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Targets Recommended: Retinoid Receptor Autophagy

2

抑制剂 & 化合物

2

天然产物

1

化合物库

6

重组蛋白

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Cat. No.	Product Name
L2520	糖代谢化合物库		702 compounds
	702 种糖代谢相关的化合物，可用于高通量和高内涵筛选；

化合物库

糖代谢化合物库

Cat.No: L2520

Compounds: 702

Cat. No.	Product Name	Target	Signaling Pathways
T6410	Bexarotene Ro 26-4455,Targretin,蓓萨罗丁,贝沙罗汀,LGD1069	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	Bexarotene (LGD1069) 是一种高亲和力的选择性类视黄醇 X 受体 (RXR) 激动剂，对 RXRα、RXRβ和 RXRγ的 EC50分别为 33、24和25 nM。它是一种类视黄醇类似物，用于治疗皮肤 T 细胞淋巴瘤的皮肤表现。
T39273	Lumasiran ALN-G01	Others	Others
	Lumasiran (ALN-G01), a siRNA product, inhibits hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes this enzyme and thereby prevents the synthesis of oxalate, the toxic metabolite directly linked to the clinical manifestations of Primary hyperoxaluria type 1 (PH1).

化合物

Cat.No: T6410

Synonym: Ro 26-4455,Targretin,蓓萨罗丁,贝沙罗汀,LGD1069

Target: Retinoid Receptor, Autophagy

Cat.No: T39273

Synonym: ALN-G01

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3158	Harmane Loturine,Harman,Aribine,哈尔满碱	Adrenergic Receptor; Monoamine Oxidase; Imidazoline Receptor	GPCR/G Protein; Neuroscience
	Harmane (Loturine) 是一种在咖啡和烟草烟雾中发现的 β-咔啉生物碱，是有效的神经毒素，可引起严重的动作震颤和精神病学表现。它还是选择性的单胺氧化酶抑制剂，具有致突变作用，对 MAO A/B 的 IC50值分别为 0.5 和 5 μM。
T0414	D-Mannitol Mannite,Mannitol,D-甘露糖醇,Osmitrol	Apoptosis; Dehydrogenase; Endogenous Metabolite	Apoptosis; Metabolism
	D-Mannitol (Mannitol) 是与山梨醇相关的利尿剂和肾脏诊断辅助剂，具有较弱的肾脏血管扩张活性。

天然产物

Cat.No: T3158

Synonym: Loturine,Harman,Aribine,哈尔满碱

Target: Adrenergic Receptor, Monoamine Oxidase, Imidazoline Receptor

Cat.No: T0414

Synonym: Mannite,Mannitol,D-甘露糖醇,Osmitrol

Target: Apoptosis, Dehydrogenase, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00828	Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His) MPS2,IDS,SIDS,iduronate 2-sulfatase	Human	HEK293 Cells
	Iduronate 2-Sulfatase, also known as IDS, is a member of the highly conserved sulfatase family of enzymes that catalyze the hydrolysis of O- and N-sulfate esters from a variety of substrates. The human Iduronate 2-Sulfatase/IDS consists of a signal peptide, a propeptide, and a mature chain that may be further processed into two chains. Among the identified 18 human sulfatases, Iduronate 2-Sulfatase/IDS is required for the lysosomal degradation of the glycosaminoglycans (GAG), heparan sulfate, an...
TMPJ-01002	SGSH Protein, Human, Recombinant (His) SGSH,N-Sulphoglucosamine Sulphohydrolase,Sulfoglucosamine Su...	Human	HEK293 Cells
	N-Sulphoglucosamine Sulphohydrolase (SGSH) is an important member of the sulfatase family which is involved in the degradation of heparin sulfate. SGSH binds one calcium ion per subunit as a cofactor. SGSH catalyzes N-sulfo-D-glucosamine and H2O to D-glucosamine and sulfate. SGSH deficiency is result in mucopolysaccharidosis type 3A (MPS3A), a recessive lysosomal storage disease characterized by neurological dysfunction but relatively mild somatic manifestations.
TMPK-01158	Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His) SCTE,KLKL2,KLK5,KLK-L2,Klnc,Kallikrein c	Mouse	HEK293 Cells
	The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-...
TMPJ-00876	FAH Protein, Human, Recombinant (His) Fumarylacetoacetate Hydrolase,β-Diketonase,FAH,FAA,Fumarylac...	Human	HEK293 Cells
	Fumarylacetoacetase belongs to the FAH family. Fumarylacetoacetase is primary expressed in liver and kidney. It exists as a homodimer and catalyzes the hydrolysis of 4-fumarylacetoacetate into fumarate and acetoacetate. Defects in Fumarylacetoacetase cause tyrosinemia type 1, which is congenital metabolism defect characterized by elevated levels of tyrosine in the blood and urine, and hepatorenal manifestations. Typical features include renal tubular injury, self-mutilation, hepatic necrosis, ep...
TMPJ-00863	GNS Protein, Human, Recombinant (His) N-Acetylglucosamine-6-Sulfatase,G6S,GNS,Glucosamine-6-Sulfat...	Human	HEK293 Cells
	N-Acetylglucosamine-6-Sulfatase is a member of the Sulfatase family. N-Acetylglucosamine-6-Sulfatase is required for the lysosomal degradation of the Glycosaminoglycans (GAG) Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase hydrolyzes the 6-Sulfate groups of the N-Acetyl-D-Glucosamine 6-Sulfate units of Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase binds 1 Calcium ion per subunit. N-Acetylglucosamine-6-Sulfatase deficiency are the cause of Mucopolysacch...
TMPJ-00704	SCO1 Protein, Human, Recombinant (GST) Protein SCO1 Homolog Mitochondrial,SCOD1,SCO1	Human	E. coli
	Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by high rates of Oxidative Phosphorylation (OxPhos). SCO1 is thought to play a important role in cellular copper homeostasis, mitochondrial redox signaling and insertion of copper into the active site of COX. The defects of SCO1 can result in Mitochondrial Complex IV Deficiency (MT-C4...

重组蛋白

Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His)

Cat.No: TMPY-00828

Species: Human

Expression System: HEK293 Cells

SGSH Protein, Human, Recombinant (His)

Cat.No: TMPJ-01002

Species: Human

Expression System: HEK293 Cells

Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01158

Species: Mouse

Expression System: HEK293 Cells

FAH Protein, Human, Recombinant (His)

Cat.No: TMPJ-00876

Species: Human

Expression System: HEK293 Cells

GNS Protein, Human, Recombinant (His)

Cat.No: TMPJ-00863

Species: Human

Expression System: HEK293 Cells

SCO1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-00704

Species: Human

Expression System: E. coli

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