h-8

H-8 hydrochloride 是一种具有可逆性和 ATP 竞争性的 PKA 抑制剂。可用研究代谢疾病。

H8-A5, a HDAC8 inhibitor, shows antiproliferation activity in MDA-MB-231 cancer cells.

H-89 是一种具有选择性和高效性的蛋白激酶 A 抑制剂（IC50：48 nM），是一种候选的心脏保护剂，可诱导大鼠的空间学习障碍，可用于研究心肌梗死。

H-89 dihydrochloride (5-Isoquinolinesulfonamide) 是一种选择性 cAMP 依赖性蛋白激酶A(PKA) 抑制剂，IC50值为 48 nM。也可轻微抑制 PKG、PKC 和酪蛋白激酶活性。

ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.

BPH-830 is a bioactive chemical.

IMB-YH-8 is an inhibitor of protein kinase B (PknB), inhibiting PknB auto-phosphorylation and the phosphorylation of GarA by PknB in a dose-dependent manner.

H-87 is a protein kinase inhibitor and vasodilator.

AJH-836为Munc13-1及PKCε α激活剂（Kd：4.5 nM PKCα），促进Munc13-1由细胞质转位至质膜，并可应用于神经退行性疾病研究。

DH-8P-DB 是一种抗癌候选化合物，对结肠癌细胞具有细胞毒性。

p-Menth-8-ene-1,2-diol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4729，CAS号为 57457-97-3。

(±)-Prenalterol (H 80 62) 是一种新的心脏选择性正性肌力化合物，是β-2-和β-1-肾上腺素受体的激动剂，可用于研究慢性充血性心力衰竭。

IDH889 是可口服有效的，脑渗透性的，变构和突变特异性的异柠檬酸脱氢酶抑制剂，对 IDH1 R132* 突变型具有高效选择性。它高效抑制细胞内 2-HG 水平，IC50为 0.014 μM。

LH846 是一种CKIδ的选择性抑制剂，IC50值为 290 nM。它对 CKIα 和 CKIε 的IC50值分别为 2.5 μM 和 1.3 μM。

AH 8532 是一种阿片类药化合物，具有镇痛效果，并能够抑制苯醌诱导的小鼠扭体反应，其口服 ED50 值为 16 mg kg。

AH 8529 是一种口服活性阿片类化合物，具有镇痛作用。

BtGH84 Activator I is a BtGH84 activator. It is the small molecule activator of a glycoside hydrolase.

CH 80 is a bio-active chemical.

Pyridinium, 1,1'-(thiodimethylene)bis(4-formyl-, dichloride, dioxime is a bioactive chemical.

Omiloxetine was a selective serotonin reuptake inhibitor drug candidate that underwent preclinical development by the Spanish pharmaceutical company, Ferrer Internacional, until 2005, when it was abandoned.

PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respectively. PF-05139962 has great selectivity against other receptors and kinases. No genotoxicity was observed on this compound and no more than 25% inhibiton was observed for major CYP enzymes (3A4, 1A2, 2C9, 2D6) at 3 uM. This compound has LE = 0.35 and LipE up to 6.8 which is in a very desirable range for a kinase inhibitor.

BI-1388 is a highly potent inhibitor of HCV NS3 protease activity, inhibiting viral replication for various HCV genotypes and for resistant mutants D168V and R155K.

ZH8667为微量胺相关受体1(TAAR1)-Gs激动剂，适用于精神分裂症研究领域。

ZH8659是一种对微量胺相关受体1(TAAR1)–Gq具有激动作用的化合物，常用于精神分裂症研究领域。