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TMPH-03529
|
Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His)
CHIPS,Chemotaxis inhibitory protein,chp
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Staphylococcus aureus
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P. pastoris (Yeast)
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|
Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Re... |
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TMPH-03528
|
Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS47), Recombinant (His & Myc)
chp,Chemotaxis inhibitory protein,CHIPS
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Staphylococcus aureus
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E. coli
|
|
Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS... |
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TMPJ-00831
|
CCL3 Protein, Mouse, Recombinant (His)
LD78 α,MIP-1 α,MIP1-a,MIP-1 alpha,LD78 alpha,chemokine (C-C ...
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Mouse
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E. coli
|
|
C-C Motif Chemokine 3 (MIP-1 alpha,CCL3 ) is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, smooth muscle cells, and epithelial cells. Mature mouse CCL3 shares 73%, 91%, and 82% amino acid sequence identity with human, rat, and cotton rat CCL3, respectively. CCL3 exerts its biological functions through interactions with CCR1, CCR3, and CCR5. It is cleared from the extra... |
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TMPK-00831
|
Galectin-3 Protein, Mouse, Recombinant (His)
Galectin3,LGALS2,AGE-R3,L31,LGALS3,Mac-2,GAL3,L29,Gal-3,GALI...
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Mouse
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HEK293 Cells
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|
Galectin-3 (Gal-3) is a 30 kDa β-galactose, highly conserved and widely distributed intracellularly and extracellularly. Gal-3 has been demonstrated in recent years to be a novel inflammatory factor participating in the process of intravascular inflammation, lipid endocytosis, macrophage activation, cellular proliferation, monocyte chemotaxis, and cell adhesion. |
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TMPJ-00562
|
PDGF-BB Protein, Mouse, Recombinant (His)
PDGFBB,PDGF-BB,血小板源生长因子
|
Mouse
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E. coli
|
|
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. As growth factor，it plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival... |
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TMPJ-00042
|
TSLP Protein, Human, Recombinant
TSLP,Thymic stromal lymphopoietin
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Human
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E. coli
|
|
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region. Human TSLP has two isoforms lfTSLP and sfTSLP produced by alternative splicing . lfTSLP is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral... |
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TMPY-02550
|
Eotaxin/CCL11 Protein, Human, Recombinant (His)
SCYA11,chemokine (C-C motif) ligand 11
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Human
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E. coli
|
|
CCL11 or chemokine (C-C motif) ligand 11 is a member of the chemokine (C-C motif) ligand family. Chemokin (C-C motif) ligand 11 is a member of the chemokine family. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. Chemokines are a family of small ... |
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TMPH-02659
|
FPR2 Protein, Mouse, Recombinant (GST & His & Myc)
Fpr2,Formyl peptide receptor 2,Formylpeptide receptor-relate...
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Mouse
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E. coli
|
|
High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophil chemotactic factors. Stimulates chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation. Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation. FPR2 Protein, Mouse,... |
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TMPH-02612
|
CXCR3 Protein, Mouse, Recombinant (His & KSI)
CXC-R3,CKR-L2,CXCR3,CD183,GPR9,Interferon-inducible protein ...
|
Mouse
|
E. coli
|
|
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response. Binds to CCL21. |
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TMPH-01773
|
ELANE Protein, Human, Recombinant (GST)
Neutrophil elastase,ELA2,Medullasin,Elastase-2,ELANE,Bone ma...
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Human
|
E. coli
|
|
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae. ELANE Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 52.6 kDa and the accession number is P08246. |
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TMPH-03523
|
Alpha-hemolysin Protein, S. aureus, Recombinant (His & SUMO)
Alpha-HL,Alpha-toxin
|
Staphylococcus aureus
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E. coli
|
|
Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity. |
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TMPH-03475
|
MglB Protein, Salmonella typhimurium, Recombinant (His)
D-galactose/D-glucose-binding protein,D-galactose-binding pe...
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Salmonella typhimurium
|
P. pastoris (Yeast)
|
|
This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor. MglB Protein, Salmonella typhimurium, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 35.4 kDa and the accession number is P23905. |
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TMPH-02696
|
GNAQ Protein, Mouse, Recombinant (His & Myc)
Guanine nucleotide-binding protein G(q) subunit alpha,Gnaq,G...
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Mouse
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E. coli
|
|
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). |
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TMPH-03522
|
Alpha-hemolysin Protein, S. aureus, Recombinant (His)
Alpha-toxin,Alpha-HL
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Staphylococcus aureus
|
P. pastoris (Yeast)
|
|
Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity. |
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TMPY-02724
|
XCL2 Protein, Human, Recombinant (His)
SCM1B,hCG_1729916,SCM-1b,chemokine (C motif) ligand 2,SCYC2
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Human
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Baculovirus Insect Cells
|
|
XCL2 is a small cytokine belonging to the XC chemokine family. Chemokines are a group of cytokines. Members of this group of so-called C-Chemokines belong to the SCY family of cytokines and are designated XCL (L for ligand) followed by a number. XCL2 is the new designation of SCM-1-beta. XCL2 is highly related to another chemokine called XCL1. XCL2 gene is located on chromosome 1 in humans. XCL2 is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated ... |
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TMPK-01316
|
CCR8 Protein, Cynomolgus, Recombinant (mFc)
GPR-CY6,CY6,CKRL1,CDw198,CMKBR8,ChemR1,CKR-L1,CD198,CCR-8,TE...
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Cynomolgus
|
HEK293 Cells
|
|
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection. CCR8 Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 29.73 kDa and the accession number is A0A8J8XUI3. |
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TMPK-00897
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CCR8 Protein, Human, Recombinant (mFc)
GPR-CY6,CY6,CKRL1,CMKBRL2,TER-1,CDw198,CCR-8,CCR8,CKR-L1,CD1...
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Human
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HEK293 Cells
|
|
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection. CCR8 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 30.25 kDa and the accession number is P51685-1. |
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TMPK-00896
|
CCR8 Protein, Human, Recombinant (hFc)
GPR-CY6,CKR-L1,CMKBRL2,ChemR1,CDw198,CCR-8,CY6,TER-1,CCR8,CM...
|
Human
|
HEK293 Cells
|
|
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection. CCR8 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 30.62 kDa and the accession number is P51685-1. |
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TMPK-00988
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ECSCR Protein, Mouse, Recombinant (hFc)
ECSCR,ARIA,ECSM2
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Mouse
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HEK293 Cells
|
|
Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC... |
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TMPK-00454
|
VEGFR2/KDR Protein, Human, Recombinant (His & Avi)
VEGFR-21,Ly73,KRD1,VEGFR2,CD309,FLK1,VEGFR,KDR
|
Human
|
HEK293 Cells
|
|
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis. VEGFR2/KDR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-H... |
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TMPH-02835
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PDGFD Protein, Mouse, Recombinant (His & SUMO)
Platelet-derived growth factor D,Pdgfd,Spinal cord-derived g...
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Mouse
|
E. coli
|
|
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including inf... |
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TMPH-01023
|
C5AR1 Protein, Human, Recombinant (Cell-Free, His)
C5a anaphylatoxin chemotactic receptor 1,C5R1,C5a-R,C5a anap...
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Human
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E. coli
|
|
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. C5AR1 Protein, Human, Recombinant (Cell-Free, His) is expressed in E. coli expression syst... |
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TMPH-01022
|
C5AR1 Protein-VLP, Human, Recombinant (His)
C5a anaphylatoxin chemotactic receptor 1,CD88,C5a anaphylato...
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Human
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HEK293 Cells
|
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Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. C5AR1 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-... |
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TMPK-00645
|
VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)
KRD1,VEGFR2,FLK1,CD309,Ly73,VEGFR,VEGFR-21,KDR
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Rhesus
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HEK293 Cells
|
|
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis. VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with ... |
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TMPJ-00658
|
CYR61/CCN1 Protein, Human, Recombinant (hFc)
Cysteine-rich angiogenic inducer 61,IGFBP10,Insulin-like gro...
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Human
|
HEK293 Cells
|
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Protein CYR61, also known as CCN family member 1, Cysteine-rich angiogenic inducer 61,Insulin-like growth factor-binding protein 10 , GIG1, CYR61, CCN1 and IGFBP10, belongs to the CCN family, CYR61 is a secreted protein and contains one CTCK (C-terminal cystine knot-like) domain,one IGFBP N-terminal domain,one TSP type-1 domain and one VWFC domain. CYR61 promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. CYR61 plays important roles in inflammation and tissue repair. CYR61 ... |
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TMPK-00978
|
ECSCR Protein, Human, Recombinant (hFc)
ECSM2,ECSCR,ARIA
|
Human
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HEK293 Cells
|
|
Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC... |
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TMPJ-00451
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IL-16 Protein, Human, Recombinant
Interleukin-16,IL16,Lymphocyte Chemoattractant Factor,IL-16,...
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Human
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E. coli
|
|
Interleukin-16 (IL-16) is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-... |
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TMPJ-00022
|
LGALS7 Protein, Human, Recombinant
Galectin-7,Gal-7,LGALS7,PI7,PIG1,LGALS7B,p53-Induced Gene 1 ...
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Human
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E. coli
|
|
The Galectin family of proteins, with specificity for Nacetyllactosamine containing glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs).They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. Although they are localized primarily in the cytoplasm and lack a classical signal peptide; they can be secreted ... |
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TMPH-00794
|
Dps Protein, Helicobacter pylori, Recombinant (His & SUMO)
napA,DNA protection during starvation protein,Bacterioferrit...
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Helicobacter pylori
|
E. coli
|
|
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role... |
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TMPJ-01292
|
Chemerin/RARRES2 Protein, Human, Recombinant (His)
RAR-responsive protein TIG2,RARRES2,Chemerin,Tazarotene-indu...
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Human
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HEK293 Cells
|
|
Retinoic acid receptor responder protein 2(RARRES2) is a secreted protein that in humans is encoded by the RARRES2 gene. It is highly expressed in skin, also found in pancreas, liver, spleen, prostate, ovary, small intestine and colon. It is a chemoattractant protein that acts as a ligand for the G protein-coupled receptor CMKLR1. RARRES2 is secreted in an inactive form as prochemerin and is activated through cleavage of the C-terminus by inflammatory and coagulation serine proteases. It is thou... |
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TMPJ-00355
|
Neuropilin-1 Protein, Human, Recombinant (aa 22-644, Avi & His), Biotinylated
CD304,VEGF165R,NRP1,NRPNP1,BDCA4
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Human
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HEK293 Cells
|
|
Neuropilin-1 (Npn-1, previously neuropilin; also CD304) is a 130 - 140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. Neuropilin-1 binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds ... |
|
TMPY-02795
|
Eotaxin-2 Protein, Human, Recombinant (His)
MPIF-2,chemokine (C-C motif) ligand 24,SCYA24,MPIF2,Ckb-6
|
Human
|
Baculovirus Insect Cells
|
|
CCL24, also known as Eotaxin-2 and MPIF-2, belongs to the intercrine beta (chemokine CC) family. CCL24 gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL24 displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. CCL24 is als... |
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TMPJ-00271
|
SMAD3 Protein, Human, Recombinant (His & Flag)
SMAD 3,Mothers against DPP homolog 3,hMAD-3,MADH3,JV15-2,SMA...
|
Human
|
E. coli
|
|
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated... |
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TMPJ-00952
|
SDF-1/CXCL12 Protein, Mouse, Recombinant
Sdf1,C-X-C motif chemokine 12,Thymic lymphoma cell-stimulati...
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Mouse
|
E. coli
|
|
Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, and lymphoid organs. Cxcl12 activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scaven... |
|
TMPJ-00654
|
LGALS8 Protein, Human, Recombinant
Prostate Carcinoma Tumor Antigen 1,Po66-CBP,Galectin-8,PCTA-...
|
Human
|
E. coli
|
|
The Galectin family of proteins, with specificity for Nacetyllactosaminecontaining glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs). They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. Although they are localized primarily in the cytoplasm and lack a classical signal peptide, galectins can also be... |
|
TMPH-01503
|
Humanin Protein, Human, Recombinant (hFc)
MT-RNR2,Humanin,Humanin mitochondrial
|
Human
|
HEK293 Cells
|
|
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation.... |
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TMPH-02521
|
PYCARD Protein, Mouse, Recombinant (His & Myc)
Pycard,PYD and CARD domain-containing protein,Apoptosis-asso...
|
Mouse
|
E. coli
|
|
Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved ... |
|
TMPH-01502
|
Humanin Protein, Human, Recombinant (GST)
Humanin,Humanin mitochondrial,MT-RNR2
|
Human
|
E. coli
|
|
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation.... |
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