142
11
163
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2098 |
Echistatin
Echistatin, α1 isoform |
||
Potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3) | |||
T76655 |
Prokineticin 2 Isoform 2 (human)
|
||
Prokineticin 2 Isoform 2 (human) 为一下丘脑神经肽,能减少食物摄入,并在啮齿动物的体温调节与能量代谢中发挥作用。此外,Prokineticin 2 对高血糖、代谢综合征 (MetS) 及肥胖研究具有潜在价值。 | |||
T16129 |
MPI_5a
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
MPI_5a 是高效的 HDAC6选择性抑制剂,IC50=36 nM,对其他 HDAC 酶几乎无抑制作用。MPI_5a 抑制细胞内酰基微管蛋白积累, IC50为 210 nM。 | |||
T76064 |
Beta-defensin 103 isoform X1, pig
|
||
Beta-defensin 103 isoform X1, pig 是一种抗菌肽、在多种生物体内被发现,参与了先天性免疫防线。 | |||
T76064L |
Beta-defensin 103 isoform X1, pig TFA
|
||
Beta-defensin 103 isoform X1, pig TFA 是一种抗菌肽、在多种生物体内被发现,参与了先天性免疫防线。 | |||
T6704 |
TG 100713
TG100713 |
PI3K | PI3K/Akt/mTOR signaling |
TG 100713 是一种PI3K 的抑制剂,抑制PI3Kδ,γ,α和β的IC50值分别为24、50、165 和 215 nM。 | |||
T12103 |
MR-L2
|
PDE | Metabolism |
MR-L2 是可逆的、非竞争性的长型异构体磷酸二酯酶 -4激活剂,可以激活代表性的 PDE4 长型异构体 (PDE4A4、PDE4B1、PDE4C3、PDE4D5)。它可抑制 PGE2- 诱导的 MDCK 细胞囊肿形成,其EC50=1.2 µM。 | |||
T2256 |
CNX-1351
1-[4-[[2-(1H-吲唑-4-基)-4-(4-吗啉基)噻吩并[3,2-D]嘧啶-6-基]甲基]-1-哌嗪基]-6-甲基-5-庚烯-1,4-二酮 |
PI3K | PI3K/Akt/mTOR signaling |
CNX1351 是有效的、选择性的 PI3Kα 抑制剂,其 IC50=6.8 nM。 | |||
T22774L |
EEF1A1 (387-394) (Multiple species) (TFA)
|
Others | Others |
eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) 是延伸因子 1 亚基。真核翻译延伸因子 1 alpha 1 (EEF1A1) 编码延伸因子 alpha 亚基的同种型- 1 复合物,负责将氨酰 tRNA 酶促递送至核糖体。这种亚型(α 1)在脑、胎盘、肺、肝、肾和胰腺中表达,另一种亚型(α 2)在脑、心脏和骨骼肌中表达。这种亚型在 66% 的 Felty 综合征患者中被鉴定为自身抗原。已发现该基因在许多染色体上具有多个拷贝,其中一些(如果不是全部)代表不同的假基因。 | |||
T15239 |
Epristeride
SKF105657,ONO-9302 |
Apoptosis; Reductase | Apoptosis; Endocrinology/Hormones; Metabolism |
Epristeride (ONO-9302) 是具有口服活性、选择性和非竞争性类固醇 5-α-还原酶亚型2抑制剂,抑制SR 同工酶 2。Episteride 可减小前列腺大小并改善良性前列腺增生男性的症状。Episteride 诱导大鼠腹侧前列腺萎缩和凋亡。 | |||
T8584 |
6-Phenyldihydropyrimidine-2,4(1h,3h)-dione
2,4(1H,3H)-Pyrimidinedione,dihydro-6-phenyl- |
Others | Others |
6-Phenyldihydropyrimidine-2,4(1h,3h)-dione 靶向多嘧啶束结合蛋白 1 亚型 a(人)。 | |||
T3985 |
GDC-0326
GDC 0326,GDC0326 |
PI3K | PI3K/Akt/mTOR signaling |
GDC-0326是一种有效,选择性的 PI3Kα抑制剂,Ki=0.2 nM。 | |||
T14089 |
AC-261066
AC 261066 |
Retinoid Receptor | Metabolism |
AC-261066是一种口服的RARβ2的同型选择性激动剂,pEC50为8.0。 | |||
T2057 |
BVT 2733
|
Dehydrogenase | Metabolism |
BVT 2733 是具有口服活性的、强效的、非甾体类11β-HSD1选择性抑制剂。它对小鼠 11β-HSD1 酶的作用 (IC50:96 nM) 比对人 11β-HSD1 酶 (IC50:3341 nM) 的作用强。它对关节炎和肥胖相关疾病具有潜在的研究价值。 | |||
T9608 |
KL201
|
Others | Others |
KL201 是一种昼夜节律调制器,是 CRY1选择性的 稳定剂, 对 CRY2 没有稳定作用。KL201 延长了细胞和组织中的昼夜节律周期。 | |||
T21529 |
(S)-Mephenytoin
|
Others | Others |
(S)-Mephenytoin 是一种抗惊厥剂。(S)-Mephenytoin 作为细胞色素 P450 (CYP) 同种型 CYP2C19 的底物,可用于分析细胞色素 P450 代谢。 | |||
T35501 |
5,6-trans-Vitamin D3
5,6-trans-Colecalciferol,5,6-trans-Cholecalciferol,Cholecalciferol EP Impurity A |
Vitamin | Metabolism |
5,6-trans-Vitamin D3(5,6-trans-Cholecalciferol)是维生素 D3 的异构体,经光照后在皮肤表面由 Vitamin D3 转化而来。 | |||
T14090 |
AC-55649
|
Retinoid Receptor | Metabolism |
AC-55649是一种有效的、高度亚型选择性的人 RARβ2受体激动剂,pEC50为6.9。 | |||
T2287 |
PIK-75 hydrochloride
PIK-75 HCl,2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐酸盐,PIK-75 |
Apoptosis; DNA-PK; PI3K | Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
PIK-75 hydrochloride (PIK-75 HCl) 是一种可逆的 DNA-PK 和 p110α-选择性抑制剂,抑制 DNA-PK,p110α和 p110γ,可诱导凋亡。 | |||
T1999 |
Taselisib
RG-7604,GDC-0032 |
PI3K; Carbonic Anhydrase | Metabolism; PI3K/Akt/mTOR signaling |
Taselisib (GDC-0032) 是 PI3K 抑制剂,靶向作用于突变 PI3KCA。它能够抑制 PI3Kα (IC50:0.29 nM),PI3Kβ (IC50:0.91 nM) 和 PI3Kγ (IC50:0.97 nM)。 | |||
T8840 |
PF-543 hydrochloride
PF-543 |
Apoptosis; S1P Receptor; Autophagy; LPL Receptor | Apoptosis; Autophagy; GPCR/G Protein |
PF-543 hydrochloride (PF-543) 是一种选择性可逆和鞘氨醇竞争性SPHK1抑制剂,对SPHK1的选择性是 SPHK2 的 100 倍以上。它还是全血中 1-磷酸鞘氨醇形成的有效抑制剂,诱导细胞凋亡、坏死和自噬。 | |||
T2002 |
PF-4708671
PF4708671 |
S6 Kinase; Autophagy | Autophagy; MAPK; PI3K/Akt/mTOR signaling |
PF-4708671 是一种可渗透细胞的 p70 核糖体 S6 激酶抑制剂,对 S6K1的Ki 为 20 nM,IC50为 160 nM。 | |||
T64377 |
AGI-41998 tautomers
|
Others | Others |
AGI-41998 tautomers 是pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one 的互变异构体。pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one 是S-adenosylmethionine synthase isoform type-2抑制剂, IC50= 0.022μM。 | |||
T16333 |
NKY80
Adenylyl cyclase type V Inhibitor |
Adenylyl cyclase | Neuroscience |
NKY80 调节心脏和肺组织中的腺苷酸环化酶催化活性。 NKY80 是腺苷酸环化酶 V 型亚型的非竞争性抑制剂(IC50 值:V、III 和 II 型分别为 8.3 µM、132 µM 和 1.7 mM)。 | |||
T27371 |
FR-167356
FR167356,FR 167356 |
ATPase | Membrane transporter/Ion channel |
FR-167356 是 a3 异构体液泡型 H+-ATPase 的特异性抑制剂,对破骨细胞质膜、肾刷状缘膜和巨噬细胞微粒体的 IC50 分别为 170 nM、370 nM 和 220 nM。 FR-167356 减少 B16-F10 细胞的骨转移。 | |||
T21938 |
AS-041164
|
PI3K | PI3K/Akt/mTOR signaling |
AS-041164 是选择性的,具有口服活性的PI3Kγ亚型抑制剂,IC50=70 nM。它对 PI3Kα (IC50:240 μM),PI3Kβ (IC50:1.45 μM) 和 PI3Kδ (IC50:1.70 μM) 的活性较低。它具有抗炎活性。 | |||
T4281 |
Endoxifen
(E/Z)-N-desmethyl-4-hydroxy Tamoxifen,N-去甲基-4-羟基-,(E/Z)-Endoxifen |
Estrogen Receptor/ERR; Aromatase; Estrogen/progestogen Receptor; Parasite; Drug Metabolite | Endocrinology/Hormones; Metabolism; Microbiology/Virology |
Endoxifen ((E/Z)-Endoxifen) 是 Tamoxifen 的关键活性代谢物,能抑制芳香酶的活性,与雌激素受体有较高的亲和力和特异性。它有潜力研究乳腺癌。 | |||
T9564 |
IRE1α kinase-IN-1
|
IRE1 | Cell Cycle/Checkpoint |
IRE1α kinase-IN-1 是IRE1α 的选择性抑制剂(IC50为 77 nM),对 IRE1α 的选择性高于 IRE1β 亚型 100 倍。它抑制内质网诱导的 IRE1α 寡聚和自磷酸化,并抑制 IRE1α RNase 活性 (IC50=80 nM)。 | |||
T24873 |
TGX-115
TGX 115 |
PI3K | PI3K/Akt/mTOR signaling |
TGX-115是一种细胞渗透性和有效的PI 3-K 异构体p110β/p110δ抑制剂(对p110β IC50值为 0.13 μM, 对p110δ值为0.63 μM),是一种调节血小板粘附过程的酶,可抑制磷酸肌苷(PI)3-激酶,可用来治疗冠状动脉闭塞、中风、急性冠状动脉综合征、急性心肌梗塞、血管再狭窄、动脉硬化和不稳定心绞痛等心血管疾病 。 | |||
T27787L |
L-797,591 hydrochloride
L-797,591 hydrochloride(217480-24-5 Free base) |
Others | Others |
L-797,591 hydrochloride 对生长抑素受体亚型 1 (SSTR1)有活性。L-797,591 hydrochloride 常与 AG1478 联合使用来增强表达 SSTR1的细胞中 p-ERK5的表达。L-797,591 hydrochloride 在共转染的细胞中显著增强了 p38的磷酸化,这一作用在与 AG1478联合处理时被逆转。 | |||
T8944 |
TTA-A2
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
TTA-A2 是一种选择性 T 型钙通道拮抗剂,是一种有效的抗惊厥药,可减少孕烷 X 受体的激活。它对 Cav3.1 (a1G) 和 Cav3.2 (a1H) 通道在 -80 mV 和- 100 mV 保持电位上具有同样的作用,IC50 值分别为 89 和 92 nM。它可用于多种人类神经系统疾病的研究,包括睡眠障碍和癫痫。 | |||
T2238L |
Cariporide Mesylate
Cariporide Mesylate salt,HOE-642,HOE 642,HOE642 |
Others | Others |
Cariporide Mesylate is a selective inhibitor of the Na+/H+ exchanger isoform 1. | |||
T26960 |
CB7833407
|
Others | Others |
CB7833407 is a selective Adenylyl Cyclase isoform-2 (AC2) inhibitor. | |||
TP2241 |
[Des-octanoyl]-Ghrelin (human)
|
Others | Others |
[Des-octanoyl]-Ghrelin (human) is a Non-acylated, major circulating isoform of ghrelin. | |||
T12616 |
(R)-CE3F4
|
Others | Others |
(R)-CE3F4 is a selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1)(IC50 of 4.2 μM), | |||
T16908 |
Sonolisib
PX-866 |
PI3K | PI3K/Akt/mTOR signaling |
Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)). | |||
T71513 |
GK-136901
|
Others | Others |
GK-136901 is a first-in-class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitor. | |||
T13113 |
Teglicar
|
Others | Others |
Teglicar is a selective and reversible liver isoform of carnitine palmitoyl-transferase 1 (L-CPT1) inhibitor. | |||
TP2242 |
[Des-octanoyl]-Ghrelin (rat)
|
Others | Others |
[Des-octanoyl]-Ghrelin (rat) is a Non-acylated, major circulating isoform of ghrelin. | |||
T24020 |
DTS
Dibenzyl trisulfide |
Others | Others |
DTS is a selective and isoform-specific RSK1 kinase inhibitor. It also has broad cancer therapeutic potential. | |||
T22774 |
eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]
|
Others | Others |
eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed | |||
T23566 |
Zoniporide dihydrochloride
|
Others | Others |
Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor | |||
T11702 |
J30-8
|
Others | Others |
J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases. J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivit | |||
T13359 |
XPC-6444
|
Others | Others |
XPC-6444 is a isoform-selective, and CNS-penetrant inhibitor of NaV1.6 with IC50 of41 nM for hNaV1.6,with anticonvulsant activity. | |||
T24224 |
JTT-010
JTT010 |
Others | Others |
JTT-010 is a selective inhibitor of protein kinase C-beta isoform. | |||
T40852 |
(Rac)-γ-Tocopherol
(Rac)-γ-Tocopherol,DMPBQ |
Others | Others |
(Rac)-γ-Tocopherol (DMPBQ) is an isoform of Vitamin E that undergoes conversion to γ-Tocopherol through the action of tocopherol cyclase. | |||
T37306 |
6-hydroxy Chlorzoxazone
6-hydroxy Chlorzoxazone,NSC 24955 |
Others | Others |
6-hydroxy Chlorzoxazone is a metabolite of chlorzoxazone. [1] It is formed by metabolism of chlorzoxazone by the cytochrome P450 (CYP) isoform CYP2E1 in human hepatic microsomes. | |||
T85296 |
(2'S)-Nicotine-1-oxide
Nicotine-N-oxide |
Others | Others |
(2'S)-Nicotine-1-oxide, a nicotine metabolite, arises from the liver's metabolism of nicotine via the cytochrome P450 (CYP) isoform CYP2A6. It has been identified in human sperm and semen. | |||
T84649 |
CAY10398
MD 85 |
Others | Others |
CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1). | |||
T84930 |
6β-hydroxy Prednisolone
|
Others | Others |
6β-Hydroxy Prednisolone, the active metabolite of prednisone and a derivative of prednisolone, is predominantly synthesized via the cytochrome P450 (CYP) isoform CYP3A4 and, to a lesser extent, CYP3A5. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2S1797 |
Santalol
檀香醇;白檀油萜醇;檀香脑,檀香醇 |
Antioxidant; Antifungal | Microbiology/Virology; oxidation-reduction |
Santalol 是一种檀香醇的 α 和 β-异构体混合物。 其中α-santalol 分离自檀香油中,是一种有前途的抗癌药,能够预防口腔癌、前列腺癌、乳腺癌和皮肤癌。 | |||
TN1778 |
Isoformononetin
异刺芒柄花素,黄豆苷元杂质 |
IL Receptor; Antifection | Immunology/Inflammation; Microbiology/Virology |
Isoformononetin shows fungitoxic activity against Cladosporium sphaerospermum; it also has immunomodulatory activity, it inhibits the differentiation of Th17 cells and B-cell lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions. | |||
T2949 |
Alizarin
Mordant Red 11,Anthraquinonic,茜素 |
P450 | Metabolism |
Alizarin (Mordant Red 11) 是一种天然红色染料,从茜草植物根部提取得到,已广泛用作纺织品和绘画中的颜料。 | |||
T5743 |
Gymnemagenin
|
Liver X Receptor | Metabolism |
Gymnemagenin 是一种分离自G. sylvestre 的三萜。 它具有抗病毒作用,对糖尿病和肥胖症具有潜在的研究价值。 | |||
T9675 |
α-Tocotrienol
|
Endogenous Metabolite | Metabolism |
α-Tocotrienol 是维生素 E 的一种亚型,存在于蔬菜、水果、种子、坚果、谷物和油脂中。α-Tocotrienol 是抗氧化剂,可以降低胆固醇和其他脂类,也是神经保护和抗癌剂,在心血管疾病的保护中发挥作用。 | |||
T6491 |
(-)-(S)-Equol
(−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) 是雌激素受体β的高亲和力配体。 | |||
T16837 |
SAICAR
|
Others | Others |
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM). | |||
TN3910 |
Ecdysone
|
Apoptosis; ATPase; Glucocorticoid Receptor; Potassium Channel; Sodium Channel; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; Membrane transporter/Ion channel; Metabolism |
Ecdysone 是存在于昆虫和草药中的主要类固醇激素,可以激活盐皮质激素受体并诱导细胞凋亡。Ecdysone 的活性代谢物 20-羟基蜕皮激素在协调发育过渡和体内稳态睡眠调节中起重要作用。 | |||
T36472 |
Tetrahydro-11-deoxy Cortisol
|
Others | Others |
Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA. | |||
TN7505 |
Thujopsene
NSC 44707 |
Others | Others |
Thujopsene, a sesquiterpene found in T. dolabrata, exhibits a wide range of biological activities. It inhibits Na+/K+-ATPase and cytochrome P450 (CYP) isoform CYP2B6 with IC50 values of 25.9 µg/ml and Ki of 0.8 µM, respectively. Additionally, thujopsene demonstrates antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, such as S. aureus, M. luteus, and S. typhimurium, with MICs ranging from 25-50 µg/ml. It also suppresses antigen-induced β-hexosaminidase release in IgE-se... | |||
T37810 |
6',7'-Epoxybergamottin
|
Others | Others |
6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transpo... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-01009 |
SIRP beta 1 isoform 3 Protein, Human, Recombinant (His & Avi), Biotinylated
DKFZp686A05192,9930027N05Rik,SIRP-beta-1 isoform 3,... |
Human | HEK293 Cells |
SIRP beta 1 isoform 3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 39.9 kDa and the accession number is Q5TFQ8-1. | |||
TMPY-01146 |
Insulin Receptor Protein, Human, Recombinant (long isoform, His)
HHF5,CD220,insulin receptor |
Human | HEK293 Cells |
Insulin Receptor Protein, Human, Recombinant (long isoform, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 107 kDa and the accession number is P06213-1. | |||
TMPK-01008 |
SIRP beta 1 isoform 3 Protein, Human, Recombinant (His & Avi)
SIRP-beta-1 isoform 3,SIRP-beta,SIRP-β-1 isofor... |
Human | HEK293 Cells |
SIRP beta 1 isoform 3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 39.9 kDa and the accession number is Q5TFQ8-1. | |||
TMPH-00005 |
YAP1 Protein, Human, Recombinant (Isoform 9, His)
Protein yorkie homolog,YAP1,Yes-associated protein YAP65 hom... |
Human | P. pastoris (Yeast) |
YAP1 Protein, Human, Recombinant (Isoform 9, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 56.4 kDa; 80 kDa, reducing conditions and the accession number is P46937-9. | |||
TMPY-02367 |
Neuropilin-1 Protein, Human, Recombinant (isoform b, His)
neuropilin 1,NRP,VEGF165R,BDCA4,Neuropilin-1,NP1,CD304 |
Human | HEK293 Cells |
Neuropilin-1 Protein, Human, Recombinant (isoform b, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is O14786-2. | |||
TMPJ-00864 |
VEGF165 Protein, Human, Recombinant
Vascular Endothelial Growth Factor Isoform 165,血管内皮... |
Human | HEK293 Cells |
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimul... | |||
TMPY-02820 |
SDF-1/CXCL12 Protein, Human, Recombinant (isoform a)
SDF1,chemokine (C-X-C motif) ligand 12,IRH,SCYB12,TPAR1,SDF-... |
Human | E. coli |
SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2. | |||
TMPH-00348 |
Car b 1 isoform 2 Protein, Carpinus betulus, Recombinant (His)
Major pollen allergen Car b 1 isoform 2,Car b 1,All... |
Carpinus betulus | E. coli |
Car b 1 isoform 2 Protein, Carpinus betulus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.4 kDa and the accession number is P38950. | |||
TMPH-01705 |
Mucin-1/MUC1 Protein, Human, Recombinant (Isoform 8, His)
Peanut-reactive urinary mucin,Isoform 8 of Mucin-1,... |
Human | E. coli |
Mucin-1/MUC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.2 kDa and the accession number is P15941-8. | |||
TMPY-01033 |
IL-32 Protein, Human, Recombinant (isoform alpha, His)
IL-32δ,IL-32beta,IL32,TAIFc,IL-32γ,白介素,IL-32 Protein(iso... |
Human | HEK293 Cells |
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,... | |||
TMPH-02095 |
PPP2R2C Protein, Human, Recombinant (His & Myc)
Serine/threonine-protein phosphatase 2A 55 kDa regulatory su... |
Human | E. coli |
PPP2R2C Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPJ-00058 |
BTC Protein, Mouse, Recombinant (His)
βcellulin,isoform CRA_a,Btc,Betacellulin,mCG_12529 |
Mouse | E. coli |
Mouse Betacellulin is a single type I membrane protein which belongs to the EGF family of cytokines. EGF family has many members including EGF, TGF-a, Amphiregulin, HB-EGF, Epiregulin, Tomoregulin and the Neuregulins. Betacellulin is characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. Betacellulin is expressed in several tissues and tumor cells including kidney, uterus, liver, pancreas and small intestine.... | |||
TMPH-00924 |
AMELX Protein, Human, Recombinant (His & Myc)
AMGX,AMG,Amelogenin, X isoform |
Human | Baculovirus Insect Cells |
AMELX Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus. | |||
TMPJ-00227 |
Follistatin 288 Protein, Human, Recombinant (His)
FSActivin-binding protein,Follistatin,follistatin isofor... |
Human | HEK293 Cells |
Follistatin 288 is a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid . Human follistatin 288 cDNA encodes a 317 amino acid (aa) protein with a 29 aa signal sequence, and a 288 aa mature region. Follistatin shows the highest affinity for activins due to its extended configuration. Genetic deletion of follistatin in mice, or expression of only the Follistatin form, is perinatally lethal due to defects of lung, skin ... | |||
TMPH-00925 |
AMELX Protein, Human, Recombinant (His & SUMO)
AMGX,Amelogenin, X isoform,AMG |
Human | E. coli |
AMELX Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPJ-00239 |
IL-2RG Protein, Mouse, Recombinant (aa 25-263, hFc)
Il2rg,Interleukin 2 receptor, gamma chain, isoform ... |
Mouse | HEK293 Cells |
The Interleukin-2 receptor gamma chain (IL-2 Rγ, CD132) of the high affinity functional mouse IL-2 receptor complex is a member the hematopoietin receptor family. It is expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. Common IL2 receptor-γ Chain is required for IL-2 receptor signaling. Besides IL-2, the Common IL2 receptor-γ chain has been shown to be a component of the functional receptor complexes for IL-4, IL-7, IL-9 and IL-15.... | |||
TMPY-06829 |
BTLA Protein, Human, Recombinant (isoform 1,mFc)
BTLA1,CD272,B and T lymphocyte associated |
Human | HEK293 Cells |
BTLA Protein, Human, Recombinant (isoform 1,mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 40.56 kDa and the accession number is NP_861445.4. | |||
TMPH-01923 |
Pro-neuregulin-1 Protein, Human, Recombinant (GST & His)
NRG1,Pro-neuregulin-1, membrane-bound isoform |
Human | E. coli |
Pro-neuregulin-1 Protein, Human, Recombinant (GST & His) is expressed in E. coli. | |||
TMPK-00252 |
SIRP beta 1 Protein, Human, Recombinant (His & Avi)
Sirpb,Sirpb1,SIRP-beta,SIRP-β-1 isoform 3,SIRP-beta... |
Human | HEK293 Cells |
SIRP beta 1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 40 kDa and the accession number is O00241-1. | |||
TMPJ-01269 |
BOC Protein, Human, Recombinant (His)
Brother of CDO,Boc homolog (Mouse),BOC protein,isoform |
Human | HEK293 Cells |
Brother of CDO is a protein that in humans is encoded by the BOC gene. CDON and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail. | |||
TMPJ-00470 |
CYB5B Protein, Human, Recombinant (His)
Cytochrome b5 outer mitochondrial membrane isoform,... |
Human | HEK293 Cells |
Cytochrome b5 type B (CYB5B) is a membrane of the cytochrome b5 family. It contains 1 cytochrome b5 heme-binding domain. Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. In the mitochondrion of eukaryotes and in aerobic prokaryotes, cytochrome b is a component of respiratory chain complex III also known as the bc1 complex or ubiquinol-cytochrome c reductase. | |||
TMPK-00253 |
SIRP beta 1 Protein, Human, Recombinant (His & Avi), Biotinylated
FLJ26614,9930027N05Rik,SIRP-beta,DKFZp686A05192,SIRP-β-1 |
Human | HEK293 Cells |
SIRP beta 1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 40 kDa and the accession number is O00241-1. | |||
TMPH-01924 |
Pro-neuregulin-3 Protein, Human, Recombinant (His & SUMO)
Pro-neuregulin-3, membrane-bound isoform,NRG3 |
Human | E. coli |
Pro-neuregulin-3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPJ-00016 |
GABARAP Protein, Human, Recombinant (GST)
GABARAP,GABA(A) Receptor-Associated Protein,GABARAP Protein,... |
Human | E. coli |
GABARAP Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 37 KDa and the accession number is Q6IAW1. | |||
TMPH-01054 |
CSNK1E Protein, Human, Recombinant (His)
Casein kinase I isoform epsilon,CKI-epsilon,CSNK1E,... |
Human | E. coli |
CSNK1E Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 51.3 kDa and the accession number is P49674. | |||
TMPY-05258 |
EGFR Protein, Human, Recombinant (Isoform Viii, hFc)
NISBD2,epidermal growth factor receptor,ERBB,PIG61,mENA,ERBB... |
Human | Baculovirus Insect Cells |
EGFR Protein, Human, Recombinant (Isoform Viii, hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 65.1 kDa and the accession number is NP_001333870.1. | |||
TMPY-02804 |
FGF-14 Protein, Human, Recombinant (isoform 1B)
SCA27,FHF-4,FGF-14,fibroblast growth factor 14,FHF4 |
Human | E. coli |
FGF-14 Protein, Human, Recombinant (isoform 1B) is expressed in E. coli expression system. The predicted molecular weight is 21.1kDa and the accession number is Q92915-2. | |||
TMPH-01179 |
COX4I1 Protein, Human, Recombinant (His & SUMO)
Cytochrome c oxidase polypeptide IV,COX4I1,Cytochrome c oxid... |
Human | E. coli |
COX4I1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-05283 |
Insulin Receptor Protein, Human, Recombinant (long isoform, His), Biotinylated
CD220,Insulin Receptor,HHF5 |
Human | HEK293 Cells |
Insulin Receptor Protein, Human, Recombinant (long isoform, His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 107 kDa and the accession number is P06213-1. | |||
TMPJ-00015 |
GABARAP Protein, Human, Recombinant (His & hFc)
GABA(A) Receptor-Associated Protein,HCG1987397 Isoform |
Human | E. coli |
GABARAP Protein, Human, Recombinant (His & hFc) is expressed in E. coli expression system with N-6xHis and C-Fc tag. The predicted molecular weight is 50 KDa and the accession number is Q6IAW1. | |||
TMPY-01149 |
Insulin Receptor Protein, Human, Recombinant (short isoform, His)
Insulin Receptor,HHF5,CD220 |
Human | HEK293 Cells |
Insulin Receptor Protein, Human, Recombinant (short isoform, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 106 kDa and the accession number is P06213-2. | |||
TMPJ-00641 |
B7-2 Protein, Rhesus macaque, Recombinant (His)
Activation B7-2 antigen,T-lymphocyte activation antigen CD86... |
Rhesus | HEK293 Cells |
B7-2 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 40-90 KDa and the accession number is H9ZFI8. | |||
TMPJ-00978 |
PIP4K2A Protein, Human, Recombinant (His)
Diphosphoinositide kinase 2-α,PtdIns(5)P-4-kinase isofor... |
Human | HEK293 Cells |
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the... | |||
TMPH-02955 |
TNNI2 Protein, Mouse, Recombinant (His & Myc)
Tnni2,Troponin I, fast skeletal muscle,Troponin I, fast-twit... |
Mouse | E. coli |
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TNNI2 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.2 kDa and the accession number is P13412. | |||
TMPJ-00632 |
B7-2 Protein, Cynomolgus, Recombinant (hFc)
T-lymphocyte activation antigen CD86 isoform 1,Acti... |
Cynomolgus | HEK293 Cells |
B7-2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 70-100 KDa and the accession number is G7NXR4. | |||
TMPY-06581 |
B7-H3 Protein, Human, Recombinant (isoform 2, His)
CD276 molecule,B7H3,B7RP-2,4Ig-B7-H3,B7-H3 |
Human | HEK293 Cells |
B7-H3 Protein, Human, Recombinant (isoform 2, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.52 kDa and the accession number is Q5ZPR3-2. | |||
TMPY-06549 |
EGFR Protein, Human, Recombinant (Isoform vIII, aa 1-378, His)
ERBB,epidermal growth factor receptor,HER1,mENA,ERBB1,PIG61,... |
Human | HEK293 Cells |
EGFR Protein, Human, Recombinant (Isoform vIII, aa 1-378, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.09 kDa and the accession number is NP_001333870.1. | |||
TMPY-06593 |
EGFR Protein, Human, Recombinant (Isoform vIII, His & Avi), Biotinylated
PIG61,ERBB1,ERBB,NISBD2,epidermal growth factor receptor,HER... |
Human | HEK293 Cells |
EGFR Protein, Human, Recombinant (Isoform vIII, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 41.90 kDa and the accession number is NP_001333870.1. | |||
TMPH-01730 |
MYBPC3 Protein, Human, Recombinant (His & SUMO)
C-protein, cardiac muscle isoform,Myosin-binding pr... |
Human | E. coli |
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. MYBPC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 50.8 kDa and the accession number is Q14896. | |||
TMPK-00828 |
Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc)
PEMT,Episialin,Mucin1,PUM,KL-6,MUC-1,Mucin-1,H23AG,PEM,CA 15... |
Human | HEK293 Cells |
MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers. | |||
TMPH-02956 |
TNNI1 Protein, Mouse, Recombinant (Flag & His & Myc)
Troponin I, slow skeletal muscle,Tnni1,Troponin I, slow-twit... |
Mouse | E. coli |
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TNNI1 Protein, Mouse, Recombinant (Flag & His & Myc) is expressed in E. coli expression system with N-10xHis-Flag and C-Myc tag. The predicted molecular weight is 29.6 kDa and the accession number is Q9WUZ5. | |||
TMPH-00118 |
Arachin Arah3 isoform Protein, Arachis hypogaea, Recombinant (His)
|
Arachis hypogaea | E. coli |
N/A. Arachin Arah3 isoform Protein, Arachis hypogaea, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 62.5 kDa and the accession number is B5TYU1. | |||
TMPH-01728 |
Myosin-6/MYH6 Protein, Human, Recombinant (E. coli, His)
Myosin-6,MYH6,Myosin heavy chain, cardiac muscle alpha i... |
Human | E. coli |
Muscle contraction. Myosin-6/MYH6 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 80.8 kDa and the accession number is P13533. | |||
TMPH-02057 |
MAT2A Protein, Human, Recombinant (His)
Methionine adenosyltransferase II,S-adenosylmethionine synth... |
Human | P. pastoris (Yeast) |
MAT2A Protein, Human, Recombinant (His) is expressed in Yeast. | |||
TMPH-02096 |
PPP2CA Protein, Human, Recombinant (His & Myc)
Serine/threonine-protein phosphatase 2A catalytic subunit al... |
Human | E. coli |
PPP2CA Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPK-00215 |
uPAR/PLAUR isoform 1 Protein, Mouse, Recombinant (His & Avi)
CD87,UPAR,PLAUR,MO3,U-PAR |
Mouse | HEK293 Cells |
The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasminogen.Regulation of the activity of u-PA is also mediated by u-PAR. uPAR/PLAUR isoform 1 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 32.92 kDa and the accession number is P35456-1. | |||
TMPH-00840 |
MAT2A Protein, Human, Recombinant (E. coli, His)
Methionine adenosyltransferase II,MAT2A,S-adenosylmethionine... |
Human | E. coli |
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. MAT2A Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 44.8 kDa and the accession number is P31153. | |||
TMPY-05211 |
EGFR Protein, Human, Recombinant (Isoform vIII, aa 1-375, His)
NISBD2,PIG61,ERBB,mENA,epidermal growth factor receptor,HER1... |
Human | Baculovirus Insect Cells |
EGFR Protein, Human, Recombinant (Isoform vIII, aa 1-375, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 39.3 kDa and the accession number is NP_001333870.1. | |||
TMPH-02470 |
PDK3 Protein, Mouse, Recombinant (His)
Pdk3,[Pyruvate dehydrogenase (acetyl-transferring)] kinase i... |
Mouse | E. coli |
PDK3 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 30.3 kDa and the accession number is Q922H2. | |||
TMPH-02469 |
PDK1 Protein, Mouse, Recombinant (His)
Pdk1,Pyruvate dehydrogenase kinase isoform 1,[Pyruv... |
Mouse | Baculovirus Insect Cells |
PDK1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 48.7 kDa and the accession number is Q8BFP9. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T69758 |
Flutamide-d7
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Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide by GC- or LC-MS. Flutamide is an androgen receptor antagonist and prodrug form of 2-hydroxy flutamide. Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50 values of 98.8 and 81.8 µM, respectively. Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft mo... | |||
T71326 |
1,3,7-Trimethyluric Acid-d9
|
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1,3,7-Trimethyluric acid-d9 is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine. It is formed from caffeine by the cytochrome P450 isoform CYP3A4. 1,3,7-Trimethyluric acid scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes. | |||
T71327 |
Paraxanthine-d6
|
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Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist. In vivo, paraxanthine increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agoni... | |||
T70313 |
Indoxyl Sulfate-d5 potassium salt
|
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Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ... |