺素能受体拮抗剂,具有抗高血压活性,抑制血清素诱导的血管收缩和血小板活化,可用于研究系统性硬化症。 | |||
T19741 |
Mesosulfuron-methyl
Mesosulfuronmethyl Mesosulfuron methyl,Mesomaxx,甲磺胺磺隆 |
Others | Others |
Mesosulfuron-methyl (Mesosulfuronmethyl Mesosulfuron methyl) 是一种内吸性除草剂。用于谷类中禾本科杂草的出苗后防治。 | |||
T4165 |
Delpazolid
LCB01-0371 |
Antibacterial; Antibiotic | Microbiology/Virology |
Delpazolid (LCB01-0371) 是一种恶唑烷酮类新型抗生素,能抑制MSSA 和MRSA 的生长,对它们的MIC90值都为 2 μg/mL。 | |||
T6710 |
Troxipide
曲昔派特,曲昔匹特,Aplace |
Others | Others |
Troxipide (Aplace) 是非分泌型胃保护剂,是口服具有活力的胃炎和胃溃疡的防御因子的增强剂,具有抗溃疡、抗炎和粘液分泌作用。 | |||
T3620 |
Solcitinib
索西替尼,GLPG-0778,GSK-2586184 |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Solcitinib (GLPG-0778) 是一种可口服的,选择性的竞争性JAK1抑制剂,IC50值为 9.8 nM,可用于银屑病的研究。它对其选择性是对 JAK2、JAK3 和 TYK2 的 11、55 和 23 倍。 | |||
T34268 |
Raxofelast
IRFI016,IRFI-016,IRFI 016 |
Others | Others |
Raxofelast (IRFI-016) 具有治疗糖尿病并发症和动脉粥样硬化的潜力 | |||
T13089 |
TAS-114
TAS114,TAS 114 |
Others | Others |
TAS-114 是一种具有口服活性的 dUTPase 和 二氢嘧啶脱氢酶 (DPD) 的双重抑制剂。 TAS-114 靶向5-FU的细胞间代谢以增强抗肿瘤活性,调节分解代谢途径以改善5-FU的全身可用性。 | |||
T12987 |
Spirodiclofen
BAJ-2740,螺螨酯 |
Parasite | Microbiology/Virology |
Spirodiclofen (BAJ-2740) 是选择性非系统性的杀螨剂,来自新的化学类特酮酸衍生物, 与目前市面上的杀螨剂无交叉耐药, 具有额外的杀虫性能。 | |||
T19940 |
Sulfoxaflor
GF 2372,氟啶虫胺腈,GF 2032,XDE 208 |
AChR | Neuroscience |
Sulfoxaflor (GF 2032) 是 nAChR1 和 nAChR2 亚型的激动剂,是一种作用于昆虫中枢神经系统的内吸性杀虫剂。 Sulfoxaflor 用于防治吸食汁液的昆虫,如褐飞虱、烟粉虱、桃蚜和棉蚜。 | |||
T76957 |
Belimumab
LymphoStat B |
TNF | Apoptosis |
Belimumab(LymphoStat B) 是一种人 IgG1λ 单克隆抗体,对 B 细胞激活因子 (BAFF)有抑制作用。Belimumab 可用于研究疲劳,治疗狼疮性肾炎和系统性红斑狼疮。 | |||
T24170 |
Iodoantipyrine
碘安替比林,Jodantipyrine,EINECS 204-966-6,Arthripur,Iodophenazone |
Others | Others |
Iodoantipyrine (Arthripur) 是一种常用的指示剂,用于在正常和高CBF 条件下通过测量全身注射指示剂后的循环静脉流出量来评价大鼠。 | |||
T4236 |
AR-M 1000390 hydrochloride
ARM390 Hydrochloride,ARM-390 HCl |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
AR-M 1000390 hydrochloride (ARM-390 HCl) 是选择性 δ 阿片受体激动剂,EC50为 7.2±0.9 nM。 | |||
T21404 |
Fluticasone furoate
Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate |
Glucocorticoid Receptor | Endocrinology/Hormones |
Fluticasone furoate (Avamys) 是一种合成的三氟化皮质类固醇,衍生自氟替卡松,Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。 | |||
T77727 |
Feeblin
IRF5-IN-1 |
Others | Others |
Feeblin(IRF5-IN-1) 是一种特异性阻断自身免疫性疾病相关促炎信号通路的蛋白降解变构诱导剂,可用于研究系统性红斑狼疮类的免疫系统疾病。 | |||
T6295 |
Dabigatran
BIBR 953,BIBR 953ZW,达比加群 |
Thrombin | Proteases/Proteasome |
Dabigatran (BIBR 953ZW) 是一种口服抗凝剂,是一种可逆的,竞争性的直接凝血酶 (thrombin) 抑制剂,Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。 | |||
T21142 |
Bupirimate
Nimrod |
Antifungal | Microbiology/Virology |
Bupirimate (Nimrod) 是植物保护产品中的一种活性成分,常用作全身杀菌剂,可用于控制玫瑰和苹果种植园中的白粉病。Bupirimate 属于嘧啶类。 | |||
T15562 |
Imazamox
CL29926,甲氧咪草烟,(±)-Imazamox |
Others | Others |
Imazamox ((±)-Imazamox) 是一种具有高选择性、高活性、安全性、广谱活性的全身性除草剂,能够抑制植物中乙酰乳酸合酶(ALS) 的产生,进而抑制植物生长并最终导致植物死亡。 | |||
T7370 |
Talarozole
R115866,他拉罗唑 |
Others; P450; Retinoid Receptor; Autophagy | Autophagy; Metabolism; Others |
Talarozole (R115866) 是一种口服性全反式维甲酸代谢阻断剂,可抑制 CYP26A1 和 CYP26B1,IC50 分别为 5.4 和 0.46 nM。它用于治疗痤疮、牛皮癣和其他角化疾病。 | |||
TP1820L |
Osteogenic Growth Peptide, OGP acetate
Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base) |
Others | Others |
Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base) 是一种短的、天然存在的 14 聚体生长因子肽,存在于血清中,浓度为 μM。成骨生长肽 OGP 是局部骨髓损伤全身成骨反应机制的关键因素。 | |||
T77432 |
Anifrolumab
MDX-1333,MEDI-546 |
IFNAR | Immunology/Inflammation |
Anifrolumab(MEDI-546) 是一种有效的 I 型干扰素 (IFN) 受体拮抗剂,是一种靶向 IFN 的人源单克隆抗体。Anifrolumab 能抑制 I 型干扰素的活性,可用于预防和治疗系统性红斑狼疮 (SLE) 。 | |||
T0860L |
Mefloquine
Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998 |
Others | Others |
Mefloquine (Ro 215998) 是一种喹啉抗疟药,是一种抗 SARS-CoV-2 进入抑制剂。 Mefloquine 也是一种 K+ 通道 (KvQT1/minK) 拮抗剂,IC50 为 ~1 μM。它可用于疟疾、系统性红斑狼疮和癌症研究。 | |||
T13666 |
Dupilumab
REGN-668,SAR-231893 |
IL Receptor | Immunology/Inflammation |
Dupilumab (REGN-668) 是一种用于AD 的全身免疫调节剂。Dupilumab 是一种针对白细胞介素-4受体α亚基的完全人类单克隆抗体,可抑制IL-4和IL-13下游信号传导,具有改善特应性皮炎的作用。 | |||
T0923 |
Busulfan
Myleran,Sulphabutin,白消安,Busulphan |
Apoptosis; DNA Alkylator/Crosslinker; DNA Alkylation | Apoptosis; DNA Damage/DNA Repair |
Busulfan (Busulphan) 是二甲磺酸盐的合成衍生物,具有抗肿瘤和细胞毒特性。是一种烷化剂,对骨髓具有选择性免疫抑制作用。 | |||
T6264 |
Bosentan
Actelion,波生坦,Ro 47-0203,Benzenesulfonamide |
Endothelin Receptor | GPCR/G Protein |
Bosentan (Benzenesulfonamide) 是 endothelin-1 (ET)拮抗剂,在人的 SMC 细胞中,它能够作用于 ETA 受体(Ki:4.7 nM)和 ETB 受体(Ki:95 nM)。 | |||
T11134 |
DZ2002
|
Others | Others |
DZ2002 是一种口服有效的、可逆的、低细胞毒性的 III 型 SAHH 抑制剂 (Ki=17.9 nM),具有较好的免疫抑制活性。DZ2002 能通过逆转各种细胞类型的促纤维化表型来防止实验性皮肤纤维化的发展。DZ2002 可用于自身免疫性疾病,如狼疮综合征和系统性硬化症的研究。 | |||
T76884 |
Spesolimab
BI 655130 |
IL Receptor | Immunology/Inflammation |
Spesolimab (BI 655130) 是一种抗白细胞介素-36 受体抗体。IL-36 在免疫系统中具有重要作用,与先天性 Th1/Th17 和中性粒细胞途径相关的生物标志物的减少有关。Spesolimab 可用于研究全身性脓疱型银屑病、掌跖脓疱病 (PPP) 和特应性皮炎。。 | |||
T1146 |
Nifedipine
BAY-a-1040,Procardia XL,Procardia,硝苯地平,Adalat |
CaMK; Potassium Channel; Calcium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Nifedipine (Procardia) 是一种二氢吡啶类钙通道阻滞剂,可抑制细胞外钙离子跨膜流入心肌和血管平滑肌细胞,导致主要冠状动脉和全身动脉扩张,降低心肌收缩力。它常用于心肌功能不全的相关研究。 | |||
T41303 |
Isoflupredone
Delta-Fluorocortisone,Isoflupredona,异氟泼尼松,Isoflupredonum,9-Fluoroprednisolone |
Others | Others |
Isoflupredone (Isoflupredonum) 是一种合成的皮质类固醇,通过与动物 (如马) 的糖皮质激素和矿皮质激素受体结合抑制炎症细胞和抑制炎症介质的表达在生物体内发挥作用。Isoflupredone 具有抗炎和免疫抑制作用, 可应用于治疗各种肌肉骨骼、过敏性和全身炎症性疾病。 | |||
T0824 |
4-Nonylphenol polyethoxylate
Nonoxynol,Nonoxinol-9,壬苯醇醚 |
COX | Immunology/Inflammation; Neuroscience |
4-Nonylphenol polyethoxylate (Nonoxinol-9) 是一种表面活性剂,普遍用作避孕药中的杀精剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN4417 |
Larixyl acetate
|
Others | Others |
Larixyl acetate 是一种生物活性化学物质。 | |||
T19458 |
N-Hydroxypipecolic acid
1-Hydroxy-2-piperidinecarboxylic acid,NHP |
Others | Others |
N-Hydroxypipecolic acid (NHP) 是植物代谢产物和系统性获得性抗性调节剂,可与免疫信号水杨酸协调建立系统性获得性抗性,诱导系统获得性耐药对细菌和卵菌感染。它在植物叶片中系统地积累,以应对病原菌的侵袭。 | |||
T5559 |
Carboxin
Carbathiin,Carboxine,Vitavax,Kisvax,萎锈灵 |
Others; Antibiotic; Antifungal | Microbiology/Virology; Others |
Carboxin (Kisvax)e 是一种内吸杀菌剂和种子保护剂。 | |||
T5235 |
5-Methoxy-DL-tryptophan
|
Others; Endogenous Metabolite | Metabolism; Others |
5-Methoxy-DL-tryptophan 是内源性代谢产物的一种。 | |||
T1330 |
Acitretin
阿曲汀,Ro 10-1670,Etretin |
Apoptosis; Retinoid Receptor; Autophagy | Apoptosis; Autophagy; Metabolism |
Acitretin (Ro 10-1670) 是一种维甲酸,可用于银屑病和阿尔兹海默症的研究。 | |||
T5731 |
1-Kestose
蔗果三糖,1-蔗果三糖 |
Others; Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology; Others |
1-Kestose 是低聚果糖成分,有效刺激了 Faecalibacterium prausnitzii 和 Bifidobacteria。它有抗羟基自由基的潜力。它可促进肠道内乳酸菌数量,影响微生物以及肠道和全身免疫反应。 | |||
T6194 |
Fidaxomicin
非达米星,Tiacumicin B,OPT-80,Clostomicin B1,PAR-101 |
Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Fidaxomicin (Tiacumicin B) 是一种大环RNA 聚合酶抑制剂,具有窄谱活性。它选择性地根除致病性艰难梭菌,对构成正常健康肠道菌群的多种细菌影响很小。 | |||
T5623 |
Bisphenol A
|
Others; Endogenous Metabolite | Metabolism; Others |
Bisphenol A 是酚类内源性代谢合成物,广泛用于环氧树脂和聚碳酸酯塑料的生产。它是生殖、发育和全身毒性物质,常被归类为内分泌干扰物。它与许多疾病有关,包括呼吸系统疾病、心血管疾病、糖尿病、肾脏疾病、肥胖和生殖障碍。 | |||
T3893 |
Forsythoside B
连翘酯苷 B,连翘脂苷B |
TNF; NF-κB | Apoptosis; NF-κB |
Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha,IL-6,IκB, 调节 NF-κB。它抑制炎症反应,具有抗氧化和神经保护作用。 | |||
T1079 |
Metronidazole
Flagyl,Metronidazol,甲硝唑,Anagiardil |
Apoptosis; NADPH; Hydrogenase; Antibacterial; Antibiotic; Parasite; Antifection | Apoptosis; Metabolism; Microbiology/Virology |
Metronidazole (Metronidazol) 是一种合成的硝基咪唑衍生物,一种抗生素和抗原虫剂,具有口服活性和血脑屏障渗透性。Metronidazole 可用于治疗或预防厌氧菌引起的系统或局部感染。 | |||
T19457 |
N-Hydroxypipecolic acid potassium
NHP potassium,1-Hydroxy-2-piperidinecarboxylic acid potassium |
Others | Others |
N-Hydroxypipecolic acid potassium is a metabolite of plant and a systemic acquired resistance (SAR) regulator. | |||
TN2255 |
Taccalonolide AJ
|
Others | Others |
Taccalonolide AJ is a microtubule stabilizer; it has excellent and highly persistent antitumor efficacy when administered directly to the tumor, suggesting that the lack of antitumor efficacy seen with systemic administration of AJ is likely due to its sh |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00114 |
C-Reactive Protein /CRP Protein, Human, Recombinant (His)
C-reactive protein,MGC88244,PTX1MGC149895,CRP,pentraxin 1,PT... |
Human | HEK293 Cells |
C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate immunity, opsonization by its properties, complement activation and immunoglobulins receptor binding. CRP is a protein of the acute systemic inflammation and is, therefore, a prime marker of inflammation.The CRP is quantified by immunonephelometry or immunoturbidimetry. C-Reactiv... | |||
TMPY-03855 |
DNase I Protein, Human, Recombinant (His)
DRNI,DNL1,deoxyribonuclease I |
Human | HEK293 Cells |
DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations i... | |||
TMPY-04830 |
GAS6 Protein, Mouse, Recombinant (His)
growth arrest-specific 6,Gas-6 |
Mouse | HEK293 Cells |
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor... | |||
TMPY-00021 |
PADI4 Protein, Human, Recombinant (His)
PADI5,PAD4,PDI4,peptidyl arginine deiminase, type IV,PAD,PDI... |
Human | Baculovirus Insect Cells |
Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase family. PADI4 is expressed in CD34+stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expres... | |||
TMPJ-00623 |
BAFF/TNFSF13B Protein, Rhesus macaque, Recombinant (hFc)
Tumor necrosis factor ligand 7A,TNF superfamily member 13b,T... |
Rhesus | HEK293 Cells |
TNFSF13B is also known as B-cell activating factor (BAFF), BLyS and TNLG7A, is a member of TNF ligand superfamily. TNFSF/TNFRSF members function as key molecules in local and systemic inflammatory network, and the plasma TNFSF13B and TNFSF14 may be the potential local and systemic inflammatory indicators of severe HAdV pneumonia in pediatric patients. Identification of TNFSF13B as candidate causative genes supports conjectures on involvement of the immune system in BVVL and amyotrophic lateral s... | |||
TMPY-02581 |
STAT4 Protein, Human, Recombinant (His)
signal transducer and activator of transcription 4,SLEB11 |
Human | Baculovirus Insect Cells |
High expression of STAT4 in gastric cancer predicted a better clinical outcome. STAT4 might be a useful biomarker to identify patients at high risk of recurrence after gastrectomy. Genetic variants in the transcription factor STAT4 are associated with increased susceptibility to systemic lupus erythematosus (SLE) and a more severe disease phenotype. | |||
TMPY-05321 |
CYP3A4 Protein, Human, Recombinant (His)
P450C3,P450PCN1,CYPIIIA4,CP34,cytochrome P450 family 3 subfa... |
Human | E. coli |
CYP3A4 is an important member of the cytochrome P450 enzyme superfamily, with 33 allelic variants. Human cytochrome P450 3A4 (CYP3A4) is an important drug metabolizing enzyme involved in a number of drug-drug and food-drug interactions. Systemic inflammation has been linked to suppressed CYP3A4 activity. | |||
TMPK-00553 |
ADAM9 Protein, Cynomolgus, Recombinant (His)
Adam9,CORD9,mKIAA0021,Meltrin-γ,Meltrin-gamma,ADAM 9,Mltng,M... |
Cynomolgus | HEK293 Cells |
A disintegrin and metalloproteinase 9 (ADAM9) is a member of the transmembrane ADAM family. It is expressed in different types of solid cancer and promotes tumor invasiveness. ADAM9 may be a prognostic marker for vestibular schwannomas (VS), and ADAM9 inhibition might have the potential as a systemic approach for the treatment of VS. | |||
TMPH-01025 |
CALCA Protein, Human, Recombinant (GST)
Calcitonin gene-related peptide 1,CGRP-I,CALCA,CALC1,Alpha-t... |
Human | E. coli |
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CALCA Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 30.6 kDa and the accession number is P06881. | |||
TMPK-01303 |
TPSAB1 protein, Cynomolgus, Recombinant (His)
Tryptase alpha/beta-1,TPSB1,Tryptase I,TPS2,TPS1,Tryptase al... |
Cynomolgus | E. coli |
TPSAB1, namely tryptase alpha/beta-1, is a serine protease with trypsinlike activity. TPSAB1 is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It may play a role in innate immunity. Diseases associated with TPSAB1 include mastocytosis and systemic mastocytosis. | |||
TMPH-03539 |
Enterotoxin type B Protein, S. aureus, Recombinant (His)
Enterotoxin type B,SEB,entB |
Staphylococcus aureus | P. pastoris (Yeast) |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. | |||
TMPH-03545 |
Enterotoxin type E Protein, S. aureus, Recombinant (His & SUMO)
Enterotoxin type E,SEE,entE |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. | |||
TMPJ-01263 |
ZBTB9 Protein, Human, Recombinant (His)
ZBTB9,Zinc finger and BTB domain-containing protein 9 |
Human | E. coli |
Zinc finger and BTB domain-containing protein 9 is a protein-coding gene. ZBTB9 is a 473 amino acids protein that Contains 1 BTB (POZ) domain and 2 C2H2-type zinc fingers. Diseases associated with ZBTB9 include systemic lupus erythematosus, and lupus erythematosus. Zinc finger and BTB domain-containing protein 9 may be involved in transcriptional regulation. | |||
TMPY-00452 |
SBDS Protein, Mouse, Recombinant (His)
4733401P19Rik,AI836084,CGI-97,SDS,Shwachman-Bodian-Diamond s... |
Mouse | E. coli |
The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment. SBDS Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His ta... | |||
TMPH-03543 |
Enterotoxin type C-3 Protein, S. aureus, Recombinant (His & SUMO)
SEC3,entC3,Enterotoxin type C-3 |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type C-3 Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system wi... | |||
TMPH-03540 |
Enterotoxin type B Protein, S. aureus, Recombinant (GST)
entB,Enterotoxin type B,SEB |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type B Protein, S. aureus, Recombinant (GST) is expressed in E. coli expression system with N-GST ... | |||
TMPH-03542 |
Enterotoxin type C-2 Protein, S. aureus, Recombinant
Enterotoxin type C-2,entC2,SEC2 |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type C-2 Protein, S. aureus, Recombinant is expressed in E. coli expression system. The predicted ... | |||
TMPH-03541 |
Enterotoxin type C-2 Protein, S. aureus, Recombinant (His & SUMO)
Enterotoxin type C-2,SEC2,entC2 |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type C-2 Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system wi... | |||
TMPJ-00532 |
PADI4 Protein, Human, Recombinant (E. coli, His)
PDI5,PADI4,Protein-arginine Deiminase type IV,HL-60 PAD,PADI... |
Human | E. coli |
Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune fe... | |||
TMPY-00518 |
SBDS Protein, Human, Recombinant (His)
CGI-97,Shwachman-Bodian-Diamond syndrome,SDS,SWDS |
Human | E. coli |
The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment. SBDS Protein, Human, Recombinant (His) is expressed in E. coli expression system with His ta... | |||
TMPK-00298 |
ANGPTL2 Protein, Human, Recombinant (His & Avi)
ANGRP2,ANGPTL2,angiopoietin-like 2,HARP,MGC8889,ARP2 |
Human | HEK293 Cells |
Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers. ANGPTL2 Protein, ... | |||
TMPJ-01110 |
IRF5 Protein, Human, Recombinant (His)
Interferon Regulatory Factor 5,IRF5,IRF-5 |
Human | E. coli |
Interferon Regulatory Factor 5 (IRF5) is a member of the IRF family. It contains one IRF tryptophan pentad repeat DNA-binding domain. IRF5 shuttles between the nucleus and the cytoplasm. IRF5 can form homodimer when it is phosphorylated. IRF5 functions as a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Genetic variations in IRF5 are associated with susceptibility to systemic lupus erythematosus type 10. In addition, ... | |||
TMPK-00299 |
ANGPTL2 Protein, Human, Recombinant (His & Avi), Biotinylated
MGC8889,ANGRP2,angiopoietin-like 2,ANGPTL2,HARP,ARP2 |
Human | HEK293 Cells |
Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers. ANGPTL2 Protein, ... | |||
TMPK-00149 |
Fc epsilon RI alpha/FCER1a Protein, Human, Recombinant (His)
Fc-ε RI-α,Fc-epsilon RI-alpha,FCER1A,Fc-epsilon RI-α,FCE1A,F... |
Human | HEK293 Cells |
Known susceptibility genes to atopy and asthma have been identified by linkage or associations with clinical phenotypes, including total serum IgE levels. IgE-mediated sensitivity reactions require a high-affinity IgE receptor (FcepsilonRI), which immobilizes the immunoglobulin on the surface of the effector cells, mostly mast cells and basophils. Similarly to the previously investigated beta subunit of the receptor, FCER1A is a good candidate for a quantitative trait locus (QTL) in allergic dis... | |||
TMPH-03544 |
Enterotoxin type D Protein, S. aureus, Recombinant (His & SUMO)
entD,SED,Enterotoxin type D |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. In addition, induces B-cell proliferation and differentiation in the presence of T-cells. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type D P... | |||
TMPJ-00064 |
OX40L/TNFSF4 Protein, Human, Recombinant (His)
TNFSF4,Glycoprotein Gp34,TAX transcriptionally-activated gly... |
Human | HEK293 Cells |
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells, T cells, dendritic cells and endothelial cells. OX40L binds to OX40 (CD134), a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40-OX40L co-stimulates signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. It involved in T-cell proli... | |||
TMPJ-00149 |
Complement Factor D/CFD Protein, Mouse, Recombinant (His)
C3 convertase activator,28 kDa adipocyte protein,Cfd,Adipsin... |
Mouse | HEK293 Cells |
Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3, which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the... | |||
TMPK-01333 |
C-Reactive Protein /CRP Protein, Cynomolgus, Recombinant (His)
C-reactive protein,pentraxin 1,PTX1,PTX1MGC149895,MGC88244,C... |
Cynomolgus | HEK293 Cells |
C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate immunity, opsonization by its properties, complement activation and immunoglobulins receptor binding. CRP is a protein of the acute systemic inflammation and is, therefore, a prime marker of inflammation.The CRP is quantified by immunonephelometry or immunoturbidimetry. C-Reactiv... | |||
TMPY-00248 |
Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His)
Lymphotoxin β,lymphotoxin β (TNF superfamily, member 3),lymp... |
Cynomolgus | Baculovirus Insect Cells |
LTB (Lymphotoxin Beta) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. Heat-labile enterotoxin B subunit (LTB) of enterotoxigenic Escherichia coli (ETEC) is both a strong mucosal adjuvant and immunogen. It is a subunit vaccine candidate to be used against ETEC-induced diarrhea. It has already been expressed in seve... | |||
TMPJ-00158 |
Apolipoprotein A-I/APOA1 Protein, Human, Recombinant
Apolipoprotein A-I,APOA1,Apo-AI,ApoA-I |
Human | E. coli |
Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various biological processes, such as Cholesterol metabolism, Lipid metabolism and transport, Steroid metabolism. APOA1 promotes cholesterol efflux from tissues to the liver and thus helps to clear cholesterol from arteries. Defects in this gene resulted in HDL deficiencies, including T... | |||
TMPY-00641 |
LEC/CCL16 Protein, Human, Recombinant (His)
SCYL4,HCC-4,ILINCK,LMC,SCYA16,NCC-4,CKb12,Mtn-1,LCC-1,LEC,ch... |
Human | E. coli |
CCL16, a chemokine poorly characterized at the functional level. Human CCL16 is a member of the CC family, and its gene maps to human chromosome 17q. In the mouse, only a pseudogene has been identified to date. CCL16 is a functional ligand for CCR1, CCR2, CCR5, and CCR8. Recombinant CCL16 demonstrated chemotactic activity on human monocytes and lymphocytes. Based on the ability of human chemokines to exert activity on and bind to murine receptors, the TSA mouse adenocarcinoma cell line was trans... | |||
TMPY-03985 |
Adenosine Deaminase Protein, Human, Recombinant (His)
ADA1,adenosine deaminase,ADA |
Human | Baculovirus Insect Cells |
Adenosine Desaminase (ADA) deficiency, is a purine metabolic disorder that cause severe combined immunodeficiency (SCID) due to the accumulation of toxic metabolites that primarily affects development, differentiation and function of T and B lymphocytes. Adenosine deaminase is a polymorphic enzyme that has an important role in immune functions and in the regulation of intracellular and extracellular concentrations of adenosine and adenosine receptor activity. ADA activity might be considered as... | |||
TMPJ-00177 |
BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated
BAFF,Dendritic cell-derived TNF-like molecule,CD257,B lympho... |
Human | HEK293 Cells |
B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). BAFF can promotes the survival, proliferation and maturation of B lymphocytes, which are key elements in the pathogenesis of systemic lupus erythematosus (SLE). This cytokine is encoded on TNFSF13B gene, and diverse single-nucleotide polymor... | |||
TMPY-03419 |
SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST)
SMAD family member 3 |
Human,Mouse,Rat | Baculovirus Insect Cells |
SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is involved in cell signalling. It modulates signals of activin and TGFβ's. Binding of SMAD3 with SMAD4 enables its transmigration into the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD3 is a receptor-regulated SMAD (R-SMAD). In mice,... | |||
TMPY-02952 |
SIAE Protein, Human, Recombinant (His)
CSE-C,AIS6,CSEC,LSE,YSG2,sialic acid acetylesterase |
Human | Baculovirus Insect Cells |
Sialate O-acetylesterase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. It is widely expressed with high expression in the testis, prostate, and colon. The systematic name of this enzyme class is N-acyl-O-acetylneuraminate O-acetylhydrolase. Other names in common use include N-acetylneuraminate acetyltransferase, sialate 9(4)-O-acetylesterase, and sialidase. Sialate O-acetylesterase catalyzes the removal of O-acetyl ester groups from position 9 of the p... | |||
TMPJ-00420 |
CTLA-4 Protein, Mouse, Recombinant (Flag)
Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-ass... |
Mouse | HEK293 Cells |
Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their fu... | |||
TMPY-03963 |
CALCB Protein, Human, Recombinant (mFc)
CGRP-II,calcitonin-related polypeptide β,calcitonin-related ... |
Human | HEK293 Cells |
CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of ... | |||
TMPH-00085 |
SIZ1 Protein, Arabidopsis thaliana, Recombinant (His)
E3 SUMO-protein ligase SIZ1,SIZ1,E3 SUMO-protein transferase... |
Arabidopsis thaliana | E. coli |
E3 SUMO protein ligase involved in regulation processes. Mediates SUMO/ attachment to PHR1, a MYB transcriptional activator controlling the phosphate deficiency responses. Functions as an upstream negative regulator of salicylic acid (SA) accumulation and subsequent SA-mediated systemic acquired resistance (SAR) signaling. Probably not involved in jasmonic acid (JA)-mediated defense response. Participates in abiotic stress-induced sumoylation. Controls heat shock-induced SUMO1 and SUMO2 conjugat... | |||
TMPJ-00789 |
Flagellin Protein, Salmonella Typhimurium, Recombinant
flaF,Phase 1-I flagellin,Flagellin,fliC,hag |
Salmonella typhimurium | E. coli |
Flagellin is the major structural protein monomer of bacterial flagella. Flagellin through binding to its receptor and activation of antigen presenting cells stimulates the innate and adaptive immune responses. Flagellin is used as an effective systemic or mucosal adjuvant to stimulate the immune system. Flagellin is an agonist of Toll-like receptor 5 (TLR5), a pattern recognition receptor (PRR) of the innate immune system expressed on the basolateral surface of intestinal epithelial cells and o... | |||
TMPJ-01337 |
IL-21R Protein, Mouse, Recombinant (aa 20-236, His)
Nilr,IL-21R,Interleukin-21 receptor,IL-21 receptor,Il21r |
Mouse | HEK293 Cells |
Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. IL-21R is expressed mainly on B cells, NK cells, and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells, and keratinocytes. Both IL-21 and IL-4 are necessary for efficient B cell IgG1 production and normal germinal center architecture. B cell IL-21 R engagement i... | |||
TMPJ-01137 |
MIA Protein, Human, Recombinant (His)
MIA,Melanoma Inhibitory Activity Protein,Melanoma-Derived Gr... |
Human | E. coli |
Melanoma Inhibitory Activity Protein (MIA) is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells, which was the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family: MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an au... | |||
TMPY-01290 |
CHIT1 Protein, Human, Recombinant (His)
chitinase 1 (chitotriosidase),CHITD,CHI3,CHIT |
Human | HEK293 Cells |
Chitotriosidase, also known as Chitinase-1 and CHIT1, is a member of the glycosyl hydrolase 18 family and Chitinase class II subfamily. It is a member of the mammalian chitinase family, structurally homologous to chitinases from other species, is synthesized and secreted by specifically activated macrophages. Chitotriosidase is a polymer of N-acetylglucosamine. Serum and plasma chitotriosidase activity is usually measured as the first step in diagnosis of Gaucher disease. Monitoring chitotriosid... | |||
TMPY-00564 |
MCP-4 Protein, Human, Recombinant (His)
MCP-4,CCL13,SCYL1,NCC-1,MCP4,NCC1,CKb10,SCYA13,chemokine (C-... |
Human | P. pastoris (Yeast) |
Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable of inducing crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells. Similar to other CC chem... | |||
TMPY-01709 |
HIF-1 alpha Protein, Human, Recombinant (His)
bHLHe78,HIF-1 α,hypoxia inducible factor 1, alpha subunit (b... |
Human | E. coli |
HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has... | |||
TMPY-01027 |
Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)
carnitine palmitoyltransferase 1B (muscle),AV080368,Mcp-1 |
Mouse | HEK293 Cells |
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared w... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T19088 |
13-cis Acitretin D3
Isoacitretin D3,13-cis Acitretin D3 |
Others | Others |
13-cis Acitretin D3 (Isoacitretin D3) is a deuterium-labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin is a second-generation, systemic retinoid. | |||
TMIJ-0467 |
Dimethoate-d6 (O,O dimethyl-d6)
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Dimethoate-d6 (O,O dimethyl-d6) 是 Dimethoate 的氘代化合物。Dimethoate 的 CAS 号为 60-51-5。Dimethoate 是一种系统性和接触性杀虫剂,用于控制牛蛴螬和农场动物的某些其他害虫。 | |||
TMIJ-0003 |
Dabigatran-13C-d3
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Dabigatran-13C-d3 是 Dabigatran 的 13C 和氘代化合物。Dabigatran 的 CAS 号为 211914-51-1。Dabigatran 是一种口服抗凝剂,是一种可逆的,竞争性的直接凝血酶 (thrombin) 抑制剂,Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。 | |||
TMIJ-0002 |
Dabigatran-13C6
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Dabigatran-13C6 是 Dabigatran 的 13C 的标记化合物。Dabigatran 的 CAS 号为 211914-51-1。Dabigatran 是一种口服抗凝剂,是一种可逆的,竞争性的直接凝血酶 (thrombin) 抑制剂,Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。 | |||
TMIH-0173 |
Dabigatran-d4 HCl
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Dabigatran-d4 HCl 是 Dabigatran HCl 的氘代化合物。Dabigatran HCl 的 CAS 号为 211914-51-1。Dabigatran 是一种口服抗凝剂,是一种可逆的,竞争性的直接凝血酶 (thrombin) 抑制剂,Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。 | |||
TMID-0076 |
Busulfan-d8
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Busulfan-d8 是 Busulfan 的氘代化合物。Busulfan 的 CAS 号为 55-98-1。Busulfan 是二甲磺酸盐的合成衍生物,具有抗肿瘤和细胞毒特性。是一种烷化剂,对骨髓具有选择性免疫抑制作用。 | |||
TMIJ-0505 |
Fluticasone Furoate-d3
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Fluticasone Furoate-d3 是 Fluticasone Furoate 的氘代化合物。Fluticasone Furoate 的 CAS 号为 397864-44-7。Fluticasone furoate 是一种合成的三氟化皮质类固醇,衍生自氟替卡松,Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。 | |||
TMIJ-0052 |
Propionicacid-d5
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Propionicacid-d5 是 Propionicacid 的氘代化合物。Propionicacid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中,并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中,作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。 | |||
TMIJ-0054 |
Propionic-2,2-d2 acid
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Propionic-2,2-d2 acid 是 Propionic acid 的氘代化合物。Propionic acid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中,并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中,作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。 |