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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39472 |
NVP-CGM097 (stereoisomer)
NVP-CGM097 (stereoisomer),CGM097 stereoisomer,(R)-Nvp-Cgm097 |
Others | Others |
NVP-CGM097 (stereoisomer) is a non-bioactive stereoisomer of NVP-CGM097, which is a potent and selective inhibitor of MDM2. | |||
T10749 |
Cebranopadol ((1α,4α)stereoisomer)
GRT6005 (1α,4α)stereoisomer |
Others | Others |
Cebranopadol ((1α,4α)stereoisomer) is a stereoisomer of cebranopadol which is a potent ORL-1 agonist. | |||
T15597L |
ISA-2011B-P2
|
Others | Others |
ISA-2011B-P2 是 ISA-2011B 的立体异构体。ISA-2011B 是有效的 PIP5K1α 抑制剂, 具有抗肿瘤活性。 | |||
T84320 |
(Iso)-WAY-260022
(Iso)-NRI-022 |
Others | Others |
(Iso)-WAY-260022 ((Iso)-NRI-022) 是 WAY-260022 的一种立体异构体。WAY-260022 是去甲肾上腺素再摄取抑制剂,也是选择性 5-羟色胺和多巴胺转运蛋白抑制剂。 | |||
T12628 |
(R)-MG-132
(S,R,S)-(-)-MG-132,N-[(苯基甲氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-D-亮氨酰胺,Z-Leu-D-leu-leu-al |
Proteasome | Proteases/Proteasome; Ubiquitination |
(R)-MG-132 (Z-Leu-D-leu-leu-al) 是一种 MG-132 的对映异构体,是一种蛋白酶体 (proteasome) 抑制剂,细胞毒性比 MG-132 弱,是一种比 MG-132 更有效的proteasome 抑制剂。 | |||
T19618 |
(R)-(-)-JQ1 Enantiomer
(R)-(-)2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂环庚烷-6-基)乙酸叔丁酯 |
Epigenetic Reader Domain | Chromatin/Epigenetic |
(R)-(-)-JQ1 Enantiomer 是 (+)-JQ1 的立体异构体。 (+)-JQ1 是一种 BET 溴结构域抑制剂,对BRD4(1/2)的IC50 为 77 和 33 nM。 | |||
T22775 |
exo-IWR-1
exo-IWR 1 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
exo-IWR-1 (exo-IWR 1) 是一种 IWR-1 的阴性对照无活性异构体。其中IWR-1是一种端锚聚合酶抑制剂,能够抑制Wnt/β-catenin 信号传导途径。 | |||
T32137 |
Idonic acid
L-Idonate,L-Idonic acid |
Others | Others |
Idonic acid is a stereoisomer of gluconic acid. | |||
T36949 |
Niaprazine
|
5-HT Receptor; Adrenergic Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Niaprazine 是有效的组胺 H1 受体拮抗剂,具有抗组胺和抗血清素活性。Niaprazine 在睡眠障碍方面有研究的价值。 | |||
T25333 |
Dilevalol
Dilevalolum |
Others | Others |
Dilevalol, the RR-stereoisomer of labetalol, is a non-cardioselective beta-adrenoceptor antagonist with substantial partial beta 2-agonist and negligible alpha 1-blocking activity. | |||
T37899 |
UDP-β-D-Glucose (sodium salt)
|
Others | Others |
UDP-β-D-Glucose is the stereoisomer of UDP-α-D-glucose (sodium salt) . The activities of the UDP-β-D-glucose isomer are not known. | |||
T35447 |
10(S)-PAHSA
|
Others | Others |
10(S)-PAHSA is a stereoisomer of 10-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). | |||
T19114 |
(2S,4S)-Sacubitril
Sacubitril Impurity C,LCZ 696杂质C |
Others | Others |
(2S,4S)-Sacubitril (Sacubitril Impurity C) 是 Sacubitril 的杂质。其中 Sacubitril 是 NEP 抑制剂,可用于研究心力衰竭。 | |||
T37457 |
C18 L-threo Ceramide (d18:1/18:0)
C18 L-threo Ceramide (d18:1/18:0) |
Others | Others |
C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 0.21 mol% (16.8 μM). | |||
T23221 |
(R)-CCG-1423
|
Others | Others |
(R)-CCG-1423 is a stereoisomer of CCG-1423. CCG-1423 is a Rho inhibitor involved in blocking signaling through myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF). | |||
T36588 |
9(R)-PAHSA
|
Others | Others |
9(R)-PAHSA is a stereoisomer of 9-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). | |||
T23296 |
(S)-CCG-1423
|
Others | Others |
(S)-CCG-1423 is a stereoisomer of CCG-1423. CCG-1423 is a Rho inhibitor involved in blocking signaling through myocardin-related transcription factor A and serum response factor. | |||
T37455 |
C18 D-threo Ceramide (d18:1/18:0)
C18 D-threo Ceramide (d18:1/18:0) |
Others | Others |
C18 D-threoCeramide (d18:1/18:0) is a synthetic ceramide and stereoisomer of C18 ceramide .1It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50value of 16.6 μM.2[Matreya, LLC. Catalog No. 1855] 1.Koolath, S., Murai, Y., Suga, Y., et al.Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthaseChirality32(3)308-313(2019) 2.Usta, J., El Bawab, S., Roddy, P., et al.Structural requirements of ceramide and sphingosine bas... | |||
T35446 |
10(R)-PAHSA
|
Others | Others |
10(R)-PAHSA is a stereoisomer of 10-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). | |||
T36621 |
Prostaglandin F2β
|
Others | Others |
Prostaglandin F2β (PGF2β) is the 9β-hydroxy stereoisomer of PGF2α. It is much less active than PGF2α in antifertility and bronchoconstrictor activities. PGF2β exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of PGF2α. | |||
T85258 |
Endosulfan II
β-Endosulfan,Endosulfan B |
Others | Others |
Endosulfan II, an organochlorine insecticide and a stereoisomer of Endosulfan I, effectively targets various insects such as bollworms and tobacco budworms, with lethal doses (LD50s) of 4.14 and 4.95 mg/g, respectively. It interacts with GABA receptors in rat brain membranes, demonstrating an inhibition concentration (IC50) of 60 nM. Notably, Endosulfan II exhibits lower toxicity in rats compared to Endosulfan I, with LD50 values of 240 and 18 mg/kg, respectively. | |||
T37010 |
D-threo Sphinganine (d18:0)
D-threo Sphinganine (d18:0) |
Others | Others |
D-threo Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and L-erythro sphinganine (d18:0) . It induces autophagy in HCT116 cells when used at a concentration of 12 μM. D-threo Sphinganine (d18:0) is metabolized via sphinganine N-acyltransferase and sphinganine kinase in vivo in rat liver. | |||
T37665 |
Endosulfan I
|
Others | Others |
Endosulfan I is an organochlorine insecticide and a stereoisomer of endosulfan II . It is active against a variety of insects, including bollworms (LD50 = 0.63 mg/g). Endosulfan I binds to GABA receptors in rat brain membranes with an IC50 value of 30 nM and is toxic to rats (LD50 = 18 mg/kg). | |||
T84617 |
15-epi Prostaglandin A1
15-epi PGA1 |
Others | Others |
15-epiProstaglandin A1 (15-epiPGA1) is an R-stereoisomer of PGA1, belonging to the A-series prostaglandins derived from gorgonian soft corals. PGA1 is known for its effects on renal vasodilation, promoting sodium excretion through urine, and reducing arterial pressure in hypertensive individuals. However, the specific biological activities of 15-epiPGA1 have not yet been documented in published reports. | |||
T69060 |
Dextrallorphan
|
Others | Others |
Dextrallorphan (DXA) is an chemical of the morphinan class that is used in scientific research. It acts as a σ1 receptor agonist and NMDA receptor antagonist. It has no significant affinity for the σ2, μ-opioid, or δ-opioid receptor, or for the serotonin or norepinephrine transporter. As an NMDA receptor antagonist, in vivo, it is approximately twice as potent as dextromethorphan, and five-fold less potent than dextrorphan. Dextrallorphan was found to have a half maximal inhibitory concentration... | |||
T60893 |
Ep vinyl quinidine
|
Others | Others |
Ep vinyl quinidine (3-Epiquinine) 是Quinidine 的一种乙烯基立体异构体。Quinidine 可用于研究疟疾,也是一种抗心律失常剂。Quinidine 是口服有效的、选择性细胞色素 P450db 抑制剂,以及钾通道的有效阻断剂,IC50值为 19.9 μM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6468 |
D-glutamine
|
Mitophagy; Ferroptosis; Endogenous Metabolite; GluR; Autophagy | Apoptosis; Autophagy; Metabolism; Neuroscience |
D-Glutamine 是有细胞渗透性谷氨酰胺的 D 型立体异构体,是标准遗传密码编码的20种氨基酸之一。 | |||
T7938 |
Quinidine
奎尼丁,奎宁树 |
Parasite | Microbiology/Virology |
Quinidine 是一种抗心律失常剂,也是 K+通道的有效阻断剂,其 IC50值为 19.9 μM。它是一种选择性细胞色素 P450db 的有效抑制剂,也可研究疟疾。 | |||
T3S0895 |
Spirostan-3-ol
剑麻皂苷元,Sarsaponin |
Others | Others |
Spirostan-3-ol (Sarsaponin) 是 Sarsasapogenin 的立体异构体,是从植物材料中分离出来的类固醇糖苷,具有潜在的通过细胞凋亡的抗肿瘤活性。它可驱赶蜜蜂。 | |||
T3813 |
20(R)-Ginsenoside Rh2
20(R)-人参皂苷 RH2,(20R)Ginsenoside Rh2,Ginsenoside Rh2,20(R)-人参皂苷Rh2 |
Apoptosis; MMP; HSV | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
20(R)-Ginsenoside Rh2 (Ginsenoside Rh2) 是人参皂苷 Rh2 的次要立体异构体,具有基质金属蛋白酶抑制作用。它有抗癌、抗炎和抗氧化活性。 | |||
T1317 |
Cinchonidine
奎宁树,α-Quinidine,辛可尼丁,L-Cinchonidine |
5-HT Receptor; Serotonin Transporter; Parasite | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Cinchonidine (L-Cinchonidine) 是在金鸡纳和角蒿中发现的一种生物碱,有抗疟活性。 它是用于有机化学中不对称合成的砌块,是血清素转运蛋白的弱抑制剂。 | |||
T4806 |
H-D-Trp-OH
D-Tryptophan,D-色氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
H-D-Trp-OH (D-Tryptophan) 是一种色氨酸的 D 型异构体。它偶尔也会在自然界多肽中被发现,如海洋毒肽。 | |||
T4751 |
(2R,3R)-Butane-2,3-diol
(2R,3R)-(-)-2,3-Butanediol,levo-2,3-Butanediol,(2R,3R)-(-)-2,3-丁二醇 |
Others; Endogenous Metabolite | Metabolism; Others |
(2R,3R)-Butane-2,3-diol (levo-2,3-Butanediol) 是内源性代谢产物的一种。 | |||
T4429 |
Rauwolscine hydrochloride
Corynanthidine hydrochloride,盐酸育亨宾碱,萝芙素盐酸盐,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Rauwolscine hydrochloride (Isoyohimbine hydrochloride) 是一种高选择性的 α2 adrenergic 受体拮抗剂,Ki=12 nM。 | |||
T5219 |
L-Alloisoleucine
L-别异亮氨酸,L-allo-Isoleucine,(3R)-LS-Isoleucine,L(+)-Alloisoleucine |
Others; Endogenous Metabolite | Metabolism; Others |
L-Alloisoleucine (L-allo-Isoleucine) 是 L-异亮氨酸的立体异构体,是一种支链氨基酸,是人血浆的常见成分 (尽管水平较低)。 | |||
T12789 |
S-1-Propenyl-L-cysteine
|
Others | Others |
S-1-Propenyl-L-cysteine, a stereoisomer of S-allyl-l-cysteine, exhibits immunomodulatory effects and has been shown to decrease blood pressure in hypertensive animal models. | |||
T38036 |
Lumisterol
|
Others | Others |
Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol. Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities[1]. [1]. Anyamanee Chaiprasongsuk, et al. Protective Effects of Novel Derivatives of Vitamin D 3 and Lumisterol Against UVB-induced Damage in Human Keratinocytes Involve Activation of Nrf2 and p53 Defense Mechanisms. Redox Biol. 2019 Jun;24:101206. | |||
TN7265 |
16-epi Latrunculin B
|
Others | Others |
16-epiLatrunculin B, a stereoisomer of the actin polymerization inhibitor latrunculin B, was initially isolated from the Red Sea sponge N. magnifica. At concentrations of 5-10 µg/ml, it disrupts microfilament activity in actin disruption assays and exhibits cytotoxic effects on mouse KA31T and NIH3T3 tumor cells, with GI50 values of 1 and 4 µg/ml, respectively. Furthermore, it shows antiviral activity against herpes simplex type 1 virus, with an ED50 of 1 µg/ml. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0174 |
Eszopiclone-d8
|
||
Eszopiclone-d8 是 Eszopiclone 的氘代化合物。Eszopiclone 的 CAS 号为 138729-47-2。 | |||
TMIH-0469 |
Quinidine-d3
|
||
Quinidine-d3 是 Quinidine 的氘代化合物。Quinidine 的 CAS 号为 56-54-2。Quinidine 是一种抗心律失常剂,也是 K+通道的有效阻断剂,其IC50值为 19.9 μM。它是一种选择性细胞色素 P450db 的有效抑制剂,也可研究疟疾。 |