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Search Results for " metastases "

Targets Recommended: Others

25

抑制剂 & 化合物

3

天然产物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6451	Clodronic acid disodium salt Loron,Clodronate Disodium,氯屈膦酸二钠,Lodronate	Others	Others
	Clodronic acid disodium salt (Lodronate) 是一种口服具有活力的破骨细胞骨吸收 (osteoclastic bone resorption) 的抑制剂，是一代双磷酸盐。它可用于高骨转换状态、Paget’s 病和溶骨性骨转移中。
T90596	Sivifene	Others	Others
	Sivifene 是一种抗肿瘤化合物。Sivifene 可用于治疗癌症皮肤转移的研究。
T6482	Efaproxiral Sodium 乙丙昔罗钠,RSR13 sodium	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Efaproxiral Sodium (RSR13 sodium) 是血红蛋白 (Hb) 合成变构调节剂，能够减少血红蛋白氧 (O2) 的结合亲和力。
T9869	N-[2-(diethylamino)ethyl]-2-iodobenzamide	Others	Others
	N-[2-(diethylamino)ethyl]-2-iodobenzamide 是一种放射性药物。用于黑色素瘤和转移的闪烁扫描检测。
T12205	Ned 19	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Ned 19 is a selective membrane-permeant non competitive antagonist of NAADP and strongly inhibits tumor growth and vascularization as well as lung metastases in mice.
T10397	ATN-161 trifluoroacetate salt ATN-161 TFA salt	Integrin	Cytoskeletal Signaling
	ATN-161 trifluoroacetate salt (ATN-161 TFA salt) 是一种新型整合素 α5β1 拮抗剂，可在小鼠模型中抑制血管生成和肝转移瘤的生长。
TP1526L1	Fibronectin CS1 Peptide acetate	Others	Others
	Fibronectin CS1 Peptide acetate 存在于 III 型同源连接段 (IIICS) 以及 C-274（细胞结合结构域）中。 Fibronectin CS1 Peptide 缺乏含有 Arg-Gly-Asp 的结构域，在自发和实验性转移模型中积极抑制肿瘤转移。
T22324	Ensartinib hydrochloride Ensartinib dihydrochloride,X-396 dihydrochloride	Others; Trk receptor; c-Met/HGFR; ALK	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	Ensartinib hydrochloride (X-396 dihydrochloride) 是双重的 ALK/MET 抑制剂，IC50分别 <0.4 nM 和 0.74 nM。
T6739	Zoledronic Acid CGP-4244,CGP42446A,唑来膦酸,Zoledronate,CGP 42446,ZOL 446,Zometa	Apoptosis; Rho; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint
	Zoledronic Acid (ZOL 446) 是一种含氮二磷酸盐，能抑制破骨细胞的分化和凋亡，具有高效的抗骨质再吸收活性，也有抗癌作用。
T39333	DOTA Zoledronate	Others	Others
	DOTA Zoledronate represents a novel, advanced compound utilized specifically in bone-targeted radionuclide therapy to diagnose bone metastases.
T38181	C17 Lactosylceramide (d18:1/17:0)	Others	Others
	C17 Lactosylceramide is a naturally occurring sphingolipid that has been found in human brain metastases of lung adenocarcinomas but not in healthy brain tissue.
T10398	ATN-161	Others	Others
	ATN-161 is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases in a murine model.
T74607	KRAS G12D inhibitor 15	Others	Others
	KRAS G12D inhibitor 15 是一种有效的 KRAS G12D 抑制剂。KRAS G12D inhibitor 15 具有研究各种疾病或病症的潜力，例如癌症或癌症转移。
T2610	BMS-599626 AC480	EGFR; MEK; HER; Src	Angiogenesis; JAK/STAT signaling; MAPK; Tyrosine Kinase/Adaptors
	BMS-599626 (AC480) 是可口服的选择性 HER1和HER2抑制剂，IC50分别为 20 和 30 nM。它对 HER4 的 IC50值为 190 nM，可抑制肿瘤细胞增殖，有治疗肿瘤的潜力。
T81522	Pendetide GYK-DTPA
	Pendetide为一种能与铟(111In)结合的螯合剂，当与Capromab（卡普罗单抗）偶联后，形成Capromab pendetide，此显像剂已获得FDA批准，用于探测前列腺软组织的转移情况。
TP2245	Endostatin (84-114)-NH2 (JKC367)	Others	Others
	Endostatin is a potent inhibitor of primary tumor growth and endothelial cell proliferation and migration. Recombinant endostatin potently inhibited angiogenesis, maintains metastases at a low level, and suppressed tumors, a reduction of over 150-fold. En
T69714	Etanidazole	Others	Others
	Etanidazole (SR-2508) is a 2-nitroimidazole drug with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This agent may also be useful as an imaging agent for identifying hypoxic, drug-resistant regions of primary tumors or metastases. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
T79050	JBI-589	Others	Others
	JBI-589为一种非共价、选择性PAD4抑制剂，可降低CXCR2表达，阻断中性粒细胞趋化性；此外，JBI-589能减小原发肿瘤体积及其转移，并增强检查点抑制剂的抗肿瘤效果。
TP1526	Fibronectin CS1 Peptide
	he connecting segment 1 (CS-1) is a cell attachment domain located in the type III homology connecting segment (IIICS) of fibronectin. CS1 peptide of fibronectin, which lacks the Arg-Gly-Asp-containing domain, actively inhibits tumor metastases in spontan
T71467	Nemorubicin HCL	Others	Others
	Nemorubicin HCL is the salt form of Nemorubicin, also known as PNU152243A, a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. It works primarily through topoisomerase I inhibition. Of note, Nemorubicin is active in cells with upregulation of the nucleotide excision repair (NER) pathway...
T35563	PF-5274857 hydrochloride	Others	Others
	PF-5274857 hydrochloride 是有效的、具有口服活性的、选择性的、可透过血脑屏障的 Smo 拮抗剂，其 IC50=5.8 nM，Ki=4.6 nM。它有用于包括激活的 Hh 途径驱动的脑肿瘤和脑转移在内的多种肿瘤的研究潜力。
T69793	VEL-0230	Others	Others
	VEL-0230, also known as NC-2300, is a potent cathespin K inhibitor. VEL-0230 has dual-acting properties that both stimulates bone formation and inhibits loss. VEL-0230 is being studied preclinically for the treatment of diseases involving bone mineral disorders such as bone loss related to multiple myeloma, osteoporosis, bone metastases, and rheumatoid arthritis. Velcura Therapeutics is currently being developed by Velcura Therapeutics. Given VEL- 0230's promotion of bone formation, inhibition o...
T80155	DOTA-LM3
	DOTA-LM3是一款靶向生长抑素受体(SSTR)的拮抗剂，其结构为p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2。该化合物通常通过同位素标记，如177Lu-DOTA-LM3和68Ga-DOTA-LM3，进行体内肿瘤示踪。68Ga-DOTA-LM3显示出有优异的生物分布特性、高度的肿瘤摄取能力、稳定的肿瘤内保留及较低的安全风险。而177Lu-DOTA-LM3则被用于研究DOTATOC阴性的肝转移案例，针对胰腺NET和广泛性的肿瘤血栓形成治疗具有潜在应用价值。
T78110	DOTA-LM3 TFA	Others	Others
	DOTA-LM3 TFA是一種特定結合生長抑素受體(SSTR)的拮抗劑。其結構為p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2。這種複合物常以177Lu-DOTA-LM3 TFA和68Ga-DOTA-LM3 TFA的形式被同位素標記，用於腫瘤的體內示踪。68Ga-DOTA-LM3 TFA展示了優異的生物分布特性、高腫瘤吸收率、良好的腫瘤保留性以及較低的安全風險。而177Lu-DOTA-LM3 TFA則被用於研究DOTATOC陰性的肝轉移，例如胰腺神經內分泌腫瘤(NET)和廣泛的腫瘤血栓形成。
T83775	STING Agonist 12L Stimulator of Interferon Genes Agonist 12L
	STING激动剂12L是一种刺激干扰素基因(STING)的激动剂。它与野生型STING结合(IC50 = 1.15 µM)，以及STING的R232、AQ和Q变体(IC50分别为1.06、0.61和1.12 µM)，并在THP-1和RAW 264.7细胞中诱导报告基因表达(EC50分别为0.38和12.94 µM)。STING激动剂12L (5 µM)在THP-1细胞中诱导IFNB1、CXCL10和IL6 mRNA的表达。在体内，STING激动剂12L (10 mg/kg)提高了血浆IFN-β水平，并且在B16/F10小鼠黑色素瘤模型中减少了肿瘤体积和肺转移灶的数量。

化合物

Clodronic acid disodium salt

Cat.No: T6451

Synonym: Loron,Clodronate Disodium,氯屈膦酸二钠,Lodronate

Target: Others

Cat.No: T90596

Target: Others

Efaproxiral Sodium

Cat.No: T6482

Synonym: 乙丙昔罗钠,RSR13 sodium

Target: Reactive Oxygen Species

N-[2-(diethylamino)ethyl]-2-iodobenzamide

Cat.No: T9869

Target: Others

Cat.No: T12205

Target: Calcium Channel

ATN-161 trifluoroacetate salt

Cat.No: T10397

Synonym: ATN-161 TFA salt

Target: Integrin

Fibronectin CS1 Peptide acetate

Cat.No: TP1526L1

Target: Others

Ensartinib hydrochloride

Cat.No: T22324

Synonym: Ensartinib dihydrochloride,X-396 dihydrochloride

Target: Others, Trk receptor, c-Met/HGFR, ALK

Zoledronic Acid

Cat.No: T6739

Synonym: CGP-4244,CGP42446A,唑来膦酸,Zoledronate,CGP 42446,ZOL 446,Zometa

Target: Apoptosis, Rho, Autophagy

DOTA Zoledronate

Cat.No: T39333

Target: Others

C17 Lactosylceramide (d18:1/17:0)

Cat.No: T38181

Target: Others

Cat.No: T10398

Target: Others

KRAS G12D inhibitor 15

Cat.No: T74607

Target: Others

Cat.No: T2610

Synonym: AC480

Target: EGFR, MEK, HER, Src

Cat.No: T81522

Synonym: GYK-DTPA

Endostatin (84-114)-NH2 (JKC367)

Cat.No: TP2245

Target: Others

Cat.No: T69714

Target: Others

Cat.No: T79050

Target: Others

Fibronectin CS1 Peptide

Cat.No: TP1526

Nemorubicin HCL

Cat.No: T71467

Target: Others

PF-5274857 hydrochloride

Cat.No: T35563

Target: Others

Cat.No: T69793

Target: Others

Cat.No: T80155

Cat.No: T78110

Target: Others

STING Agonist 12L

Cat.No: T83775

Synonym: Stimulator of Interferon Genes Agonist 12L

Cat. No.	Product Name	Target	Signaling Pathways
T75643	Isoxanthohumol	HSV	Microbiology/Virology
	Isoxanthohumol 是一种从啤酒花和啤酒中提取的一种前黄酮类化合物，对几种人类癌细胞株具有抗增殖活性。Isoxanthohumol对肿瘤细胞肺转移灶的转移或侵袭有抑制作用。Isoxanthohumol具有抗病毒活性，对疱疹病毒（HSV1和HSV2）和牛病毒性腹泻病毒（BVDV）具有抑制作用。
T68233	Kadsurenone	Others	Others
	Kadsurenone is a platelet-activating factor receptor antagonist from Chinese herbal plant, haifenteng. It is a useful and promising treatment strategy for breast cancer bone metastases by blocking the PAF/PTAFR signaling pathway.
T35624	Ajoene	Others	Others
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Cat.No: T75643

Target: HSV

Cat.No: T68233

Target: Others

Cat.No: T35624

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00377	DPPIV/CD26 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) DPP4,DPPIV,ADCP2,CD26,ADABP,TP103,EC 3.4.14.5	Cynomolgus,Rhesus	HEK293 Cells
	CD26/dipeptidyl peptidase (DPP)IV is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is longstanding evidence that various primary tumors and also metastases express DPPIV/CD26 to a variable extent.
TMPK-01299	CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His) Carcinoembryonic,CEA,CEACD66e,DKFZp781M2392,CEACAM-5,CD66e,M...	Cynomolgus	HEK293 Cells
	Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated.
TMPJ-00799	ANXA2 Protein, Human, Recombinant ANXA2,Calpactin I Heavy Chain,ANX2,p36,LPC2D,PAP-IV,ANX2L4,C...	Human	E. coli
	Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. ANXA2 protein is associated with sickle cell osteonecrosis and the expression reduce of ANXA2 is associated with osteosarcoma metastases. ANXA2 functions as an autocrine factor, it can increases osteoclast formation and bone resorption. ANXA2 is involved in muscular dystrophies. In humans, the up-regulation of ANXA2 is related with colon adenocarcinoma cell...
TMPY-04765	PKLR Protein, Human, Recombinant (His) PKRL,PKR,RPK,PKL,PK1,pyruvate kinase, liver and RBC	Human	E. coli
	Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variabl...
TMPY-02404	ADAM9 Protein, Mouse, Recombinant (His) mKIAA0021,AU020942,ADAM metallopeptidase domain 9,Mltng,MDC9	Mouse	HEK293 Cells
	ADAM9 (A disintegrin and metallopeptidase domain 9, MDC9, meltrin gamma), is a type 1 transmembrane protein that has been associated with cancer development and metastases. ADAM9 is consistently overexpressed in various human cancers, and plays a role in tumorigenesis in mouse models. ADAM9 cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as EGF, FGFR2iiib, Tie-2, Flk-1, EphB4, CD40, VCAM-1, and VE-cadherin, and could represent a potential t...
TMPJ-00884	CXCL9 Protein, Mouse, Recombinant (His) Protein m119,C-X-C motif chemokine 9,γ-interferon-induced mo...	Mouse	HEK293 Cells
	Chemokine (C-X-C motif) ligand 9 (CXCL9, MIG), is a small cytokine belonging to the CXC chemokine family. CXCL9 functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. It together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour e...
TMPY-00886	MMP-1 Protein, Human, Recombinant (His) CLGN,CLG,matrix metallopeptidase 1	Human	HEK293 Cells
	MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and some bioactive molecules. MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP...
TMPY-01709	HIF-1 alpha Protein, Human, Recombinant (His) bHLHe78,HIF-1 α,hypoxia inducible factor 1, alpha subunit (b...	Human	E. coli
	HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has...

重组蛋白

DPPIV/CD26 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00377

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His)

Cat.No: TMPK-01299

Species: Cynomolgus

Expression System: HEK293 Cells

ANXA2 Protein, Human, Recombinant

Cat.No: TMPJ-00799

Species: Human

Expression System: E. coli

PKLR Protein, Human, Recombinant (His)

Cat.No: TMPY-04765

Species: Human

Expression System: E. coli

ADAM9 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02404

Species: Mouse

Expression System: HEK293 Cells

CXCL9 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00884

Species: Mouse

Expression System: HEK293 Cells

MMP-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00886

Species: Human

Expression System: HEK293 Cells

HIF-1 alpha Protein, Human, Recombinant (His)

Cat.No: TMPY-01709

Species: Human

Expression System: E. coli

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