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Search Results for " retinoid "

Targets Recommended: Retinoid Receptor Others

82

抑制剂 & 化合物

6

天然产物

6

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1120L	IRBP acetate(211426-18-5 free base) Interphotoreceptor Retinoid Binding Protein Fragment IRBP	Others	Others
	IRBP acetate(211426-18-5 free base) (Interphotoreceptor Retinoid Binding Protein Fragment IRBP) 是一种含有 20 个残基的肽，是一种主要的致病表位。它存在于间质视觉色素结合蛋白肽（IRBP 161-180）的第一个同源重复序列中，可诱导葡萄膜炎后（EAU）。
TP1120	Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) IRBP,Interphotoreceptor Retinoid Binding Protein Fragment IRBP
	Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) is a 20-residue peptide, which is a major pathogenic epitope. It exists in the first homologous repeat of interstitial visual pigment Binding Protein peptide (IRBP 161-180) and can induce post-uv
T6831	Etretinate Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359,依曲替酯	Apoptosis; Others	Apoptosis; Others
	Etretinate (Ro 10-9359) 是一种口服芳香族维甲酸，对牛皮癣和其他皮肤病综合征有效。它激活类视黄醇受体，引起细胞分化的诱导、细胞增殖的抑制和炎症细胞对组织浸润的抑制。
TP1119	Interphotoreceptor retinoid-binding protein(668-687) IRBP(668-687)
	Interphotoreceptor retinoid-binding protein(668-687)is an amino acid residue of human retinoid-binding protein(IRBP) 668-687, which can induce uveitis.
T15585	IRBP(668-687) (TFA) Interphotoreceptor retinoid-binding protein(668-687) TFA	Others	Others
	Interphotoreceptor retinoid-binding protein TFA is the amino acid residue 668 to 687 of human interphotoreceptor retinoid-binding protein (IRBP). It also induces uveitis.
T83700	IRBP (651-670) (human) TFA IRBP651-670,Interphotoreceptor Retinoid-Binding Protein (651-670)
	IRBP651-670（Interphotoreceptor retinoid-binding protein (651-670)）是IRBP（亦称为retinoid-binding protein 3）的肽段，参与色素再生，通过将视黄醇和视黄醛从光感受细胞传输到视网膜色素上皮。在C57BL/6小鼠中，利用IRBP651-670诱导自身免疫性葡萄膜炎，这些小鼠携带H-2b单体型。用IRBP651-670（300 µg/动物）免疫增加了小鼠眼部IL-1β、IL-6、IL-17、TNF-α和IFN-γ水平，免疫细胞浸润及光感受器损伤。
T83681	IRBP (1-20) (human, rat) TFA IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)
	IRBP1-20（1-20）是IRBP的一个十二肽片段，亦称视黄醇结合蛋白3，负责运输视锥细胞中的视黄醇和视黄醛至视网膜色素上皮，参与色素再生。在携带H-2b等位基因型的C57BL/6小鼠中，IRBP1-20用于诱导自身免疫性葡萄膜视网膜炎。IRBP1-20（3 µM）能增加初级小鼠脾淋巴细胞分泌IL-4、IL-5和IL-6的水平。用IRBP1-20免疫并再次挑战，可增加IFN-γ缺乏小鼠的耳部肿胀、眼部血管炎症、免疫细胞浸润和视锥细胞层损伤，以及视网膜脱落。
T82059	Interphotoreceptor retinoid-binding protein(668-687) TFA IRBP(668-687) TFA
	Interphotoreceptor retinoid-binding protein(668-687) TFA 为光受体视黄醇结合蛋白的668至687氨基酸片段，具有诱发葡萄膜炎的能力。
T1093	Adapalene CD271,阿达帕林	Apoptosis; Retinoid Receptor; Autophagy	Apoptosis; Autophagy; Metabolism
	Adapalene (CD271) 是一种合成类视黄醇，局部应用于痤疮。它以非竞争性方式抑制 GOT1的酶活性，具有抗肿瘤活性。它是一种 RAR 激动剂，对 RARβ、RARγ、RARα的AC50值分别为 2.3 nM、9.3 nM 和 22 nM。
TP1118	IRBP(668-687) (TFA) (1977546-93-2 free base) IRBP(668-687) (TFA),Interphotoreceptor retinoid-binding protein(668-687) TFA
	Interphotoreceptor retinoid-binding protein(668-687) TFA is the 668-687 amino acid residue of human Interphotoreceptor retinoid binding protein(IRBP), which can induce uveitis.
T8529	WYC-210	Others	Others
	WYC-210 是一种视黄醇类化合物，是 Tazarotene 的衍生物，具有较低的抗癌活性。
T17209	UVI 3003	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	UVI 3003 是一种高度选择性的类视黄醇 X 受体拮抗剂。在 Cos7 细胞中，它抑制非洲爪蟾蜍和人RXRα的活性，IC50值分别为 0.22 和 0.24 μM。
T21714	BMS453 BMS 453,BMS-189453	Retinoid Receptor	Metabolism
	BMS453 (BMS-189453) 是一种合成类维生素 A，是一种 RARβ激动剂，也是一种 RARα/RARγ拮抗剂。它主要通过诱导活性 TGFβ 来抑制乳腺细胞生长。
T6410	Bexarotene Ro 26-4455,Targretin,蓓萨罗丁,贝沙罗汀,LGD1069	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	Bexarotene (LGD1069) 是一种高亲和力的选择性类视黄醇 X 受体 (RXR) 激动剂，对 RXRα、RXRβ和 RXRγ的 EC50分别为 33、24和25 nM。它是一种类视黄醇类似物，用于治疗皮肤 T 细胞淋巴瘤的皮肤表现。
T5341	WYC-209 WYC209	Apoptosis; Retinoid Receptor; Autophagy	Apoptosis; Autophagy; Metabolism
	WYC-209 是一种合成类视黄醇，是维甲酸受体激动剂。它主要通过 caspase 3途径抑制恶性鼠黑色素瘤肿瘤再生细胞的增殖，IC50值为 0.19 μM。
T23384	SR 11302	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SR 11302 是一种类视黄醇，是一种激活蛋白-1 转录因子抑制剂，能够特异性抑制 AP-1 活性，而不会激活视黄酸反应元件 (RARE) 的转录。
T22843	HX 531	Retinoid Receptor	Metabolism
	HX 531 是的RXR 拮抗剂 (IC50:18 nM) 。它能减少高脂饮食小鼠的骨骼肌、白色脂肪组织和肝脏中的甘油三酯含量。
TQ0097	AGN 193109	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	AGN 193109 是一种类视黄醇类似物，是一种有效的特异性 RAR 拮抗剂，可抑制 RARα、RARβ和 RARγ的活性，Kd 值分别为 2 nM、2 nM 和 3 nM。
T15811	LY2955303	Others; Retinoid Receptor	Metabolism; Others
	LY2955303 是一种有效的特异性视黄酸受体 γ 拮抗剂（RARγ，Ki = 1.09 nM）。
T3955	AR7	Retinoid Receptor	Metabolism
	AR7 是一种非典型的 RARA/RARα(视黄酸受体 α) 拮抗剂，能够特异性激活伴侣介导的自噬活性，对自噬无影响。
TQ0064	Peretinoin NIK333	HCV Protease; Retinoid Receptor; S1P Receptor; Autophagy	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Peretinoin (NIK333) 是口服非环状类视黄醇，靶向类视黄醇核受体，结构类维生素 A 。
T7586	trifarotene CD5789,曲法罗汀	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	Trifarotene (CD5789) 是一种有效的选择性 RARγ 激动剂，对 RARγ 的选择性是 RARα 和 RARβ 的 65 倍和 16 倍，EC50分别为7.7、500和125 nM。
T7370	Talarozole R115866,他拉罗唑	Others; P450; Retinoid Receptor; Autophagy	Autophagy; Metabolism; Others
	Talarozole (R115866) 是一种口服性全反式维甲酸代谢阻断剂，可抑制 CYP26A1 和 CYP26B1，IC50 分别为 5.4 和 0.46 nM。它用于治疗痤疮、牛皮癣和其他角化疾病。
T6694	Tamibarotene NSC 608000,Am 80,Amnolake,他米巴罗汀	Apoptosis; Retinoid Receptor; Autophagy	Apoptosis; Autophagy; Metabolism
	Tamibarotene (Amnolake) 是一种具有口服活性的合成维甲酸，旨在克服全反式维甲酸耐药性，具有潜在的抗肿瘤活性。它也是视黄酸受体α/β 的激动剂，比RARγ的选择性高。
T4538	palovarotene Ro 3300074,R 667,帕罗伐汀	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	Palovarotene (Ro 3300074) 是核视网膜酸受体γ 的激动剂。
T21314	Amsilarotene TAC-101,TAC 101,TAC101	CDK	Cell Cycle/Checkpoint
	Amsilarotene (TAC101) 是口服有活性的合成类视黄醇，对视黄酸受体 α (RAR-α) 具有选择性亲和力，对 RAR-α 和 RAR-β 的 Ki=为 2.4 nM 和 400 nM。它可造成人胃癌、卵巢癌细胞及肝细胞癌的凋亡，可用于研究癌症。
T23383	SR11237 SR 11237	Others; RAR/RXR	Metabolism; Others
	SR11237 是一种泛视黄醇 X 受体 (RXR) 激动剂。 SR11237 导致 RXR/RXR 同源二聚体形成并反式激活包含 RXR 反应元件的报告基因。
T6696	Tazarotene 他扎罗汀,Tazorac,AGN 190168,Zorac	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	Tazarotene (Zorac) 是一种选择性视黄酸受体激动剂，用于研究寻常痤疮和斑块状银屑病。
T11844	LG-100064 4-[(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)羰基]苯甲酸	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	LG-100064 是一种类视黄醇 X 受体激动剂，对 RXRα、RXRβ 和 RXRγ 的 EC50值分别为 330、200 和 260 nM，可用于癌症研究。
T5843	Tarenflurbil MPC7869,(R)-Flurbiprofen,R-flurbiprofen,氟比洛芬,R-氟比洛芬	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	Tarenflurbil ((R)-Flurbiprofen) 是 Flurbiprofen 的 R 型对映体，可抑制 [3H]9-cis-RA 结合到 RXRαLBD，IC50为 75 μM。它可研究阿尔兹海默症。
T11847L	Liarozole R75251 dihydrochloride,利阿唑	P450; Retinoid Receptor	Metabolism
	Liarozole (R75251 dihydrochloride) 是一种咪唑衍生物，是一种具有口服活性的维甲酸 (RA) 代谢阻断剂(RAMBA)，具有抗肿瘤作用。它能够抑制维甲酸依赖的细胞色素P450(CYP26) 4- 羟基化 (IC50=7 μM)，导致组织维甲酸水平增加。
T1872	Fenretinide 4-HPR,MK-4016,芬维A胺,4-hydroxy(phenyl)retinamide	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	Fenretinide (4-HPR) 是一种可口服的合成类维生素 A 衍生物，具有潜在的抗肿瘤和化学预防活性。
T7894	Tazarotenic acid 6-[2-(3,4-二氢-4,4-二甲基-2H-1-苯并噻喃-6-基)乙炔基]-3-吡啶甲酸,AGN-190299	Others	Others
	Tazarotenic acid (AGN-190299) 是 Tazarotene 的代谢物。它与视黄酸受体 (RAR) 的结合位点是类视黄醇作用的可能的分子靶点。它对疣状角化不良具有潜在的研究价值。
T5854	AM580 NSC608001,CD336,Ro 40-6055	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	AM580 (CD336) 是一种视黄酸受体激动剂，对 RARα 具有选择性，IC50和EC50分别为 8 和 0.36 nM。
T4371	CD437 AHPN,O-Desmethyl Adapalene,6-[3-(1-金刚烷基)-4-羟基苯基]-2-萘甲酸,Apoptosis Activator VI	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	CD437 (AHPN) 是一种特异性视黄酸受体激动剂。
T0499	Oxybenzone 二苯酮-3,KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,紫外线吸收剂UV-9,Escalol 567	Apoptosis; Retinoid Receptor; Autophagy	Apoptosis; Autophagy; Metabolism
	Oxybenzone 是晒黑和皮肤保护剂中常用的紫外线过滤剂。它是二苯甲酮的衍生物，用作破坏内分泌的化学物质，可穿透胎盘和血脑屏障。它损害自噬，改变表观遗传状态并破坏凋亡神经元细胞中的类维生素 X 受体信号传导。
T1288	TTNPB AGN191183,Arotinoid acid,Ro 13-7410,AGN-191183,Ro 13-7410	Apoptosis; Retinoid Receptor; Autophagy	Apoptosis; Autophagy; Metabolism
	TTNPB (Ro 13-7410,AGN-191183) 是一种RAR 激动剂。在使用人RARs 进行竞争性结合实验中，作用于RARα，RARβ和RARγ，IC50分别为 5.1 nM，4.5 nM 和 9.3 nM。
T78404	Pyridinium bisretinoid A2E TFA A2E TFA	Apoptosis	Apoptosis
	Pyridinium bisretinoid A2E TFA作为一种荧光团，能从视网膜色素上皮(RPE)的脂褐素中分离得到，是蓝光诱导的细胞凋亡(apoptosis)诱导剂。该化合物具有光活化特性，可介导自噬(autophagy)和活性氧(reactive oxygen species)的产生，常用于视网膜退行性疾病的研究。
T74051	Pyridinium bisretinoid A2E	Others	Others
	Pyridinium bisretinoid A2E (A2E) 是蓝光诱导条件下的细胞凋亡 (apoptosis) 的引发剂。Pyridinium bisretinoid A2E 的的光活化介导自噬 (autophagy) 和活性氧 (reactive oxygen species) 的产生。
T14912	CD3254	Retinoid Receptor	Metabolism
	CD3254 是一种具有选择性和强效性的类视黄醇 X 受体 (RXR) 激动剂，可抑制伴有OGD/再氧合的神经元细胞死亡。
T7388	GSK805	ROR	Metabolism
	GSK805 是能够生物利用的、具有 CNS 穿透性的 RORγt 抑制剂。
T15196	EC23 BASF-46928,AGN 190205	Others	Others
	EC23 (AGN 190205) 是一种稳定的合成类视黄醇类似物，能够促使神经元分化。
T9635	Cedirogant ABBV-157	ROR	Metabolism
	Cedirogant (ABBV-157) 是一种口服有活性的 RORγt 反向激动剂，可用于研究银屑病。
TP1313L	Cecropin B acetate Cecropin B acetate(80451-05-4 Free base)	P450; Retinoid Receptor; Parasite	Metabolism; Microbiology/Virology
	Cecropin B acetate 通过破坏 PXR/类视黄醇 X 受体 α (RXR-α) 复合物与 DNA 序列的结合来诱导 NF-κB 活化并抑制 CYP3A29。 Cecropin B acetate 具有很强的抗菌活性。
T11303	Fluorobexarotene	Retinoid Receptor	Metabolism
	Fluorobexarotene 是一种有效的类视黄醇 X 受体 (RXR) 激动剂。Fluorobexarotene 对 RXRα 受体的 Ki 值为 12 nM，EC50 值为 43 nM。Fluorobexarotene 具有明显的 RXR 结合亲和力，比 Bexarotene 高75%。
T77499	MSU-42011	NOS; Retinoid Receptor; NO Synthase; PERK; Lipid	Apoptosis; Immunology/Inflammation; Metabolism
	MSU-42011 是一种具有口服活性的类视黄醇 X 受体 (RXR) 激动剂。MSU-42011 有效抑制iNOS，低SREBP 诱导和激活RXR 以及 p-ERK 蛋白水平的表达。MSU-42011在kras 驱动的肺癌小鼠模型中表现出抗肿瘤活性。MSU-42011可有效治疗临床前Krasdriven 肺癌且具有免疫调节活性。
T77600	Methyl-4-oxoretinoate	Apoptosis	Apoptosis
	Methyl-4-oxoretinoate 是一种合成的类视黄醇化合物，具有抗癌化合物，可可以诱导癌细胞分化和凋亡。Methyl-4-oxoretinoate 可用于治疗痤疮、牛皮癣和其他皮肤病。Methyl-4-oxoretinoate 具有治疗各种眼部疾病（如年龄相关性黄斑变性）的潜力。
T34299	Retinaloxime trans-Retinaloxime	Others	Others
	Retinaloxime is a retinoid.
T33908	Pelretin	Others	Others
	Pelretin is a synthetic retinoid.
T23665	AGN 191701 AGN-191701,AGN191701	Others	Others
	AGN 191701 is an agonist of the Retinoid X receptor.

化合物

IRBP acetate(211426-18-5 free base)

Cat.No: TP1120L

Synonym: Interphotoreceptor Retinoid Binding Protein Fragment IRBP

Target: Others

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)

Cat.No: TP1120

Synonym: IRBP,Interphotoreceptor Retinoid Binding Protein Fragment IRBP

Cat.No: T6831

Synonym: Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359,依曲替酯

Target: Apoptosis, Others

Interphotoreceptor retinoid-binding protein(668-687)

Cat.No: TP1119

Synonym: IRBP(668-687)

IRBP(668-687) (TFA)

Cat.No: T15585

Synonym: Interphotoreceptor retinoid-binding protein(668-687) TFA

Target: Others

IRBP (651-670) (human) TFA

Cat.No: T83700

Synonym: IRBP651-670,Interphotoreceptor Retinoid-Binding Protein (651-670)

IRBP (1-20) (human, rat) TFA

Cat.No: T83681

Synonym: IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)

Interphotoreceptor retinoid-binding protein(668-687) TFA

Cat.No: T82059

Synonym: IRBP(668-687) TFA

Cat.No: T1093

Synonym: CD271,阿达帕林

Target: Apoptosis, Retinoid Receptor, Autophagy

IRBP(668-687) (TFA) (1977546-93-2 free base)

Cat.No: TP1118

Synonym: IRBP(668-687) (TFA),Interphotoreceptor retinoid-binding protein(668-687) TFA

Cat.No: T8529

Target: Others

Cat.No: T17209

Target: Retinoid Receptor, Autophagy

Cat.No: T21714

Synonym: BMS 453,BMS-189453

Target: Retinoid Receptor

Cat.No: T6410

Synonym: Ro 26-4455,Targretin,蓓萨罗丁,贝沙罗汀,LGD1069

Target: Retinoid Receptor, Autophagy

Cat.No: T5341

Synonym: WYC209

Target: Apoptosis, Retinoid Receptor, Autophagy

Cat.No: T23384

Target: DNA/RNA Synthesis

Cat.No: T22843

Target: Retinoid Receptor

Cat.No: TQ0097

Target: Retinoid Receptor, Autophagy

Cat.No: T15811

Target: Others, Retinoid Receptor

Cat.No: T3955

Target: Retinoid Receptor

Cat.No: TQ0064

Synonym: NIK333

Target: HCV Protease, Retinoid Receptor, S1P Receptor, Autophagy

Cat.No: T7586

Synonym: CD5789,曲法罗汀

Target: Retinoid Receptor, Autophagy

Cat.No: T7370

Synonym: R115866,他拉罗唑

Target: Others, P450, Retinoid Receptor, Autophagy

Cat.No: T6694

Synonym: NSC 608000,Am 80,Amnolake,他米巴罗汀

Target: Apoptosis, Retinoid Receptor, Autophagy

Cat.No: T4538

Synonym: Ro 3300074,R 667,帕罗伐汀

Target: Retinoid Receptor, Autophagy

Cat.No: T21314

Synonym: TAC-101,TAC 101,TAC101

Target: CDK

Cat.No: T23383

Synonym: SR 11237

Target: Others, RAR/RXR

Cat.No: T6696

Synonym: 他扎罗汀,Tazorac,AGN 190168,Zorac

Target: Retinoid Receptor, Autophagy

Cat.No: T11844

Synonym: 4-[(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)羰基]苯甲酸

Target: Retinoid Receptor, Autophagy

Cat.No: T5843

Synonym: MPC7869,(R)-Flurbiprofen,R-flurbiprofen,氟比洛芬,R-氟比洛芬

Target: Retinoid Receptor, Autophagy

Cat.No: T11847L

Synonym: R75251 dihydrochloride,利阿唑

Target: P450, Retinoid Receptor

Cat.No: T1872

Synonym: 4-HPR,MK-4016,芬维A胺,4-hydroxy(phenyl)retinamide

Target: Retinoid Receptor, Autophagy

Tazarotenic acid

Cat.No: T7894

Synonym: 6-[2-(3,4-二氢-4,4-二甲基-2H-1-苯并噻喃-6-基)乙炔基]-3-吡啶甲酸,AGN-190299

Target: Others

Cat.No: T5854

Synonym: NSC608001,CD336,Ro 40-6055

Target: Retinoid Receptor, Autophagy

Cat.No: T4371

Synonym: AHPN,O-Desmethyl Adapalene,6-[3-(1-金刚烷基)-4-羟基苯基]-2-萘甲酸,Apoptosis Activator VI

Target: Retinoid Receptor, Autophagy

Cat.No: T0499

Synonym: 二苯酮-3,KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,紫外线吸收剂UV-9,Escalol 567

Target: Apoptosis, Retinoid Receptor, Autophagy

Cat.No: T1288

Synonym: AGN191183,Arotinoid acid,Ro 13-7410,AGN-191183,Ro 13-7410

Target: Apoptosis, Retinoid Receptor, Autophagy

Pyridinium bisretinoid A2E TFA

Cat.No: T78404

Synonym: A2E TFA

Target: Apoptosis

Pyridinium bisretinoid A2E

Cat.No: T74051

Target: Others

Cat.No: T14912

Target: Retinoid Receptor

Cat.No: T7388

Target: ROR

Cat.No: T15196

Synonym: BASF-46928,AGN 190205

Target: Others

Cat.No: T9635

Synonym: ABBV-157

Target: ROR

Cecropin B acetate

Cat.No: TP1313L

Synonym: Cecropin B acetate(80451-05-4 Free base)

Target: P450, Retinoid Receptor, Parasite

Fluorobexarotene

Cat.No: T11303

Target: Retinoid Receptor

Cat.No: T77499

Target: NOS, Retinoid Receptor, NO Synthase, PERK, Lipid

Methyl-4-oxoretinoate

Cat.No: T77600

Target: Apoptosis

Cat.No: T34299

Synonym: trans-Retinaloxime

Target: Others

Cat.No: T33908

Target: Others

Cat.No: T23665

Synonym: AGN-191701,AGN191701

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN6735	Bigelovin	Apoptosis; Reactive Oxygen Species; Retinoid Receptor; Autophagy; RAR/RXR	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Bigelovin 是从海百合中分离得到的一种倍半萜内酯，是选择性视黄素 X 受体 α 激动剂。它通过抑制ROS 的生成来调节 mTOR 信号通路。它诱导凋亡和自噬，有抗肿瘤活性。
T1330	Acitretin 阿曲汀,Ro 10-1670,Etretin	Apoptosis; Retinoid Receptor; Autophagy	Apoptosis; Autophagy; Metabolism
	Acitretin (Ro 10-1670) 是一种维甲酸，可用于银屑病和阿尔兹海默症的研究。
T1611	Isotretinoin 13-cis-Retinoic acid,异维A酸	Retinoid Receptor; Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Isotretinoin (13-cis-Retinoic acid) 是一种天然存在的维甲酸，具有潜在的抗肿瘤活性。它结合并激活核视黄酸受体 (RAR)，活化的 RARs 作为促进细胞分化和凋亡的转录因子。它是一种类维生素A 和维生素A 衍生物，用于治疗严重的痤疮和某些形式的皮肤、头颈癌。
T1051	Retinoic acid 维生素A酸,Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin	Retinoid Receptor; Endogenous Metabolite; PPAR; Autophagy	Autophagy; DNA Damage/DNA Repair; Metabolism
	Retinoic acid (Tretinoin) 是维生素 A 的代谢产物，是一种视黄酸受体 RAR 的天然激动剂，激动 RARα/β/γ (IC50=14 nM)。Retinoic acid 可以诱导细胞分化、减少细胞增殖和抑制肿瘤发生。
T3000	Magnolol NSC 293099,厚朴酚,5,5'-Diallyl-2,2'-biphenyldiol	NF-κB; Retinoid Receptor; Antibacterial; PPAR; p53; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB
	Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) 是RXRα和PPARγ的激动剂，EC50值分别为 10.4 µM 和 17.7 µM。他是从厚朴的树皮中分离得到的一种木脂素。
T19169	9-cis-Retinal	Others	Others
	9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to CRBP-I and CRBP-II (Kds: 8 nM and 5 nM). It expedites differentiation and maturation of rod photoreceptors in r

天然产物

Cat.No: TN6735

Target: Apoptosis, Reactive Oxygen Species, Retinoid Receptor, Autophagy, RAR/RXR

Cat.No: T1330

Synonym: 阿曲汀,Ro 10-1670,Etretin

Target: Apoptosis, Retinoid Receptor, Autophagy

Cat.No: T1611

Synonym: 13-cis-Retinoic acid,异维A酸

Target: Retinoid Receptor, Endogenous Metabolite, Autophagy

Cat.No: T1051

Synonym: 维生素A酸,Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin

Target: Retinoid Receptor, Endogenous Metabolite, PPAR, Autophagy

Cat.No: T3000

Synonym: NSC 293099,厚朴酚,5,5'-Diallyl-2,2'-biphenyldiol

Target: NF-κB, Retinoid Receptor, Antibacterial, PPAR, p53, Autophagy

Cat.No: T19169

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00829	RBP3 Protein, Human, Recombinant (His) Retinol-binding protein 3,Interstitial retinol-binding prote...	Human	E. coli
	RBP3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 38 and 75-80 KDa and the accession number is P10745.
TMPH-02033	RPE65 Protein, Human, Recombinant (His & Myc) Retinol isomerase,Retinoid isomerohydrolase,All-tra...	Human	Baculovirus Insect Cells
	RPE65 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus.
TMPH-01792	RORC Protein, Human, Recombinant (His & SUMO) Nuclear receptor subfamily 1 group F member 3,RAR-related or...	Human	E. coli
	RORC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 74.2 kDa and the accession number is P51449.
TMPH-01791	RORA Protein, Human, Recombinant (His) Retinoid-related orphan receptor-alpha,Nuclear rece...	Human	E. coli
	RORA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 57.6 kDa and the accession number is P35398.
TMPH-02032	GPRC5A Protein, Human, Recombinant (GST) G-protein coupled receptor family C group 5 member A,GPRC5A,...	Human	E. coli
	Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor. GPRC5A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 37.0 kDa and the accession number i...
TMPH-00916	ADH1B Protein, Human, Recombinant (His & SUMO) ADH2,Alcohol dehydrogenase subunit beta,All-trans-retinol de...	Human	E. coli
	Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. ADH1B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli...

重组蛋白

RBP3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00829

Species: Human

Expression System: E. coli

RPE65 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02033

Species: Human

Expression System: Baculovirus Insect Cells

RORC Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01792

Species: Human

Expression System: E. coli

RORA Protein, Human, Recombinant (His)

Cat.No: TMPH-01791

Species: Human

Expression System: E. coli

GPRC5A Protein, Human, Recombinant (GST)

Cat.No: TMPH-02032

Species: Human

Expression System: E. coli

ADH1B Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-00916

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T19088	13-cis Acitretin D3 Isoacitretin D3,13-cis Acitretin D3	Others	Others
	13-cis Acitretin D3 (Isoacitretin D3) is a deuterium-labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin is a second-generation, systemic retinoid.
T11240	Ethacrynic acid D5	Others	Others
	Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by...

同位素标记化合物

13-cis Acitretin D3

Cat.No: T19088

Synonym: Isoacitretin D3,13-cis Acitretin D3

Target: Others

Ethacrynic acid D5

Cat.No: T11240

Target: Others

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