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Lucinactant是一种新型合成肽,模仿表面活性剂蛋白B,具有抗炎特性。Lucinactant也是一种KL4表面活性剂,能够保护人类气道上皮细胞免受高氧侵害。
Lucinactant是一种新型合成肽,模仿表面活性剂蛋白B,具有抗炎特性。Lucinactant也是一种KL4表面活性剂,能够保护人类气道上皮细胞免受高氧侵害。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 待询 | |
50 mg | 询价 | 待询 |
产品描述 | Lucinactant, a novel synthetic peptide, functionally mimics the anti-inflammatory properties of surfactant protein B. As a KL4-Surfactant, it protects human airway epithelium from hyperoxia [1] [2] [3]. |
体外活性 | Lucinactant (140 μL; 24 h and 72 h) offers anti-inflammatory benefits by outperforming both an animal-derived surfactant and saline control throughout 72 hours of moderate hyperoxia [1]. In addition, at the same dosage and a 24-hour exposure, it significantly lowers IL-8 and IL-6 secretion in hyperoxically exposed Calu-3 monolayers compared to normal saline [1]. Furthermore, Lucinactant mitigates the presence of swollen nuclei and intracellular vacuoles in Calu-3 cells during similar hyperoxic conditions [1]. In a Cell Viability Assay, hyperoxically exposed Calu-3 monolayers treated with Lucinactant for 72 hours displayed improved cell viability and transepithelial resistance [1]. |
体内活性 | Lucinactant (175 mg total phospholipid/5.8 mL/kg; intratracheal medication; single dose) reduces pulmonary inflammation, maintains lung structure, and enhances physiological outcomes in preterm lambs (125-128 days gestation) with respiratory distress syndrome (RDS) [2]. The administration of 175 mg total phospholipid/kg (5.8 mL/kg) resulted in diminished lung and systemic inflammatory responses, improved oxygenation with lower ventilatory demands, and better-preserved lung structural integrity. |
别名 | Surfaxin |
分子量 | 2529.45 |
分子式 | C128H242N26O24 |
CAS No. | 825600-90-6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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