4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenol

4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-derived PROTAC linker employed for the synthesis of PROTACs[1].

Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接，得到 PROTAC IRAK4 degrader-1。

Thalidomide-4-OH (E3 ligase Ligand 2) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。

N-Boc-4-pentyne-1-amine 是一种基于烷基链的PROTAC连结剂，用于PROTAC MG-277[1]的合成。

m-PEG7-4-nitrophenyl carbonate 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid)可用于后续化学的带有烷基接头和末端酸的 Cereblon 配体。

BSJ-4-116 是一种高效的选择性 CDK12 降解剂，IC50 为 6 nM，是由 Cereblon 配体和 CDK 配体相连的 PROTAC。它通过提前终止转录来下调 DDR 基因，主要是通过增加聚腺苷酸化，具有抗增殖作用。

N-Boc-cis-4-hydroxy-L-proline methyl ester为不可降解(non-cleavable)的ADC linker，用于抗体药物偶联体(ADCs)合成。该化合物同时作为基于烷基链(alkyl chain)的PROTAC linker，适用于PROTAC合成。

Thalidomide 4'-ether-alkylC2-amine hydrochloride (halidomide-linker 6) 包含基于 Thalidomide 的 cereblon 配体和 linker，是合成的 E3 连接酶配体-linker 偶联物，可应用于 PROTAC 技术。

Pomalidomide 4'-PEG2-azide 是由E3 连接酶配体和linker 组成的偶联物，包括基于 Pomalidomide 的 cereblon 配体和linker。

1H-Isoindole-1,3(2H)-dione, 4-(2-aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)- 在生命科学相关研究中具有广泛的应用。

Lenalidomide-4-aminomethyl is a CRBN ligand derived from Lenalidomide, which is utilized for the recruitment of CRBN protein. By linking Lenalidomide-4-aminomethyl to the ligand, a PROTAC can be formed.

PROTACBRD9 Degrader-4 是一种针对BRD9的双功能降解剂，用于癌症研究。

Pomalidomide 4'-alkylC6-azide，一种Pomalidomide基础上的E3泛素连接酶cereblon(CRBN)配体，其作用为募集cereblon蛋白。通过linker连接至蛋白质配体，Pomalidomide 4'-alkylC6-azide能够形成PROTAC。

Methyl 3-hydroxypropanoate is a PROTAC linker compound, which belongs to the alkyl ether family. It is commonly employed in the synthesis of PROTACs.

PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9, thereby modulating transcriptional activity.

PROTACAR Degrader-4 包含IAP 配体结合基团，linker 和雄激素受体 (AR) 配体结合基团。基于cIAP1的降解剂也被称为SNIPER。

Negative control for TBK1 PROTAC 3i. Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64585。

PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4).

cis-4-Hydroxy-D-proline hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66933，CAS号为 77449-94-6。

D-Proline, 4-hydroxy-, methyl ester hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65606，CAS号为 114676-59-4。

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a short PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Thalidomide - linker 11 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-based PROTAC linker suitable for synthesizing PROTACs[1].

PROTAC ER Degrader-4 is a PROTAC degrader of the estrogen receptor (ER) with an IC50 of 0.8 nM.

Lenalidomide 4'-alkyl-C3-azide（化合物4a）是经过点击化学修饰的Lenalidomide，用于PROTACs的合成。作为一种口服活性免疫调节剂，Lenalidomide是泛素E3连接酶cereblon（CRBN）的配体。该化合物含Azide基团，能够通过铜催化的叠氮-炔环加成反应（CuAAc）与含Alkyne基团的分子反应，同时也能与含DBCO或BCN基团的分子通过菌株促进的炔-叠氮环加成反应（SPAAC）进行反应。

Lenalidomide 4'-PEG2-azide是一种Cereblon配体，基于Lenalidomide开发，用于招募CRBN蛋白。通过linker，Lenalidomide 4'-PEG2-azide能与蛋白质配体连接，进而形成PROTAC。

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66976，CAS号为 147266-92-0。

Thalidomide-4-O-C10-NH2 hydrochloride 是一种Thalidomide衍生的cereblon配体，能募集CRBN蛋白。该化合物可利用linker与特定的靶蛋白配体结合，用以构建PROTAC分子，如THAL-SNS-032。

Phenyl-glutarimide 4'-piperazine是一种具有piperazine功能化的cereblon配体，可用于PROTACDegrader的开发。该化合物可用于开发PG-PROTACs，与使用IMiD（immunomodulatory imide drug）类似物合成的PROTACs相比，展示出改善的水解稳定性和效力。

N-Boc-cis-4-hydroxy-D-proline methyl ester 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66907，CAS号为 114676-69-6。

DNA crosslinker 4 (dihydrochloride) 作为高效的DNA小沟结合剂，对NCI-H460、A2780和MCF-7癌细胞表现出显著抑制活性，适用于抗癌研究。

4-Boc-amino-22-dimethylbutyric acid is an alkyl ether-derived PROTAC linker, suitable for the synthesis of PROTACs.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG2 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

ZXH-4-130 is a potent and selective CRBN degrader, functioning as a hetero-PROTAC compound with the inclusion of CRBN-VHL.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG3 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Thalidomide amide-alkylC8-amine PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Lenalidomide-4-OH is a cereblon (CRBN) ligand derived from Lenalidomide, utilized in the recruitment of the CRBN protein. It can be conjugated to the protein ligand via a linker, facilitating the formation of PROTAC.

Thalidomide-4-C3-NH2 hydrochloride is a Thalidomide-derived cereblon ligand utilized for the recruitment of CRBN protein. This compound can be linked to the ligand for protein using a linker to create PROTACs.

4-(N-Boc-amino)-1,6-heptanedioic acid is an alkyl ether-based linker, suitable for PROTAC synthesis [1].

4-Bromobutylphosphonic acid is an alkyl chain-derived PROTAC linker employed for the synthesis of PROTACs[1].

Tetraethyl butane- 1, 4- diylbis(phosphoramid ate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

4-Maleimidobutyric acid is an alkyl chain-derived PROTAC linker that enables the synthesis of PROTACs[1].

(4-Oxo-4H-quinazolin-3-yl)-acetic acid is an alkyl chain-derived PROTAC linker suitable for the synthesis of PROTACs[1].

cIAP1 ligand 4, a ligand for E3 ligase, is utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras).

PROTACFLT-3degrader 4 是一种口服活性强的 CRBN 基于的 FLT3-PROTAC 降解剂，能够通过泛素-蛋白酶体系统有效降解 FLT3-ITD。此化合物对 FLT3-ITD 突变的急性髓性白血病 (AML) 细胞展现出高度选择性。

Thalidomide-4-O-C12-NH2 hydrochloride为基于Thalidomide的cereblon配体，能够招募CRBN蛋白。该化合物可利用linker与目标蛋白配体结合，构建PROTAC分子，如THAL-SNS-032。