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Targets Recommended: Adrenergic Receptor

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抑制剂 & 化合物

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化合物库

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Cat. No.	Product Name
L2910	抗氧化化合物库		1314 compounds
	氧化应激（Oxidative Stress，OS）是指体内氧化与抗氧化作用失衡的一种状态。氧化应激导致活性氧（ROS）大量积累，氧化程度超出抗氧化物的清除能力，从而引起氧化损伤，氧化应激损伤是许多疾病发生的基础，不同程度的氧化应激造成的细胞效应与心脑血管疾病、神经退行性病变、炎症和肿瘤密切相关。抗氧化剂是一类能够对抗氧化应激，降低氧化损伤的一类化合物。 TargetMol 抗氧化化合物库是1314 种对氧化应激具有抑制作用的小分子特有集合，是研究氧化应激的有用工具，可以用于高通量筛选和高内涵筛选。

化合物库

抗氧化化合物库

Cat.No: L2910

Compounds: 1314

Cat. No.	Product Name	Target	Signaling Pathways
T2320	Indacaterol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Indacaterol 是一种超长效β-肾上腺素受体激动剂。
T15108	DG-041	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	DG-041 是高亲和力，选择性的，有效的 EP3受体拮抗剂，在结合和 FLIPR 试验中，IC50分别为 4.6 nM 和 8.1 nM。DG-041通过抑制 PGE2促进血小板聚集。DG-041具有血脑屏障渗透性。
T4330	CaCCinh-A01	Chloride channel	Membrane transporter/Ion channel
	CaCCinh-A01 是钙激活氯离子通道和TMEM16A 抑制剂，IC50值分别为 10 和 2.1 μM。
T15418	GS-6201 CVT-6883	Adenosine Receptor	GPCR/G Protein; Neuroscience
	GS-6201 (CVT-6883) 是选择性腺苷 A2B 受体拮抗剂。它对人腺苷 A2B 受体具有高亲和力和选择性 (Ki=22 nM)。它降低了小鼠急性心肌梗死后心脏中 caspase-1 的活性，并减弱了心脏重塑。它减弱了致敏小鼠 NECA，AMP 或变应原诱导的气道反应性。
T5329	Trandolapril	Angiotensin-converting Enzyme (ACE)	Metabolism
	Trandolapril 是 Trandolaprilat 的前体药物。Trandolapril 是一种口服血管紧张素转换酶抑制剂，在高血压和充血性心力衰竭及心肌梗死领域有研究价值。
T1239	Indacaterol maleate 马来酸茚达特罗,QAB149	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Indacaterol maleate (QAB149) 是一种超长效的 β-肾上腺素受体激动剂。
T1479	Isosorbide dinitrate 硝酸异山梨酯,Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate	Others; NO Synthase	Immunology/Inflammation; Others
	Isosorbide dinitrate (Isordil) 是 NO 供体，可预防心肌梗死 (MI) 引起的左室重构及心功能退化。
T7714	Temocapil	Tyrosinase	Proteases/Proteasome
	Temocapil 是一种酪氨酸激酶抑制剂。
T3461	Losartan Carboxylic Acid EXP-3174,E-3174	RAAS	Endocrinology/Hormones
	Losartan Carboxylic Acid (E-3174) 是 Losartan 的活性羧酸代谢产物，是血管紧张素Ⅱ受体 1 型(AT1)拮抗剂。它能够阻断血管紧张素 II 诱导的血管平滑肌细胞反应，可以提高血浆肾素活性，降低平均动脉压。
T3230	NLRP3-IN-2 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺,NLRP3 Inflammasome Inhibitor I	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide) 是一种能够合成格列本脲的中间物，对心肌细胞中NLRP3炎症小体的形成具有抑制作用，在小鼠心肌缺血/再灌注后限制梗死面积，且对代谢无影响。
T6698	Temocapril hydrochloride CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利	RAAS	Endocrinology/Hormones
	Temocapril hydrochloride (CS-622 HCl) 是血管紧张素转化酶 (ACE) 抑制剂。Temocapril HCl 能够用于充血性心力衰竭、急性心肌梗死、高血压、胰岛素抵抗和肾脏疾病的研究。
T11239	Ethacizine hydrochloride NIK-244,Ethacizin,NIK-244 hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	Ethacizine hydrochloride (NIK-244) 具有抗心律失常活性，其作用于心脏活动有关，可用于研究心律失常和心肌梗死。
T11740L	Delcasertib acetate KAI-9803,KID1-1,CS-9803,BMS-875944,Delcasertib acetate（949100-39-4 free base）	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Delcasertib acetate 是一种选择性 δ 蛋白激酶C (δPKC) 抑制剂，可用于研究急性心肌梗死和疼痛。
T31213L	Dazmegrel HCl UK-38,485 HCl,Dazmegrel HCl（76894-77-4 Free base)	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Dazmegrel HCl 是一种血小板血栓素抑制剂，可用于研究心肌梗死和心律失常。
T24115	GSK854 GSK-854,GSK 854	Apoptosis	Apoptosis
	GSK854 是一种具有高选择性和有效性的肌钙蛋白 I 相互作用激酶 (TNNI3K) 抑制剂，抑制小鼠心肌梗死损伤细胞焦亡和细胞凋亡，可限制缺血性心脏的氧化应激、损伤和不良重塑。
TQ0272	Balaglitazone DRF 2593,NN 2344,NN-2344,DRF2593,DRF-2593,NN2344	PPAR	DNA Damage/DNA Repair; Metabolism
	Balaglitazone 是一种选择性的过氧化物酶体增殖物激活受体(PPARγ)部分激动剂，对人 PPARγ 的 EC50 值为 1.351 μM。Balaglitazone 可作为胰岛素治疗的补充剂，可调节血糖，可用于研究心力衰竭和心肌梗塞。
T67941	PDE5-IN-9	Others	Others
	PDE5-IN-9对Phosphodiesterase PDE1c 具有抑制作用，可用来治疗高血压、心力衰竭、心肌梗塞、肾衰竭、哮喘、支气管炎和痴呆。
T84368	Caldaret HCl MCC-135 HCl,Caldaret HCl（192509-24-3 Free base）	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Caldaret HCl 是一种细胞内 Ca2+ 调节剂，可调节肌浆网和细胞膜处的钙稳态，可用于研究急性心肌梗死和心力衰竭。
T32105	Cipepofol HSK3486,HSK-3486,CS-0064163,HSK 3486	Apoptosis; GABA Receptor	Apoptosis; Membrane transporter/Ion channel; Neuroscience
	Cipepofol (HSK3486) 是一种 GABAA 受体激动剂，具有镇静作用，在多种心血管疾病中起保护作用。Cipepofol 可激活 Sirtuin1 (Sirt1)/Nrf2 通路，可诱导心肌细胞凋亡，可用于研究心肌梗塞、心肌缺血再灌注损伤和章鱼壶综合征。
T16286	Nelonemdaz Salfaprodil free base,Neu2000	Antioxidant; NMDAR	Neuroscience; oxidation-reduction
	Nelonemdaz (Neu2000) 是一种 NMDA 受体拮抗剂，具有抗氧化活性和神经保护活性，可用于研究脑梗死再灌注损伤和急性缺血性卒中。
T21821L	REV 5901A REV 5901 HCl,REV 5901A（101910-24-1 Free base）	Leukotriene Receptor; Lipoxygenase; Antibiotic	GPCR/G Protein; Metabolism; Microbiology/Virology
	REV 5901A (REV 5901 HCl) 是一种具有口服活性的白三烯受体 (leukotriene receptor) 拮抗剂，也是一种 5-脂氧合酶 (5-lipoxygenase) 抑制剂，具有抗菌活性，可减弱小鼠体内结肠癌的生长。REV 5901A 可用于研究哮喘和心肌梗死。
T12078	ML334 LH601A	Nrf2	Immunology/Inflammation
	ML334 (LH601A) 是一种可穿过细胞膜且具有有效性的 NRF2 激活剂，抑制 Keap1-NRF2 蛋白质相互作用，抑制心脏成纤维细胞活化和增殖来改善心肌梗死诱导的心脏纤维化。
T68022L	Sulotroban potassium BM 13177 potassium,Sulotroban potassium(72131-33-0 Free base)	PPAR	DNA Damage/DNA Repair; Metabolism
	Sulotroban potassium 是一种小分子血栓素A2受体（TXA2R）拮抗剂，可用于研究心肌梗塞和血栓形成。
T0407	Edaravone 依达拉奉右莰醇,依达拉奉,MCI-186	Apoptosis; MMP; Free radical scavengers	Apoptosis; oxidation-reduction; Proteases/Proteasome
	Edaravone (MCI-186) 是一种新型自由基清除剂，能够抑制大鼠与 MMP-9有关的脑出血。
T83977	BIIB 722 Mesylate	Sodium Channel	Membrane transporter/Ion channel
	BIIB 722 Mesylate 是一种选择性钠氢交换抑制剂，具有心脏保护作用，可用于研究心肌缺血和心肌梗死。
TP2279L	Obestatin (rat) acetate	GHSR	GPCR/G Protein
	Obestatin (rat) acetate 是 G 蛋白偶联受体 39 (GPR39) 的内源性配体。它具有抗炎、抗心肌梗塞和抗氧化特性。它抑制食物摄入，抑制空肠收缩，并减少体重增加。
T0230	Prasugrel LY640315,CS-747,普拉格雷,PCR 4099	P2Y Receptor	GPCR/G Protein; Neuroscience
	Prasugrel (CS-747) 是一种噻吩吡啶和前药，是一种可口服的 P2Y12受体拮抗剂，抑制 ADP 诱导的血小板聚集，用于预防急性冠状动脉综合征患者的血栓形成、不稳定型心绞痛和心肌梗塞，以及接受经皮冠状动脉介入治疗的患者。
T39115	ABR-238901	TLR	Immunology/Inflammation
	ABR-238901是一种可口服的、有作用的 S100A8/A9阻滞剂，对 S100A8/A9与其受体 RAGE(晚期糖基化终产物受体)和TLR4 (toll 样受体4)的相互作用具有抑制作用。ABR-238901具有作为治疗心肌梗死(MI)化合物的潜力。
T77611	DAPK-IN-2 WAY-380496	DAPK	Apoptosis
	DAPK-IN-2 (WAY-380496) 是一种 DAPK 抑制剂。 DAPK-IN-2 具有潜在的抗癌活性，可调节细胞发生自噬反应，可用于研究脑梗死和缺血性疾病。
T31206	Darexaban YM 150,Darexaban, Tanexaban,YM150	Factor Xa	Metabolism
	Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂，IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。
T39442	AM-8123	Apelin receptor	GPCR/G Protein
	AM-8123 是一种可口服的非肽 APJ 激动剂。AM-8123 可减少胶原蛋白负荷并改善心脏功能。AM-8123 可改善大鼠心肌梗死，可用于研究心力衰竭等心血管疾病。
T36569	KR-32568	Sodium Channel	Membrane transporter/Ion channel
	KR-32568是一种钠/氢交换器1（NHE-1）抑制剂（IC50：230 nM）。KR-32568具有强大的心脏保护作用。当使用浓度为10μM 时，它能在离体的缺血大鼠心脏模型中恢复心脏收缩功能。KR-32568（0.3mg/kg）在缺血和再灌注损伤的大鼠模型中减少了心肌梗死的大小。
T22323	Enoxaparin sodium	Thrombin	Proteases/Proteasome
	Enoxaparin sodium 是一种低分子量肝素 (LMWH)，已获得美国 FDA 批准，可用于医疗管理的 ST 段心肌梗死 (STEMI) 或 STEMI 及随后的经皮冠状动脉介入治疗 (PCI) 患者。它与抗凝血酶结合并增强其作用，并抑制凝血因子 XIa、IXa、Xa 和 IIa（凝血酶），从而防止血栓形成。
T20656	Verapamil NSC 135784,维拉帕米,NSC-135784,CP-16533-1,(±)-Verapamil	P450; Calcium Channel; P-gp	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Verapamil (CP-16533-1) 是一种非二氢吡啶类钙通道阻滞剂，一种 P-gp 抑制剂，也是一种 CYP3A4 抑制剂，具有口服活性。Verapamil 可以用于治疗高血压、心绞痛、心肌梗塞等。
T24873	TGX-115 TGX 115	PI3K	PI3K/Akt/mTOR signaling
	TGX-115是一种细胞渗透性和有效的PI 3-K 异构体p110β/p110δ抑制剂(对p110β IC50值为 0.13 μM, 对p110δ值为0.63 μM），是一种调节血小板粘附过程的酶，可抑制磷酸肌苷（PI）3-激酶，可用来治疗冠状动脉闭塞、中风、急性冠状动脉综合征、急性心肌梗塞、血管再狭窄、动脉硬化和不稳定心绞痛等心血管疾病。
T0815L	Warfarin sodium	Others	Others
	Warfarin sodium 是一种抗凝血剂，通过抑制维生素 K 依赖性凝血因子的合成起作用。华法林适用于预防和/或治疗静脉血栓形成及其延伸、肺栓塞和房颤栓塞。它还用作预防心肌梗塞后全身性栓塞的辅助剂。华法林也用作杀鼠剂。
T21206	Triphenyltetrazolium bromide AI3-62388	Others	Others
	Triphenyltetrazolium bromide may be used to detect experimental cerebral infarction and biochemical analysis.
T34327	Ridogrel R-70416,R 68070,R-68070,R70416,R 70416,R68070	Others	Others
	Lidogrell is a dual-acting agent that can be used to prevent systemic thromboembolism and as an adjunct to thrombolytic therapy in acute myocardial infarction.
T28130	Naltiazem RO 236152,RO-236152,RO236152	Others	Others
	Naltiazem, a calcium channel antagonist, is used potentially for the treatment of arrhythmias, hypertension and myocardial infarction.
T27581	Icrocaptide ITF 1697,ITF-1697,ITF1697	Others	Others
	Icrocaptide is used potentially for the treatment of acute myocardial infarction.
T37697	D-GsMTx4 D-GsMTx4
	TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion.
T24746	Zalunfiban RUC4,RUC 4,RUC-4	Others	Others
	RUC-4 is an aIIb 3 antagonist. It is also used for prehospital therapy of myocardial infarction.
T22685	CP-471474 CP 471474	Others	Others
	Broad spectrum MMP inhibitor (IC<sub>50</sub> values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.
T62878	Zalunfiban dihydrochloride	Others	Others
	Zalunfiban (RUC-4) dihydrochloride 是一种选择性的、有效的血小板αIIbβ3拮抗剂，其 IC50 值为 45 nM。Zalunfiban dihydrochloride 能够用于研究心肌梗死。
T73240	PDE5-IN-4	Others	Others
	PDE5-IN-4为磷酸二酯酶5（PDE5）抑制剂，应用于急性心肌梗死及再灌注损伤、消化系统疾病、糖尿病相关损害及肝功能衰竭的研究。
T71800	Metoprolol HCl	Others	Others
	Metoprolol is a selective β1 receptor blocker medication. It is used to treat high blood pressure, chest pain due to poor blood flow to the heart, and a number of conditions involving an abnormally fast heart rate. It is also used to prevent further heart problems after myocardial infarction and to prevent headaches in those with migraines.
T69078	Tiapamil Free Base	Others	Others
	Tiapamil Free Base is a phenylethylamine derivative that acts as a calcium antagonist showing hemodynamic effects in patients with acute myocardial infarction.
T73661	Delcasertib hydrochloride
	Delcasertib (KAI-9803) hydrochloride 是有效，选择性的 δ 蛋白激酶 C (δPKC) 抑制剂。Delcasertib (KAI-9803) hydrochloride 可改善急性心肌梗死动物模型的缺血再灌注损伤。
T11448	GOAT-IN-1	Others	Others
	GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of diabetes, hyperlipidemia, non-alcoholic fatty liver, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral infa
T78026	LQVTDSGLYRCVIYHPP TFA
	LQVTDSGLYRCVIYHPP (LP17) TFA 是一种针对髓系细胞表面的触发受体1 (TREM-1) 的抑制肽。该化合物能有效减缓缺血导致的梗塞及神经元损害，并可穿透血脑屏障，阻断 TREM-1的活性。

化合物

Cat.No: T2320

Target: Adrenergic Receptor

Cat.No: T15108

Target: Prostaglandin Receptor

Cat.No: T4330

Target: Chloride channel

Cat.No: T15418

Synonym: CVT-6883

Target: Adenosine Receptor

Cat.No: T5329

Target: Angiotensin-converting Enzyme (ACE)

Indacaterol maleate

Cat.No: T1239

Synonym: 马来酸茚达特罗,QAB149

Target: Adrenergic Receptor

Isosorbide dinitrate

Cat.No: T1479

Synonym: 硝酸异山梨酯,Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate

Target: Others, NO Synthase

Cat.No: T7714

Target: Tyrosinase

Losartan Carboxylic Acid

Cat.No: T3461

Synonym: EXP-3174,E-3174

Target: RAAS

Cat.No: T3230

Synonym: 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺,NLRP3 Inflammasome Inhibitor I

Target: NOD-like Receptor (NLR), NOD

Temocapril hydrochloride

Cat.No: T6698

Synonym: CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利

Target: RAAS

Ethacizine hydrochloride

Cat.No: T11239

Synonym: NIK-244,Ethacizin,NIK-244 hydrochloride

Target: Sodium Channel

Delcasertib acetate

Cat.No: T11740L

Synonym: KAI-9803,KID1-1,CS-9803,BMS-875944,Delcasertib acetate（949100-39-4 free base）

Target: PKC

Cat.No: T31213L

Synonym: UK-38,485 HCl,Dazmegrel HCl（76894-77-4 Free base)

Target: Prostaglandin Receptor

Cat.No: T24115

Synonym: GSK-854,GSK 854

Target: Apoptosis

Cat.No: TQ0272

Synonym: DRF 2593,NN 2344,NN-2344,DRF2593,DRF-2593,NN2344

Target: PPAR

Cat.No: T67941

Target: Others

Cat.No: T84368

Synonym: MCC-135 HCl,Caldaret HCl（192509-24-3 Free base）

Target: Calcium Channel

Cat.No: T32105

Synonym: HSK3486,HSK-3486,CS-0064163,HSK 3486

Target: Apoptosis, GABA Receptor

Cat.No: T16286

Synonym: Salfaprodil free base,Neu2000

Target: Antioxidant, NMDAR

Cat.No: T21821L

Synonym: REV 5901 HCl,REV 5901A（101910-24-1 Free base）

Target: Leukotriene Receptor, Lipoxygenase, Antibiotic

Cat.No: T12078

Synonym: LH601A

Target: Nrf2

Sulotroban potassium

Cat.No: T68022L

Synonym: BM 13177 potassium,Sulotroban potassium(72131-33-0 Free base)

Target: PPAR

Cat.No: T0407

Synonym: 依达拉奉右莰醇,依达拉奉,MCI-186

Target: Apoptosis, MMP, Free radical scavengers

BIIB 722 Mesylate

Cat.No: T83977

Target: Sodium Channel

Obestatin (rat) acetate

Cat.No: TP2279L

Target: GHSR

Cat.No: T0230

Synonym: LY640315,CS-747,普拉格雷,PCR 4099

Target: P2Y Receptor

Cat.No: T39115

Target: TLR

Cat.No: T77611

Synonym: WAY-380496

Target: DAPK

Cat.No: T31206

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

Cat.No: T39442

Target: Apelin receptor

Cat.No: T36569

Target: Sodium Channel

Enoxaparin sodium

Cat.No: T22323

Target: Thrombin

Cat.No: T20656

Synonym: NSC 135784,维拉帕米,NSC-135784,CP-16533-1,(±)-Verapamil

Target: P450, Calcium Channel, P-gp

Cat.No: T24873

Synonym: TGX 115

Target: PI3K

Warfarin sodium

Cat.No: T0815L

Target: Others

Triphenyltetrazolium bromide

Cat.No: T21206

Synonym: AI3-62388

Target: Others

Cat.No: T34327

Synonym: R-70416,R 68070,R-68070,R70416,R 70416,R68070

Target: Others

Cat.No: T28130

Synonym: RO 236152,RO-236152,RO236152

Target: Others

Cat.No: T27581

Synonym: ITF 1697,ITF-1697,ITF1697

Target: Others

Cat.No: T37697

Synonym: D-GsMTx4

Cat.No: T24746

Synonym: RUC4,RUC 4,RUC-4

Target: Others

Cat.No: T22685

Synonym: CP 471474

Target: Others

Zalunfiban dihydrochloride

Cat.No: T62878

Target: Others

Cat.No: T73240

Target: Others

Cat.No: T71800

Target: Others

Tiapamil Free Base

Cat.No: T69078

Target: Others

Delcasertib hydrochloride

Cat.No: T73661

Cat.No: T11448

Target: Others

LQVTDSGLYRCVIYHPP TFA

Cat.No: T78026

Cat. No.	Product Name	Target	Signaling Pathways
T2893	Muscone 3-Methylcyclopentadecanone,Methylexaltone,麝香酮	MMP; TNF; NF-κB; NOD-like Receptor (NLR); P-gp; Interleukin	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; NF-κB; Proteases/Proteasome
	Muscone (3-Methylcyclopentadecanone) 是中药麝香的一种主要活性单体。它抑制NF-κB 和NLRP3炎性小体的活化，显著降低炎性细胞因子水平，并最终改善心脏功能和存活率。
T3S0289	Araloside X	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane peroxidation induced by oxygen free radi

天然产物

Cat.No: T2893

Synonym: 3-Methylcyclopentadecanone,Methylexaltone,麝香酮

Target: MMP, TNF, NF-κB, NOD-like Receptor (NLR), P-gp, Interleukin

Cat.No: T3S0289

Target: Calcium Channel

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00545	Dermcidin Protein, Human, Recombinant (hFc) AIDD,PIF,HCAP,dermcidin,DCD-1,DSEP	Human	HEK293 Cells
	Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely diagnoses. Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. And the role of DCD in ischemic heart disease has drawn increasing attention in particular its relationship with insulin secretion and glycemic control, nitric oxide (NO) synthesis ...
TMPY-00369	LY6D Protein, Human, Recombinant (mFc) E48,lymphocyte antigen 6 complex, locus D,Ly-6D	Human	HEK293 Cells
	LY6D (Lymphocyte Antigen 6 Family Member D) is a Protein Coding gene. It may act as a specification marker at the earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. The expression of LY6D is induced in MCF10A cells by X-ray irradiation. The induction of LY6D expression is triggered through a pathway regulated by ATM, CHK2, and p53. This method is a new Ab-directed proteomic strategy for the analysis of membrane protein...
TMPK-01229	IL-19 Protein, Human, Recombinant (hFc) NG.1,IL-10C,Interleukin-19,白介素,白细胞介素,MDA1,IL-19,ZMDA1	Human	HEK293 Cells
	Interleukin-19 (IL-19) has been shown to be involved in coronary artery diseases and atherosclerosis, while its expression in myocardial infarction is poorly understood. In this study, the dynamic increase in circulating IL-19 in acute ST-segment elevation myocardial infarction (STEMI) patients was detected.IL-19 is correlated with the severity of acute myocardial infarction, which may be a new idea for the clinical treatment of myocardial infarction.
TMPJ-00753	Myoglobin Protein, Human, Recombinant (His) MGC13548,PVALB,MB,Myoglobin	Human	E. coli
	Myoglobin(MB) is a cytoplasmic protein expressed in myocytes of the heart and skeletal muscle that reversibly binds oxygen. It belongs to the globin family. Functions of myoglobin include oxygen storage and transport, as well as scavenging of NO and reactive oxygen species. MB serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Myoglobin also serves as a sensitive marker for muscle injury resulting from cardiac infarction. Surprisingly, mice in which myogl...
TMPY-03756	BBOX1 Protein, Human, Recombinant (His & GST) butyrobetaine (γ), 2-oxoglutarate dioxygenase (γ-butyrobetai...	Human	Baculovirus Insect Cells
	BBOX1, also known as gamma-BBH, belongs to thegamma-BBH/TMLD family. It is highly expressed in kidney and moderately expressed in liver. BBOX1 catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. BBOX1 is an inhibition target for mildronate which can be used to treatanginaandmyocardial infarctio...
TMPY-01481	FLAP Protein, Human, Recombinant (His) FLAP,arachidonate 5-lipoxygenase-activating protein	Human	Baculovirus Insect Cells
	Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP), also known as FLAP, belongs to the MAPEG family. ALOX5AP/FLAP is an essential partner of 5-LO for this process. The FLAP (ALOX5AP) gene has been linked to risk for myocardial infarction, stroke and restenosis, reigniting pharmaceutical interest in this target. It had been found that ALOX5AP/FLAP is a key enzyme in leukotriene formation, in both human pulmonary microvascular endothelial cells and a transformed human brain endothelial cell ...
TMPJ-00091	G-CSF Protein, Mouse, Recombinant (His) Csf3,G-CSF,Granulocyte colony-stimulating factor,集落刺激因子	Mouse	HEK293 Cells
	Granulocyte colony-stimulating factor (G-CSF) is a growth factor and an essential cytokine which belongs to the IL-6 superfamily. Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. G-CSF binding to its receptor G-CSF-R which belongs to the cytokine receptor type I family depends on the interaction of ...
TMPJ-00785	FABP3 Protein, Human, Recombinant (His) H-FABP,FABP11,Fatty Acid-Binding Protein Heart,MDGIMuscle Fa...	Human	E. coli
	Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, FABP3 is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-types. They form 14-15 kDa proteins and are thought to p...
TMPJ-00402	CD117 Protein, Human, Recombinant (hFc) KIT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog...	Human	HEK293 Cells
	C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing sti...
TMPY-04387	AKT2 Protein, Human, Recombinant (His & GST) RAC-β,RAC-BETA,HIHGHH,PKBBETA,PKBβ,PRKBB,PKBB,v-akt murine t...	Human	Baculovirus Insect Cells
	AKT (AK mouse plus Transforming or Thymoma) is a frequent oncogene expressed in most tissues which includes three isoforms AKT1, AKT2, and AKT3. Hyperactivation of AKT signaling is a central key in many human cancer progressions, through modulating angiogenesis, tumor growth, and cell migration, invasion, metastasis, and chemoresistance. Among all three isoforms, AKT2 is most related to cancer cell invasion, metastasis, and survival. Amplification and overexpression of AKT2 have been shown in ma...
TMPJ-00952	SDF-1/CXCL12 Protein, Mouse, Recombinant Sdf1,C-X-C motif chemokine 12,Thymic lymphoma cell-stimulati...	Mouse	E. coli
	Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, and lymphoid organs. Cxcl12 activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scaven...

重组蛋白

Dermcidin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00545

Species: Human

Expression System: HEK293 Cells

LY6D Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00369

Species: Human

Expression System: HEK293 Cells

IL-19 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01229

Species: Human

Expression System: HEK293 Cells

Myoglobin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00753

Species: Human

Expression System: E. coli

BBOX1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03756

Species: Human

Expression System: Baculovirus Insect Cells

FLAP Protein, Human, Recombinant (His)

Cat.No: TMPY-01481

Species: Human

Expression System: Baculovirus Insect Cells

G-CSF Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00091

Species: Mouse

Expression System: HEK293 Cells

FABP3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00785

Species: Human

Expression System: E. coli

CD117 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00402

Species: Human

Expression System: HEK293 Cells

AKT2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04387

Species: Human

Expression System: Baculovirus Insect Cells

SDF-1/CXCL12 Protein, Mouse, Recombinant

Cat.No: TMPJ-00952

Species: Mouse

Expression System: E. coli

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