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TMPY-00395
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Insulin Protein, Human, Recombinant
IDDM1,MODY10,ILPR,IDDM2,IRDN,IDDM,insulin,INS
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Human
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P. pastoris (Yeast)
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INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with ... |
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TMPJ-01302
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ACAT2 Protein, Human, Recombinant (His)
ACTL,Acetyl-CoA transferase-like protein,Acetyl-CoA acetyltr...
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Human
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E. coli
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ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB. ACAT2 deficiency contributes to severe mental retardation and hypotonus. |
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TMPJ-00158
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Apolipoprotein A-I/APOA1 Protein, Human, Recombinant
Apolipoprotein A-I,APOA1,Apo-AI,ApoA-I
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Human
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E. coli
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Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various biological processes, such as Cholesterol metabolism, Lipid metabolism and transport, Steroid metabolism. APOA1 promotes cholesterol efflux from tissues to the liver and thus helps to clear cholesterol from arteries. Defects in this gene resulted in HDL deficiencies, including T... |
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TMPH-03536
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FabI Protein, S. aureus, Recombinant (His & SUMO)
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI,fabI,NAD...
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Staphylococcus aureus
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E. coli
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Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism. FabI Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.0 kDa and the accession number is Q6GI75. |
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TMPH-03128
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TSPO Protein, Pig, Recombinant (His & Myc & SUMO)
TSPO,Peripheral-type benzodiazepine receptor,Translocator pr...
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Sus scrofa (Pig)
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E. coli
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Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. TSPO Protein, Pig, Recombinant (His & Myc & SUMO) is expressed in E. coli e... |
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TMPY-01584
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PR-Set7 Protein, Human, Recombinant
SET8,SET07,PR-Set7,SET domain containing (lysine methyltrans...
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Human
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E. coli
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KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. Inhibition of KMT5A attenuated proliferation and induced apoptosis. Elevated KMT5A expression was significantly correlated with extrathyroidal extension, lymph node metastasis and advanced pathological stage of papillary thyroid cancer. KMT5A may be a novel oncogenic factor, specifically a re... |
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TMPY-01140
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ACOT13/THEM2 Protein, Human, Recombinant (His)
THEM2,HT012,ACOT13,PNAS-27,acyl-CoA thioesterase 13
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Human
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E. coli
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The metabolites of fatty acyl-Coenzyme A (CoA) and metabolic enzymes contribute to lipid biosynthesis, signal transduction, and gene transcription. Members of the acyl-CoA thioesterase (Acot) gene family hydrolyze fatty acyl-CoAs, but their biological functions remain incompletely understood. Thioesterase superfamily member 2 (Them2; synonym Acot13) is enriched in oxidative tissues, associated with mitochondria, and relatively specific for long chain fatty acyl-CoA substrates. Using Them2(-/-) m... |
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TMPJ-01255
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CFHR4 Protein, Human, Recombinant (His)
CFHL4,Complement factor H-related protein 4,FHR-4,CFHR4
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Human
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HEK293 Cells
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Complement factor H-related protein 4 is a protein that in humans is encoded by the CFHR4 gene. It is a secreted protein that belongs to the complement factor H protein family. Members of the H-related protein family are exclusively composed of individually folded protein domains. CFHR4 is synthesized as a 578 amino acid precursor that contains an 19 amino acid signal peptide and a 569 amino acid mature chain. Human CFHR4 is involved in complement regulation. It can associate with lipoproteins a... |
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TMPK-00284
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ANGPTL3 Protein, Human, Recombinant (His & Avi)
FHBL2,Angiopoietin-like Protein 3,ANG-5,ANGPTL3,ANGPT5,Angio...
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Human
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HEK293 Cells
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ANGPTL3 is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C‑terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. ANGPTL3... |
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TMPK-00285
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ANGPTL3 Protein, Human, Recombinant (His & Avi), Biotinylated
ANGPTL3,FHBL2,ANGPT5,Angiopoietin-5,ANL3,ANG-5,Angiopoietin-...
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Human
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HEK293 Cells
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ANGPTL3 is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C‑terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. ANGPTL3... |
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TMPY-03810
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GALNT2 Protein, Human, Recombinant (His)
GalNAc-T2,polypeptide N-acetylgalactosaminyltransferase 2
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Human
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HEK293 Cells
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GALNT2, also known as GalNAc-T2, is a member of the GalNAc-transferases family. Members of this family transfer an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. GALNT2 may play a role in lipid metabolism. It catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. GALNT2 has a broa... |
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TMPY-02174
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FABP5 Protein, Human, Recombinant
PA-FABP,E-FABP,fatty acid binding protein 5 (psoriasis-assoc...
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Human
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E. coli
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Fatty acid-binding protein, also known as Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Psoriasis-associated fatty acid-binding protein homolog, E-FABP and FABP5, is a cytoplasm protein which Belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid-binding proteins ( FABPs ) are postulated to serve as lipid shuttles that solubilize hydrophobic fatty acids and deliver them to appropriate intracellular sites. E-FABP / FABP5 is pre... |
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TMPY-03061
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CFHR2 Protein, Human, Recombinant (His)
HFL3,FHR2,CFHL2,complement factor H-related 2
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Human
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HEK293 Cells
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CFHR2 belongs to the complement factor H protein family. The human complement factor H protein family consists of the complement and immune regulators factor H, the factor H-like protein 1(FHL-1) and five factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. CFHR2 contains 4 Sushi (CCP/SCR) domains and is expressed by the liver and secr... |
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TMPY-03174
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CFHR1 Protein, Human, Recombinant (His)
CFHL1,H36-1,CFHL1P,HFL2,CFHR1P,HFL1,complement factor H rela...
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Human
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HEK293 Cells
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CFHR1 is a secreted protein belonging to the complement factor H protein family.The human complement factor H protein family consists of the complement and immune regulators factor H, the factor H-like protein 1(FHL-1) and five factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. CFHR1 binds to Pseudomonas aeruginosa elongation factor ... |
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TMPJ-01071
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Apolipoprotein H/APOH Protein, Mouse, Recombinant (His)
Beta-2-glycoprotein 1,Apoh,β-2-glycoprotein 1
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Mouse
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HEK293 Cells
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Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. Its carbohydrate content is approximately 19% of the molecular weight and it is present in the blood associated with plasma lipoproteins. Mature mouse ApoH shares 76% and 42% aa sequence identity with human and rat ApoH, respectively. The activity of APOH appears to involve the binding of agglutenating, inhibits agglutinati... |
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TMPY-03755
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Glycerol 3 Phosphate Dehydrogenase/GPD1 Protein, Human, Recombinant (His)
GPDH-C,HTGTI,GPD-C,glycerol-3-phosphate dehydrogenase 1 (sol...
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Human
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E. coli
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GPD1 (Glycerol-3-Phosphate Dehydrogenase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. GPD1 is a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. It also reduces nicotine adenine dinucleotide... |
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TMPY-03495
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MID1IP1 Protein, Human, Recombinant (His)
MIG12,S14R,MID1 interacting protein 1,THRSPL,STRAIT11499,G12...
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Human
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E. coli
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MID1IP1 (MID1 Interacting Protein 1) is a Protein Coding gene. The encoded protein belongs to the SPOT14 family. It is a homodimer in the absence of THRSP. MID1IP1 interacts with ACACA and ACACB. Its interaction with THRSP interferes with ACACA binding. It up-regulates ACACA enzyme activity and plays a role in the regulation of lipogenesis in the liver. MID1IP1 is required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol, and phospholipid. MID1IP1 is involved in the st... |
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TMPY-01588
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ALDH7A1 Protein, Human, Recombinant (His)
ATQ1,aldehyde dehydrogenase 7 family, member A1,EPD,PDE
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Human
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E. coli
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ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Mammalian ALDH7A1 is homologous to plant ALDH7B1 which protects against various forms of stress such as increased salinity, dehydration and treatment with oxidants or pesticides. In mammals, ALDH7A1 is known to play a primary role during lysine... |
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TMPY-06810
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SFTPB Protein, Human, Recombinant (His)
SFTP3,SMDP1,PSP-B,SFTB3,SP-B
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Human
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CHO Cells
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Pulmonary surfactant-associated protein B, also known as SFTPB and SP-B, contains one saposin A-type domain and three saposin B-type domains. SP-B is produced primarily by alveolar type II cells (AEC2) but also by nonciliated respiratory epithelial cells lining distal portions of the respiratory tract. Its secretion promotes alveolar homeostasis, stabilizing lipid layers and lowering surface tension at the air-liquid interface in the peripheral air spaces. Alveolar SP-B influences surfactant for... |
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TMPJ-01415
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ANGPTL4 Protein, Mouse, Recombinant (hFc)
Angptl4,HFARP,Fasting-induced adipose factor,Fiaf,Secreted p...
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Mouse
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HEK293 Cells
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Angiopoietin-related protein 4（ANGPTL4）is a secreted protein and contains 1 fibrinogen C-terminal domain. The protein may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity... |
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TMPY-01878
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L-FABP Protein, Human, Recombinant (His)
fatty acid binding protein 1, liver,FABPL,L-FABP
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Human
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E. coli
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Fatty acid-binding protein, liver, also known as Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, FABP1 and FABPL,is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is t... |
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TMPY-02051
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FABP2 Protein, Human, Recombinant (His)
MGC133132,fatty acid binding protein 2,FABPI,I-FABP
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Human
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E. coli
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Fatty acid binding protein (FABP) is one of the intracellular proteins, with a low molecular weight of approximately 15 kDa, that plays important roles in the transportation and metabolism of long-chain fatty acids. FABP family proteins could be used as tissue specific injury marker based on the following characteristics of FABP. The intestinal fatty acid binding protein (I-FABP), or fatty acid-binding protein 2 (FABP2), an intracellular protein expressed only in the intestine, involved in the a... |
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TMPJ-00292
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CD36 Protein, Human, Recombinant (hFc)
FATCHDS7,Glycoprotein IIIb,SCARB3,CD36,Fatty acid translocas...
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Human
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HEK293 Cells
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Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal muscle, epithelial cells of the retina, breast, and intestine, smooth muscle cells, erythroid precursors, platelets, megakaryocytes, dendritic cells, monocytes/macrophages, and microglia. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition rece... |
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TMPH-02690
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PLA2G10 Protein, Mouse, Recombinant (His & Myc)
Pla2g10,Group X secretory phospholipase A2,Phosphatidylcholi...
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Mouse
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E. coli
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Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density li... |
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TMPH-01664
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OMA1 Protein, Human, Recombinant (His & SUMO)
Overlapping with the m-AAA protease 1 homolog,OMA1,Metallopr...
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Human
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E. coli
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Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Also acts as a regulator of apoptosis: upon BAK and BAX ag... |
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TMPH-01689
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PLD6 Protein, Human, Recombinant (His)
Mitochondrial phospholipase,Choline phosphatase 6,Protein zu...
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Human
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E. coli
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Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger sig... |
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