136
26
3
40
3
Cat. No. | Product Name | ||
---|---|---|---|
L5400 | 抗心血管疾病化合物库 | 1408 compounds | |
1408 种心血管疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L7200 | 钙通道分子库 | 140 compounds | |
140 种钙通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L1310 | 细胞骨架化合物库 | 759 compounds | |
759 种细胞骨架相关的化合物,可以用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2176 |
2,3-Butanedione 2-Monoxime
Diacetyl monoxime,2,3-Butanedione-2-monoxime |
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
2,3-Butanedione 2-Monoxime (Diacetyl monoxime) 是一种肌球蛋白 ATP 酶(myosin ATPase) 抑制剂。它诱导肌质网 Ca2+释放,能够有效抑制骨骼肌和心肌收缩。 | |||
T34280 |
Regrelor disodium
INS-50589,INS50589,Regrelor sodium,Regrelor,INS 50589 |
P2Y Receptor | GPCR/G Protein; Neuroscience |
Regrelor disodium (INS 50589) 是一种 p2y12 受体拮抗剂,可预防血栓形成,可有效抑制血管平滑肌细胞收缩,抑制细胞增殖,减少炎症。 | |||
T25719 |
Lidamidine
Lidamidina,Lidamidinum,利达脒 |
Others | Others |
Lidamidine (Lidamidinum) 是一种临床有效的止泻化合物,可抑制肠道分泌,减少肠道转运,并抑制平滑肌收缩。 | |||
T4054 |
Dantrolene sodium hemiheptahydrate
Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,丹曲林钠五水合物,Sodium dantrolene |
Calcium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Dantrolene sodium hemiheptahydrate (Sodium dantrolene) 是一种钙通道蛋白抑制剂, 抑制钙离子从肌浆释放, 它是一种乙内酰脲衍生物和直接作用的骨骼肌松弛剂。 | |||
TP2419 |
V-9-M Cholecystokinin nonapeptide
V 9 M,Prepro CCK Fragment V-9-M,Val-pro-val-glu-ala-val-asp-pro-met,Cholecystokinin Precursor (24-32),V9M,V-9-M |
Beta Amyloid | Neuroscience |
V-9-M Cholecystokinin nonapeptide (Prepro CCK Fragment V-9-M) 是胆囊收缩素(CCK)的前体化合物。胆囊收缩素(CCK)是一种刺激胆囊收缩和胰腺外分泌的脑肠肽,可从狗和猫的小肠中提取的,可以引起胆囊收缩。 | |||
T25372 |
EMD57033
EMD-57033,(+)-EMD 57033,EMD 57033 |
Calcium Channel; Carbonic Anhydrase | Membrane transporter/Ion channel; Metabolism |
EMD57033是一种心脏肌钙蛋白C(cTnC)激活剂,是一种显性的Ca2+增敏剂。EMD57033通过与心脏/慢速骨骼肌钙蛋白C 异构体结合从而发挥促进心脏收缩的功能。 | |||
TP2036L |
DPDPE TFA (88373-73-3 free base)
DPDPE TFA |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
DPDPE TFA 是选择性 δ-阿片受体激动剂肽,在体内具有镇痛作用。 | |||
T28164 |
Nexopamil
LU49938,LU 49938,LU-49938 |
Calcium Channel; 5-HT Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Nexopamil (LU-49938) 是一种钙通道拮抗剂,是一种5-羟色胺2A 受体拮抗剂。Nexopamil 可抑制5-HT 诱导的间质细胞收缩和增殖。 | |||
T13541 |
α,β-Methylene ATP trisodium
|
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
α,β-Methylene ATP trisodium 是 ATP 的膦酸酯类似物,是选择性 P2X 激动剂,诱导UBSM 收缩增强。α,β-Methylene ATP trisodium 抑制 P2X1 和 P2X3 但对 P2X2, 4 和 7 没有活性。 | |||
TP1883 |
[Lys5,MeLeu9,Nle10]-NKA(4-10)
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
[Lys5,MeLeu9,Nle10]-NKA(4-10) 是高选择性和强效 NK2 受体激动剂,IC50值为 6.1 nM,可诱导大鼠眼底和膀胱收缩,EC50 值分别为 117 和 10 nM。 | |||
T30503 |
BMS-195270
UNII-20UM0T170J,BMS 195270,BMS195270,CHEMBL13637,SCHEMBL5754043 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
BMS-195270 是一种具有组织特异性的大鼠膀胱肌张力和自发收缩抑制剂,能够在膀胱离体模型中抑制离体大鼠膀胱组织条的 Carbachol 引发的张力,抑制钙离子通量。 | |||
T1215 |
Nicardipine hydrochloride
盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride |
Calcium Channel; Adrenergic Receptor; AChR; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Nicardipine hydrochloride (YC-93 Hydrochloride) 是一种钙通道阻滞剂,IC50为 1 μM。它可阻断某些细胞壁中的钙离子并抑制冠状动脉和外周动脉的收缩,从而降低对氧气的需求心肌和减少动脉收缩和痉挛。它在临床上用作脑和冠状血管扩张剂。 | |||
T6625 |
Ozagrel hydrochloride
Ozagrel HCl,盐酸奥扎格雷,OKY-046 HCl |
Thrombin; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Ozagrel hydrochloride (OKY-046 HCl) 是一种选择性血栓素 A(2) 合成酶抑制剂,用于改善术后脑血管收缩和伴随的脑缺血。它是一种抗血小板剂,可选择性抑制人血小板聚集,IC50为 53.12 μM。 | |||
T6236 |
Ozagrel
奥扎格雷,OKY-046,Domenan |
Thrombin; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Ozagrel (Domenan) 是血栓烷 A2(TXA2) 合酶抑制剂,可抑制哮喘。它也是一种抗血小板剂,可选择性抑制人血小板聚集,IC50为 53.12 μM。 | |||
TP1198 |
Sincalide ammonium
SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium |
cholecystokinin | GPCR/G Protein |
Sincalide ammonium (CCK-8 ammonium) 是一种有效的氨基酸多肽激素胆囊收缩素 (CCK) 的类似物,是保留了 CCK 的大部分生物活性的活性片段。Sincalide ammonium 促进胆汁的分泌,使胆囊收缩并使 Oddi 的括约肌松弛,从而促进胆汁排入十二指肠。Sincalide ammonium 可通过注射促进胆囊收缩,常用于辅助诊断胆囊、胰腺疾病和胆囊造影术。 | |||
TP2279L |
Obestatin (rat) acetate
|
GHSR | GPCR/G Protein |
Obestatin (rat) acetate 是 G 蛋白偶联受体 39 (GPR39) 的内源性配体。它具有抗炎、抗心肌梗塞和抗氧化特性。 它抑制食物摄入,抑制空肠收缩,并减少体重增加。 | |||
T4132 |
BPTU
BMS-646786 |
P2Y Receptor | GPCR/G Protein; Neuroscience |
BPTU (BMS-646786) 是一种非核苷酸类P2Y1受体变构拮抗剂,能够阻断位于胃肠道神经肌肉接头的 P2Y1受体,具有抗血栓活性。 | |||
T10101 |
Calcium channel-modulator-1
|
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Calcium channel-modulator-1是钙离子通道调节剂(IC50:0.8 μM),具有阻塞主动脉收缩的专业化。 | |||
T5856 |
Barnidipine hydrochloride
盐酸巴尼地平,YM-09730-5 hydrochloride,Mepirodipine (hydrochloride) |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Barnidipine hydrochloride (YM-09730-5 hydrochloride) 是一种二氢吡啶类钙通道阻滞剂,对 CaA 受体具有选择性作用。它是一种抗高血压药物,通过减少其血管扩张作用继发的外周血管阻力起作用。 | |||
T11918L |
Lysipressin acetate(50-57-7(fb_acetate))
Lysine vasopressin acetate,[Lys8]-Vasopressin acetate |
Others | Others |
Lysipressin acetate(50-57-7(fb_acetate)) ([Lys8]-Vasopressin acetate) 诱导兔膀胱平滑肌收缩,激活腺苷酸环化酶。 Lysipressin 是一种抗利尿激素,已在猪和一些有袋动物家族中发现。 | |||
T0077 |
Dantrolene sodium
Lapatinib ditosylate monohydrate,丹曲林钠,Dantrolene sodium salt |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Dantrolene sodium (Lapatinib ditosylate monohydrate) salt 是一种骨骼肌松弛药,是一种钙通道蛋白抑制剂,可抑制钙离子从肌浆释放。 | |||
T2525 |
Alosetron hydrochloride
Lotronex,盐酸阿洛司琼,GR 68755C,GR 68755,GR 68755X |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Alosetron hydrochloride (GR 68755) 是一种高选择性的 5-HT3 受体拮抗剂,可减轻清醒或麻醉犬直肠扩张的内脏伤害性效应,具有抗炎活性,用于肠易激综合征的研究。它阻断 5HT3 介导的豚鼠肌间和粘膜下神经元的快速去极化,IC50约为 55 nM。 | |||
T1613 |
Hydralazine hydrochloride
Hydralazine HCl,Apresoline,盐酸肼屈嗪 |
MAO; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Neuroscience |
Hydralazine hydrochloride (Apresoline) 是一种直接作用的血管舒张剂,可抗高血压。 | |||
TP2106L |
Urantide acetate(669089-53-6 free base)
|
Neurotensin Receptor | GPCR/G Protein |
Urantide acetate(669089-53-6 free base) 是一种选择性和竞争性的 urotensin-II (UT) 受体拮抗剂 (pKB = 8.3)。体外阻断 hU-II 诱导的胸主动脉收缩。对去甲肾上腺素或内皮素 1 诱导的收缩或乙酰胆碱诱导的松弛没有影响。在钙动员测定(在表达 hUT 受体的 CHO 细胞中)中表现为部分激动剂。 | |||
T72038 |
YM-58790
YM-58790 free base |
AChR | Neuroscience |
YM-58790 free base 是一种高效的 mAChR 拮抗剂。YM-58790 free base 对 M1 mAChR、M2 mAChR 和 M3 mAChR具有抑制作用, Ki 值分别为 28 nM ,260 nM ,和 15 nM 。YM-58790 free base 通过抑制膀胱加压来抑制大鼠的反射性节律性膀胱收缩。 | |||
T1115 |
Doxylamine succinate
琥珀酸多西拉敏,Decapryn |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Doxylamine succinate (Decapryn) 是一种吡啶衍生物组胺 H1 拮抗剂,具有明显的镇静特性。它竞争性阻断组胺 H1 受体并限制典型的过敏和过敏反应,可防止组胺引起的皮肤和粘膜疼痛和瘙痒。 | |||
T1139 |
Salbutamol
Albuterol,沙丁胺醇,AH-3365 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Salbutamol (Albuterol) 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病(COPD) 引发的支气管痉挛的研究。 | |||
T68123 |
Oxodipine
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Oxodipine 是一种二氢吡啶型钙拮抗剂 ,抑制了KCl 诱导的兔主动脉收缩,降低了效力较低的大鼠心室试纸收缩的心脏力量。在大鼠培养的新生儿心室肌细胞中,Oxodipine 降低了L 型Ca 电流(I),IC 为0.24μM,对T 型Ca 电流(I)的IC 为0.41μM。Oxodipine 会使小鼠便秘和狗牙龈增生。 | |||
T21610 |
Bradykinin (acetate)
|
Bradykinin Receptor | GPCR/G Protein |
Bradykinin (acetate) 是一种由激肽释放酶-激肽系统产生的活性肽。它是一种炎症介质,也被认为是多种血管和肾功能的神经介质和调节剂。它由血液中的 kallidin 酶促产生,是一种强大的血管扩张剂,可引起平滑肌收缩,并可能介导炎症。它具有作为人血清代谢物和血管扩张剂的作用。它是缓激肽 (2+) 的互变异构体。 | |||
T1577 |
Midodrine hydrochloride
Pro-Amatine,盐酸米多君 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Midodrine hydrochloride (Pro-Amatine) 通过去甘氨酸反应转化为其活性代谢物 desglymidodrine。Desglymidodrine 选择性地结合并激活小动脉和静脉血管系统的 α-1-肾上腺素能受体。这会导致平滑肌收缩并导致血压升高。 Desglymidodrine 在血脑屏障中的扩散很差,因此与对中枢神经系统的影响无关。Midodrine hydrochloride 是 midodrine 的盐酸盐形式,是一种直接作用的前药和拟交感神经药,具有抗低血压特性。 | |||
T6707 |
Tiotropium Bromide hydrate
BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物 |
AChR | Neuroscience |
Tiotropium Bromide hydrate (BA-679 BR hydrate) 是长效的毒蕈碱受体拮抗剂,可用于治疗慢性阻塞性气道疾病 (COPD)。 | |||
T27364 |
FR 75513
FR-75513,FR75513 |
Others | Others |
FR 75513 inhibits the contraction of guinea pig detrusor muscle . | |||
T68882 |
Clodanolene sodium
|
Others | Others |
Clodanolene sodium is a skeletal muscle contraction antagonist. | |||
T71443 |
Amphidinolide D
|
Others | Others |
Amphidinolide D is a powerful activator of actomyosin ATPase enhances skeletal muscle contraction. | |||
T70917 |
NA 0362
|
Others | Others |
NA 0362 is a derivative of SF 2370 that inhibits smooth muscle contraction. | |||
T23739 |
Antho-riamide I
|
Others | Others |
Antho-Riamide I is an active peptide. It also inhibits the spontaneous contraction of sea anemone muscles. | |||
T26970 |
CD-349
CD 349,CD349 |
Others | Others |
CD-349 is a calcium channel antagonist. CD-349 inhibits the noradrenaline (NA)-induced contraction of aortas in Ca2(+)-free medium. | |||
TP1098 |
Motilin, canine
Motilin (canine) |
||
Motilin canine, a 22-amino acid peptide, functions as a robust gastrointestinal smooth muscle contraction agonist. | |||
T68698 |
VPC 23153
|
Others | Others |
VPC 23153 is a sphingosine 1-phosphate 4 receptor agonist. This hygroscopic phospholipid causes contraction of pulmonary artries in rats. | |||
T27829 |
Lidamidine Hydrochloride
WHR1142A,WHR-1142A,Lidaral,WHR 1142A |
Others | Others |
Lidamidine Hydrochloride is an alpha2-adrenergic receptor agonist. Lidamidine Hydrochloride inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscle contraction. | |||
T71579 |
GOE-5438
|
Others | Others |
GOE-5438 is a calcium antagonist that has been shown to inhibit the excitation and contraction of single cardiomyocytes. | |||
T11629 | Ifenprodil glucuronide | Others | Others |
Ifenprodil glucuronide, a derivative of Ifenprodil, is a vasodilator and an inhibitor of platelet aggregation. In contrast to Ifenprodil, Ifenprodil glucuronide does not affect platelet aggregation nor arterial contraction. | |||
T34762 |
T-0201
T 0201,TA0201,TA-0201,TA 0201 |
Others | Others |
T-0201 (TA 0201) is a highly potent, long-acting, orally active, and selective ETA receptor antagonist. T-0201 also inhibited ET-1-induced pulmonary artery contraction in isolated rabbits. | |||
T37493 |
11-trans Leukotriene D4
11-trans Leukotriene D4 |
Others | Others |
11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea. | |||
T40563 |
Sandaracopimaric acid
|
Others | Others |
Sandaracopimaric acid is an anti-inflammatory diterpenoid compound that effectively reduces the contraction of phenylephrine-induced pulmonary arteries. With an EC50 of 43.93 μM, it exhibits noteworthy anti-inflammatory properties. | |||
T27164 |
DHP-218
PAK-9,PAK9,PAK 9,DHP218 |
Others | Others |
DHP-218 is a calcium channel antagonist. DHP-218 inhibits Calcium-induced contraction of the rat aorta in high K+ solution with the pA2 value of 9.11. The IC50 value for the inhibitory effects of DHP-218 in high K+-induced and phenylephrine-induced contra | |||
T71021 |
Fendiline
|
Others | Others |
Fendiline is a coronary vasodilator that inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as an antiarrhythmic and antianginal agent. | |||
T34458 |
Ryanodol
|
Others | Others |
Ryanodol is a complex diterpenoid that modulates intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission. | |||
T34958 |
TRK-380
TAC301,TAC 301,TAC-301,TRK 380,TRK380 |
Others | Others |
TRK-380 (TAC-301) is an effective and selective β3-adrenergic receptor agonist. TRK-380 improves formalin-induced frequent urination in rats and carbachol-induced bladder contraction in dogs (a decrease of 37.6%). | |||
T78030 |
GRGESP
|
||
GRGESP为胶原凝胶收缩抑制剂,能够抑制人成纤维细胞在胶原凝胶中的扩散,显著减少凝胶收缩,适用于结缔组织形态发生研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14865 |
Carboprost tromethamine
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Carboprost tromethamine 是合成的前列腺素 F2α的15-甲基类似物,能有效促进子宫的规律收缩,显着减少产中及产后出血量。 | |||
T3A2467 |
Allocryptopine
Thalictrimine,Fagarine I,别隐品碱 |
Potassium Channel | Membrane transporter/Ion channel |
Allocryptopine (Thalictrimine) 是一种延胡索乙素的衍生物,提取自Corydalis decumbens。Allocryptopine 具有抗心律失常作用,能有效阻断hERG 电流。 | |||
T6S0109 |
Sipeimine
Kashmirine,西贝母碱,Imperialine,西贝碱 |
Others | Others |
Sipeimine (Kashmirine) 是一种天然产物,从平贝母中分离得到。 | |||
T20604L |
Litorin acetate(55749-97-8 Free base)
|
Bombesin Receptor | GPCR/G Protein |
Litorin acetate 是一种两栖类铃蟾肽衍生物,是一种铃蟾肽受体激动剂。它刺激平滑肌收缩,刺激胃泌素、胃酸和胰腺分泌,抑制体内营养。 | |||
T5014 |
Prostaglandin E2
地诺前列酮,前列腺素 E2,PGE2,Dinoprostone,Prostaglandin E2 (PGE2) |
Endogenous Metabolite; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism |
Prostaglandin E2 (PGE2) 是一种天然激素,参与人体内的各种生理过程,包括平滑肌收缩和放松、调节血管扩张和收缩、调节血压和炎症调节。 | |||
T4739 |
Sodium creatine phosphate dibasic tetrahydrate
磷酸肌酸二钠盐,Creatine phosphate disodium salt tetrahydrate |
Others; Endogenous Metabolite | Metabolism; Others |
Sodium creatine phosphate dibasic tetrahydrate (Creatine phosphate disodium salt tetrahydrate) 主要存在于脊椎动物的骨骼肌中,是测定肌酸激酶的底物,能够用于骨骼肌收缩过程中 ATP 的再生。 | |||
TN1528 |
Cotoin
|
AChE | Neuroscience |
Cotoin 是从 Garcinia virgate 茎皮中分离出的一种天然产物。Cotoin 具有解痉活性,可降低孤立的兔肠的音调和收缩。它部分抑制乙酰胆碱、毛果芸香碱和 BaCl 对分离肠的影响。 | |||
T7995 |
α-Angelica lactone
α-当归内酯,当归内酯,Alpha-Angelica Lactone |
Others; GST | Others; oxidation-reduction |
α-Angelica lactone 是一种乙烯基亲核试剂,也是一种天然存在的抗癌剂。它可以得到手性的 δ-氨基 γ,γ-二取代丁烯醇内酯羰基衍生物,并在 γ-碳上表现出亲电子俘获。它通过选择性增强谷胱甘肽-S-硫转移酶 (GST) 和 UDP-葡糖苷转移酶 (UGT) 解毒酶发挥强大的化学保护作用。 | |||
T4S0998 |
Trifolirhizin
红车轴草根甙/三叶豆紫檀苷,三叶豆紫檀苷 |
TNF; Tyrosinase | Apoptosis; Proteases/Proteasome |
Trifolirhizin 是一种从苦参根中分离出的 pterocarpan 黄酮类化合物。它具有酪氨酸酶高抑制活性,IC50=506 μM。它具有抗炎和抗癌的潜能。 | |||
T4S1619 |
L-Hyoscyamine sulfate
Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate,硫酸天仙子胺水合物,L-莨菪碱硫酸盐 |
AChR | Neuroscience |
L-Hyoscyamine sulfate (Levsin Sulfate) 是来自山莨菪的一种托烷生物碱,是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。 | |||
T0962 |
L-Hyoscyamine
Daturine,Hyoscyamine,L-莨菪碱,L-天仙子胺 |
AChR | Neuroscience |
L-Hyoscyamine (Daturine) 是从山莨菪中提取的一种托烷生物碱,是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。 | |||
TN4051 |
Fargesone B
|
cAMP; Calcium Channel | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective manner. | |||
T20604 |
Litorin
|
Others | Others |
Litorin, an amphibian bombesin peptide derivative, is found to suppress the nutriment, to stimulate the contraction of smooth muscle, to stimulate gastrin, gastric acid, and pancreatic secretion. | |||
T10913 |
Cyclobuxine D
|
Others | Others |
Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclostatin D has obvious bradycardia effect on rat heart, and inhibits acetylcholine and Ba ++ induced longitudinal muscle contraction isolated from rabbit jejunum. | |||
TN4713 |
Onitisin
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum. | |||
TN4812 |
Pluviatolide
|
AChR | Neuroscience |
(-)-Pluviatolide can inhibit electrically-induced and acetylcholine-induced contraction in the isolated guinea-pig ileum. | |||
TN4484 | Macrophylline | Others | Others |
Macrophylline A shows weak inhibitory action on KCl-induced contraction. | |||
T38609 |
Mycalolide B
|
Others | Others |
Mycalolide-B is a marine sponge-derived compound that functions as a selective inhibitor of actomyosin ATPase. It effectively hinders ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+. | |||
TN3483 |
Bakkenolide D
|
IL Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have obvious anti-histamine activities. | |||
TN5330 |
Lacinilene C
3,10-Dihydroxy-1,3,5,7-cadinatetraen-9-one |
||
Lacinilene C, lacinilene C 7-methyl ether, scopoletin, 2-hydroxy-7-methoxycadalene and 2,7-dihydroxycadalene are 5 induced phytoalexins in cotton leaves. Lacinilene C methyl ether elicits contraction of TSM by enhancing the movement of calcium through pot | |||
T83454 |
13-Hydroxylupanine hydrochloride
Hydroxylupanine hydrochloride |
||
13-Hydroxylupanine是甜羽扇豆中一种典型的生物碱。它具有阻断神经节传递、降低心肌收缩力以及收缩子宫平滑肌的作用。 | |||
T75520 |
Aplyronine A
|
Others | Others |
Aplyronine A是具有特异性肌动蛋白解聚活性、抗肿瘤及促凋亡功能的化合物,适用于癌症、肌肉收缩、细胞运动和细胞分裂等研究领域。 | |||
T41276 |
Peimisine hydrochloride
|
||
Peimisine hydrochloride 非竞争性拮抗气管平滑肌 M 受体,抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放,促进一氧化氮释放,可舒张气管平滑肌,有平喘作用。 | |||
TN5061 |
Stephanine
|
Adrenergic Receptor; Antifection | GPCR/G Protein; Microbiology/Virology; Neuroscience |
l-Stephanine is a potent and highly selective alpha 1 adrenoceptor blocker, inhibits anococcygeus muscle contraction induced by phenylephrine with pA2 values of 6.76. Stephanine shows significant antiplasmodial activities with IC(50) ranged from 1.2 uM to 52.3 uM. Stephanine and crebanine have high inhibitory activity against gram-positive animal pathogenic bacteria, with MIC values of 0.078-0.312g/l, but low inhibitory activity against gram-negative animal pathogenic bacteria, they also inhibit... | |||
TN1790 |
Isopteropodine
Uncarine E |
5-HT Receptor; Antibacterial; AChR | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Isopteropodine (Uncarine E) 是从 Hamelia patens micropropagated 分离得到的一种异育亨宾型辛吲哚生物碱.具有抗菌活性,可刺激机体免疫系统。Isopteropodine 是 M1 型毒蕈碱乙酰胆碱 (muscarinic M1) 受体及 5-HT2 受体的正向调节剂,是PXR激活剂,可诱导大鼠子宫肌层收缩。 | |||
T3229 |
Cytochalasin D
|
ATPase; p38 MAPK; Calcium Channel; Akt; PI3K | Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02252 |
TPM3 Protein, Human, Recombinant (GST)
Gamma-tropomyosin,Tropomyosin alpha-3 chain,Tropomyosin-3,TP... |
Human | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. | |||
TMPH-00780 |
CACNA1C Protein, Guinea Pig, Recombinant (His)
CACNA1C,CACNL1A1,CACH2,CACN2,Voltage-dependent L-type calciu... |
Guinea pig | E. coli |
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressur... | |||
TMPH-03212 |
TPM1 Protein, Rabbit, Recombinant (His & Myc)
TPM1,Alpha-tropomyosin,Tropomyosin alpha-1 chain,Tropomyosin... |
Rabbit | Baculovirus Insect Cells |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. TPM1 Protein, Rabbit, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 3... | |||
TMPH-01727 |
Myosin-6/MYH6 Protein, Human, Recombinant (His)
Myosin heavy chain 6,Myosin heavy chain, cardiac muscle alph... |
Human | P. pastoris (Yeast) |
Muscle contraction. Myosin-6/MYH6 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 76.8 kDa and the accession number is P13533. | |||
TMPH-01728 |
Myosin-6/MYH6 Protein, Human, Recombinant (E. coli, His)
Myosin-6,MYH6,Myosin heavy chain, cardiac muscle alpha isofo... |
Human | E. coli |
Muscle contraction. Myosin-6/MYH6 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 80.8 kDa and the accession number is P13533. | |||
TMPH-02308 |
CACNA2D1 Protein, Human, Recombinant (His & SUMO)
MHS3,Voltage-dependent calcium channel subunit alpha-2/delta... |
Human | E. coli |
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling. | |||
TMPH-02253 |
TPM2 Protein, Human, Recombinant (His)
TPM2,Tropomyosin-2,Tropomyosin beta chain,Beta-tropomyosin |
Human | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. | |||
TMPH-00285 |
Myosin-1 Protein, Bovine, Recombinant (His & Myc)
Myosin heavy chain 2x,MYH1,Myosin heavy chain, skeletal musc... |
Bovine | E. coli |
Muscle contraction. Myosin-1 Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 30.9 kDa and the accession number is Q9BE40. | |||
TMPH-03213 |
TPM1 Protein, Rabbit, Recombinant (E. coli, His & Myc)
Tropomyosin alpha-1 chain,TPM1,Alpha-tropomyosin,Tropomyosin... |
Rabbit | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. TPM1 Protein, Rabbit, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular w... | |||
TMPJ-01261 |
PPP1R14A Protein, Human, Recombinant (His)
17 kDa PKC-Potentiated Inhibitory Protein of PP1,CPI17,PPP1R... |
Human | E. coli |
Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA su... | |||
TMPH-00763 |
Parvalbumin beta Protein, Gadus morhua subsp. callarias, Recombinant (His)
Allergen Gad c I,Parvalbumin beta,Allergen M |
Gadus callarias | E. coli |
In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. Parvalbumin beta Protein, Gadus morhua subsp. callarias, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 16.1 kDa and the accession number is P02622. | |||
TMPH-00762 |
Parvalbumin beta Protein, Gadus morhua, Recombinant (His & SUMO)
Parvalbumin beta |
Gadus morhua | E. coli |
In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. Parvalbumin beta Protein, Gadus morhua, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 27.4 kDa and the accession number is Q90YK9. | |||
TMPY-03600 |
TPM4 Protein, Human, Recombinant (His)
tropomyosin 4,HEL-S-108,TPM4 |
Human | HEK293 Cells |
TPM4, also known as tropomyosin 4, is a member of the tropomyosin family. Members of this family are actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM4 is expressed in cardiac tissue and platelets. It is highly expressed in the platelets of hypertensive patients. TPM4 plays a central role, in association with the troponin complex, in the calcium-dependent regulation of vertebrate striated muscle contraction. Smo... | |||
TMPH-01820 |
OXT Protein, Human, Recombinant (His)
OXT,Oxytocin-neurophysin 1 |
Human | P. pastoris (Yeast) |
Neurophysin 1 specifically binds oxytocin.; Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR). OXT Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 11.6 kDa and the accession number is P01178. | |||
TMPH-01821 |
OXT Protein, Human, Recombinant (His & Myc & SUMO)
OXT,Oxytocin-neurophysin 1 |
Human | E. coli |
Neurophysin 1 specifically binds oxytocin.; Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR). OXT Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 29.6 kDa and the accession number is P01178. | |||
TMPJ-00044 |
TNNC1 Protein, Human, Recombinant (His)
TNNC1,Troponin I,CMH7,TNNI3 |
Human | E. coli |
Troponin I, also known as TNI, is a 24 kDa component of a protein complex on striated muscle thin filaments.Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Troponin I inhibits the calcium-dependent muscle contraction mediated by Troponins... | |||
TMPH-01730 |
MYBPC3 Protein, Human, Recombinant (His & SUMO)
C-protein, cardiac muscle isoform,Myosin-binding protein C, ... |
Human | E. coli |
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. MYBPC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 50.8 kDa and the accession number is Q14896. | |||
TMPH-03749 |
CYSLTR1 Protein, Human, Recombinant (His)
Cysteinyl leukotriene receptor 1,G-protein coupled receptor ... |
Human | E. coli |
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. | |||
TMPH-03753 |
MYLK Protein, Human, Recombinant (His)
MYLK,Myosin light chain kinase, smooth muscle,Telokin,Kinase... |
Human | E. coli |
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl... | |||
TMPY-03438 |
Calsequestrin 1 Protein, Human, Recombinant
CASQ,PDIB1,VMCQA,calsequestrin 1 (fast-twitch, skeletal musc... |
Human | E. coli |
Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. Two forms of calsequestrin have been identified: Calsequestrin-2 and Calsequestrin-1. Calsequestrin-1 is found in fast skeletal muscle. The release of calsequestrin-boun... | |||
TMPH-01032 |
Calponin-2/CNN2 Protein, Human, Recombinant (His & SUMO)
Calponin-2,Calponin H2, smooth muscle,Neutral calponin,CNN2 |
Human | E. coli |
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Calponin-2/CNN2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 49.6 kDa and the accession number is Q99439. | |||
TMPH-01731 |
MYBPC2 Protein, Human, Recombinant (His)
C-protein, skeletal muscle fast isoform,Myosin-binding prote... |
Human | E. coli |
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. MYBPC2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 49.5 kDa and the accession number is Q14324. | |||
TMPY-03458 |
Sorcin/SRI Protein, Human, Recombinant
sorcin,SCN,CP22,V19,CP-22 |
Human | Baculovirus Insect Cells |
Sorcin was originally identified in multidrug-resistant cells. It is a calcium-binding protein. Sorcin modulates excitation-contraction coupling in the heart, contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Sorcin is overexpressed in the multi-drug resistant chinese hamster ovary cell line CHRC5 and a variety of multidrug-resistant tumor cell lines, but overexpression is not a sufficient or necessary condition for the acquisition of the multidrug-resistant phenotype. Sorc... | |||
TMPJ-00793 |
TPM3 Protein, Human, Recombinant
Tropomyosin α-3 Chain,γ-Tropomyosin,hTM5,Tropomyosin Alpha-3... |
Human | E. coli |
Tropomyosin Alpha-3 Chain (TPM3) is a member of the Tropomyosin family. TPM3 exists as a heterodimer consisting of an alpha and a beta chain. TPM3 plays a central role in association with the Troponin complex and in the calcium dependent regulation of vertebrate striated muscle contraction. Defects in TPM3 are the cause of thyroid papillary carcinoma. Mutations in the TPM3 gene cause autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are... | |||
TMPH-02405 |
LqqIT1 Protein, Leiurus quinquestriatus quinquestriatus, Recombinant (His & Myc)
Beta-insect excitatory toxin LqqIT1 |
Egyptian scorpion | E. coli |
Excitatory insect beta-toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin induces a fast excitatory contraction paralysis on fly larvae. It is active only on insects. LqqIT1 Protein, Leiurus quinquestriatus quinquestriatus, Recombinant (His & Myc) is expressed in E. coli expre... | |||
TMPH-03107 |
Complement C5a Protein, Pig, Recombinant (His)
Complement C5a anaphylatoxin,C5 |
Sus scrofa (Pig) | P. pastoris (Yeast) |
Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.... | |||
TMPJ-00475 |
Kallikrein 1/KLK1 Protein, Human, Recombinant (aa 19-262, His)
Tissue Kallikrein,Kidney/Pancreas/Salivary Gland Kallikrein,... |
Human | HEK293 Cells |
Kallikrein-1 (KLK1) is a member of human tissue Kallikrein family. Human KLK1 precursor contains a singal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262). The function of KLK1 is to cleave Kininogen in order to release the vasoactive Kinin peptide (Lysyl-Bradykinin or Bradykinin). The Kinin peptide controls blood pressure reduction, vasodilation, smooth muscle relaxation and contraction, pain induction and inflammation. KLK1 also plays ... | |||
TMPY-03267 |
Sorcin/SRI Protein, Human, Recombinant (His & GST)
CP-22,CP22,sorcin,V19,SCN |
Human | Baculovirus Insect Cells |
Sorcin was originally identified in multidrug-resistant cells. It is a calcium-binding protein. Sorcin modulates excitation-contraction coupling in the heart, contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Sorcin is overexpressed in the multi-drug resistant chinese hamster ovary cell line CHRC5 and a variety of multidrug-resistant tumor cell lines, but overexpression is not a sufficient or necessary condition for the acquisition of the multidrug-resistant phenotype. Sorc... | |||
TMPY-03957 |
Troponin C Protein, Human, Recombinant
TN-C,CMD1Z,TNNC,TNC,CMH13,troponin C type 1 (slow) |
Human | E. coli |
Troponin I, also known as TNNC1, is part of the troponin complex. This complex contains 3 subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC). Troponin I is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which... | |||
TMPJ-01112 |
PRKG1 Protein, Human, Recombinant (His)
PRKGR1B,PRKG1B,cGKI,cGMP-Dependent Protein Kinase 1,cGK1,cGK... |
Human | HEK293 Cells |
cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one protein kinase domain. PRKG1 is mainly expressed in the lung and placenta. PRKG1 acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. PRKG1 can phosphorylate many proteins that regulate platelet activation and adhesion, smooth muscle contraction, cardiac function,... | |||
TMPY-03984 |
TPM1 Protein, Human, Recombinant (His)
TMSA,tropomyosin 1 (alpha),LVNC9,CMH3,HTM-alpha,CMD1Y,C15orf... |
Human | E. coli |
TPM1, also known as tropomyosin-1, is a member of the tropomyosin family. Members of this family are highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM1 is one type of alpha-helical chain that forms the predomin... | |||
TMPH-01640 |
MRGPRX2 Protein, Human, Recombinant (His)
Mas-related G-protein coupled receptor member X2,MRGPRX2 |
Human | E. coli |
Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway c... | |||
TMPY-04207 |
Motilin Protein, Human, Recombinant (His)
MLN,Motilin |
Human | HEK293 Cells |
MLN (Motilin) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. The encoded protein belongs to the motilin family. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). MLN plays an important role in the regulation of Interdigestive... | |||
TMPY-02945 |
Prokineticin 1/EG-VEGF Protein, Human, Recombinant (His)
PK1,EGVEGF,PRK1,prokineticin 1 |
Human | Baculovirus Insect Cells |
EG-VEGF, also known as prokineticin-1, is a member of the AVIT (prokineticin) family. Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. EG-VEGF can be detected in the steroidogenic glands, ovary, testis, adrenal and placenta. EG-VEGF has little or no effect on a variety of other endothelial and non-endothelial cell types. It induces proliferation, migration and fenestration (the formation of membrane discontinuities) i... | |||
TMPJ-00734 |
KNG1 Protein, Human, Recombinant (His)
KNG1,High Molecular Weight Kininogen,BDK,HMWK,KNG,Williams-F... |
Human | HEK293 Cells |
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation... | |||
TMPY-02977 |
PDE1C Protein, Human, Recombinant (His & GST)
hCam-3,phosphodiesterase 1C, calmodulin-dependent 70kDa,cam-... |
Human | Baculovirus Insect Cells |
PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a s... | |||
TMPY-01854 |
DPP10 Protein, Human, Recombinant (His)
DPPY,DPRP3,DPRP-3,DPL2,dipeptidyl-peptidase 10 (non-function... |
Human | HEK293 Cells |
Inactive dipeptidyl peptidase 1, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP1, is a single-pass type II membrane protein which belongs to thepeptidase S9B family.DPPIV subfamily. It may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. DPP1 / DPRP3 has no detectable protease activity, most likely due to the absence of the conserved serine residue normally p... | |||
TMPY-02081 |
PDE2A Protein, Human, Recombinant (aa 215-900, His)
phosphodiesterase 2A, cGMP-stimulated,cGSPDE,PED2A4,PDE2A1,C... |
Human | Baculovirus Insect Cells |
cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac ... | |||
TMPY-04385 |
ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST)
death-associated protein kinase 3,DLK,ZIP,ZIPK |
Human | Baculovirus Insect Cells |
Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. DAPK3 / ZIPK contains oneprotein kinase domain. It is a serine/threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 / ZIPK is a homodimer or forms heterodimers with AT... | |||
TMPJ-00029 |
CALM1 Protein, Human, Recombinant
Calmodulin,CAMIII,CAMC,CALM,CALML2,CALM2,CAM2,CALM3,CAM1,CAM... |
Human | E. coli |
Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+ is required for the activation of Calmodulin. Once bound to Ca2+, Calmodulin acts as part of a calcium signal transduction pathway by modifying its interactions with various target proteins such as kinases or phosphatases. Calmodulin is a small, highly conserved protein that is 148 amino acid... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIH-0512 |
Salbutamol-d3
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Salbutamol-d3 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。 | |||
TMID-0233 |
Salbutamol-d9
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Salbutamol-d9 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。 | |||
T71141 |
Fenspiride-d5
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Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from ... |