Carlinoside could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction. Carlinoside upregulates Nrf2 gene expression, increases its nuclear translocation and stimulates UGT1A1 promoter activity.
Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt PKB activation, MITF, and also by the subsequent downregulation of tyrosinase and TRP-1 production. Hag
2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran exhibits radical scavenging activities and inhibits mushroom tyrosinase with an IC50 value of 5.2 [micronM], acting as a competitive inhibitor.