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Search Results for " amp-activated protein kinase "

Targets Recommended: AMPK STAT Autophagy

50

抑制剂 & 化合物

22

天然产物

1

化合物库

5

重组蛋白

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Cat. No.	Product Name
L1120	AMPK靶向分子库		80 compounds
	80 个靶向AMPK 的分子集合，可用于高通量和高内涵筛选；

化合物库

AMPK靶向分子库

Cat.No: L1120

Compounds: 80

Cat. No.	Product Name	Target	Signaling Pathways
T8476	RSVA405 RSVA 405	AMPK; STAT; Autophagy	Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells
	RSVA405 是一种具有口服活性的AMPK 激活剂，EC50值为 1 μM。它也是一种 STAT3 抑制剂，具有抗炎作用，可研究肥胖症。它通过促进 CaMKKβ 依赖的 AMPK 活化，从而抑制mTOR，并促进自噬以增加 Aβ 的降解。
T2374	HTH-01-015	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	HTH-01-015 是一种选择性 NUAK1 抑制剂，IC50为 100 nM。它抑制 NUAK1 的效力比抑制 NUAK2 高 100 倍以上，IC50大于10 μM。
T6285	GSK-690693 GSK690693	Serine Protease; Akt; PKC; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	GSK-690693 是一种泛 Akt 抑制剂，对 Akt1、Akt2和 Akt3的 IC50分别为 2 nM、13 nM 和9 nM。它也是一种 AMPK 的抑制剂，影响 ULK1 的活性，并能显著抑制 STING 依赖的 IRF3 的激活。
T13173	TMPA	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	TMPA 是一种核受体 Nur77 和 LKB1 相互作用的拮抗剂。
T7362	O-304	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	O-304 是 AMP 活化蛋白激酶 (AMPK) 的泛激活剂，可通过抑制 pAMPK 的去磷酸化来增加 AMPK 活性，可用于 2 型糖尿病和相关心血管并发症的研究。
T16099	MK8722	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	MK8722 是一种全身性泛 AMPK 激活剂。
T6291	WZ4003	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	WZ4003 是一种高度特异性 NUAK 激酶的有效抑制剂，能够抑制 NUAK1 和 NUAK2 的活性，IC50值分别为 20 和 100 nM。
T13411	ZLN024	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	ZLN024 是有效的 AMPK 变构激活剂，直接激活重组 AMPK α1β1γ1，AMPK α2β1γ1，AMPK α1β2γ1 和 AMPK α2β2γ1 异源三聚体，EC50分别为 0.42 μM，0.95 μM，1.1 μM 和 0.13 μM。
T11947	MARK4 inhibitor 1	Apoptosis; Others; AMPK	Apoptosis; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	MARK4 inhibitor 1 是一种MARK4的抑制剂，IC50值为1.54 μM。它抑制癌细胞增殖、转移，诱导凋亡。
T8740	COH-SR4 COH-SR4 (Mitochondria uncoupler SR4)	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) 是线粒体氧化磷酸化的解偶联剂，可调节 amp 依赖性激酶 (ampk)-雷帕霉素 (mtor) 信号的哺乳动物靶点，并抑制 hepg2 肝癌细胞的增殖。它对白血病、黑色素瘤、乳腺癌和肺癌显示出强大的抗增殖活性。它是一种AMPK 活化剂，通过激活 AMPK 来抑制脂肪细胞分化，可用于肥胖及代谢紊乱相关的研究。
T5187	MK-3903 MK 3903	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	MK-3903 是一种有选择性 AMP 激活的蛋白激酶 (AMPK) 激活剂，其EC50值为 8 nM。
T2468	A-769662 A 769662	AMPK; Fatty Acid Synthase	Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling
	A-769662 是一种可逆 AMPK 激活剂，EC50值为 0.8 μM。
T4427	PF-06409577 PF 06409577	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	PF-06409577 是一种具有口服活性的特异性 AMPK 变构激活剂，对α1β1γ1的EC50值为7 nM。
T10789	Chitosan oligosaccharide COS,壳聚糖低聚乳酸酯	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Chitosan oligosaccharide (COS) 是 β-(1→4)-连接的 D-氨基葡萄糖的寡聚体，Chitosan oligosaccharide可激活 AMPK ，抑制NF-κB 和 MAPK在内的炎症信号通路。
T8432	ASP4132	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	ASP4132 是一种口服活性的 AMPK 激活剂，EC50为 18 nM，具有抗癌活性。
T3546	STO-609 STO 609	CaMK; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; Neuroscience; PI3K/Akt/mTOR signaling
	STO-609 是一种特异性和细胞渗透性的 Ca2+/钙调蛋白依赖性蛋白激酶激酶抑制剂，用于重组 CaM-KKα 和 CaM-KKβ，Ki 值分别为 80 和 15 ng/mL。它抑制 Hela 细胞溶解物中的 AMP 活化蛋白激酶激酶活性，IC50值约为 0.02 g/ml。
T7955	EB-3D	Apoptosis; AMPK; AChR	Apoptosis; Chromatin/Epigenetic; Neuroscience; PI3K/Akt/mTOR signaling
	EB-3D 是一种选择性胆碱激酶 α 抑制剂，对 ChoKα1 的IC50值为 1 μM。它影响 ChoKα 表达、AMPK 激活、细胞凋亡、内质网应激和脂质代谢，具有抗癌活性。
T41162	ZLN 024 hydrochloride	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	ZLN 024 hydrochloride 是一种 AMPK 变构激活剂，可刺激无活性的 α1 亚基截短 α1 (1-394) 和 α1 (1-335)，但不刺激 α1 (1-312)。
T6854	GSK621	Apoptosis; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	GSK621 是一种特异性AMPK 激动剂，对 AML 细胞系的IC50值为13-30 μM。它可诱导自噬和凋亡，还可诱导eiF2α磷酸化。
TQ0028	EX229 Compound 991,C991	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	EX229 (C991) 是一种 AMP 活化蛋白激酶 (AMPK) 的有效变构激动剂，是苯并咪唑衍生物，其对 α1β1γ1、α2β1γ1 和 α1β2γ1 的Kd 值分别为 0.06、0.06 和 0.51 μM。
T6920	ON123300	FGFR; c-RET; JAK; CDK; PDGFR; Src; AMPK	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	ON123300 是一种可透过血脑屏障的多激酶抑制剂，作用于 CDK4、CDK6、Ark5、PDGFRβ、FGFR1、RET 和 Fyn，IC50值为3.9、9.82、5、26、26、9.2和11 nM。它在脑肿瘤中抑制 Akt 磷酸化及激活 Erk。
T1453	Phenformin hydrochloride Phenformin HCl,Phenethylbiguanide hydrochloride,盐酸苯乙福明	Potassium Channel; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; PI3K/Akt/mTOR signaling
	Phenformin hydrochloride (Phenformin HCl) 是一种具有抗高血糖活性的双胍类抗糖尿病药物，能够使 AMPK 活化。
T16156	MT 63-78	Apoptosis; AMPK; mTOR	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	MT 63-78 是一种有效的直接AMPK 激活剂，EC50为 25 μM。它诱导细胞有丝分裂阻滞和细胞凋亡，通过抑制脂肪生成和mTORC1途径来阻止前列腺癌的生长，具有抗肿瘤作用。
T1477	AICAR NSC105823,AICA Riboside,Acadesine,阿卡地新,AICAR (Acadesine)	Mitophagy; YAP; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells
	AICAR (NSC105823) 是一种腺苷类似物，是一种 AMP 激活的蛋白激酶激活剂，可用于治疗急性淋巴细胞白血病和糖尿病。
T19659	Annaosanchun 雄甾-3,5,6三醇,YC6,YC-6,YC 6	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	Annaosanchun (YC-6) 有可能用于治疗急性缺血性中风(AIS)。
T8526	Metformin 甲福明,二甲双胍,1,1-Dimethylbiguanide	Mitophagy; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Metformin (1,1-Dimethylbiguanide) 是一种 AMPK 激活剂，具有血脑屏障渗透性。Metformin 可通过提高胰岛素敏感性和减少肠道对葡萄糖的吸收来改善血糖控制，常用于 2 型糖尿病的研究。
T1977	Dorsomorphin Compound C,BML-275	AMPK; Autophagy; TGF-beta/Smad	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells
	Dorsomorphin (BML-275) 是一种 AMPK 抑制剂 (Ki=109 nM)，具有选择性和 ATP 竞争性。Dorsomorphin 可以抑制 BMP I 型受体 ALK2、ALK3 和 ALK6。Dorsomorphin 可诱导自噬，具有抗肿瘤活性。
T3625	Bempedoic acid ETC1002,ESP-55016,ETC 1002,ETC-1002	ATP Citrate Lyase; AMPK	Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling
	Bempedoic acid (ETC1002) 是一种 ATP-柠檬酸裂解酶抑制剂，可激活AMPK。它是脂质和碳水化合物代谢的调节剂。
T0858	Flufenamic acid Arlef,Nichisedan,氟灭酸,氟芬那酸,Achless	Potassium Channel; Calcium Channel; Chloride channel; COX; AMPK; Parasite	Chromatin/Epigenetic; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling
	Flufenamic acid (Arlef) 是一种非甾体类抗炎剂，是一种邻氨基苯甲酸衍生物，具有镇痛、抗炎和解热的特性。它用于肌肉骨骼和关节疾病。
T20029	Buformin hydrochloride NSC528218,NSC-528218,盐酸丁双胍,NSC 528218	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Buformin hydrochloride (NSC-528218) 是一种有效的 AMPK 激活剂，是一种双胍类的口服抗糖尿病药物。Buformin 延缓胃肠道对葡萄糖的吸收，增加胰岛素敏感性和葡萄糖对细胞的吸收，并抑制肝脏对葡萄糖的合成。Buformin 也具有抗癌活性，可用于各种癌症研究。
T9010	IMM-H007	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	IMM-H007 是一种新型降脂剂，可增加 abca1 蛋白的表达。
T0740	Metformin hydrochloride Metformin HCl,盐酸二甲双胍,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride	Mitophagy; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) 是一种抗糖尿病药物，抑制结肠、前列腺等多种 Y 细胞的增殖，具有作为抗 Y 药物的潜在功能。它可以透过血脑屏障，诱导自噬。
T8929	BC1618 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-	Mitophagy; Others; E1/E2/E3 Enzyme; AMPK	Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling; Ubiquitination
	BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) 是一种具有口服活性的 Fbxo48 抑制剂，可刺激 Ampk 依赖性信号传导。它促进线粒体分裂，促进自噬并提高肝脏胰岛素敏感性。
T6146	Dorsomorphin dihydrochloride BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride	AMPK; Autophagy; TGF-beta/Smad	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells
	Dorsomorphin dihydrochloride (BML-275 2HCl) 是一种 AMPK 抑制剂 (Ki=109 nM)，具有选择性和 ATP 竞争性。Dorsomorphin dihydrochloride 可以抑制 BMP I 型受体 ALK2、ALK3 和 ALK6。Dorsomorphin dihydrochloride 可诱导自噬，具有抗肿瘤活性。
TP1760L	AMARA peptide acetate(163560-19-8 free base)	Others	Others
	AMARA peptide acetate(163560-19-8 free base) 是 SIK 和 AMPK 的底物。AMARA 肽是蛋白激酶家族几个成员的底物。它由 AMP 激活的蛋白激酶 (AMPK) 的磷酸化位点组成。
T7535	RGX-202 胍基丙酸,β-GPA,3-Guanidinopropionic Acid	AMPK; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	RGX-202 (β-GPA) 是口服有活性的SLC6A8转运蛋白抑制剂。它在体内外均能够强烈地抑制肌酸输入，降低细胞内磷酸肌酸和 ATP 水平，诱导肿瘤凋亡，可于研究肿瘤。
T36420	IM-156 acetate HL271 acetate	Others	Others
	IM-156 acetate 是一种 NADH 脱氢酶（IC50=2.2μM）和 AMP-激活蛋白激酶α（AMPKα）的激活剂，是一种可口服且具有生物利用的线粒体氧化磷酸化（OxPhos）抑制剂。IM-156 acetate 可增加 AMPKα活性，抑制氯己酮诱导的大鼠腹膜纤维化，抑制肿瘤生长。
T19661	8-Chloroadenosine NSC 354258,8-Cl-Ado,NSC354258,NSC-354258,8-氯腺嘌呤核苷	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	8-Chloroadenosine (NSC-354258) 是一种 5' AMP 激活的蛋白激酶激动剂，可能用于治疗慢性淋巴细胞白血病。它的活性与 mTOR 通路的抑制有关。它是一种核苷类似物。在体内代谢为 8-氯-ATP。在转录过程中掺入 RNA 并抑制 RNA 合成。在 MM.1S、RPMI-8226 和 U266 癌细胞系中表现出细胞毒性；在 A549 和 H1299 细胞中诱导 G2/M 细胞周期停滞和有丝分裂灾难。它已被证明可消耗 ATP 并抑制血液恶性肿瘤以及肺癌和乳腺癌细胞系中的肿瘤生长。
T70085	IND 1316	Others	Others
	IND 1316 is an activator of AMP-activated protein kinase (AMPK).
T70806	Metformin icosapent	Others	Others
	Metformin icosapent is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.
T71222	Metformin glycinate	Others	Others
	Metformin glycinate is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.
TP1812	SAMS
	SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).
T69405	Metformin embonate	Others	Others
	Metformin embonate is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.
T69049	Metformin orotate	Others	Others
	Metformin orotate is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.
T20028	Janumet Efficib,Janumet XR,Metformin / sitagliptin,Metformin hydrochloride mixture with sitagliptin phosphate	Others	Others
	Metformin hydrochloride mixture with sitagliptin phosphate is an AMP-activated protein kinase stimulant. It is also a CD26 antigen inhibitor, Gluconeogenesis inhibitor, and Glucose modulator.
TP1760	AMARA peptide
	AMARA peptide is a substrate for SIK and AMPK.AMARA peptide is a minimal substrate of several members of the protein kinases family. It consists of the phosphorylation site for AMP-activated Protein Kinase (AMPK).
T83740	Ziptide TFA
	Ziptide是多种丝氨酸/苏氨酸蛋白激酶的肽底物，包括MAPK激活蛋白激酶2（MAPKAPK2）、MAPKAPK3、MAPKAPK5、checkpoint kinase 1（Chk1）、AMP激活蛋白激酶（AMPK）和钙/钙调蛋白依赖型蛋白激酶II（CamKII）。它被用来评估CamKII活性以用于抑制剂的开发。
T73224	AMPK-IN-1	Others	Others
	AMPK-IN-1 是一种 AMPK 激活剂 (对亚型α2β2γ1的 EC50为 551 nM)。AMPK-IN-1 可导致 eEF2 的 mTORC1-非依赖性磷酸化。
T63177	AMPK activator 8	Others	Others
	AMPK activator 8 (Compound 2) 是一种 AMP 激活的蛋白激酶 (AMPK) 激活剂，能够作用于 rAMPK α1β1γ1 (EC50: 11 nM)、rAMPK α2β1γ1 (EC50: 27 nM)、rAMPK α1β2γ1 (EC50: 4 nM)、rAMPK α2β2γ1 (EC50: 2 nM)、rAMPK α2β2γ3 (EC50: 4 nM)。AMPK activator 8 能够用于研究 2 型糖尿病。
T79226	AMPK activator 11	Mitochondrial Metabolism	Metabolism
	AMPK activator11 是一种抗肿瘤活性纳米级化合物，有效针对多种CRC。通过激活AMPK及上调OXPHOS（mitochondrial metabolism），该化合物能选择性抑制RKO异种移植物生长，应用于肿瘤和代谢性疾病研究领域。

化合物

Cat.No: T8476

Synonym: RSVA 405

Target: AMPK, STAT, Autophagy

Cat.No: T2374

Target: AMPK

Cat.No: T6285

Synonym: GSK690693

Target: Serine Protease, Akt, PKC, AMPK, Autophagy

Cat.No: T13173

Target: Others, AMPK

Cat.No: T7362

Target: AMPK

Cat.No: T16099

Target: AMPK

Cat.No: T6291

Target: AMPK

Cat.No: T13411

Target: AMPK

MARK4 inhibitor 1

Cat.No: T11947

Target: Apoptosis, Others, AMPK

Cat.No: T8740

Synonym: COH-SR4 (Mitochondria uncoupler SR4)

Target: Others, AMPK

Cat.No: T5187

Synonym: MK 3903

Target: AMPK

Cat.No: T2468

Synonym: A 769662

Target: AMPK, Fatty Acid Synthase

Cat.No: T4427

Synonym: PF 06409577

Target: AMPK

Chitosan oligosaccharide

Cat.No: T10789

Synonym: COS,壳聚糖低聚乳酸酯

Target: AMPK

Cat.No: T8432

Target: AMPK

Cat.No: T3546

Synonym: STO 609

Target: CaMK, AMPK, Autophagy

Cat.No: T7955

Target: Apoptosis, AMPK, AChR

ZLN 024 hydrochloride

Cat.No: T41162

Target: AMPK

Cat.No: T6854

Target: Apoptosis, AMPK, Autophagy

Cat.No: TQ0028

Synonym: Compound 991,C991

Target: AMPK

Cat.No: T6920

Target: FGFR, c-RET, JAK, CDK, PDGFR, Src, AMPK

Phenformin hydrochloride

Cat.No: T1453

Synonym: Phenformin HCl,Phenethylbiguanide hydrochloride,盐酸苯乙福明

Target: Potassium Channel, AMPK, Autophagy

Cat.No: T16156

Target: Apoptosis, AMPK, mTOR

Cat.No: T1477

Synonym: NSC105823,AICA Riboside,Acadesine,阿卡地新,AICAR (Acadesine)

Target: Mitophagy, YAP, AMPK, Autophagy

Cat.No: T19659

Synonym: 雄甾-3,5,6三醇,YC6,YC-6,YC 6

Target: Others, AMPK

Cat.No: T8526

Synonym: 甲福明,二甲双胍,1,1-Dimethylbiguanide

Target: Mitophagy, AMPK, Autophagy

Cat.No: T1977

Synonym: Compound C,BML-275

Target: AMPK, Autophagy, TGF-beta/Smad

Cat.No: T3625

Synonym: ETC1002,ESP-55016,ETC 1002,ETC-1002

Target: ATP Citrate Lyase, AMPK

Flufenamic acid

Cat.No: T0858

Synonym: Arlef,Nichisedan,氟灭酸,氟芬那酸,Achless

Target: Potassium Channel, Calcium Channel, Chloride channel, COX, AMPK, Parasite

Buformin hydrochloride

Cat.No: T20029

Synonym: NSC528218,NSC-528218,盐酸丁双胍,NSC 528218

Target: AMPK

Cat.No: T9010

Target: Others, AMPK

Metformin hydrochloride

Cat.No: T0740

Synonym: Metformin HCl,盐酸二甲双胍,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride

Target: Mitophagy, AMPK, Autophagy

Cat.No: T8929

Synonym: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-

Target: Mitophagy, Others, E1/E2/E3 Enzyme, AMPK

Dorsomorphin dihydrochloride

Cat.No: T6146

Synonym: BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride

Target: AMPK, Autophagy, TGF-beta/Smad

AMARA peptide acetate(163560-19-8 free base)

Cat.No: TP1760L

Target: Others

Cat.No: T7535

Synonym: 胍基丙酸,β-GPA,3-Guanidinopropionic Acid

Target: AMPK, PPAR

Cat.No: T36420

Synonym: HL271 acetate

Target: Others

8-Chloroadenosine

Cat.No: T19661

Synonym: NSC 354258,8-Cl-Ado,NSC354258,NSC-354258,8-氯腺嘌呤核苷

Target: AMPK

Cat.No: T70085

Target: Others

Metformin icosapent

Cat.No: T70806

Target: Others

Metformin glycinate

Cat.No: T71222

Target: Others

Cat.No: TP1812

Metformin embonate

Cat.No: T69405

Target: Others

Metformin orotate

Cat.No: T69049

Target: Others

Cat.No: T20028

Synonym: Efficib,Janumet XR,Metformin / sitagliptin,Metformin hydrochloride mixture with sitagliptin phosphate

Target: Others

Cat.No: TP1760

Cat.No: T83740

Cat.No: T73224

Target: Others

AMPK activator 8

Cat.No: T63177

Target: Others

AMPK activator 11

Cat.No: T79226

Target: Mitochondrial Metabolism

Cat. No.	Product Name	Target	Signaling Pathways
T3889	Platycodin D	Prostaglandin Receptor; AMPK	Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Platycodin D 是从桔梗中分离得到的一种皂苷类天然产物，是AMPKα的激活剂，具有抗肥胖活性。它可刺激 TNF-α 合成或抑制 TNF-α mRNA 的降解。
TN1828	Kahweol	Apoptosis; NF-κB; AMPK	Apoptosis; Chromatin/Epigenetic; NF-κB; PI3K/Akt/mTOR signaling
	Kahweol 是小果咖啡的成分之一，可诱导细胞凋亡，具有抗炎、抗血管生成和抗癌活性。它通过激酶的活化抑制的脂肪生成和增加葡萄糖摄取。
TN1100	Nepodin	transporter; COX; AMPK; Parasite	Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling
	Nepodin 是从Rumex crispus 中分离的一种醌氧化还原酶抑制剂，具有抗糖尿病和抗疟疾的作用。。它通过激活 AMPK 刺激 GLUT4 向质膜的转运。
T7327	7-Methoxyisoflavone	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	7-Methoxyisoflavone 是单磷酸腺苷活化蛋白激酶 (AMPK) 的激活剂，是异黄酮衍生物。
T4S0800	Demethyleneberberine	P450; NOS; NF-κB; HIF; AMPK	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	Demethyleneberberine 是从黄连中提取的一种天然产物，是线粒体靶向抗氧化剂。它也可作为AMPK 激活剂，用于非酒精性脂肪性肝病的研究。它通过抑制NF-κB 通路和调节 Th 细胞的平衡来减轻小鼠结肠炎并抑制炎症反应。
T3904	Gomisin J	Calcium Channel; AMPK	Chromatin/Epigenetic; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Gomisin J 是在五味子中发现的小分子量木脂素，具有血管舒张活性，在非酒精性脂肪性肝病方面有研究潜力。它通过激活 AMPK、LKB1 和 Ca2+/钙调蛋白依赖性蛋白激酶 II 以及抑制 HepG2 细胞中的胎球蛋白 A 来调节脂肪生成酶和脂肪分解酶以及炎症分子的表达，从而抑制脂质积累。
T3881	Vaccarin	Integrin; Akt; PERK; AMPK	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Vaccarin 是从王不留行中提取的一种黄酮糖苷，可显著促进伤口愈合以及伤口部位的内皮和成纤维细胞增殖。它通过激活 AMPK 信号通路改善胰岛素抵抗和脂肪变性。
T5497	AMAROGENTIN 苦杏苷,苦龙胆酯苷	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Amarogentin 是要从 Swertia 和 Gentiana 根中提取的裂环烯醚萜苷，有抗氧化、抗肿瘤和抗糖尿病活性，具有保肝和免疫调节作用。它通过激活 AMPK 发挥有益的血管代谢作用。它促进细胞凋亡，阻止 G2/M 细胞周期和下调 PI3K/Akt/mTOR 信号通路。
T2S0820	Karanjin 干华豆晶 4,水黄皮素	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Karanjin 是干花豆中的主要活性呋喃黄酮醇成分，可通过细胞周期阻滞诱导癌细胞死亡，促进细胞凋亡，还通过提高AMPK 的方式诱导骨骼肌细胞 GLUT4 易位。
T3405	[6]-Gingerol 6-Gingerol,gingerol,(S)-(+)-[6]Gingerol,6-姜酚	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	[6]-Gingerol ((S)-(+)-[6]Gingerol) 是一种从生姜中分离的活性物质，具有抗癌，抗炎和抗氧化活性。
T5552	Methyl cinnamate	Tyrosinase; Antibacterial; AMPK	Chromatin/Epigenetic; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Methyl cinnamate 是花椒的有效成分，也是一种天然香料。它是一种防止食品褐变的酪氨酸酶抑制剂，具有抗菌活性。它通过由 CaMKK2-AMPK 信号途径介导的机制具有抗脂活性。
TN1911	Marein 马里苷,马里甙	transporter; Akt; HDAC; AMPK	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	Marein 能通过CaMKK/AMPK/GLUT1促进葡萄糖摄取，IRS/Akt/GSK-3β增加糖原合成，并通过Akt/FoxO1减少糖异生，从而改善 HepG2 细胞中高葡萄糖诱导的胰岛素抵抗。它对甲基乙二醛诱导的 PC12 细胞损伤具有神经保护作用，还有抗氧化、降压、降血脂和抗糖尿病作用。
T2851	Daphnetin 7,8-Dihydroxycoumarin,Daphnetol,瑞香素	EGFR; PKA; PKC; Parasite; Autophagy	Angiogenesis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Daphnetin (7,8-Dihydroxycoumarin) 是从 Genus Daphne 中分离得到的香豆素衍生物，有抗氧化、抗炎、抗疟疾和解热作用，可用于凝血功能障碍、类风湿性关节炎等疾病的相关研究。
TN1499	Cimiracemoside C 千层纸素A-7-0-Β-D-葡萄糖醛酸苷,Cimicifugoside M	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Cimiracemoside C (Cimicifugoside M) 是在升麻中发现的一种天然产物，可激活 AMPK 并具有抗糖尿病的潜在活性。
T19500	Palmitelaidic Acid trans-Palmitoleic acid,9-trans-Hexadecenoic acid,软脂酸	Glucokinase; AMPK; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	trans-Palmitelaidic Acid (trans-Palmitoleic acid) 是palmitoleic acid 的反式异构体。Palmitoleic acid 是血清和组织中最丰富的脂肪酸之一。
T13265	Urolithin B 尿石素B,3-羟基-6H-苯并[C]苯并吡喃-6-酮	ERK; NF-κB; Akt; Endogenous Metabolite; JNK; AMPK	Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	Urolithin B 是一种 ellagitannins 的肠道微生物代谢产物，具有抗炎和抗氧化作用。它也是骨骼肌质量的调节因子，通过减少 IκBα 的磷酸化和降解来抑制 NF-κB 活性，并抑制 JNK、ERK 和 Akt 的磷酸化，并增强 AMPK 的磷酸化。
T2750	Ginkgolide C 银杏内酯C,BN-52022	MMP; Sirtuin; Endogenous Metabolite; AMPK	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Ginkgolide C (BN-52022) 是从银杏叶中分离到的一种黄酮类天然产物，可增强体内大鼠的心脏功能，具有减少血小板聚集，改善阿尔兹海默症等作用。
T0800	Danthron Dantron,1,8-Dihydroxyanthraquinone,1,8-二羟基蒽醌,丹蒽醌,Chrysazin,Antrapurol	Virus Protease; Antibacterial; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Danthron (Antrapurol) 是一种从中药 rhubarb 中提取的天然产物，可通过激活 AMPK 来调节葡萄糖和脂质代谢。
T1020	Doxorubicin hydrochloride Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,DOX hydrochloride,盐酸阿霉素,NSC 123127	Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素，是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化，还可诱导凋亡和自噬。
T1456	Doxorubicin Hydroxydaunorubicin,DOX,阿霉素,Adriamycin	Topoisomerase; AMPK; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素，具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II，IC50分别为0.8 μM 和2.67 μM，从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬。
T5S1172	Tiliroside 银椴甙,Tribuloside,银椴苷；椴树苷	Antioxidant	oxidation-reduction
	Tiliroside (Tribuloside) 是糖苷类黄酮，是 α-淀粉酶的非竞争性抑制剂(Ki:84.2 μM)。它抑制胃肠道中碳水化合物的消化和葡萄糖的吸收，具有抗糖尿病作用。
T28021	meso-Dihydroguaiaretic acid
	meso-Dihydroguaiaretic acid is an LXR-α antagonist, it inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells.

天然产物

Cat.No: T3889

Target: Prostaglandin Receptor, AMPK

Cat.No: TN1828

Target: Apoptosis, NF-κB, AMPK

Cat.No: TN1100

Target: transporter, COX, AMPK, Parasite

7-Methoxyisoflavone

Cat.No: T7327

Target: AMPK

Demethyleneberberine

Cat.No: T4S0800

Target: P450, NOS, NF-κB, HIF, AMPK

Cat.No: T3904

Target: Calcium Channel, AMPK

Cat.No: T3881

Target: Integrin, Akt, PERK, AMPK

Cat.No: T5497

Synonym: 苦杏苷,苦龙胆酯苷

Target: Apoptosis, AMPK

Cat.No: T2S0820

Synonym: 干华豆晶 4,水黄皮素

Target: Apoptosis, AMPK

Cat.No: T3405

Synonym: 6-Gingerol,gingerol,(S)-(+)-[6]Gingerol,6-姜酚

Target: Apoptosis, AMPK

Methyl cinnamate

Cat.No: T5552

Target: Tyrosinase, Antibacterial, AMPK

Cat.No: TN1911

Synonym: 马里苷,马里甙

Target: transporter, Akt, HDAC, AMPK

Cat.No: T2851

Synonym: 7,8-Dihydroxycoumarin,Daphnetol,瑞香素

Target: EGFR, PKA, PKC, Parasite, Autophagy

Cimiracemoside C

Cat.No: TN1499

Synonym: 千层纸素A-7-0-Β-D-葡萄糖醛酸苷,Cimicifugoside M

Target: AMPK

Palmitelaidic Acid

Cat.No: T19500

Synonym: trans-Palmitoleic acid,9-trans-Hexadecenoic acid,软脂酸

Target: Glucokinase, AMPK, PPAR

Cat.No: T13265

Synonym: 尿石素B,3-羟基-6H-苯并[C]苯并吡喃-6-酮

Target: ERK, NF-κB, Akt, Endogenous Metabolite, JNK, AMPK

Cat.No: T2750

Synonym: 银杏内酯C,BN-52022

Target: MMP, Sirtuin, Endogenous Metabolite, AMPK

Cat.No: T0800

Synonym: Dantron,1,8-Dihydroxyanthraquinone,1,8-二羟基蒽醌,丹蒽醌,Chrysazin,Antrapurol

Target: Virus Protease, Antibacterial, AMPK, Autophagy

Doxorubicin hydrochloride

Cat.No: T1020

Synonym: Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,DOX hydrochloride,盐酸阿霉素,NSC 123127

Target: Apoptosis, Mitophagy, HBV, HIV Protease, Topoisomerase, Antibacterial, Antibiotic, AMPK, Autophagy, ADC Cytotoxin

Cat.No: T1456

Synonym: Hydroxydaunorubicin,DOX,阿霉素,Adriamycin

Target: Topoisomerase, AMPK, ADC Cytotoxin

Cat.No: T5S1172

Synonym: 银椴甙,Tribuloside,银椴苷；椴树苷

Target: Antioxidant

meso-Dihydroguaiaretic acid

Cat.No: T28021

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02481	PRKAG1 Protein, Mouse, Recombinant (His) Prkag1,5'-AMP-activated protein <...	Mouse	E. coli
	PRKAG1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.6 kDa and the accession number is O54950.
TMPH-02480	PRKAB1 Protein, Mouse, Recombinant (His) 5'-AMP-activated protein kina...	Mouse	E. coli
	PRKAB1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.1 kDa and the accession number is Q9R078.
TMPH-02479	PRKAA1 Protein, Mouse, Recombinant (E. coli, His) 5'-AMP-activated protein kina...	Mouse	E. coli
	PRKAA1 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.8 kDa and the accession number is Q5EG47.
TMPH-02478	PRKAA1 Protein, Mouse, Recombinant (His) Prkaa1,Tau-protein kinase PRKAA1,Hydroxyme...	Mouse	Baculovirus Insect Cells
	PRKAA1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with N-6xHis tag. The predicted molecular weight is 65 kDa and the accession number is Q5EG47.
TMPJ-00886	ATF1 Protein, Human, Recombinant (His) Cyclic AMP-dependent transcription factor ATF-1,Act...	Human	E. coli
	Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. ATF1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It also binds to the ...

重组蛋白

PRKAG1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02481

Species: Mouse

Expression System: E. coli

PRKAB1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02480

Species: Mouse

Expression System: E. coli

PRKAA1 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02479

Species: Mouse

Expression System: E. coli

PRKAA1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02478

Species: Mouse

Expression System: Baculovirus Insect Cells

ATF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00886

Species: Human

Expression System: E. coli

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