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PF-06649298 是一种钠偶联柠檬酸盐转运蛋白抑制剂,可用于调节糖代谢以及脂代谢的研究。PF-06649298 在人类肝细胞中与 NaCT 特异性结合从而抑制柠檬酸盐的转运,IC50值为 16.2 μM。
PF-06649298 是一种钠偶联柠檬酸盐转运蛋白抑制剂,可用于调节糖代谢以及脂代谢的研究。PF-06649298 在人类肝细胞中与 NaCT 特异性结合从而抑制柠檬酸盐的转运,IC50值为 16.2 μM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 3,730 | 5日内发货 | |
10 mg | ¥ 6,990 | 5日内发货 | |
1 mL x 10 mM (in DMSO) | ¥ 4,120 | 5日内发货 |
产品描述 | PF-06649298 is an inhibitor of sodium-coupled citrate transporter which specifically interacts with NaCT with an IC 50 value of 16.2 μM to inhibits the transport of citrate in human hepatocytes. PF-06649298 can be used in regulating metabolism of glucose and metabolism of lipid [1] [2]. |
体外活性 | PF-06649298 (0-100 μM; 30 min) inhibits citrate uptaken in cells [2]. Cell Viability Assay [1] Cell Line: HEK-293 cells expressing NaCT, NaDC1 or NaDC3, human hepatocytes and mouse epatocytes Concentration: 0-100 μM Incubation Time: 30 min Result: Showed a selectivity for NaCT over the dicarboxylate transporters NaDC1 and NaDC3. Inhibited citrate uptake in HEK-293 cells expressing NaCT, NaDC1 or NaDC3, human hepatocytes and mouse epatocytes with IC 50 s of 408 nM, >100 μM, >100 μM, 16.2 μM and 4.5 μM, respectively. |
体内活性 | PF-06649298 (250 mg/kg; p.o. twice a day; for 21 days) reverses glucose intolerance of HFD mice [1]. Animal Model: Mice with HFD administration [2] Dosage: 250 mg/kg Administration: Oral gavage; 250mg/kg twice a day; for 21 days Result: Decreased plasma glucose, hepatic triglycerides, diacylglycerides, and acyl-carnitines concentration of livers in HFD mice. Totally reversed glucose intolerance of HFD mice. |
分子量 | 294.34 |
分子式 | C16H22O5 |
CAS No. | 1854061-16-7 |
存储 | Shipping with blue ice. |
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