26
5
58
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4546 |
Dinoprost tromethamine salt
Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,地诺前列素氨丁三醇,Prostaglandin F2α THAM |
Apoptosis; Endogenous Metabolite; Prostaglandin Receptor; Autophagy; PROTAC Linker | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; PROTAC |
Dinoprost tromethamine salt (PGF2α THAM) 是一种口服有效的前列腺素 F 受体激动剂。它是在子宫内膜腔上皮和黄体中局部产生的溶酶激素,在分娩过程中起关键作用。 | |||
T4977 |
Sofalcone
索法酮,SU-88 |
Antibacterial; Autophagy | Autophagy; Microbiology/Virology |
Sofalcone (SU-88) 可诱导血红素加氧酶-1在胃肠上皮中的表达,是一种抗胃溃疡剂。 | |||
T4182 |
lavendustin B
薰草菌素B |
Tyrosinase; transporter; HIV Protease | Metabolism; Microbiology/Virology; Proteases/Proteasome |
Lavendustin B 是一种酪氨酸激酶抑制剂,是 HIV-1 整合酶 (IN) 与其同源细胞辅助因子、晶状体上皮衍生生长因子 (LEDGF/p75) 相互作用的抑制剂。 | |||
T25466 |
GS-9191
GS 9191 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
GS-9191是一种DNA 聚合酶α和ß 的强效抑制剂 ,是一种新型核苷类似物9-(2-膦酰甲氧基乙基)鸟嘌呤(PMEG)的原药 ,可渗透皮肤并在上皮层代谢为活性核苷三磷酸类似物。GS-9191具有抗增殖活性,以剂量相关的方式减少乳头瘤的大小。GS-9191可能对治疗HPV 引起的病变有作用。 | |||
TP2253 |
GLP-2(rat)
GLP-2 (rat) |
Others | Others |
intestinal epithelium-specific growth factor | |||
T34710 |
STA 2
ONO 11113,STA-2,STA2 |
Others | Others |
STA 2 is an analogue of TXA2, a thromboxane receptor in the colonic epithelium. | |||
T34566 |
Sch 12223
Sch12223,Sch-12223 |
Others | Others |
SCH 12223 is a unique drug that protects the stomach and intestinal epithelium from harmful irritation. | |||
T68682 |
Piriprost
|
Others | Others |
Piriprost is a leukotriene inhibitor attenuates the smoke-induced increase in alveolar-capillary barrier permeability and decrease in plasminogen activator activity and causes a swelling of type I alveolar epithelium. | |||
T34551 |
SC 32855
SC-32855,SC32855 |
Others | Others |
SC 32855 is a 1,4-benzodiazepine that has been shown to arrest of spermatogenesis and degeneration of the germinal epithelium. | |||
T81341 |
Pyr-Gly
|
||
Pyr-Gly为抑制肽类化合物,能够抑制视网膜色素上皮(RPE)细胞及成纤维细胞的增殖作用。 | |||
TP1157 |
GLP-2(1-33)(human)
GLP-2 (human),Glucagon-like peptide 2 (human) |
||
GLP-2(1-33) (human) is an enteroendocrine hormone which stimulates the growth of the intestinal epithelium. | |||
TP1487 |
Glucagon-Like Peptide (GLP) II, human
|
||
Glucagon-like peptide 2 (GLP-2) is a recently identified intestinal epithelium-specific growth factor that has been shown to reduce the severity of inflammatory disorders of the intestine in rodent models. Currently Glucagon-Like Peptide 2 is used as a po | |||
T69429 |
Y27632 HCl hydrate
|
Others | Others |
Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepatic fibrosis in rats, increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium, affects initial heart myofibrillogenesis in cultured chick blastoderm, promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord... | |||
T76806 | Bezlotoxumab | ||
Bezlotoxumab 是一种针对 C. difficile 毒素 B 的人单克隆抗体。Bezlotoxumab 与 C. difficile 毒素 B 结合,可预防肠上皮损伤和结肠炎。 | |||
T74699 |
Avacincaptad pegol
|
Others | Others |
Avacincaptad pegol 是核酸适配体,作为 C5 补体抑制剂,用以减轻炎症导致的视网膜色素上皮 (RPE) 损伤。该化合物可用于研究 stargardt 黄斑营养不良 (STGD1) 与地理萎缩 (GA)。 | |||
T81720 |
N,N'-Dinitrosopiperazine
1,4-Dinitrosopiperazine,DNP |
Others | Others |
N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) 为已知致癌物,与鼻咽癌发展及其转移关联。该化合物通过影响包括LYRIC在内的多条信号通路,特别是通过蛋白磷酸化作用于丝氨酸568位,发挥作用。 | |||
T78404 |
Pyridinium bisretinoid A2E TFA
A2E TFA |
Apoptosis | Apoptosis |
Pyridinium bisretinoid A2E TFA作为一种荧光团,能从视网膜色素上皮(RPE)的脂褐素中分离得到,是蓝光诱导的细胞凋亡(apoptosis)诱导剂。该化合物具有光活化特性,可介导自噬(autophagy)和活性氧(reactive oxygen species)的产生,常用于视网膜退行性疾病的研究。 | |||
T36714 |
Sucrose octasulfate (potassium salt)
|
Others | Others |
Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. It can bind to exosite II of thrombin (KD = ~1.4 μM) and inhibit its catalytic activity (IC50 = 4.5 μM) and, as such, has been used as a surrogate for heparin. Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by pr... | |||
TP1749 |
IRBP (1-20), human
|
||
IRBP (1-20), human is the 1-20 fragment of interphotoreceptor retinoid binding protein (IRBP).This peptide is a 1 to 20 amino acid fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP is a 140-kDa glycolipoprotein residing in the inter | |||
T38220 |
11-cis Retinol
|
Others | Others |
11-cisRetinol is an isomer of vitamin A . It is formed from vitamin A,viaatrans-retinyl ester intermediate, by the enzyme RPE65 in the retinal pigment epithelium and then converted to 11-cis retinal as part of the visual cycle.1,211-cisRetinol is an agonist of salamander and human red rod opsins expressed in COS cells and an inverse agonist of salamander red cone opsin, as well as human red and green cone opsins expressed in COS cells.3It promotes pigment formation in cone, but not rod, photorec... | |||
T81900 |
LVGRQLEEFL (mouse) (TFA)
|
||
LVGRQLEEFL (mouse) TFA,即G*肽,对应[113,122]apoJ中的第113至122位氨基酸序列,表现出抗炎与抗动脉粥样硬化的特性。该肽能够整合至apoJ模拟物,生成HM-10/10肽,一种新型嵌合高密度脂蛋白模拟肽。HM-10/10肽能够保护视网膜色素上皮(RPE)及光感受器,防止氧化剂引起的细胞死亡。 | |||
T81901 |
LVGRQLEEFL (mouse)
|
||
LVGRQLEEFL(mouse)即G*肽,为[113,122]apoJ中113至122位氨基酸序列。该化合物展现抗炎与抗动脉粥样硬化功能。将LVGRQLEEFL(mouse)整合至apoJ模拟物,可生成HM-10/10肽,此为一种模拟肽及新型嵌合高密度脂蛋白。HM-10/10肽能守护视网膜色素上皮(RPE)及光感受器,防止氧化剂诱导下的细胞死亡。 | |||
T38309 |
LL-37 amide (trifluoroacetate salt)
|
Others | Others |
LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. ... | |||
T83700 |
IRBP (651-670) (human) TFA
IRBP651-670,Interphotoreceptor Retinoid-Binding Protein (651-670) |
||
IRBP651-670(Interphotoreceptor retinoid-binding protein (651-670))是IRBP(亦称为retinoid-binding protein 3)的肽段,参与色素再生,通过将视黄醇和视黄醛从光感受细胞传输到视网膜色素上皮。在C57BL/6小鼠中,利用IRBP651-670诱导自身免疫性葡萄膜炎,这些小鼠携带H-2b单体型。用IRBP651-670(300 µg/动物)免疫增加了小鼠眼部IL-1β、IL-6、IL-17、TNF-α和IFN-γ水平,免疫细胞浸润及光感受器损伤。 | |||
T83681 |
IRBP (1-20) (human, rat) TFA
IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20) |
||
IRBP1-20(1-20)是IRBP的一个十二肽片段,亦称视黄醇结合蛋白3,负责运输视锥细胞中的视黄醇和视黄醛至视网膜色素上皮,参与色素再生。在携带H-2b等位基因型的C57BL/6小鼠中,IRBP1-20用于诱导自身免疫性葡萄膜视网膜炎。IRBP1-20(3 µM)能增加初级小鼠脾淋巴细胞分泌IL-4、IL-5和IL-6的水平。用IRBP1-20免疫并再次挑战,可增加IFN-γ缺乏小鼠的耳部肿胀、眼部血管炎症、免疫细胞浸润和视锥细胞层损伤,以及视网膜脱落。 | |||
T8761 |
[Leu15]-Gastrin I human
Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2 |
Others | Others |
[Leu15]-Gastrin I human (Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2) 基因编码人体内的蛋白质 [Leu15]-胃泌素 I。在人类染色体中,GAST 基因定位于 17q21.2。胃窦中的 G 细胞产生 [Leu15]-胃泌素 I 的前体前胃泌素。前胃泌素经过裂解和加工产生胃泌素,它对整个胃肠道上皮细胞具有营养作用。胃泌素对消化系统的生长至关重要,并刺激壁细胞产生胃酸。胃泌素通过称为胆囊收缩素(CCK) 或 CCK-B 受体 (CCK-BR) 的 G 蛋白偶联受体发挥其功能。胃泌素的释放受到食物的刺激,尤其是蛋白质饮食,并受到非常低的 pH 值的抑制。萎缩性胃炎、幽门螺杆菌感染和长期服用质子泵抑制剂感染可能导致胃泌素过度表达。胃腺癌显示高水平的胃泌素。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15133 |
Dinoprost
Prostaglandin F2a,PGF2α,地诺前列素 |
Endogenous Metabolite | Metabolism |
Dinoprost (Prostaglandin F2a) 是口服有效的、内源性的前列腺素 F 受体激动剂。它是在子宫内膜腔上皮和黄体中局部产生的溶酶激素。它在分娩过程中起关键作用。 | |||
T10938 |
D-Kynurenine
D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103 |
GPR; AhR; Endogenous Metabolite | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism |
D-Kynurenine (ZINC901103) 是 D-色氨酸的代谢物和 GPR109B 的激动剂。 D-Kynurenine 激活 AhR 并促进上皮细胞向间充质的转化。 D-Kynurenine 在 D-氨基酸氧化酶的荧光分析中用作底物。 | |||
T3S0509 |
Gaultherin
|
COX | Immunology/Inflammation; Neuroscience |
Gaultherin 是一种分离自 Gaultheria yunnanensis 中的天然水杨酸酯衍生物。它是一种非甾体类抗炎药,具有止痛和抗炎作用,与 Aspirin 相比没有胃溃疡作用。 | |||
T11124 |
Duramycin
Lancovutide,Moli1901 |
Others | Others |
Duramycin is a cyclic peptide lantibiotic derived from Streptomyces cinnamoneuma. Duramycin interacts with phosphatidylethanolamine (PE) and has antibacterial, antiviral effects. Duramycin stimulates chloride secretion in airway epithelium and has the potential for cystic fibrosis treatment. | |||
T75608 |
Myricetin 3-O-α-L-arabinopyranoside
|
Others | Others |
Myricetin 3-O-α-L-arabinopyranoside 抑制 A2E 光氧化诱导的RPE 细胞死亡。Myricetin 3-O-α-L-arabinopyranoside 对视网膜变性具有保护作用,可保护蓝光 (BL) 诱导对 RPE 细胞和小鼠模型的损伤。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00265 |
Serpin F1 Protein, Mouse, Recombinant
Pedf,Caspin,Stromal cell-derived factor 3,Sdf3,Pigment e... |
Mouse | E. coli |
Serpin F1 is secreted Neurotrophic protein and belongs to the serpin family. Serpin F1 Highly expressed in the liver, gastric glandular mucosa and renal tubules. It is also expressed in the brain, heart, lung retina and testes. It induces extensive neuronal differentiation in retinoblastoma cells. It is potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, exhibits no serine protease inhibitory activi... | |||
TMPH-02033 |
RPE65 Protein, Human, Recombinant (His & Myc)
Retinol isomerase,Retinoid isomerohydrolase,All-trans-retiny... |
Human | Baculovirus Insect Cells |
RPE65 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus. | |||
TMPH-01851 |
PSIP1 Protein, Human, Recombinant (His & SUMO)
Lens epithelium-derived growth factor,PC4 and SFRS1... |
Human | E. coli |
PSIP1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 76.1 kDa and the accession number is O75475. | |||
TMPH-01850 |
PNPLA2 Protein, Human, Recombinant (His & SUMO)
Transport-secretion protein 2,Patatin-like phospholipase dom... |
Human | E. coli |
PNPLA2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 71.3 kDa and the accession number is Q96AD5. | |||
TMPJ-00375 |
HGF Protein, Human, Recombinant (His)
Scatter factor,Hepatocyte growth factor,HGF,SF,Hepatopoietin... |
Human | HEK293 Cells |
HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha and 30 kDa beta chain. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET. HGF regulates epithelia... | |||
TMPH-02857 |
Wnt10a Protein, Mouse, Recombinant (His & Myc)
Wnt10a,Protein Wnt-10a |
Mouse | E. coli |
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in normal ectoderm development. Required for normal tooth development. Required for normal postnatal development and maintenance of tongue papillae and sweat ducts. Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae. Requir... | |||
TMPH-03259 |
Carbonic Anhydrase 2 Protein, Rat, Recombinant (His)
CA-II,Carbonate dehydratase II,Carbonic anhydrase II,Cyanami... |
Rat | E. coli |
Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Carbonic Anhydrase 2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.7 kDa and the accession number is P27139. | |||
TMPH-00643 |
K99 fimbrial Protein, E. coli, Recombinant
fanC,K99 fimbrial protein |
E. coli | E. coli |
Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs.; FanC is the main component of the K99 fimbriae. | |||
TMPH-03120 |
OBP Protein, Pig, Recombinant (His & Myc)
Odorant-binding protein |
Sus scrofa (Pig) | E. coli |
This protein is found in nasal epithelium and it binds a wide variety of chemical odorants. OBP Protein, Pig, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.2 kDa and the accession number is P81245. | |||
TMPH-00748 |
FimA Protein, E. coli, Recombinant (His & SUMO)
fimA,Type-1 fimbrial protein, A chain,Type-1A pilin |
E. coli | E. coli |
Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs. FimA Protein, E. coli, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 31.8 kDa and the accession number is P04128. | |||
TMPH-01517 |
FCGRT Protein, Human, Recombinant (GST)
IgG Fc fragment receptor transporter alpha chain,Neonatal Fc... |
Human | E. coli |
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and exten... | |||
TMPJ-01024 |
Galectin-4 Protein, Human, Recombinant (His)
gal-4,Antigen NY-CO-27,L36LBP,galectin 4,LGALS4,Lactose-bind... |
Human | E. coli |
Galectins are a family of carbohydrate-binding proteins with specificity for N-acetyl-lactosamine-containing glycoproteins. Galectin-4 is a 36 kDa tandem-repeat galectin found throughout the gastrointestinal tract, but also present in well-differentiated breast and liver carcinomas. Galectin-4 expression is concentrated within microvilli in the gastrointestinal epithelium, where it can interact with CD3 and bind activated T cells in the lamina propria during intestinal inflammation. | |||
TMPH-03026 |
CARDS Protein, Mycoplasma pneumoniae, Recombinant (His & Myc)
ADP-ribosylating toxin CARDS,CARDX TX,ADP-ribosyltransferase... |
Mycoplasma pneumoniae | E. coli |
Acts as an ADP-ribosylating toxin, which may transfer the ADP-ribosyl group from NAD(+) to specific amino acids in target proteins. Elicits cytopathic effects in mammalian cells, such as disorganization and disruption of respiratory epithelial integrity in tracheal epithelium and vacuolization in the cytoplasm of CHO and HeLa cells. | |||
TMPH-00619 |
F17 fimbrial Protein, E. coli, Recombinant (His & SUMO)
F17 fimbrial protein,F17a-A,F17 fimbrial adhesive antigen,F1... |
E. coli | E. coli |
Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs. F17 fimbrial Protein, E. coli, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.4 kDa and the accession number is P11312. | |||
TMPH-00642 |
K99 fimbrial Protein, E. coli, Recombinant (His & SUMO)
fanC,K99 fimbrial protein |
E. coli | E. coli |
Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs.; FanC is the main component of the K99 fimbriae. K99 fimbrial Protein, E. coli, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.5 kDa and the accession number is P18103. | |||
TMPH-00620 |
F41 fimbrial Protein, E. coli, Recombinant (His & Myc)
Adhesin F41,F41 fimbrial protein,FimF41a |
E. coli | E. coli |
Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs. F41 fimbrial Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.4 kDa and the accession number is P11900. | |||
TMPK-00930 |
GM-CSFR alpha Protein, Mouse, Recombinant (His)
CSF2RAX,CSF2RX,CD116,CSF2RAY,GM-CSF-R-α,GMCSFR-α,GMCSFR-alph... |
Mouse | HEK293 Cells |
In the first trimester, the GM-CSF-R was found to be present on villous cytotrophoblast and all populations of extravillous trophoblast. Expression by villous syncytiotrophoblast was weak or absent, but this increased markedly by term. GM-CSF-R were also expressed by fetal Hofbauer cells within the mesenchyme of the chorionic villi and by uterine glandular epithelium and decidual macrophages within maternal decidua. GM-CSFR alpha Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian... | |||
TMPK-01055 |
TEM7R/PLXDC2 Protein, Human, Recombinant (His)
PLXDC2,TEM7R |
Human | HEK293 Cells |
Plexin domain containing 2 (PLXDC2), a cell surface transmembrane protein receptor for pigment epithelium derived factor, is expressed in many tissues including the eye. Plxdc2 is a type I transmembrane protein with some homology to nidogen and to plexins. It is expressed in a highly discrete and dynamic pattern in the developing nervous system, with prominent expression in various patterning centres. TEM7R/PLXDC2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-Hi... | |||
TMPH-01516 |
FCGRT Protein, Human, Recombinant (His)
Neonatal Fc receptor,IgG receptor FcRn large subunit p51,FCG... |
Human | HEK293 Cells |
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and exten... | |||
TMPJ-01233 |
AGR3 Protein, Mouse, Recombinant (His)
AGR3,Anterior gradient protein 3,BCMP11,AG3 |
Mouse | HEK293 Cells |
Anterior gradient protein 3 (AGR3) is an 18 kDa member of the AGR family of proteins. It is expressed in the ciliated cells of the airway epithelium, not detected in the mucous cells. Mature human AGR3 shares 92% amino acid sequence identity with mouse AGR3. It is required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. AGR3 might be involved in the regulation of intracellular calcium in tracheal epithelial cells. | |||
TMPK-00418 |
MERTK/Mer Protein, Human, Recombinant (mFc)
MER,Tyro12,MERTK,c-Eyk,MGC133349,c-mer,RP38 |
Human | HEK293 Cells |
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans. MERTK/Mer Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 78.9 kDa and the accession ... | |||
TMPK-01022 |
MERTK/Mer Protein, Mouse, Recombinant (His)
Tyro12,c-Eyk,MGC133349,RP38,c-mer,MERTK,MER |
Mouse | HEK293 Cells |
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans. MERTK/Mer Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.38 kDa and the accession... | |||
TMPK-00417 |
MERTK/Mer Protein, Human, Recombinant (His)
Tyro12,MGC133349,c-mer,MERTK,c-Eyk,RP38,MER |
Human | HEK293 Cells |
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans. MERTK/Mer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.73 kDa and the accession... | |||
TMPK-01167 |
TEM7R/PLXDC2 Protein, Mouse, Recombinant (His)
PLXDC2,TEM7R |
Mouse | HEK293 Cells |
Plexin domain containing 2 (PLXDC2), a cell surface transmembrane protein receptor for pigment epithelium derived factor, is expressed in many tissues including the eye. Plxdc2 is a type I transmembrane protein with some homology to nidogen and to plexins. It is expressed in a highly discrete and dynamic pattern in the developing nervous system, with prominent expression in various patterning centres. TEM7R/PLXDC2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-Hi... | |||
TMPH-02690 |
PLA2G10 Protein, Mouse, Recombinant (His & Myc)
Pla2g10,Group X secretory phospholipase A2,Phosphatidylcholi... |
Mouse | E. coli |
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density li... | |||
TMPK-00737 |
EVA-1/MPZL2 Protein, Human, Recombinant (hFc)
Eva,Mpzl2,EVA-1,EVA 1,EVA1,Epithelial V-like antigen 1 |
Human | HEK293 Cells |
MPZL2 encodes myelin protein zero-like 2, an adhesion molecule that mediates epithelial cell-cell interactions in several (developing) tissues.Deleterious variants of Mplz2/MPZL2 affect adhesion of the inner-ear epithelium and result in loss of structural integrity of the organ of Corti and progressive degeneration of hair cells, supporting cells, and spiral ganglion neurons. EVA-1/MPZL2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecu... | |||
TMPK-00738 |
EVA-1/MPZL2 Protein, Mouse, Recombinant (hFc)
EVA 1,Mpzl2,Epithelial V-like antigen 1,EVA-1,Eva,EVA1 |
Mouse | HEK293 Cells |
MPZL2 encodes myelin protein zero-like 2, an adhesion molecule that mediates epithelial cell-cell interactions in several (developing) tissues.Deleterious variants of Mplz2/MPZL2 affect adhesion of the inner-ear epithelium and result in loss of structural integrity of the organ of Corti and progressive degeneration of hair cells, supporting cells, and spiral ganglion neurons. EVA-1/MPZL2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecu... | |||
TMPH-00208 |
Serotype 3 fimbrial subunit Protein, Bordetella pertussis, Recombinant (His)
fim3,Serotype 3 fimbrial subunit |
Bordetella pertussis | E. coli |
Bordetella pertussis is the causative agent of whooping cough. An essential step in the disease process is the attachment of the bacteria to the ciliated epithelium of the respiratory tract, enabling the organism to resist normal host-clearance mechanisms. It is unclear which bacterial cell surface component are responsible for adherence but the fimbriae of B.pertussis are prime candidates for being involved in this process. Serotype 3 fimbrial subunit Protein, Bordetella pertussis, Recombinant ... | |||
TMPK-00490 |
GM-CSFR alpha Protein, Cynomolgus, Recombinant (His)
CSF2RY,SMDP4,GMCSFR-α,GMR-alpha,CSF2RAY,CDw116,GM-CSF-R-alph... |
Cynomolgus | HEK293 Cells |
In the first trimester, the GM-CSF-R was found to be present on villous cytotrophoblast and all populations of extravillous trophoblast. Expression by villous syncytiotrophoblast was weak or absent, but this increased markedly by term. GM-CSF-R were also expressed by fetal Hofbauer cells within the mesenchyme of the chorionic villi and by uterine glandular epithelium and decidual macrophages within maternal decidua. GM-CSFR alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mamm... | |||
TMPK-00254 |
GM-CSFR alpha Protein, Human, Recombinant (His & Avi), Biotinylated
GM-CSF-R-α,GMR-α,GMR-alpha,GM-CSF-R-alpha,CSF2R,GMCSFR-alpha... |
Human | HEK293 Cells |
In the first trimester, the GM-CSF-R was found to be present on villous cytotrophoblast and all populations of extravillous trophoblast. Expression by villous syncytiotrophoblast was weak or absent, but this increased markedly by term. GM-CSF-R were also expressed by fetal Hofbauer cells within the mesenchyme of the chorionic villi and by uterine glandular epithelium and decidual macrophages within maternal decidua. GM-CSFR alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed... | |||
TMPH-01805 |
ODAM Protein, Human, Recombinant (His)
ODAM,Apin,Odontogenic ameloblast-associated protein |
Human | E. coli |
Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. ODAM Protein, Human, Recombinant (His) is expressed in E. col... | |||
TMPJ-00200 |
EpCAM/TROP1 Protein, Mouse, Recombinant (hFc)
17-1A,323/A3,TROP1,EGP314,ACSTD1,CD326,EGP-2,MOC31,EGP40,TAC... |
Mouse | HEK293 Cells |
Epithelial Cellular Adhesion Molecule (Ep-CAM), also known as EGP314, mEGP314, Protein 289A, Tumor-associated calcium signal transducer 1, CD326, belongs to the EPCAM family. Its’ monomer subunit structure interacts with phosphorylated CLDN7. Ep-CAM may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection... | |||
TMPJ-01372 |
Cornulin Protein, Human, Recombinant (His)
Tumor-Related Protein,58 kDa Heat Shock Protein,PDRC1,C1orf1... |
Human | E. coli |
Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and ... | |||
TMPY-02249 |
FABP6 Protein, Human, Recombinant
I-BABP,I-BAP,ILLBP,I-15P,ILBP3,I-BALB,ILBP,fatty acid bindin... |
Human | E. coli |
Gastrotropin, also known as Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-BABP and FABP6, is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Isoform2 of FABP6 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform1of FABP6 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isof... | |||
TMPJ-01206 |
Sting Protein, Human, Recombinant (Sumo & His)
TMEM173,Mediator of IRF3 activation,Stimulator of interferon... |
Human | E. coli |
Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). It ubiquitously expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophagesand. Its subunit structure associated with the MHC-II complex and Interacts with DDX58/RIG-I, MAVS and SSR2,... | |||
TMPH-01551 |
IFNLR1 Protein, Human, Recombinant (His & SUMO)
Cytokine receptor class-II member 12,Likely interleukin or c... |
Human | E. coli |
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primar... | |||
TMPY-00585 |
Annexin A8 Protein, Human, Recombinant (His)
ANX8,annexin A8 |
Human | E. coli |
We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA8 mRNA is expressed in low-proliferative isolated pubertal mouse mammary ductal epithelium and after enforced involution, but not in isolated highly proliferative terminal end buds (TEB) or during pregnancy. ANXA8 as a potential mediator of quiescence in the normal mouse mammary ... | |||
TMPY-02299 |
ALDH3A1 Protein, Human, Recombinant (His)
ALDHIII,aldehyde dehydrogenase 3 family, member A1,ALDH3 |
Human | Baculovirus Insect Cells |
Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (e.g., corneal epithelium), express ALDH3A1 at high levels and its abundance in such tissues is perceived to help to maintain cellular homeostasis under conditions of oxidative stress. Metabolic as well as non-metabolic roles for ALDH3A1 have been associated with its mediated resi... | |||
TMPJ-00056 |
AG-2 Protein, Human, Recombinant (His)
HPC8,AG2,AG-2,hAG-2,Anterior Gradient Protein 2 Homolog,AGR2... |
Human | HEK293 Cells |
Anterior Gradient 2 (AGR2) is an 18-21 kDa member of the PDI family of enzymes. AGR2 is widely expressed in secretory cells, such as small intestine goblet, prostate epithelium, enteroendocrine cells, and multiple carcinoma cell types. AGR2 forms transient disulfide linkages with molecules destined for secretion, possibly aiding protein folding. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of E... | |||
TMPK-00084 |
IL-17C Protein, Human, Recombinant (His & Avi)
IL-17C,Cytokine CX2,IL17C,CX2,IL-17CMGC126884 |
Human | HEK293 Cells |
Interleukin‑17C (IL‑17C) is a 15‑20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold. IL‑17C is Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by sig... | |||
TMPY-03851 |
BPIFB1 Protein, Human, Recombinant (His)
LPLUNC1,BPI fold containing family B, member 1,C20orf114 |
Human | HEK293 Cells |
BPIFB1, also known as LPLUNC1, belongs to the BPI/LBP/Plunc superfamily, plunc family. BPIFB1 may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. BPIFB1 is expressed in the upper respiratory tract and oral cavity, which may function in host defence. The expression of BPIF proteins is associated with CF lung disease in humans and mice. It is unclear if this elevation of protein production, which results from phenotypic alteration of the cel... | |||
TMPY-01249 |
Cathepsin V Protein, Human, Recombinant (His)
CTSV,cathepsin V,MGC125957,CATL2,CTSU,CTSL2 |
Human | HEK293 Cells |
Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and to a lesser extent in conjuctival epithelium and skin. It is a lysosomal cysteine proteinase that may play an important role in corneal physiology. It has about 75% protein sequence identity to murine cathepsin L. The fold of this enzyme is similar to the fold adopted by other mem... | |||
TMPJ-00741 |
PTH Protein, Human, Recombinant (His)
Parathyroid hormone,Parathyrin,PTH,Parathormone |
Human | HEK293 Cells |
Parathyroid hormone (PTH) is a critical hormone in the regulation of Ca++ homeostasis. Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. This hormone is secreted from cells of the parathyroid glands and finds its major target cells in bone and kidney. Another hormone, parathyroid hormone-related protein, binds to the same receptor as parathyroid hormone and has major effects on development. Like most other protein hormon... | |||
TMPY-02117 |
Marapsin Protein, Human, Recombinant (His)
UNQ1884/PRO4327,protease, serine 27,CAPH2,MPN |
Human | HEK293 Cells |
The name "Pancreasin" because it is transcribed strongly in the pancreas. This secreted, tryptic serine protease, also known as Marapsin or PRSS27 (Protease, serine, 27), is a member of the peptidase S1 family. Pancreasin is inhibited by benzamidine and leupeptin but resists several classic inhibitors of trypsin. Marapsin was constitutively expressed in nonkeratinizing stratified squamous epithelia of human esophagus, tonsil, cervix, larynx, and cornea. In fact, marapsin was the second most stro... | |||
TMPJ-00045 |
Podoplanin Protein, Human, Recombinant (hFc)
T1A,PDPN,GP36,Podoplanin,Aggrus,T1-α,PA2.26 Antigen,T1-Alpha... |
Human | HEK293 Cells |
Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cy... | |||
TMPJ-01432 |
CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated
mucin 16, cell surface associated,CA-125,CA125 ovarian cance... |
Human | HEK293 Cells |
MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by tumor cells including ovarian and mesothelial cancers. The transmembrane form can adhere to mesothelin in the peritoneum, facilitating metastasis of ovarian cancer to the peritoneal cavity. MUC16 also binds galectin-1 on immune cells and enhances its expression on tumor cells. MUC... | |||
TMPJ-01028 |
Claudin-18.2 Protein, Human, Recombinant (Twin strep & Flag)
Claudin 18.2,CLDN18,Claudin-18,CLDN18.2,Claudin-18.2 |
Human | HEK293 Cells |
Claudin-18 (CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. Human CLDN18.2 is highly expressed in a signifcant proportion of gastric and pancreat... | |||
TMPY-03861 |
Amelotin Protein, Human, Recombinant (mFc)
amelotin,UNQ689 |
Human | HEK293 Cells |
Amelotin (AMTN) is a tooth enamel protein which is expressed in maturation-stage ameloblasts and also in the internal basal lamina of junctional epithelium, a unique epithelial structure attached to the tooth surface which protects against the constant microbiological challenge to the periodontium. TNF-α stimulates AMTN gene transcription in human gingival epithelial cells via C/EBP1, C/EBP2, and YY1 elements in the human AMTN gene promoter.AMTN mRNA levels increased at 6 h and reached maximum a... | |||
TMPH-02526 |
Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)
Arginase II,Kidney-type arginase,Type II arginase,Arg2,Argin... |
Mouse | E. coli |
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium.... | |||
TMPY-04828 |
TFF3 Protein, Human, Recombinant (His)
trefoil factor 3 (intestinal),ITF,P1B,TFI |
Human | HEK293 Cells |
Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Trefoil factor-3 (TFF3) is an estrogen-regulated gene associated with prognosis in different types of cancer. The presence and localization of TFF3 peptide was associated with the embryonic stage and tissue differentiation. TFF3 peptide distribution specific to the germ layers was not observed. The role of TFF3 peptide in cell migration and differentiation, immune response, an... | |||
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