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Palovarotene (Ro 3300074) 是核视网膜酸受体γ 的激动剂。
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Palovarotene (Ro 3300074) 是核视网膜酸受体γ 的激动剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 279 | 现货 | |
5 mg | ¥ 659 | 现货 | |
10 mg | ¥ 987 | 现货 | |
25 mg | ¥ 1,970 | 现货 | |
50 mg | ¥ 2,930 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 778 | 现货 |
产品描述 | Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ). |
体内活性 | Palovarotene inhibits post-traumatic chondrogenesis and osteogenesis and mitigated trauma-induced ectopic bone formation. Palovarotene inhibits subcutaneous and intramuscular heterotopic ossification (HO) in mice. Palovarotene (1 mg/kg/day ) is given orally for 14 days starting on a postoperative day (POD) 1 or POD-5, and HO amount wound dehiscence and related processes are monitored for up to 84 days post-injury. Compared to vehicle-control animals, Palovarotene significantly decreases HO by 50 to 60% regardless of when the treatment started and if the infection is present[1]. Starting from day 1 of injury, half of the Acvr1cR206H/+ mice are treated with Palovarotene by daily gavage for 14 days and the other half received a vehicle as control. Analysis by mCT and 3D image reconstruction at day 14 shows that large HO tissue masses have formed in the targeted leg of Acvr1cR206H/+ mutant mice receiving the vehicle, but HO formation is greatly diminished in Palovarotene-treated companions by more than 80% based on bone volume/total volume quantification[2]. |
别名 | 帕罗伐汀, Ro 3300074, R 667 |
分子量 | 414.54 |
分子式 | C27H30N2O2 |
CAS No. | 410528-02-8 |
Smiles | CC1(C)CCC(C)(C)c2cc(\C=C\c3ccc(cc3)C(O)=O)c(Cn3cccn3)cc12 |
密度 | 1.11 g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 5.5 mg/mL (13.27 mM) | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
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