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Search Results for " glioblastoma "

Targets Recommended: JNK

116

抑制剂 & 化合物

7

天然产物

12

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T7008	Vacquinol-1 Vacquinol 1	JNK	MAPK
	Vacquinol-1 能够激活 MAPK 通路，是MKK4特异性激活剂。它可以诱导肝细胞癌细胞凋亡，在多形性胶质母细胞瘤小鼠模型中特异性诱导人胶质母细胞瘤细胞死亡、减缓肿瘤进展并延长生存期。
T10140	4-Diethylaminobenzaldehyde	Dehydrogenase	Metabolism
	4-Diethylaminobenzaldehyde 是醛脱氢酶(ALDHs)的可逆抑制剂，对 ALDH1 的 Ki 为 4 nM，具有较强的抗雄激素作用，IC50为1.71 μM。
T9575	MRTX9768	Histone Methyltransferase	Chromatin/Epigenetic
	MRTX-9768 是一种有效的、选择性的、具有口服活性的 PRMT5-MTA 复合体抑制剂，可选择性靶向 MTAP/CDKN2A 缺失的肿瘤。
T8961	GW280264X Carbamic acid	MMP	Proteases/Proteasome
	GW280264X (Carbamic acid) 是一种 ADAM10/TACE (ADAM17)金属蛋白酶抑制剂。它有效阻断 TACE (ADAM17)和 ADAM10的 IC50分别为 8.0 nM 和 11.5 nM。其中ADAM10/17 能够调节胶质母细胞瘤起始细胞的免疫原性。
T14214	AMG 511	PI3K	PI3K/Akt/mTOR signaling
	AMG 511 是一种高效的、口服有效的 I 类 pan-PI3K 抑制剂，对 PI3Kα, β, δ 和 γ 作用的 Ki 值分别为 4 nM, 6 nM, 2 nM 和 1 nM。它它显著抑制了 PI3K 信号，减少 p-Akt (Ser473)。它在小鼠胶质母细胞瘤移植瘤模型中具有抗肿瘤作用。
T8657	KYP-2047	Others	Others
	KYP-2047 是一种非常有效的选择性脯氨酰寡肽酶 (POP) 抑制剂。
T8421	TED-347	YAP	Stem Cells
	TED-347 是不可逆的、共价的 YAP-TEAD 蛋白质-蛋白质相互作用变构抑制剂，对 TEAD4•Yap1 蛋白质-蛋白质相互作用的 EC50为 5.9 μM。它与 TEAD4 中央口袋内的 Cys-367 特异性共价结合(Ki:10.3 μM)。它可以抑制 TEAD 的转录活性，并且具有抗肿瘤作用。
T22318	Taletrectinib DS-6051b,AB-106	Trk receptor; ROS; ROS Kinase	Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Taletrectinib (AB-106) 是具有口服活力的、选择性的 ROS1/NTRK 抑制剂。它对重组 ROS1、NTRK1、NTRK2 和 NTRK3 有较强的抑制作用，IC50值分别为 0.207、0.622、2.28 和 0.98 nM。它还抑制 ROS1 G2032R 和其他抗 Crizotinib 的 ROS1 突变体。
T8545	FEN1-IN-4 FEN1 Inhibitor C2	Others	Others
	FEN1-IN-4 (FEN1 Inhibitor C2) 是人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂。
T5622	BAY-218 AHR antagonist 1	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	BAY-218 (AHR antagonist 1) 是一种芳基烃受体(AHR)拮抗剂，在人细胞系中的IC50值为 39.9 nM。
T0440	Oxcarbazepine GP 47680,奥卡西平	Apoptosis; Sodium Channel	Apoptosis; Membrane transporter/Ion channel
	Oxcarbazepine (GP 47680) 是一种钠通道阻滞剂，有效抑制胶质母细胞瘤细胞生长并诱导胶质母细胞瘤细胞凋亡或 G2/M 停滞，具有抗癌和抗惊厥作用。
T0192	Levetiracetam 左乙拉西坦,UCB L059,SIB-S1	DNA Methyltransferase; Others; Calcium Channel	Chromatin/Epigenetic; Membrane transporter/Ion channel; Metabolism; Others
	Levetiracetam (SIB-S1) 是一种化学增敏剂，增强 Temozolomide 对胶质母细胞瘤干细胞增殖和凋亡的影响。它调节 HDAC 水平，最终使 MGMT 沉默从而提高 Temozolomide 的有效性。它是一种抗癫痫药，可结合突触小泡蛋白 SV2A。
T8333	Aurintricarboxylic acid ATA,NSC-4056,NSC4056,金精三羧酸,NSC 4056	Apoptosis; P2X Receptor; Influenza Virus; Topoisomerase	Apoptosis; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Aurintricarboxylic acid (NSC-4056) 是高效的αβ-亚甲基-ATP 敏感选择性P2X1Rs 和P2X3Rs 变构拮抗剂。它是核糖核酸酶和拓扑异构酶 II 的有效抑制剂，可阻止核酸与酶结合。
T6303L	CCT128930 hydrochloride CCT128930 hydrochloride(885499-61-6 Free base)	Apoptosis; Akt; PKA; mTOR; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	CCT128930 hydrochloride (CCT128930 hydrochloride) 是一种选择性 AKT 抑制剂，具有抗肿瘤活性。它通过靶向 AKT 的 Met282 (PKA-AKT 嵌合体的 Met173)，对 PKA 激酶具有 28 倍的选择性，对 p70S6K 具有 20 倍的选择性。
T6303	CCT128930	Akt; PKA; S6 Kinase; Autophagy	Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	CCT128930 是一种 ATP 竞争性，选择性 AKT 抑制剂。它通过靶向 AKT 的 Met282 (PKA-AKT 嵌合体的 Met173)，对 PKA 激酶具有 28 倍的选择性，对 p70S6K 具有 20 倍的选择性，具有抗肿瘤活性。
T41151L	K34c hydrochloride K34c hydrochloride(939769-93-4 Free base)	Integrin	Cytoskeletal Signaling
	K34c hydrochloride 是一种α5β1 integrin 拮抗剂，可用于胶质母细胞瘤研究。
T9411	KX2-361	Others; Microtubule Associated; Src	Angiogenesis; Cytoskeletal Signaling; Others; Tyrosine Kinase/Adaptors
	KX2-361 是一种口服生物可利用的小分子双 Src/微管蛋白抑制剂，可在小鼠胶质母细胞瘤模型中提供长期存活。
T19807	Dithiazanine iodide Delvex,Telmide,Vercidon,Abminthic,Netocyd,NSC 221154	Others	Others
	Dithiazanine iodide (Netocyd) 是一种苯并噻唑。它已被用作抗虫剂。它作为纳米颗粒在治疗胶质母细胞瘤方面也很有效。
T10655	c-Met inhibitor 1 3-[(2-甲基-2H-吲唑-5-基)硫基]-6-(1-甲基-1H-吡唑-4-基)-1,2,4-三唑并[4,3-B]哒嗪	c-Met/HGFR	Tyrosine Kinase/Adaptors
	c-Met inhibitor 1 是一种 c-Met 受体信号通路抑制剂，可用于癌症的治疗，包括胶质母细胞瘤、胃癌和胰腺癌。
T26892	Braco-19	Antiviral; Telomerase	DNA Damage/DNA Repair; Immunology/Inflammation
	Braco-19 是一种端粒酶/端粒抑制剂，也是一种 HAdV 病毒复制抑制剂，具有抗病毒活性，可减少脂肪细胞脂质空泡化，抑制人胶质母细胞瘤细胞中的增殖并降低端粒酶活性。
T84285	MM0299	Others	Others
	MM0299 具有脑渗透性，具有抗胶质母细胞瘤活性，抑制羊毛甾醇合酶（LSS），诱导原位GBM肿瘤中EPC的产生。
T15373	Gboxin	ATPase; Mitochondrial Metabolism	Membrane transporter/Ion channel; Metabolism
	Gboxin 是一种氧化磷酸化抑制剂，可靶向抑制胶质母细胞瘤生长，还抑制 F0F1 ATP 合成，具有抗肿瘤活性。
T40222	FTO-IN-3	Others	Others
	FTO-IN-3 是一种 FTO 抑制剂，可以抑制胶质母细胞瘤干细胞自我更新。
T5335	S-Gboxin	Others	Others
	S-Gboxin 是 Gboxin 的功能类似物，能够抑制小鼠和人胶质母细胞瘤的生长(IC50:470 nM)。它具有抗肿瘤作用。
T77706	4-Borono-L-phenylalanine (s)-2-amino-3-(4-boronophenyl)propanoic acid,L-p-Boronophenylalanine	Others	Others
	4-Borono-L-phenylalanine 具有抗肿瘤活性，可用于硼中子俘获疗法治疗黑色素瘤和多形性胶质母细胞瘤的临床试验。
T60077	SCP1-IN-1	Others	Others
	SCP1-IN-1 (compound SH T-62) 是SCP1的强效选择性共价抑制剂。SCP1-IN-1 促进 REST 降解并降低转录活性。在一些胶质母细胞瘤细胞中，高水平的 REST 蛋白驱动肿瘤生长。SCP1-IN-1 具有研究由 REST 转录活动驱动生长的胶质母细胞瘤的潜力。
T16754	RIPGBM	Apoptosis	Apoptosis
	RIPGBM 是一种选择性诱导多形性胶质母细胞瘤癌症的细胞凋亡诱导剂，EC50≤500 nM。
T5017	Nimustine Hydrochloride 盐酸尼莫司汀,Nidran hydrochloride	Apoptosis; Others; DNA Alkylator/Crosslinker; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Nimustine Hydrochloride (Nidran hydrochloride) 是一种 DNA 交联剂和 DNA 烷基化剂，能诱导 DNA 复制损伤和 DNA 双链断裂，抑制DNA 合成，已用于研究胶质母细胞瘤治疗的试验。
T2116	AEE788 NVP-AEE 788	Apoptosis; EGFR; c-Fms; FLT; Bcr-Abl	Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	AEE788 (NVP-AEE 788)是EGFR 和ErbB2的抑制剂，IC50值分别为2和6 nM。它已用于研究癌症、多形性胶质母细胞瘤以及脑和中枢神经系统肿瘤治疗的试验。
T21463	Temozolomide Acid TMZA,3,4-二氢-3-甲基-4-氧代咪唑并[5,1-D]-1,2,3,5-四嗪-8-甲酰胺酸	Others	Others
	Temozolomide Acid (TMZA) 是 temozolomide (TMZ) 的代谢物。TMZ 在体外具有抗癌活性。TMZ 是一种口服烷化剂，用于治疗多形性胶质母细胞瘤 (GBM) 和星形细胞瘤。
T33467	MOMIPP	PI3K	PI3K/Akt/mTOR signaling
	MOMIPP 是一种 PIKfyve 抑制剂，是一种巨胞饮作用的诱导剂，可穿过血脑屏障 (BBB)。
T2365	Pilaralisib SAR245408,XL-147	PI3K	PI3K/Akt/mTOR signaling
	Pilaralisib (XL-147) 是一种有效的、选择性的 I 类PI3Ks 抑制剂，能够抑制 PI3Kα (IC50:39 nM)，PI3Kβ (IC50:383 nM)，PI3Kγ (IC50:23 nM) 和 PI3Kδ (IC50:36 nM)。
T11728	JR-AB2-011	mTOR	PI3K/Akt/mTOR signaling
	JR-AB2-011 是一种选择性 mTORC2抑制剂，IC50值为 0.36 μM。JR-AB2-011 通过阻断 Rictor-mTOR 联合体 (Ki: 0.19 μM) 抑制 mTORC2 活性，并且具有抗多形性胶质母细胞瘤 (GBM) 的活性。
T60102L	Dimethylaminomicheliolide HCl	PKM	Metabolism
	Dimethylaminomicheliolide HCl 具有潜在的抗炎和抗肿瘤活性，通过靶向丙酮酸激酶 2 （PKM2）和重新连接有氧细胞群来抑制胶质母细胞瘤细胞的增殖。
T60039	KSQ-4279 USP1-IN-1	PARP; DUB	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Ubiquitination
	KSQ-4279 (USP1-IN-1)是 USP1 和 PARP 的抑制剂。KSQ-4279 具有抗癌活性，可用于研究非小细胞肺癌、骨肉瘤、卵巢癌、乳腺癌、胶质母细胞瘤、膀胱癌、子宫癌和胰腺癌。
T9089	FTO-IN-1 UUN44923	Others	Others
	UUN44923 是脂肪及肥胖相关酶(FTO) 抑制剂(IC50<1 μM)。其中FTO-IN-1 (UUN44923) 可用于研究癌症。
T61046	Anticancer agent 43	Apoptosis	Apoptosis
	Anticancer agent 43 是一种有效的抗癌剂，通过 caspase 3， PARP1，Bax 蛋白依赖性途径诱导癌细胞凋亡 (apoptosis)。Anticancer agent 43 能够诱导 DNA 损伤，可用于研究大鼠胶质母细胞瘤。
T23016	MRS1220 MRS 1220	Adenosine Receptor	GPCR/G Protein; Neuroscience
	MRS1220 是一种高效、选择性的人 A3 腺苷受体 (hA3AR) 拮抗剂，Ki 为 0.59 nM，可用于中枢神经系统疾病的研究。MRS1220 在体内还减少了胶质母细胞瘤的肿瘤大小和血管形成。
T40221	FTO-IN-2	Others	Others
	FTO-IN-2 is a FTO inhibitor that impairs self-renewal in glioblastoma stem cells.
T11268	FD 12-9 Ac12Az9	Others	Others
	FD 12-9, Anti-glioblastoma activity. is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively.
T78771	Tubulin inhibitor 36	Others	Others
	Tubulin inhibitor 36 (Compound 10) 是新型高效微管蛋白抑制剂，可阻止微管蛋白聚合并诱发细胞凋亡，IC50值为1.5±0.1 μM。该化合物在抗有丝分裂中表现出显著活性，并对胶质母细胞瘤（GBM）细胞线有效，适用于胶质母细胞瘤（GBM）的抗肿瘤研究。
T29028	TZD18 TZD-18,TZD 18	Others	Others
	TZD18, a novel PPAR alpha/gamma dual agonist, inhibits cell growth and induces apoptosis in human glioblastoma T98G cells.
T70890	ML309	Others	Others
	ML309 is a potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells. ML309 is capable of potent and selective inhibition of mutant IDH1 and effectively lowers cell-based production of 2-HG in a U87MG mutant glioblastoma cell line.
T82722	CIDD-0149897	Estrogen Receptor/ERR	Endocrinology/Hormones
	CIDD-0149897为一选择性、能穿越血脑屏障的ERβ激动剂，具有效性。该化合物在胶质母细胞瘤治疗中显示出抗肿瘤活性。
T79412	SHP2-IN-16	Others	Others
	SHP2-IN-16（化合物222）作为SHP2抑制剂，具有1 nM的IC50值，适用于胶质母细胞瘤研究。
T38004	ML-309 (hydrochloride)	Others	Others
	ML-309 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). It reversibly and selective inhibits IDH1R132H over wild-type IDH1 (IC50s = 96 and 36,500 nM, respectively). ML-309 reduces 2-hydroxyglutarate production in U87 MG glioblastoma cells (EC50 = 55 nM).
T83912	HR68 PP21	Others	Others
	HR68是一种抗癌化合物，是过氧化物酶体增殖物激活受体（PPAR）激动剂非诺贝酯的衍生物。它能降低LN-229胶质母细胞瘤细胞的存活率（IC50 = 1.17 µM）。HR68能够穿越血脑屏障，在对替莫唑胺耐药的原位患者衍生的异种移植（PDX）小鼠胶质母细胞瘤模型中发挥作用。
T81162	SHP2-IN-20	Others	Others
	SHP2-IN-20 (compound 193)为SHP2抑制剂，具有3 nM的IC50值，适用于胶质母细胞瘤研究。
T72138	Mitochondrial respiration-IN-2	Others	Others
	Mitochondrial respiration-IN-2 是Virginiamycin M1 的氟衍生物。Mitochondrial respiration-IN-2 可以抑制胶质母细胞瘤干细胞的线粒体翻译。
T27052	CMP3a CMP-3a,CMP 3a	Others	Others
	CMP3a is a NEK2 kinase inhibitor. CMP3a efficiently attenuated GBM growth in a mouse model and exhibited a synergistic effect with radiotherapy. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase E

化合物

Cat.No: T7008

Synonym: Vacquinol 1

Target: JNK

4-Diethylaminobenzaldehyde

Cat.No: T10140

Target: Dehydrogenase

Cat.No: T9575

Target: Histone Methyltransferase

Cat.No: T8961

Synonym: Carbamic acid

Target: MMP

Cat.No: T14214

Target: PI3K

Cat.No: T8657

Target: Others

Cat.No: T8421

Target: YAP

Cat.No: T22318

Synonym: DS-6051b,AB-106

Target: Trk receptor, ROS, ROS Kinase

Cat.No: T8545

Synonym: FEN1 Inhibitor C2

Target: Others

Cat.No: T5622

Synonym: AHR antagonist 1

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T0440

Synonym: GP 47680,奥卡西平

Target: Apoptosis, Sodium Channel

Cat.No: T0192

Synonym: 左乙拉西坦,UCB L059,SIB-S1

Target: DNA Methyltransferase, Others, Calcium Channel

Aurintricarboxylic acid

Cat.No: T8333

Synonym: ATA,NSC-4056,NSC4056,金精三羧酸,NSC 4056

Target: Apoptosis, P2X Receptor, Influenza Virus, Topoisomerase

CCT128930 hydrochloride

Cat.No: T6303L

Synonym: CCT128930 hydrochloride(885499-61-6 Free base)

Target: Apoptosis, Akt, PKA, mTOR, Autophagy

Cat.No: T6303

Target: Akt, PKA, S6 Kinase, Autophagy

K34c hydrochloride

Cat.No: T41151L

Synonym: K34c hydrochloride(939769-93-4 Free base)

Target: Integrin

Cat.No: T9411

Target: Others, Microtubule Associated, Src

Dithiazanine iodide

Cat.No: T19807

Synonym: Delvex,Telmide,Vercidon,Abminthic,Netocyd,NSC 221154

Target: Others

c-Met inhibitor 1

Cat.No: T10655

Synonym: 3-[(2-甲基-2H-吲唑-5-基)硫基]-6-(1-甲基-1H-吡唑-4-基)-1,2,4-三唑并[4,3-B]哒嗪

Target: c-Met/HGFR

Cat.No: T26892

Target: Antiviral, Telomerase

Cat.No: T84285

Target: Others

Cat.No: T15373

Target: ATPase, Mitochondrial Metabolism

Cat.No: T40222

Target: Others

Cat.No: T5335

Target: Others

4-Borono-L-phenylalanine

Cat.No: T77706

Synonym: (s)-2-amino-3-(4-boronophenyl)propanoic acid,L-p-Boronophenylalanine

Target: Others

Cat.No: T60077

Target: Others

Cat.No: T16754

Target: Apoptosis

Nimustine Hydrochloride

Cat.No: T5017

Synonym: 盐酸尼莫司汀,Nidran hydrochloride

Target: Apoptosis, Others, DNA Alkylator/Crosslinker, DNA/RNA Synthesis

Cat.No: T2116

Synonym: NVP-AEE 788

Target: Apoptosis, EGFR, c-Fms, FLT, Bcr-Abl

Temozolomide Acid

Cat.No: T21463

Synonym: TMZA,3,4-二氢-3-甲基-4-氧代咪唑并[5,1-D]-1,2,3,5-四嗪-8-甲酰胺酸

Target: Others

Cat.No: T33467

Target: PI3K

Cat.No: T2365

Synonym: SAR245408,XL-147

Target: PI3K

Cat.No: T11728

Target: mTOR

Dimethylaminomicheliolide HCl

Cat.No: T60102L

Target: PKM

Cat.No: T60039

Synonym: USP1-IN-1

Target: PARP, DUB

Cat.No: T9089

Synonym: UUN44923

Target: Others

Anticancer agent 43

Cat.No: T61046

Target: Apoptosis

Cat.No: T23016

Synonym: MRS 1220

Target: Adenosine Receptor

Cat.No: T40221

Target: Others

Cat.No: T11268

Synonym: Ac12Az9

Target: Others

Tubulin inhibitor 36

Cat.No: T78771

Target: Others

Cat.No: T29028

Synonym: TZD-18,TZD 18

Target: Others

Cat.No: T70890

Target: Others

Cat.No: T82722

Target: Estrogen Receptor/ERR

Cat.No: T79412

Target: Others

ML-309 (hydrochloride)

Cat.No: T38004

Target: Others

Cat.No: T83912

Synonym: PP21

Target: Others

Cat.No: T81162

Target: Others

Mitochondrial respiration-IN-2

Cat.No: T72138

Target: Others

Cat.No: T27052

Synonym: CMP-3a,CMP 3a

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN2080	Pinoresinol 松脂酚，松脂素,(+)-Pinoresinol	Apoptosis; NF-κB; CDK; p53	Apoptosis; Cell Cycle/Checkpoint; NF-κB
	Pinoresinol ((+)-Pinoresinol) 是一种植物来源的木质素，具有抗炎、保肝和杀真菌活性。它导致 CDK 抑制剂 p21(WAF1/Cip1) 在 mRNA 和蛋白质水平上调，抑制 NF-kappaB 和激活蛋白 1 。
T1166	Ellipticine 玫瑰树碱,NSC 71795,Elliptisine	Topoisomerase	DNA Damage/DNA Repair
	Ellipticine (Elliptisine) 是一种有效的抗肿瘤剂，抑制 DNA 拓扑异构酶 II 活性，对白血病、神经母细胞瘤和胶质母细胞瘤有部分活性。
T5646	Cinnamic acid 3-Phenylacrylic acid,β-Phenylacrylic acid,肉桂酸	Endogenous Metabolite	Metabolism
	Cinnamic acid (β-Phenylacrylic acid) 在癌症干预中具有潜在的应用价值，对胶质母细胞瘤，黑色素瘤，前列腺癌，肺癌细胞的IC50=1-4.5 mM。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 属于生物碱类天然产物，可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。
TN1724	Harmalol hydrochloride Harmidol hydrochloride	P450; Antioxidant	Metabolism; oxidation-reduction
	Harmalol hydrochloride (Harmidol hydrochloride) 是一种可从Peganum harmala L.的种子中提取出来的β-咔啉生物碱。Harmalol hydrochloride 是Harmaline 的主要代谢产物，在转录和翻译后水平上显著抑制二恶英介导的 CYP1A1 诱导。Harmalol hydrochloride 在去氧肾上腺素或KCl 预先收缩的分离大鼠胸主动脉制剂中显示出血管松弛活性。 Harmalol hydrochloride 具有抗氧化活性.
TN1832	Kanzonol C	Others; NF-κB; Tyrosinase	NF-κB; Others; Proteases/Proteasome
	Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it shows the inhibition of matrix metalloproteinase (MMP)-2 secretion from brain tumor-derived glioblastoma cells.
TN5369	Dehydroleucodine Dehydroleucodin
	Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulat

天然产物

Cat.No: TN2080

Synonym: 松脂酚，松脂素,(+)-Pinoresinol

Target: Apoptosis, NF-κB, CDK, p53

Cat.No: T1166

Synonym: 玫瑰树碱,NSC 71795,Elliptisine

Target: Topoisomerase

Cat.No: T5646

Synonym: 3-Phenylacrylic acid,β-Phenylacrylic acid,肉桂酸

Target: Endogenous Metabolite

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Harmalol hydrochloride

Cat.No: TN1724

Synonym: Harmidol hydrochloride

Target: P450, Antioxidant

Cat.No: TN1832

Target: Others, NF-κB, Tyrosinase

Dehydroleucodine

Cat.No: TN5369

Synonym: Dehydroleucodin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00261	TGF beta 2 Protein, Mouse/Rat, Recombinant transforming growth factor β-2,BSC-1 cell growth inhibitor,G...	Mouse,Rat	HEK293 Cells
	Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n...
TMPJ-00258	TGF beta 2 Protein, Human, Recombinant Glioblastoma-derived T-cell suppressor factor,TGF-β...	Human	HEK293 Cells
	Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be...
TMPJ-00259	TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated G-TSF,转化生长因子,Cetermin,Transforming growth factor beta-2 prop...	Human	HEK293 Cells
	TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with N-Avi tag. The predicted molecular weight is 10-14 KDa and the accession number is P61812.
TMPY-01442	DMBT1 Protein, Human, Recombinant (His) GP340,deleted in malignant brain tumors 1,muclin	Human	HEK293 Cells
	Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo...
TMPK-00563	EPHB2 Protein, Cynomolgus, Recombinant (His) DRT,Nuk,Sek3,TYRO5,EPHT3,HEK5,EphB2,Qek2,PCBC,EPHT3MGC87492,...	Cynomolgus	HEK293 Cells
	EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated pathologic characteristics of glioblastoma multiforme (GBM) such as invasion and migration. EPHB2 is epigenetically overexpressed in hypoxia, a condition highly prevalent in malignancy. Furthermore, HIF-2α is required for EPHB2 stabilization by hypoxia.
TMPK-00732	WISP1/CCN4 Protein, Mouse, Recombinant (His) ELM-1,WISP1tc,WISP1c,CCN4,WISP-1,WISP1i	Mouse	HEK293 Cells
	The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin α6β1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.
TMPJ-01266	CDH11 Protein, Human, Recombinant (hFc & His) OSF-4,Osteoblast cadherin,CDH11,Cadherin-11	Human	HEK293 Cells
	Cadherin-11, also known as OSF-4, Osteoblast cadherin and CDH11, is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells, may thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in brain. Mature cadherin proteins consists of a large N-terminal extracellular doma...
TMPJ-00546	EFNA1 Protein, Human, Recombinant (hFc) TNFAIP4,LERK1,Tumor Necrosis Factor α-Induced Protein 4,Imme...	Human	HEK293 Cells
	Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the...
TMPJ-01267	CDH11 Protein, Human, Recombinant (His) Cadherin 11 Type 2 OB-Cadherin (Osteoblast) Isoform CRA_c,Ca...	Human	HEK293 Cells
	Cadherin-11 is a type II classical cadherin member of the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells, and thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in the brain. Mature cadherin proteins consists of a large N-terminal extracellular domain, a single membrane-spanning domain, and...
TMPY-04270	GPR133 Protein, Human, Recombinant (His) PGR25,GPR133	Human	HEK293 Cells
	ADGRD1 (Adhesion G Protein-Coupled Receptor D1, also known as GPR133) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. ADGRD1, an orphan member of the adhesion family of G-protein-coupled receptors, is a critical regulator of the response to hypoxia and tumor growth in Glioblastoma (GBM). ADGRD1 represents a novel molecular target in GBM and possibly other malignancies where hypoxia is fundamental to pathogenesis. Variations in the ADGRD1 locus are linked with...
TMPJ-00685	BAI3 Protein, Human, Recombinant (His) BAI3,KIAA0550,Brain-Specific Angiogenesis Inhibitor 3	Human	HEK293 Cells
	Human Brain-Specific Angiogenesis Inhibitor 3 (BAI3) is a 177 kDa seven-span transmembrane (TM) protein, which is thought to be a member of the secretin receptor family. It is synthesized by neurons of the CNS and likely is a negative regulator of angiogenesis. BAI3 is 1498 amino acids in size. It contains three distinct regions: an N-terminal extracellular domain (ECD) (aa25-883), a 7-TM segment, and a C-terminal cytoplasmic region. The ECD contains four antiangiogenic TSP type 1 repeat (aa296-...
TMPY-01710	IkB alpha/NFKBIA Protein, Human, Recombinant (His) IkB α,IKBA,nuclear factor of kappa light polypeptide gene en...	Human	E. coli
	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. Also, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper function...

重组蛋白

TGF beta 2 Protein, Mouse/Rat, Recombinant

Cat.No: TMPJ-00261

Species: Mouse,Rat

Expression System: HEK293 Cells

TGF beta 2 Protein, Human, Recombinant

Cat.No: TMPJ-00258

Species: Human

Expression System: HEK293 Cells

TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated

Cat.No: TMPJ-00259

Species: Human

Expression System: HEK293 Cells

DMBT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01442

Species: Human

Expression System: HEK293 Cells

EPHB2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00563

Species: Cynomolgus

Expression System: HEK293 Cells

WISP1/CCN4 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00732

Species: Mouse

Expression System: HEK293 Cells

CDH11 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-01266

Species: Human

Expression System: HEK293 Cells

EFNA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00546

Species: Human

Expression System: HEK293 Cells

CDH11 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01267

Species: Human

Expression System: HEK293 Cells

GPR133 Protein, Human, Recombinant (His)

Cat.No: TMPY-04270

Species: Human

Expression System: HEK293 Cells

BAI3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00685

Species: Human

Expression System: HEK293 Cells

IkB alpha/NFKBIA Protein, Human, Recombinant (His)

Cat.No: TMPY-01710

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T11067	VX-984 M9831	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用，可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。

同位素标记化合物

Cat.No: T11067

Synonym: M9831

Target: DNA-PK

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