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Search Results for " stomach cancer "

Targets Recommended: Glucokinase Autophagy

5

抑制剂 & 化合物

2

天然产物

1

化合物库

4

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L6600	胃肠炎天然产物库		219 compounds
	219 种胃肠炎相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

胃肠炎天然产物库

Cat.No: L6600

Compounds: 219

Cat. No.	Product Name	Target	Signaling Pathways
T2455	PFK-015 PFK15,PFK 015	Glucokinase; Autophagy	Autophagy; Metabolism
	PFK-015 (PFK15) 是一种有效的 PFKFB3 抑制剂，对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性，IC50为20 nM。
T1575	Nizatidine Axid,Acinon,尼扎替丁,Zanizal	AChE; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Nizatidine (Acinon) 是一种竞争性和可逆的组胺 H2 受体拮抗剂，具有抗酸活性，可用于胃溃疡的研究。
T72107	Werner syndrome RecQ helicase-IN-1	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Werner syndrome RecQ helicase-IN-1 是一种有效的 Werne r 综合征 RecQ DNA 解旋酶 (WRN) 抑制剂，可用研究像结肠癌和胃癌等癌症。
T18310	AZ1508 MC-Lys-MMETA	Others	Others
	AZ1508, a tubulin inhibitor[1], serves as a drug-linker conjugate for antibody-drug conjugates (ADC) targeting breast and stomach cancer treatment.
T37594	Pericosine A	Others	Others
	Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 μM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 μg/ml. It also reacts with organosulfur compounds in skunk spray to form stable t...

化合物

Cat.No: T2455

Synonym: PFK15,PFK 015

Target: Glucokinase, Autophagy

Cat.No: T1575

Synonym: Axid,Acinon,尼扎替丁,Zanizal

Target: AChE, Histamine Receptor

Werner syndrome RecQ helicase-IN-1

Cat.No: T72107

Target: DNA/RNA Synthesis

Cat.No: T18310

Synonym: MC-Lys-MMETA

Target: Others

Cat.No: T37594

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5S0384	Rhapontin Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside	Apoptosis; Others	Apoptosis; Others
	Rhapontin (Ponticin) 是药用大黄的一种成分，可减轻KK/Ay 糖尿病小鼠肝脏脂肪变性，改善血糖和血脂，表明其具有显着的降糖作用，有望成为治疗2型糖尿病及其并发症的新药。
TN5952	2,3-Dihydro-3α-methoxynimbolide
	2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in stomach (AZ521) cancer cell line.

天然产物

Cat.No: T5S0384

Synonym: Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside

Target: Apoptosis, Others

2,3-Dihydro-3α-methoxynimbolide

Cat.No: TN5952

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01456	Mucin-17/MUC17 Protein, Human, Recombinant (His) Mucin-17, MUC-17, MUC17, MUC3, MUC-3	Human	HEK293 Cells
	Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin17 (MUC17) was more highly expressed in gastric cancer (GC) specimens, with favourable prognosis for patients. And that p38 signalling is a key factor involved in MUC17-mediated inhibition of GC cell proliferation and protection against inflammatory stimulation, MUC17 upregulates the expression ...
TMPY-03601	PDRG1 Protein, Human, Recombinant (His) PDRG,p53 and DNA-damage regulated 1,C20orf126	Human	E. coli
	PDRG1, also known as C2orf126, belongs to the prefoldin subunit beta family. It is predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs. PDRG1 may play a role in chaperone-mediated protein folding. PDRG1 is overexpressed in tumors relative to normal tissues. Its expression is upregulated in multiple malignancies including cancers of the colon, rectum, ovary, lung, stomach, breast and uterus when compared to their respective matched normal tissue...
TMPY-00519	Gastrokine 1 Protein, Human, Recombinant (His) UNQ489/PRO1005,CA11,foveolin,BRICD1,AMP18,gastrokine 1,FOV	Human	Baculovirus Insect Cells
	Gastrokine 1 (GKN1) belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. GKN1 is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in gastric cancer. GKN1-mediated inhibition of APP processing might represent a new approach for the prevention and therapy of Alzheimer's disease (AD). In the presence of GKN2, GKN1 loses its ability to decrease cell proliferation, induce apoptosis, and inhibit epigenetic alterati...
TMPY-01033	IL-32 Protein, Human, Recombinant (isoform alpha, His) IL-32δ,IL-32beta,IL32,TAIFc,IL-32γ,白介素,IL-32 Protein(isoform...	Human	HEK293 Cells
	IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,...

重组蛋白

Mucin-17/MUC17 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01456

Species: Human

Expression System: HEK293 Cells

PDRG1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03601

Species: Human

Expression System: E. coli

Gastrokine 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00519

Species: Human

Expression System: Baculovirus Insect Cells

IL-32 Protein, Human, Recombinant (isoform alpha, His)

Cat.No: TMPY-01033

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T71055	Albendazole-d7
	Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Alben...

同位素标记化合物

Cat.No: T71055

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