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Ifabotuzumab (KB004) 是靶向 EphA3的 IgG1κ 抗体 (KD=610 pM)。Ifabotuzumab 能够导致肿瘤细胞凋亡,并激活抗体依赖性细胞介导的细胞毒作用 (ADCC),破坏肿瘤脉管系统。Ifabotuzumab 能够减少人特发性肺纤维化 (IPF) CCR10+细胞,改善肺纤维化。
Ifabotuzumab (KB004) 是靶向 EphA3的 IgG1κ 抗体 (KD=610 pM)。Ifabotuzumab 能够导致肿瘤细胞凋亡,并激活抗体依赖性细胞介导的细胞毒作用 (ADCC),破坏肿瘤脉管系统。Ifabotuzumab 能够减少人特发性肺纤维化 (IPF) CCR10+细胞,改善肺纤维化。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | 询价 | 期货 |
产品描述 | Ifabotuzumab (KB004), an IgG1κ antibody, specifically binds to EphA3 (K D =610 pM), inducing tumor cell apoptosis, activating antibody-dependent cell-mediated cytotoxicity (ADCC), and damaging tumor vasculature. Additionally, Ifabotuzumab effectively reduces CCR10+ cells in human idiopathic pulmonary fibrosis (IPF) and ameliorates pulmonary fibrosis, demonstrating its therapeutic potential [1] [2]. |
CAS No. | 2147698-66-4 |
存储 | Shipping with blue ice. |
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