首页工具

登录

搜索结果

Search Results for " cardiac fibrosis "

Targets Recommended: Others Histone Acetyltransferase STAT

11

抑制剂 & 化合物

4

天然产物

3

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T11807	L002	Others; Histone Acetyltransferase; STAT	Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells
	L002 是一种细胞可渗透的，可逆特定性乙酰转移酶 p300(KAT3B)抑制剂，IC50为 1.98 μM。它结合乙酰辅酶 A 口袋并竞争性抑制 FATp300 催化结构域，阻断组蛋白乙酰化和 p53 乙酰化，且抑制 STAT3 激活，有用于高血压引起的心脏肥大和纤维化的研究潜力。
T1449	Hydrochlorothiazide HCTZ,双氢氯噻嗪,氢氯噻嗪	Potassium Channel; Carbonic Anhydrase; TGF-beta/Smad	Membrane transporter/Ion channel; Metabolism; Stem Cells
	Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。
T3096	Canrenoate potassium 坎利酸钾,Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone	Glucocorticoid Receptor	Endocrinology/Hormones
	Canrenoate potassium (Soldactone) 是一种有效的竞争性盐皮质激素受体 (mineralocorticoid receptor) 拮抗剂，是一种释放 canrenone 的前药。它作为一种利尿剂，用于高血压的研究。
T9010	IMM-H007	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	IMM-H007 是一种新型降脂剂，可增加 abca1 蛋白的表达。
T12078	ML334 LH601A	Nrf2	Immunology/Inflammation
	ML334 (LH601A) 是一种可穿过细胞膜且具有有效性的 NRF2 激活剂，抑制 Keap1-NRF2 蛋白质相互作用，抑制心脏成纤维细胞活化和增殖来改善心肌梗死诱导的心脏纤维化。
T30778	CCG-257081 MRTF/SRF-IN-1,CCG257081,CCG 257081	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CCG-257081 (MRTF/SRF-IN-1) 是心肌素相关转录因子和血清反应因子 (MRTF/SRF) 的抑制剂,通过抑制 Rho/MRTF/SRF 通路来发挥作用。CCG-257081 已在多个小鼠模型中显示出预防博莱霉素诱导的纤维化的功效。CCG-257081 可用于预防癌症和纤维化的研究。
T38424	(R)-Fadrozole FAD286,(R)-CGS 16949A free base,(R)-Fadrozole	Others	Others
	(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats..
T27247	EGFR-IN-542	Others	Others
	EGFR-IN-542 is a novel EGFR inhibitor. EGFR-IN-542 significantly reduces myocardial inflammation, fibrosis, apoptosis and dysfunction. It shows promise for use in the treatment of obesity-induced cardiac complications.
T60266	(Rac)-Indoximod	Others	Others
	(Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardiac myofibroblasts (hCMs) and promotes apoptosis by up-regulating the genes IRF-1, Fas, and FasL. Moreover, this co-treatment effectively improves cardiac fibrosis[1].
T60713	TK-129	Others	Others
	TK-129 是具有口服活性的 KDM5B 的有效抑制剂，IC50值为44 nM，并且具有低毒性。TK-129 发挥心脏保护作用，通过抑制 KDM5B 和阻断 KDM5B 相关的 Wnt 通路。TK-129 可用于研究心血管疾病，它能在体内减少异丙肾上腺素诱导的心肌重塑和纤维化，并且在体外减少 Ang II 诱导的心脏成纤维细胞活化。
T65994	(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide	Others	Others
	Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation...

化合物

Cat.No: T11807

Target: Others, Histone Acetyltransferase, STAT

Hydrochlorothiazide

Cat.No: T1449

Synonym: HCTZ,双氢氯噻嗪,氢氯噻嗪

Target: Potassium Channel, Carbonic Anhydrase, TGF-beta/Smad

Canrenoate potassium

Cat.No: T3096

Synonym: 坎利酸钾,Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone

Target: Glucocorticoid Receptor

Cat.No: T9010

Target: Others, AMPK

Cat.No: T12078

Synonym: LH601A

Target: Nrf2

Cat.No: T30778

Synonym: MRTF/SRF-IN-1,CCG257081,CCG 257081

Target: Rho, Ras

Cat.No: T38424

Synonym: FAD286,(R)-CGS 16949A free base,(R)-Fadrozole

Target: Others

Cat.No: T27247

Target: Others

(Rac)-Indoximod

Cat.No: T60266

Target: Others

Cat.No: T60713

Target: Others

(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

Cat.No: T65994

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5247	Trimethylamine N-oxide dihydrate 二水氧化三甲胺,TMANO Dihydrate	Others; Endogenous Metabolite	Metabolism; Others
	Trimethylamine N-oxide dihydrate (TMANO Dihydrate) 是内源性代谢产物的一种。
T41245	Trimethylamine N-oxide	Reactive Oxygen Species; NOD-like Receptor (NLR); TGF-beta/Smad	Immunology/Inflammation; Metabolism; NF-κB; Stem Cells
	Trimethylamine N-oxide (TMAO）是由胆碱、甜菜碱和肉碱通过肠道微生物代谢产生的一种无色氧化胺，积聚在海洋动物的组织中，可预防尿素对蛋白质的破坏作用。Trimethylamine N-oxide 通过激活 ROS/NLRP3 炎性体诱导炎症，可诱导纤维细胞的分化和心脏纤维化。
T3753	Sinapinic Acid Sinapic acid,芥子酸,Synapoic acid	Apoptosis; RAAS; Reactive Oxygen Species; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类，是HDAC 抑制剂，对ACE-I 的活性也有抑制作用。它有抗肿瘤活性，诱导肿瘤细胞凋亡，具有抗氧化、抗糖尿病的作用。
T10554	Bixin	Others	Others
	Bixin is isolated from the seeds of Bixa orellana and possesses anti-tumor, anti-inflammatory, and antioxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation, and ROS generation.

天然产物

Trimethylamine N-oxide dihydrate

Cat.No: T5247

Synonym: 二水氧化三甲胺,TMANO Dihydrate

Target: Others, Endogenous Metabolite

Trimethylamine N-oxide

Cat.No: T41245

Target: Reactive Oxygen Species, NOD-like Receptor (NLR), TGF-beta/Smad

Cat.No: T3753

Synonym: Sinapic acid,芥子酸,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Cat.No: T10554

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05004	FGF-4 Protein, Human, Recombinant HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,HST,HBGF-4	Human	E. coli
	FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a...
TMPY-00566	CCL18 Protein, Human, Recombinant (His) PARC,CCL18,CKb7,DC-CK1,chemokine (C-C motif) ligand 18,MIP-4...	Human	P. pastoris (Yeast)
	CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. CCL18 chemokine has an important role in chemokine-mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. (CCL18) is predominantly secreted by M2-tumor associated macrophages (TAMs) a...
TMPY-01826	Relaxin 1/RLN1 Protein, Human, Recombinant (His) RLXH1,H1RLX,relaxin 1,bA12D24.3.1,H1,RLN1,bA12D24.3.2	Human	HEK293 Cells
	Relaxin-1, also known as Prorelaxin H1 and RLN1, is a secreted protein that belongs to the insulin family. It is a peptide hormone that was first described in 1926 by Frederick Hisaw. Since its discovery as a reproductive hormone 8 years ago, relaxin has been implicated in a number of pregnancy-related functions involving extracellular matrix (ECM) turnover and collagen degradation. It is now becoming evident that relaxin's ability to reduce matrix synthesis and increase ECM degradation has impo...

重组蛋白

FGF-4 Protein, Human, Recombinant

Cat.No: TMPY-05004

Species: Human

Expression System: E. coli

CCL18 Protein, Human, Recombinant (His)

Cat.No: TMPY-00566

Species: Human

Expression System: P. pastoris (Yeast)

Relaxin 1/RLN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01826

Species: Human

Expression System: HEK293 Cells

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼