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Search Results for " kinetic "

Targets Recommended: Others

32

抑制剂 & 化合物

2

天然产物

3

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T72285	LC kinetic stabilizer-1	Others	Others
	LC kinetic stabilizer-1 为一种高效、选择性的淀粉样免疫球蛋白轻链动力学稳定剂，对 WIL-FL* 与 WIL-FL*T46L/F49Y 的EC50值分别为140 nM与74.1 nM。其中，WIL-FL 为一种淀粉样变FL-LC二聚体。
T72286	LC kinetic stabilizer-2	Others	Others
	LC kinetic stability-2 是一种有效的淀粉样免疫球蛋白轻链 (LC) 动力学稳定剂，EC50为 24 nM。
T0699	Sulfamonomethoxine 磺胺间甲氧嘧啶,磺胺间甲氧嘧啶钠	Antibacterial; Antibiotic	Microbiology/Virology
	Sulfamonomethoxine 是一种磺胺类抗菌剂。它可研究血液动力学，竞争性抑制剂二氢叶酸合成，从而阻断叶酸合成。
T18888	4-Methylumbelliferyl phosphate 4-甲基伞形酮磷酸酯,4-MUP	Others	Others
	4-Methylumbelliferyl phosphate (4-MUP) 是碱性磷酸酶的荧光底物。
T76306	Adipokinetic hormone I (Locusta migratoria)
	Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) 是昆虫脂肪运动激素(AKH)类，可促进脂肪体内cAMP水平升高。AKH通过与AKH受体结合，并通过刺激性鸟嘌呤核苷酸结合蛋白(Gs)偶联，促进cAMP生成及糖原磷酸化酶活化，从而控制飞蝗动员脂肪体存储的碳水化合物和脂质。
T83165	Adipokinetic hormone (Manduca sexta) Manse-AKH
	Adipokinetic Hormone (Apis mellifera ligustica, Bombyx mori, Heliothis zea, Manduca sexta) 是昆虫肽类激素，能强烈诱导促脂肪/高海藻素反应，但不具备糖原动员功能，亦不能在脂肪体内有效储存及利用糖原。
T76304	Adipokinetic hormone II (Locusta migratoria)
	Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II)，一昆虫AKH，可提升脂肪体cAMP水平。AKHs通过其受体和Gs蛋白相互作用，增强cAMP生成与糖原磷酸化酶活性，从而直接调控飞蝗脂肪体中碳水化合物与脂质的动员。
TP1757	Adipokinetic Hormone (AKH) (24-32), locust
	Adipokinetic Hormone (AKH) (24-32), locust is a peptide hormone isolated from locusts.
T76655	Prokineticin 2 Isoform 2 (human)
	Prokineticin 2 Isoform 2 (human) 为一下丘脑神经肽，能减少食物摄入，并在啮齿动物的体温调节与能量代谢中发挥作用。此外，Prokineticin 2 对高血糖、代谢综合征 (MetS) 及肥胖研究具有潜在价值。
T83167	Adipokinetic Hormone (AKH) (24-32), locust TFA
	Adipokinetic Hormone (AKH) (24-32), locust (TFA)，是从蝗虫心脏分离的一种神经激素，调节飞行过程中的脂质利用。
T83166	Adipokinetic hormone (Gryllus bimaculatus) Grybi-AKH
	Adipokinetic hormone Gryllus bimaculatus (Grybi-AKH) 是调节昆虫能量平衡的脂肪动力激素，主要功能是动员脂肪体内的脂质和碳水化合物。此外，Grybi-AKH也能增强双斑蟋蟀的运动活性，并在人体体重调节、体重减轻及糖原贮积障碍缓解的研究中具有应用潜力。
T9447	AG-10 Acoramidis	Others	Others
	AG-10 (Acoramidis) 是选择性的、口服有效的甲状腺素转运蛋白 (TTR (transthyretin)) 的稳定剂，显示出对野生型和 V1221 突变型均有效。
T39740	Acoramidis hydrochloride AG10 hydrochloride,Alxn2060 hydrochloride	Others	Others
	Acoramidis hydrochloride (Alxn2060 hydrochloride) 是具有口服活性的、选择性的甲状腺素转运蛋白 (TTR (transthyretin)) 的稳定剂，对野生型和 V1221 突变型均有效。Acoramidis hydrochloride 可用于转体甲状腺素淀粉样变性的研究。
T7582	tafamidis meglumine Fx-1006A,他发米帝司甲葡胺	Others	Others
	Tafamidis meglumine (Fx-1006A) 是transthyretin (TTR)的选择性稳定剂，对野生型 WT-TTR 和突变型同源四聚体 V30M-TTR，V122I-TTR 的活性相当，EC50值为 2.7-3.2 μM。它能够阻碍淀粉样蛋白的生成。
T13688	Eribulin ER-086526,E7389,B1939	Microtubule Associated; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Cytoskeletal Signaling
	Eribulin (B1939) 是非紫杉烷微管动力学抑制剂，具有抗癌活性，通过防止细胞分裂过程中微管的延长和缩短来抑制微管蛋白亚基的聚合。Eribulin 可用于研究转移性乳腺癌和实体瘤。
T9361	5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	Others	Others
	5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione (5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) 是一种合成化合物。它已被用作催化剂以及酶动力学研究中的工具；还被用于酶抑制的研究，以及药物受体相互作用的研究。
T21537L	TMC647055 Choline Hydroxide Salt TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	TMC647055 Choline Hydroxide Salt 是一种新型有效的 HCV NS5B 聚合酶非核苷抑制剂，可用于治疗 HCV 感染。它具有纳摩尔级细胞效力（EC(50) 为 82 nM），相关细胞毒性较小（CC(50)>20 μM），在大鼠和狗中具有良好的药代动力学特征。 TMC647055 显示出有体外生化、动力学和病毒学特征的前景。
T4565	Tafamidis 他发米帝司甲葡胺,氯苯唑酸,Fx-1006A	Others	Others
	Tafamidis (Fx-1006A) 是选择性的transthyretin (TTR)稳定剂，对野生型 WT-TTR 、突变型同源四聚体 V30M-TTR、V122I-TTR 的活性相当，它们的EC50值为2.7-3.2 μM。它对淀粉样蛋白的生成具有抑制作用。
T6707	Tiotropium Bromide hydrate BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物	AChR	Neuroscience
	Tiotropium Bromide hydrate (BA-679 BR hydrate) 是长效的毒蕈碱受体拮抗剂，可用于治疗慢性阻塞性气道疾病 (COPD)。
T24001	Diisopropyl tartrate Diisopropyl (+)-L-tartrate,L-DIPT,BRN 1727863	Others	Others
	Diisopropyl tartrate is a reagent for kinetic resolution of racemic allylic alcohols and α-furfuryl amides. It acts by enantioselective epoxidation.
T78233	Sulfamonomethoxine sodium	Antibiotic	Microbiology/Virology
	Sulfamonomethoxine sodium用作血液动力学研究中的竞争性抑制剂，通过抑制二氢叶酸合成，进而阻断叶酸的生成。
T68192	OK-1035	Others	Others
	OK-1035 is a potent and selective DNA-PK inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM. OK-1035 inhibited the phosphorylation by DNA-PK of consensus peptide as well as that of recombinant human wild type-p53. Kinetic studies indicated that OK-1035 inhibited DNA-PK activity in an ATP-competitive manner.
T26964	CBS-3595 CBS3595	Others	Others
	CBS-3595 is a potent and dual Inhibitor of p38α MAPK/PDE-4 with a superior profile regarding its anti-inflammatory effects. CBS-3595 features moderate inhibition of p38α MAPK and PDE-4 in the higher nanomolar range in combination with excellent kinetic pr
T60255	α-Amylase/α-Glucosidase-IN-1	Others	Others
	α-Amylase/α-Glucosidase-IN-1 (compound 33) 是一种有效的α-淀粉酶/α-葡萄糖苷酶抑制剂，对α-淀粉酶和 α-葡萄糖苷酶的IC50值分别为 2.01、2.09 μM。动力学研究预测α-Amylase/α-Glucosidase-IN-1 具有抗高血糖的潜力。
T70639	AM-9514	Others	Others
	AM-9514 is a novel, potent Glucokinase (GK) activator. AM-9514 showed a favorable combination of in vitro potency, enzyme kinetic properties, acceptable pharmacokinetic profiles in preclinical species, and robust efficacy in a rodent PD model. Glucokinase (GK) activators represent a class of type 2 diabetes therapeutics actively pursued due to the central role that GK plays in regulating glucose homeostasis.
T37797	Coumarin-Quinone Conjugate	Others	Others
	Coumarin-quinone conjugate is a fluorescent substrate for NADH:ubiquinone oxidoreductases.1It is comprised of a coumarin fluorophore conjugated to a ubiquinone analog that can be reduced by NADH:ubiquinone oxidoreductases. It has been used to measure the kinetic parameters of apoptosis-inducing factor mitochondria-associated 2/ferroptosis suppressor protein 1 (AIFM2/FSP1). 1.Doll, S., Freitas, F.P., Shah, R., et al.FSP1 is a glutathione-independent ferroptosis suppressorNature575(7784)693-698(20...
T71000	RO-5328673	Others	Others
	RO-5328673 is a dual NK2/NK3 antagonist. O5328673. [(3)H]RO5328673 bound to a single saturable site on hNK2, hNK3 and gpNK3 with high-affinity. RO5328673 acted as an insurmountable antagonist at both human and guinea-pig NK3 receptors in the [(3)H]IP accumulation assay. In binding kinetic analyses, [(3)H]RO5328673 had fast association and dissociation rates at hNK2 while it had a fast association rate and a remarkably slow dissociation rate at gp and hNK3. In electrophysiological recordings of g...
T35572	Adenosine 3',5'-diphosphate sodium salt 3'-Phosphoadenosine 5'-phosphate	Endogenous Metabolite	Metabolism
	Adenosine 3',5'-diphosphate sodium salt 是一种羟类固醇磺基转移酶 (hydroxysteroid sulfotransferases) 抑制剂，是一种腺嘌呤核苷酸，在戊糖核糖的 3'和 5'位置含有一个磷酸基团。Adenosine 3',5'-diphosphate (sodium salt)是 3'-phosphoadenosine 5'-phosphosulfonate (PAPS) 的产物，是磺基转移酶（SULTs）的辅助因子，已被用于研究 SULTs 的动力学特性和结构。
T70538	PD-85639	Others	Others
	PD-85639 is a voltage-gated sodium (Na+) channel blocker (75% in 10 min & >95% in 25 min blockage of Na+ current by 25 μM PD85,639; whole-cell patch clamp using primary rat brain neurons) that is shown to target rat brain Nav1.2 with simultaneous high- and low-affinity modes of binding (EC50 = 56 nM/40% & 20 μM/60% at pH 9.0, 5 nM/28% & 3 μM/72% at pH 7.4, against 2 nM [3H]-PD85,639 for binding rat brain synaptosomes; EC50 = 17 nM/39% & 10 μM/61% using at pH 9.0 using rat brain synaptosome membr...
T37585	Ensartinib	Others	Others
	Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. The ability of Ensartinib (X-396) to inhibit the growth of different cancer cell lines harboring ALK fusions or point mutations is tested. Ensartinib is potent in H3122 lung cancer cells harboring EML4-ALK E13;A20 (IC50: 15nM). Ensartinib is also potent in H2228 lung cancer cells harboring EML4-ALK E6a/b; A20 (IC50: 45 nM). Furthermore, X-376 is potent in SUDHL-1 lymphoma cells harboring N...
T35416	α-D-Glucose-1-phosphate (sodium salt hydrate)	Others	Others
	α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen breakdownviaphosphorolytic cleavage of glycogen by glycogen phosphorylase.1It can be converted to glucose-6-phosphate by phosphoglucomutase. α-D-Glucose-1-phosphate is combined with CTP by α-D-glucose-1-phosphate cytidylyltransferase to form CDP-glucose in the first step of CDP-...
T36679	Rp-cAMPS sodium salt	Others	Others
	Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6]. A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic t...

化合物

LC kinetic stabilizer-1

Cat.No: T72285

Target: Others

LC kinetic stabilizer-2

Cat.No: T72286

Target: Others

Sulfamonomethoxine

Cat.No: T0699

Synonym: 磺胺间甲氧嘧啶,磺胺间甲氧嘧啶钠

Target: Antibacterial, Antibiotic

4-Methylumbelliferyl phosphate

Cat.No: T18888

Synonym: 4-甲基伞形酮磷酸酯,4-MUP

Target: Others

Adipokinetic hormone I (Locusta migratoria)

Cat.No: T76306

Adipokinetic hormone (Manduca sexta)

Cat.No: T83165

Synonym: Manse-AKH

Adipokinetic hormone II (Locusta migratoria)

Cat.No: T76304

Adipokinetic Hormone (AKH) (24-32), locust

Cat.No: TP1757

Prokineticin 2 Isoform 2 (human)

Cat.No: T76655

Adipokinetic Hormone (AKH) (24-32), locust TFA

Cat.No: T83167

Adipokinetic hormone (Gryllus bimaculatus)

Cat.No: T83166

Synonym: Grybi-AKH

Cat.No: T9447

Synonym: Acoramidis

Target: Others

Acoramidis hydrochloride

Cat.No: T39740

Synonym: AG10 hydrochloride,Alxn2060 hydrochloride

Target: Others

tafamidis meglumine

Cat.No: T7582

Synonym: Fx-1006A,他发米帝司甲葡胺

Target: Others

Cat.No: T13688

Synonym: ER-086526,E7389,B1939

Target: Microtubule Associated, ADC Cytotoxin

5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

Cat.No: T9361

Synonym: 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Target: Others

TMC647055 Choline Hydroxide Salt

Cat.No: T21537L

Synonym: TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)

Target: HCV Protease

Cat.No: T4565

Synonym: 他发米帝司甲葡胺,氯苯唑酸,Fx-1006A

Target: Others

Tiotropium Bromide hydrate

Cat.No: T6707

Synonym: BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物

Target: AChR

Diisopropyl tartrate

Cat.No: T24001

Synonym: Diisopropyl (+)-L-tartrate,L-DIPT,BRN 1727863

Target: Others

Sulfamonomethoxine sodium

Cat.No: T78233

Target: Antibiotic

Cat.No: T68192

Target: Others

Cat.No: T26964

Synonym: CBS3595

Target: Others

α-Amylase/α-Glucosidase-IN-1

Cat.No: T60255

Target: Others

Cat.No: T70639

Target: Others

Coumarin-Quinone Conjugate

Cat.No: T37797

Target: Others

Cat.No: T71000

Target: Others

Adenosine 3',5'-diphosphate sodium salt

Cat.No: T35572

Synonym: 3'-Phosphoadenosine 5'-phosphate

Target: Endogenous Metabolite

Cat.No: T70538

Target: Others

Cat.No: T37585

Target: Others

α-D-Glucose-1-phosphate (sodium salt hydrate)

Cat.No: T35416

Target: Others

Rp-cAMPS sodium salt

Cat.No: T36679

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4S0145	Corylifol A Corylinin,补骨脂异黄酮A	hCE; STAT; UGT	JAK/STAT signaling; Metabolism; Stem Cells
	Corylifol A (Corylinin) 是补骨脂中的一种天然产物，可抑制IL-6 诱导的STAT3激活和磷酸化，IC50值为0.81 μM。
T36448	(E)-Ajoene	Others	Others
	(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth...

天然产物

Cat.No: T4S0145

Synonym: Corylinin,补骨脂异黄酮A

Target: hCE, STAT, UGT

Cat.No: T36448

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02945	Prokineticin 1/EG-VEGF Protein, Human, Recombinant (His) PK1,EGVEGF,PRK1,prokineticin 1	Human	Baculovirus Insect Cells
	EG-VEGF, also known as prokineticin-1, is a member of the AVIT (prokineticin) family. Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. EG-VEGF can be detected in the steroidogenic glands, ovary, testis, adrenal and placenta. EG-VEGF has little or no effect on a variety of other endothelial and non-endothelial cell types. It induces proliferation, migration and fenestration (the formation of membrane discontinuities) i...
TMPJ-00463	BDH2 Protein, Human, Recombinant (His) Oxidoreductase UCPA,Dehydrogenase/Reductase SDR Family Membe...	Human	E. coli
	3-Hydroxybutyrate Dehydrogenase Type 2 belongs to the short-chain dehydrogenases/reductases (SDR) family. 3-Hydroxybutyrate Dehydrogenase Type 2 may play an important role in the peripheral utilization of 3-hydroxybutyrate. The cytoplasmic localization with its high ratio of oxidized NAD+, the NAD+ dependence and the kinetic parameters of 3-Hydroxybutyrate Dehydrogenase Type 2 make it suitable to conbert high levels of circulating 3-hydroxybutyrate into acetoacetate.
TMPY-02599	MDH1 Protein, Rat, Recombinant (His) malate dehydrogenase 1, NAD (soluble)	Rat	E. coli
	Malate dehydrogenases 1(MDH1 / MDHA) is a soluble form of malate dehydrogenases. Malate dehydrogenases (MDH) is a group of multimeric enzymes consisting of identical subunits usually organized as either dimer or tetramers with subunit molecular weights of 30-35 kDa. MDH has been isolated from different sources including archaea, eubacteria, fungi, plants, and mammals. MDH catalyzes the NAD/NADH-dependent interconversion of the substrates malate and oxaloacetate. This reaction plays a key part in...

重组蛋白

Prokineticin 1/EG-VEGF Protein, Human, Recombinant (His)

Cat.No: TMPY-02945

Species: Human

Expression System: Baculovirus Insect Cells

BDH2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00463

Species: Human

Expression System: E. coli

MDH1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-02599

Species: Rat

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T13032	Sulfamonomethoxine-d4	Others	Others
	Sulfamonomethoxine D4 is a deuterium labeled Sulfamonomethoxine. Sulfamonomethoxine is an agent of long acting sulfonamide antibacterial, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.
TMIH-0549	Tafamidis-d3
	Tafamidis-d3 是 Tafamidis 的氘代化合物。Tafamidis 的 CAS 号为 594839-88-0。Tafamidis 是选择性的transthyretin (TTR)稳定剂，对野生型 WT-TTR 、突变型同源四聚体 V30M-TTR、V122I-TTR 的活性相当，它们的EC50值为2.7-3.2 μM。它对淀粉样蛋白的生成具有抑制作用。

同位素标记化合物

Sulfamonomethoxine-d4

Cat.No: T13032

Target: Others

Cat.No: TMIH-0549

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