32
2
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19
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Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0004 |
Phosphatase Inhibitor Cocktail III (2 Tubes, 100x)
磷酸酶抑制剂 Cocktail III (2 Tubes, 100x) |
2 Tube Solution (100×) | Each Tube has different specificity of inhibition |
C0002 |
Phosphatase Inhibitor Cocktail I (100× ddH2O)
磷酸酶抑制剂 Cocktail I (100× ddH2O) |
Solution (100× in ddH2O) | Acid Phosphatase, Alkaline phosphatase, PTPs, ATPases |
C0003 |
Phosphatase Inhibitor Cocktail II (100× DMSO)
磷酸酶抑制剂 Cocktail II (100× DMSO) |
Solution (100× in DMSO) | Alkaline <em>phosphatases</em>, Ser/Thr <em>phosphatases</em>, Acid and PP1 and PP2A |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T18888 |
4-Methylumbelliferyl phosphate
4-甲基伞形酮磷酸酯,4-MUP |
Others | Others |
4-Methylumbelliferyl phosphate (4-MUP) 是碱性磷酸酶的荧光底物。 | |||
T21980 |
PD 198306
|
MEK | MAPK |
PD 198306 是一种具有抗痛觉过敏作用的 MAPK/ERK 激酶 (MEK) 选择性抑制剂。 PD 198306 可降低链脲佐菌素诱导的活性 ERK1 水平升高。 | |||
T2160 |
Suramin Sodium Salt
苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060 |
Apoptosis; Phosphatase; SARS-CoV; Sirtuin; Reverse Transcriptase; Topoisomerase; Parasite | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Suramin Sodium Salt (BAY-205) 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K,是抗寄生虫,抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂,也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。 | |||
T31458 |
DiFMUP
6,8-Difluoro-4-methylumbelliferyl phosphate |
||
DiFMUP (6,8-Difluoro-4-methylumbelliferyl phosphate) 是一种荧光底物,抑制蛋白酪氨酸磷酸酶(PTPs),可用于检测苏氨酸磷酸酶的活性。 | |||
T9325 |
2-(2-Aminothiazole-4-yl)-2-methoxyiminoa
|
Others | Others |
2-(2-Aminothiazole-4-yl)-2-methoxyiminoa 是一种蛋白质酪氨酸磷酸酶的抑制剂,蛋白质酪氨酸磷酸酶可以导致细胞信号通路的变化,从而影响细胞的行为。 | |||
T16554 |
PNPP
|
Others | Others |
PNPP 是用于 ELISA 和常规分光光度测定的碱性和酸性磷酸酶的非蛋白质显色底物。 | |||
T16350 |
NSC-87877
|
Apoptosis; Phosphatase | Apoptosis; Metabolism |
NSC-87877 是一种Shp2和Shp1蛋白质酪氨酸磷酸酶抑制剂,IC50值分别为0.318 μM 和0.355 μM。它还抑制双特异性磷酸酶26。 | |||
T3045 |
Salubrinal
|
Apoptosis; Phosphatase; PERK; Autophagy; HSV | Apoptosis; Autophagy; Metabolism; Microbiology/Virology |
Salubrinal 是一种磷酸酶抑制剂 ,对真核翻译起始因子 2 亚基 (eIF2α) 发挥作用。它作为双特异性磷酸酶 2 抑制剂,抑制抗胶原蛋白抗体诱导的关节炎。它具有抗HSV-1病毒的活性,并抑制由HSV-1蛋白 ICP34.5 介导的eIF2α的去磷酸化。 | |||
T34973 |
Tyrphostin 8
4-Hydroxybenzylidenemalononitrile |
EGFR; GTPase | Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) 是一种有效的 GTP 酶抑制剂,对 EGFR 激酶有抑制作用, IC50 值为 560 μM。Tyrphostin 8 可抑制蛋白丝氨酸/苏氨酸钙调磷酸酶 (IC50=21 μM),增强 Caco-2 细胞中转铁蛋白受体介导的转吞作用,并增加口服胰岛素 - 转铁蛋白的降血糖作用。 | |||
T23132 |
Pentamidine dihydrochloride
喷他脒二盐酸盐,MP-601205 dihydrochloride |
Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal | Metabolism; Microbiology/Virology |
Pentamidine dihydrochloride (MP-601205 dihydrochloride) 是一种抗微生物剂,会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病,抗锑利什曼病和卡氏肺孢子虫肺炎的研究,有抗肿瘤活性,抗菌活性。 | |||
T7084 |
2-Bromo-4'-hydroxyacetophenone
SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮 |
Phosphatase | Metabolism |
2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) 是一种PTP1B 的有效抑制剂,其Ki=42 μM。 | |||
T22276 |
Bis(maltolato)oxovanadium(IV)
双(麦芽醇)氧钒(IV),BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV) |
Phosphatase; Others | Metabolism; Others |
Bis(maltolato)oxovanadium(IV) (BMOV) 是一种有效的胰岛素增敏剂,也是一种有效的、竞争性的、可逆的、口服具有活性的光谱蛋白酪氨酸磷酸酶 (PTP) 抑制剂。它抑制HCPTPA,PTP1B,HPTPβ和SHP2的IC50分别为 126 nM,109 nM,26 nM 和 201 nM。 | |||
T70523 |
RK-682
|
Others | Others |
RK-682 is a natural selective inhibitor of protein tyrosine phosphatases (PTPases). | |||
T13095 |
Tautomycin
|
Others | Others |
Tautomycin is a potent and specific protein phosphatases 1 and 2A inhibitor (Kiapp of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively), and is an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus. | |||
T20421 |
Fluorescein diphosphate
Fluorescein diphosphate Tetraammonium salt,FDP |
Others | Others |
Fluorescein diphosphate is a colorless and nonfluorescent substrate for alkaline phosphatases. The sequential alkaline phosphatase mediated hydrolysis of its two phosphate substituents yielding weakly fluorescent fluorescein monophosphate followed by stro | |||
T35877 |
MurA-IN-1
|
Others | Others |
MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC50 values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively[1]. (A family of human MAPK-specific protein tyrosine phosphatases) [1]. Jeyanthy Eswaran, et al. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. Biochem J. 2006 May 1;395(3):483-91. | |||
T40846 |
3,5-Difluoro-L-tyrosine
|
Others | Others |
3,5-Difluoro-L-tyrosine is a functional and tyrosinase-resistant mimic of tyrosine, commonly utilized for evaluating the substrate specificity of protein tyrosine phosphatases (PTPs). | |||
TP1698 |
Microcystin-LA
|
||
Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC50s of 0.3 and 0.3 nM, respectively. | |||
T41370 |
(Rac)-RK-682
|
Others | Others |
(Rac)-RK-682 是 RK-682 的外消旋体。(Rac)-RK-682 是一种蛋白质酪氨酸磷酸酶 (PTPases) 抑制剂。(Rac)-RK-682 抑制蛋白酪氨酸磷酸酶 1B (PTP-1B)、低分子量蛋白酪氨酸磷酸酶 (LMW-PTP)、细胞分裂周期 25B (CDC-25B),IC50分别为 8.6 μM、12.4 μM 和 0.7 μM。 | |||
T68458 |
Fostriecin (free base)
|
Others | Others |
Fostriecin (free base) is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antib... | |||
T75366 |
Naphthol AS-GR phosphate disodium
|
Others | Others |
Naphthol AS-GR phosphate disodium 为酸性及碱性磷酸酶底物,此化合物展现出强烈绿色荧光,广泛应用于组织化学研究中。 | |||
T71845 |
Lockdown
|
Others | Others |
Lockdown is a reversible and non-competitive PPM1F inhibitor. Lockdown is selective for PPM1F, because this compound does not inhibit other protein phosphatases in vitro and does not induce additional phenotypes in PPM1F knockout cells. Lockdown acts in a dose-dependent, allosteric manner with high selectivity for PPM1F | |||
T40968 |
MLS-0437605
|
Others | Others |
MLS-0437605 is a potent and selective inhibitor of dual-specificity phosphatase 3 (DUSP3), with an IC50 of 3.7 μM. It exhibits higher selectivity towards DUSP3 in comparison to DUSP22 and other protein tyrosine phosphatases (PTPs). | |||
T40216 |
PTPN22-IN-1
PTPN22-IN-1 |
Others | Others |
PTPN22-IN-1 is a potent PTPN22 inhibitor ( IC 50 =1.4 μM; K i =0.50 μM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses. From WO2021007491A1 compound L-1. | |||
T75340 |
4-Methylumbelliferyl phosphate disodium
|
||
4-Methylumbelliferyl phosphate disodium (4-MUP) 是一种阴离子有机磷酸酯,作为酸性和碱性磷酸酶(phosphatase)的荧光底物,同时也用作神经毒剂模拟剂。 | |||
T36367 |
RK-682 (calcium salt)
|
Others | Others |
Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. RK-682, a bioactive compound originally isolated from the fermentation of Streptomyces sp. 88-682, is an inhibitor of the... | |||
T11314 |
Fosmanogepix
APX001,E1211 |
Others | Others |
Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections. | |||
T39183 |
Okadaic acid ammonium salt
|
Others | Others |
Okadaic acid ammonium salt, a marine toxin, serves as an inhibitor of protein phosphatases (PP), displaying a higher affinity for PP2A (IC 50 =0.1-0.3 nM) alongside inhibitory effects on PP1 (IC 50 =15-50 nM), PP3 (IC 50 =3.7-4 nM), PP4 (IC 50 =0.1 nM), and PP5 (IC 50 =3.5 nM), but does not affect PP2C. By inhibiting PPs, this compound promotes protein phosphorylation and acts as a tumor promoter. Additionally, it is involved in inducing tau phosphorylation. | |||
T81548 |
PAP-IN-1
|
Others | Others |
PAP-IN-1(化合物28)为紫色酸性磷酸酶(PAP)的抑制剂,后者是一种普遍存在的双核金属水解酶。该抑制剂对哺乳动物PAP显示出较强的抑制活性,具有Ki值为168 nM;对猪PAP的抑制活性亦显著,具有Kic值为0.17 μM。此类PAP抑制剂主要用于抗骨质疏松药物研究。 | |||
T76486 |
Ac-MBP (4-14) Peptide
|
||
Ac-MBP (4-14) Peptide 是一种乙酰化的 MBP (4-14) Peptide。MBP (4-14) Peptide 是一种选择性的 (蛋白激酶 C)PKC 底物。Ac-MBP (4-14) Peptide 可用于提取物中的PKC 检测,无需事先纯化便可消除干扰蛋白激酶或磷酸酶。 | |||
T75303 |
Suramin
|
Others | Others |
Suramin为一种可逆的,竞争性PTPases抑制剂,有效抑制sirtuins:SirT1(IC50=297 nM),SirT2(IC50=1.15 μM),SirT5(IC50=22 μM)。同时,Suramin作为DNAtopoisomeraseII(IC50=5 μM)的竞争性逆转录酶抑制剂,以及SARS-CoV-2 RdRp有效抑制剂。此外,Suramin还能有效抑制IP5K,具有抗寄生虫、抗肿瘤及抗血管生成的作用。 | |||
T63405 |
NAZ2329
|
Others | Others |
NAZ2329 是受体型蛋白质酪氨酸磷酸酶 (RPTPs) R5 亚家族的一个细胞可渗透抑制剂,与其他 PTPs 相比,其变构且能够优先抑制 PTPRZ (hPTPRZ1 的IC50= 7.5 μM) 和PTPRG (hPTPRGIC50= 4.8 μM)。NAZ2329 能够与PTPRZ 的 D1结构域结合,与PTPRZ 整个 (D1 + D2) 片段相比,其能够更有效地抑制 PTPRZ1-D1片段 (IC50: 1.1 μM)。NAZ2329 能够抑制胶质母细胞瘤细胞的肿瘤生长,并表现出抑制干细胞样特性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38587 |
Chrysophanol triglucoside
|
Others | Others |
Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia , inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC 50 s of 80.17 and 197.06 μM, respectively. Chrysophanol triglucoside has the potential for diabetes research. | |||
T16381 |
Okadaic acid
|
Others | Others |
Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A, and PP3 inhibitor (IC50s: 10-15 nM, 0.5 nM, and 4 nM, respectively). Okadaic acid is extracted from black sponges of the genus Halic |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00387 |
IL-4R alpha Protein, Mouse, Recombinant (hFc)
Soluble IL-4R-alpha,Interleukin-4 receptor subunit alpha,Sol... |
Mouse | HEK293 Cells |
Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic ... | |||
TMPK-00742 |
PRL-3/PTP4A3 Protein, Human, Recombinant (His)
PRL-R,PRLR,PRL3,PTP4A3,PRL-3 |
Human | E. coli |
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PTP4A3 (PRL-3) plays an important role in the tumorigenesis and metastasis of multiple tumors. | |||
TMPK-01132 |
PRL-1/PTP4A1 Protein, Human, Recombinant (His)
PTPCAAX1,PRL1,PRL-1,PTP(CAAXI),PTP4A1 |
Human | E. coli |
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PRL-1 (PTP4A1) is a key molecule that activates tyrosine phosphorylation, which is important for cancer progression and metastasis. | |||
TMPH-03161 |
Alkaline Phosphatase Protein, Prevotella intermedia, Recombinant (GST & His & Myc)
PiALP,ALPase |
Prevotella intermedia | E. coli |
Acts against tyrosine-phosphatases. Alkaline Phosphatase Protein, Prevotella intermedia, Recombinant (GST & His & Myc) is expressed in E. coli expression system with N-10xHis-GST and C-Myc tag. The predicted molecular weight is 32.1 kDa and the accession number is P81800. | |||
TMPY-02002 |
PHPT1 Protein, Human, Recombinant (His)
phosphohistidine phosphatase 1,CGI-202,HSPC141,HEL-S-132P,PH... |
Human | E. coli |
PHPT1, also known as 14 kDa phosphohistidine phosphatase, phosphohistidine phosphatase 1, protein janus-A homolog, PHP14, is a cytoplasm protein which belongs to the janus family. PHPT1 / PHP14 is expressed abundantly in heart and skeletal muscle. Phosphatases are a diverse group of enzymes that regulate numerous cellular processes. Much of what is known relates to the tyrosine, threonine, and serine phosphatases, whereas the histidine phosphatases have not been studied as much. Protein histidin... | |||
TMPY-02595 |
DUSP14 Protein, Human, Recombinant (His & MBP)
MKP6,MKP-L,dual specificity phosphatase 14 |
Human | E. coli |
Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosphotyrosine and phosphoserine / phosphothreonine residues in substrates. Unlike many other DUSPs, DUSP14 only contains a catalytic domain within the C-terminal region. In signal transduction, DUSP14 has been considered as negative regulator of the mitogen-activated protein kinase (... | |||
TMPJ-00996 |
VHR Protein, Human, Recombinant (His)
DUSP3,VHR,Dual specificity protein phosphatase VHR,Vaccinia ... |
Human | E. coli |
Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs are major modulators of critical signalling pathways that are dysregulated in various diseases. They negatively ... | |||
TMPH-02757 |
LILRB3 Protein, Mouse, Recombinant (aa 25-642, His)
Paired immunoglobulin-like receptor B,Lilrb3,Cell-surface gl... |
Mouse | HEK293 Cells |
May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). LILRB3 Protein, Mouse, Recombinant (aa 25-642, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 70.8 kDa and the accession number is P97484. | |||
TMPJ-01117 |
INPP5A Protein, Human, Recombinant (His)
INPP5A,Type I inositol 1,5-trisphosphate 5-phosphatase,Type ... |
Human | HEK293 Cells |
Type I inositol 1,4,5-trisphosphate 5-phosphatase is a 412 amino acids protein that belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene. It is expressed in brain and high level in Purkinje cells. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. | |||
TMPJ-01326 |
HDHD2 Protein, Human, Recombinant (His)
HDHD2,Haloacid Dehalogenase-Like Hydrolase Domain-Containing... |
Human | E. coli |
Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 22 (HDHD2) is a member of the HAD-like hydrolase superfamily. HDHD2 includes L-2-Haloacid Dehalogenase, Epoxide Hydrolases and Phosphatases. There are two active sites in HDHD2 - an L-2-Haloacid Dehalogenase and a Carboxylate group. The L-2-Haloacid Dehalogenase active site catalyzes the hydrolytic dehalogenation of D- and L-2-Haloalkanoic Acids, producing L- and D-2-Hydroxyalkanoic Acids. | |||
TMPY-02386 |
PTP4A2 Protein, Human, Recombinant (GST)
HNMT-S2,PRL-2,HNMT-S1,protein tyrosine phosphatase type IVA,... |
Human | E. coli |
PRL-2 (Protein-tyrosine phosphatase of regenerating liver 2), also known as PTP4A2 (Protein tyrosine phosphatase type IVA, member 2), is a member of PTP family and has an important function in controlling cell growth. PRL-2 phosphatases may be multifunctional enzymes with diverse roles in a variety of tissue and cell types. The phosphatase of regenerating liver (PRL) family, comprising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer biomarkers and therapeu... | |||
TMPK-00177 |
LAIR1 Protein, Human, Recombinant (His & Avi)
CD305,LAIR1,LAIR-1,HLAIR1 |
Human | HEK293 Cells |
LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium ... | |||
TMPJ-00307 |
BLK Protein, Human, Recombinant (His)
Tyrosine-Protein Kinase Blk,BLK,B Lymphocyte Kinase,p55-Blk |
Human | E. coli |
Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B t... | |||
TMPJ-01081 |
Dtk Protein, Human, Recombinant (His)
RSE,SKY,DTK,Tyrosine-protein kinase DTK,Tyrosine-protein kin... |
Human | HEK293 Cells |
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to th... | |||
TMPY-02388 |
SIRP beta 1 Protein, Mouse, Recombinant (His)
SIRP-beta,SIRP-β,99327N5Rik,Sirpb,Sirpb1,Sirpb1a,SIRP-β/Sirp... |
Mouse | HEK293 Cells |
SIRPB1A (Signal-regulatory protein beta 1A), also known as SIRP beta 1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing 11- to 113-amino acid long, or... | |||
TMPJ-00029 |
CALM1 Protein, Human, Recombinant
Calmodulin,CAMIII,CAMC,CALM,CALML2,CALM2,CAM2,CALM3,CAM1,CAM... |
Human | E. coli |
Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+ is required for the activation of Calmodulin. Once bound to Ca2+, Calmodulin acts as part of a calcium signal transduction pathway by modifying its interactions with various target proteins such as kinases or phosphatases. Calmodulin is a small, highly conserved protein that is 148 amino acid... | |||
TMPY-01840 |
TLT-1/TREML1 Protein, Human, Recombinant (His)
PRO3438,TLT-1,triggering receptor expressed on myeloid cells... |
Human | HEK293 Cells |
Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1 / TLT-1 contains the characteristic single V-set immunoglobulin (Ig) do... | |||
TMPH-01689 |
PLD6 Protein, Human, Recombinant (His)
Mitochondrial phospholipase,Choline phosphatase 6,Protein zu... |
Human | E. coli |
Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger sig... | |||
TMPH-01692 |
MAPK3 Protein, Human, Recombinant (His)
MAP kinase isoform p44,p44-ERK1,MAPK3,Extracellular signal-r... |
Human | E. coli |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T68918 |
Phenytoin-d10
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Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal... |