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TargetMol产品目录中 "

CNS-penetration

"的结果
  • 抑制剂&激动剂
    29
    TargetMol | Inhibitors_Agonists
  • AC1-IN-1
    T600032762422-55-7
    AC1-IN-1 是 1 型腺苷酸环化酶的选择性抑制剂(AC1,IC50 = 0.54 µM)。
    • ¥ 798
    In stock
    规格
    数量
  • Ganciclovir
    更昔洛韦, RS-21592, BW 759, 2'-Nor-2'-deoxyguanosine
    T068882410-32-0
    Ganciclovir (2'-Nor-2'-deoxyguanosine) 是核苷类似物和口服抗病毒药物,对CMV 具有抗病毒活性。它用于治疗与艾滋病相关的巨细胞病毒感染的并发症。
    • ¥ 344
    In stock
    规格
    数量
  • Ganciclovir sodium
    更昔洛韦钠, RS-21592 sodium, Cytovene IV sodium, BW 759 sodium, 2'-Nor-2'-deoxyguanosine sodium
    T22337107910-75-8
    Ganciclovir sodium (Cytovene IV sodium) 是核苷类似物和口服抗病毒药物,具有抗病毒活性,尤其是针对巨细胞病毒和单纯疱疹病毒 1 型。
    • ¥ 142
    In stock
    规格
    数量
  • Lamivudine
    拉米夫定, GR109714X, BCH-189
    T0682134678-17-4
    Lamivudine (BCH-189) 是一种核苷逆转录酶抑制剂,可抑制HIV 逆转录酶1和2 以及乙型肝炎病毒的逆转录酶。
    • ¥ 325
    In stock
    规格
    数量
  • Entrectinib
    恩曲替尼, RXDX-101, NMS-E628
    T36781108743-60-7
    Entrectinib (RXDX-101) 是一种 Trk、ROS1 和 ALK 抑制剂,抑制 TrkA、TrkB、TrkC、ROS1 和 ALK (IC50=1 3 5 12 7 nM),具有口服活性和血脑屏障渗透性。Entrectinib 具有抗肿瘤和中枢神经活性。
    • ¥ 297
    In stock
    规格
    数量
  • (Rac)-VU 6008667
    T126792092917-63-8
    (Rac)-VU 6008667 是一种选择性的毒蕈碱乙酰胆碱受体亚型 5(M5 NAM)负异位调节剂,IC50 为 1.8 μM,pIC50 为 5.75,具有较高的中枢神经系统渗透性。
    • ¥ 289
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Etilevodopa hydrochloride
    Levodopa ethyl ester, Etilevodopa HCl,  L-DOPA ethyl ester
    T2404739740-30-2
    Etilevodopa hydrochloride (L-DOPA ethyl ester) 是 Levodopa 的前药,在胃肠道中被非特异性酯酶快速水解产生 Levodopa 和乙醇。Levodopa 是多巴胺的前体,有助于中枢神经系统的渗透和传递多巴胺。Etilevodopa HCl 可用于帕金森病 (PD)的相关研究。
    • ¥ 137
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • RO-3
    T55131026582-88-6
    RO3 是一种能透过大脑的P2X3和P2X2 3拮抗剂,口服有活性。它对人同型多聚体 P2X3和异型多聚体 P2X2 3受体的 pIC50分别为 5.9 和 7.0。
    • ¥ 786
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • TAK-285
    TAK285, TAK 285
    T6039871026-44-7
    TAK-285 是一种新型 HER2 和 EGFR(HER1) 双重抑制剂,IC50 分别为 17 和 23 nM。它可穿过血脑屏障,有抗肿瘤活性,对 HER1 2 的选择性是 HER4 的 10 倍以上。
    • ¥ 593
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Auglurant
    VU0424238
    T172411396337-04-4
    Auglurant is a novel and selective mGlu5 antagonist (IC50: 11 nM (rat) and an IC50: 14 nM (human)). Auglurant has an acceptable CNS penetration.
    • ¥ 3190
    5日内发货
    规格
    数量
  • A 784168
    T21750824982-41-4
    A-784168 是一种有效的、口服活性的香草素受体 1 型 (TRPV1) 抑制剂。香草素受体 1 型 (TRPV1) 是一种配体门控非选择性阳离子通道,被认为是各种疼痛刺激 (如内源性脂质、辣椒素、热和低 pH 值) 的重要整合剂。口服给药时,A-784168 具有良好的 CNS 渗透性。
    • 待估
    35日内发货
    规格
    数量
  • AZ599
    AZ-599,AZ 599
    T25124910798-82-2
    AZ599 is a full agonist of CB1 with good solubility and low CNS penetration.
    • ¥ 10600
    6-8周
    规格
    数量
  • ML350
    SR-2311,SR 2311,SR2311,ML-350,ML 350
    T258191565852-90-5
    ML350 (CYM-50202) is a KOR (IC50: 12.6 nM) antagonist with good and moderate selectivity against the DOR and MOR. CYM-50202 displayed high solubility and excellent CNS penetration. CYM-50202 did not display long-lasting pharmacodynamic effects observed wi
    • ¥ 10600
    6-8周
    规格
    数量
  • AZD7268
    AZD-7268, AZD 7268
    T267221018988-00-5
    AZD7268 is a potent, selective, reversible, and orally bioavailable agonist of δ-opioid receptor with CNS penetration.
    • ¥ 11700
    6-8周
    规格
    数量
  • GSK-345931A
    GSK 345931A, GSK-345931A free acid, GSK 345931A free acid
    T27474869499-38-7
    GSK-345931A, an EP(1) receptor antagonist, shows measurable CNS penetration in the mouse and rat and potent analgesic efficacy in acute and sub-chronic models of inflammatory pain.
    • ¥ 10600
    6-8周
    规格
    数量
  • ML372
    ML 372,ML-372
    T280671331745-61-9
    ML372 is a potent and selective SMN Modulator (EC50 = 12 nM, 325% increase inSMN2) with good potency, pharmacokinetics, tolerance, and CNS penetration.
    • ¥ 2180
    5日内发货
    规格
    数量
  • vu6001966
    VU-6001966, VU 6001966
    T291422009052-76-8
    VU6001966 is a potent and selective mGlu2 inhibitor (mGlu2 IC50 = 78 nM) and negative allosteric modulator. VU6001966 exhibits excellent central nervous system (CNS) penetration.
    • 待估
    35日内发货
    规格
    数量
  • WAY267464 HCl
    WAY-267464 HCl, WAY-267,464 dihydrochloride, WAY 267464 dihydrochloride, WAY 267,464 dihydrochloride, WAY 267464 HCl
    T291511432043-31-6
    WAY267464 is a nonpeptide small-molecule OT agonists with anxiolytic activity. WAY267464 may be used for modulation of potency, selectivity over the structurally similar vasopressin receptors, CNS penetration, and oral bioavailability.
    • 待估
    35日内发货
    规格
    数量
  • PF-06767832
    PF-6767832,PF6767832,PF 6767832,PF 06767832
    T339501859081-58-5
    PF-06767832 is a high quality M1 selective PAM (M1 PAM EC50 = 60 nM; M2-M5 PAM EC50 > 10 microM; CNS MPO = 4.9). PF-06767832 has well aligned physicochemical properties, good brain penetration and pharmacokinetic properties. Extensive safety profiling
    • ¥ 10600
    6-8周
    规格
    数量
  • VU0486321
    VU 0486321,VU-0486321
    T350811816301-67-3
    VU0486321 is a potent mGlu1 PAM with moderate rat PK (CLp = 13.3. mL min kg,t1 2 = 54 min), good free fraction (human fu = 0.05, rat fu =0.03) and excellent CNS penetration (Kp = 1.02).
    • ¥ 10600
    6-8周
    规格
    数量
  • MW-150 hydrochloride
    MW-150 hydrochloride, MW01-18-150SRM hydrochloride
    T393431923773-01-6
    MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a potent and selective inhibitor of p38α MAPK, with a Ki value of 101 nM. It exhibits excellent CNS penetration and oral bioavailability. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) effectively suppresses the phosphorylation of MK2, a substrate of endogenous p38α MAPK, in activated glial cells.
    • ¥ 10600
    待询
    规格
    数量
  • TTBK1-IN-1
    TTBK1-IN-1
    T403482735015-60-6
    TTBK1-IN-1(compound 31)是一种强效和选择性的 tau 微管蛋白激酶 1 (TTBK1) 抑制剂(IC50=315 nM),具有中枢神经(CNS)渗透性,能够抑制疾病相关的Ser 422表位的tau磷酸化,可用于研究阿尔茨海默病。
    • ¥ 1460
    In stock
    规格
    数量
  • R-PSOP
    T612101185189-97-2
    R-PSOP is a potent and selective nonpeptidic NMUR2 antagonist, exhibiting binding affinity to human and rat NMUR2 with Ki values of 52 nM and 32 nM, respectively. This compound demonstrates moderate central nervous system (CNS) penetration and is valuable in the study of eating disorders, obesity, pain, and stress-related disorders [1].
    • ¥ 2890
    5日内发货
    规格
    数量
  • rho-kinase-in-2
    T614972573071-18-6
    Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK), which can penetrate the central nervous system (CNS). It exhibits a high affinity for ROCK2 with an inhibition constant (IC50) of 3 nM. This compound is of potential interest for further investigations in the field of Huntington's disease research [1].
    • ¥ 2980
    5日内发货
    规格
    数量